Structure, Organization, and Dynamics of Promyelocytic Leukemia Protein Nuclear Bodies

Jak-STAT Pathways and Transcriptional Activation in Response to IFNs and Other Extracellular Signaling Proteins

1994 • 5,932 citations

A decade of molecular biology of retinoic acid receptors

1996 • 2,893 citations

Role of the histone deacetylase complex in acute promyelocytic leukaemia

1998 • 1,091 citations

Fusion proteins of the retinoic acid receptor-α recruit histone deacetylase in promyelocytic leukaemia

1998 • 1,021 citations

Structure and Function in the Nucleus

1998 • 925 citations

A novel macromolecular structure is a target of the promyelocyte-retinoic acid receptor oncoprotein

1994 • 798 citations

Conjugation with the ubiquitin-related modifier SUMO-1 regulates the partitioning of PML within the nucleus

1998 • 676 citations

Retinoic acid regulates aberrant nuclear localization of PML-RARα in acute promyelocytic leukemia cells

1994 • 668 citations

Does this have a familiar RING?

1996 • 632 citations

Distinct interactions of PML-RARα and PLZF-RARα with co-repressors determine differential responses to RA in APL

1998 • 571 citations

Ataxin-1 with an expanded glutamine tract alters nuclear matrix-associated structures

1997 • 528 citations

Role of PML in Cell Growth and the Retinoic Acid Pathway

1998 • 522 citations

A novel ubiquitin-specific protease is dynamically associated with the PML nuclear domain and binds to a herpesvirus regulatory protein

1997 • 484 citations

The p300/CBP family: integrating signals with transcription factors and chromatin

1997 • 482 citations

APMLRARα transgene initiates murine acute promyelocytic leukemia

1997 • 455 citations

Structure, localization and transcriptional properties of two classes of retinoic acid receptor alpha fusion proteins in acute promyelocytic leukemia (APL): structural similarities with a new family of oncoproteins.

1992 • 441 citations

Arsenic-induced PML targeting onto nuclear bodies: Implications for the treatment of acute promyelocytic leukemia

1997 • 430 citations

The Disruption of ND10 during Herpes Simplex Virus Infection Correlates with the Vmw110- and Proteasome-Dependent Loss of Several PML Isoforms

1998 • 402 citations

Altered Myeloid Development and Acute Leukemia in Transgenic Mice Expressing PML-RARα Under Control of Cathepsin G Regulatory Sequences

1997 • 373 citations

Acute leukemia with promyelocytic features in PML/RARα transgenic mice

1997 • 366 citations

HSV-1 IE protein Vmw110 causes redistribution of PML.

1994 • 354 citations

PIC 1, a novel ubiquitin-like protein which interacts with the PML component of a multiprotein complex that is disrupted in acute promyelocytic leukaemia.

1996 • 347 citations

The periphery of nuclear domain 10 (ND10) as site of DNA virus deposition.

1996 • 336 citations

The solution structure of the RING finger domain from the acute promyelocytic leukaemia proto-oncoprotein PML.

1995 • 324 citations

Adenovirus replication is coupled with the dynamic properties of the PML nuclear structure.

1996 • 307 citations

Reduced Retinoic Acid-Sensitivities of Nuclear Receptor Corepressor Binding to PML- and PLZF-RARα Underlie Molecular Pathogenesis and Treatment of Acute Promyelocytic Leukemia

1998 • 303 citations

PML, a growth suppressor disrupted in acute promyelocytic leukemia.

1994 • 296 citations

Identification of a novel nuclear domain.

1991 • 285 citations

Fusion of retinoic acid receptor α to NuMA, the nuclear mitotic apparatus protein, by a variant translocation in acute promyelocytic leukaemia

1997 • 279 citations

Developmentally regulated expression of a human "finger"-containing gene encoded by the 5' half of the ret transforming gene.

1988 • 246 citations

Spatial Organization of Large-Scale Chromatin Domains in the Nucleus: A Magnified View of Single Chromosome Territories

1997 • 246 citations

Localization of nascent RNA and CREB binding protein with the PML-containing nuclear body

1998 • 244 citations

The PML growth-suppressor has an altered expression in human oncogenesis.

1995 • 241 citations

A dominant negative retinoic acid receptor blocks neutrophil differentiation at the promyelocyte stage.

1993 • 233 citations

Resistance to Virus Infection Conferred by the Interferon-Induced Promyelocytic Leukemia Protein

1998 • 229 citations

The Nuclear Domain 10 (ND10) Is Disrupted by the Human Cytomegalovirus Gene Product IE1

1996 • 213 citations

Human Cytomegalovirus Immediate Early Interaction with Host Nuclear Structures: Definition of an Immediate Transcript Environment

1997 • 205 citations

The Promyelocytic Leukemia Gene Product (PML) Forms Stable Complexes with the Retinoblastoma Protein

1998 • 166 citations

PML nuclear bodies are general targets for inflammation and cell proliferation.

1995 • 163 citations

An Arenavirus RING (Zinc-Binding) Protein Binds the Oncoprotein Promyelocyte Leukemia Protein (PML) and Relocates PML Nuclear Bodies to the Cytoplasm

1998 • 160 citations

The nucleolus

1994 • 156 citations

The Architectural Organization of Nuclear Metabolism

1996 • 150 citations

Nuclear dots: Actors on Many Stages

1997 • 148 citations

Nuclear domain 10 (ND10) associated proteins are also present in nuclear bodies and redistribute to hundreds of nuclear sites after stress

1995 • 142 citations

Exclusion of Int-6 from PML Nuclear Bodies by Binding to the HTLV-I Tax Oncoprotein

1996 • 135 citations

Coiled Bodies and Gems: Janus or Gemini?

1998 • 134 citations

Effects on differentiation by the promyelocytic leukemia PML/RARalpha protein depend on the fusion of the PML protein dimerization and RARalpha DNA binding domains.

1996 • 133 citations

Molecular Cloning of a New Interferon-induced PML Nuclear Body-associated Protein

1997 • 132 citations

Analysis of the Growth and Transformation Suppressor Domains of Promyelocytic Leukemia Gene, PML

1996 • 129 citations

Characterization of cryptic rearrangements and variant translocations in acute promyelocytic leukemia.

1997 • 128 citations

Leukemia-associated retinoic acid receptor α fusion partners, PML and PLZF, heterodimerize and colocalize to nuclear bodies

1997 • 123 citations

In vivo and in vitro characterization of the B1 and B2 zinc-binding domains from the acute promyelocytic leukemia protooncoprotein PML.

1996 • 116 citations

PML-containing nuclear bodies: Their spatial distribution in relation to other nuclear components

1996 • 108 citations

Recombinant PML adenovirus suppresses growth and tumorigenicity of human breast cancer cells by inducing G1 cell cycle arrest and apoptosis

1998 • 101 citations

Disruption of PML-associated nuclear bodies during human cytomegalovirus infection

1995 • 96 citations

Ret finger protein is a normal component of PML nuclear bodies and interacts directly with PML

1998 • 90 citations

Stable overexpression of PML alters regulation of cell cycle progression in HeLa cells

1997 • 83 citations

Cooperation between the RING+B1-B2 and coiled-coil domains of PML is necessary for its effects on cell survival

1998 • 72 citations

PML, a Growth Suppressor Disrupted in Acute Promyelocytic Leukemia

1994 • 72 citations

The PML nuclear compartment and cancer

1996 • 52 citations

Characterisation of the PML/RARα Rearrangement Associated with t(15;17) Acute Promyelocytic Leukaemia

1997 • 51 citations

Developmentally Regulated Expression of a Human "Finger"-Containing Gene Encoded by the 5′ Half of the ret Transforming Gene

1988 • 50 citations

Nuclear organization: Uniting replication foci, chromatin domains and chromosome structure

1995 • 50 citations

PML, PLZF and NPM genes in the molecular pathogenesis of acute promyelocytic leukemia.

1996 • 47 citations

Surface residue mutations of the PML RING finger domain alter the formation of nuclear matrix-associated PML bodies

1997 • 38 citations

Overexpression of retinoic acid receptor alpha suppresses myeloid cell differentiation at the promyelocyte stage.

1995 • 29 citations

Growth suppression of transformed human bronchial epithelial cells by all-trans-retinoic acid occurs through specific retinoid receptors.

1995 • 28 citations

Cystine Starvation Induces Reversible Large-Body Formation from Nuclear Bodies in T24 Cells

1997 • 13 citations

PML shuttles between nuclear bodies and the cytoplasm

1997 • 11 citations

PML Shuttles between nuclear bodies and the cytoplasm

1997 • 7 citations