Nuclear structure in normal and Bloom syndrome cells

Positional Cloning of the Werner's Syndrome Gene

1996 • 1,696 citations

REPLICATION PROTEIN A: A Heterotrimeric, Single-Stranded DNA-Binding Protein Required for Eukaryotic DNA Metabolism

1997 • 1,417 citations

The Bloom's syndrome gene product is homologous to RecQ helicases

1995 • 1,371 citations

The Genetic Basis of Human Cancer

1999 • 827 citations

Pml Is Critical for Nd10 Formation and Recruits the Pml-Interacting Protein Daxx to This Nuclear Structure When Modified by Sumo-1

1999 • 809 citations

A novel macromolecular structure is a target of the promyelocyte-retinoic acid receptor oncoprotein

1994 • 798 citations

Monoclonal antibody analysis of the proliferating cell nuclear antigen (PCNA) structural conservation and the detection of a nucleolar form

1990 • 736 citations

A Human Telomeric Protein

1995 • 689 citations

The yeast type I topoisomerase Top3 interacts with Sgs1, a DNA helicase homolog: a potential eukaryotic reverse gyrase.

1994 • 686 citations

Telomerase-negative immortalized human cells contain a novel type of promyelocytic leukemia (PML) body.

1999 • 659 citations

Mutations in RECQL4 cause a subset of cases of Rothmund-Thomson syndrome

1999 • 657 citations

Pml is essential for multiple apoptotic pathways

1998 • 564 citations

Bloom Syndrome

1993 • 529 citations

The Bloom's Syndrome Helicase Unwinds G4 DNA

1998 • 524 citations

Dynamic organization of DNA replication in mammalian cell nuclei: spatially and temporally defined replication of chromosome-specific alpha-satellite DNA sequences.

1992 • 478 citations

Sgs1: A eukaryotic homolog of E. coil RecQ that interacts with topoisomerase II in vivo and is required for faithful chromosome segregation

1995 • 402 citations

Accelerated Aging and Nucleolar Fragmentation in Yeast sgs1 Mutants

1997 • 399 citations

RPA involvement in the damage-recognition and incision steps of nucleotide excision repair

1995 • 387 citations

Sister Chromatid Exchange

1983 • 387 citations

PML induces a novel caspase-independent death process

1998 • 384 citations

rqh1+, a fission yeast gene related to the Bloom's and Werner's syndrome genes, is required for reversible S phase arrest

1997 • 354 citations

Selective Entrapment of Extrachromosomally Amplified DNA by Nuclear Budding and Micronucleation during S Phase

1998 • 342 citations

Accelerated telomere shortening in ataxia telangiectasia

1996 • 334 citations

Bloom’s and Werner’s syndrome genes suppress hyperrecombination in yeast sgs1 mutant: Implication for genomic instability in human diseases

1998 • 298 citations

Identification of a novel nuclear domain.

1991 • 285 citations

Nuclear domain 10, the site of DNA virus transcription and replication

1998 • 273 citations

RecQ and RecJ process blocked replication forks prior to the resumption of replication in UV-irradiated Escherichia coli

1999 • 253 citations

Cloning of Two New Human Helicase Genes of the RecQ Family: Biological Significance of Multiple Species in Higher Eukaryotes

1998 • 252 citations

A role for PML and the nuclear body in genomic stability

1999 • 230 citations

A retarded rate of DNA chain growth in Bloom's syndrome.

1975 • 210 citations

Nucleolar localization of the Werner syndrome protein in human cells

1998 • 210 citations

The Yeast Type I Topoisomerase Top3 Interacts with Sgsl, a DNA Helicase Homolog: a Potential Eukaryotic Reverse Gyrase

1994 • 209 citations

Cloning and characterization of RECQL, a potential human homologue of the Escherichia coli DNA helicase RecQ.

1994 • 202 citations

Stage-specific apoptosis, developmental delay, and embryonic lethality in mice homozygous for a targeted disruption in the murine Bloom’s syndrome gene

1998 • 199 citations

Structure, Organization, and Dynamics of Promyelocytic Leukemia Protein Nuclear Bodies

1998 • 174 citations

Spatial and temporal distribution of DNA replication sites localized by immunofluorescence and confocal microscopy in mouse fibroblasts

1991 • 170 citations

In situ analysis of changes in telomere size during replicative aging and cell transformation.

1996 • 152 citations

Werner Helicase Is Localized to Transcriptionally Active Nucleoli of Cycling Cells

1998 • 141 citations

The DNA Helicase Activity of BLM Is Necessary for the Correction of the Genomic Instability of Bloom Syndrome Cells

1999 • 135 citations

Evidence for chromosome instability in vivo in bloom syndrome: Increased numbers of micronuclei in exfoliated cells

1985 • 121 citations

An abnormal profile of DNA replication intermediates in Bloom's syndrome.

1990 • 107 citations

Bloom’s syndrome protein, BLM, colocalizes with replication protein A in meiotic prophase nuclei of mammalian spermatocytes

1999 • 103 citations

Evolution of the RECQ Family of Helicases: A Drosophila Homolog, Dmblm, Is Similar to the Human Bloom Syndrome Gene

1999 • 100 citations

Bloom syndrome: an analysis of consanguineous families assigns the locus mutated to chromosome band 15q26.1.

1994 • 89 citations

Detection by Epitope-defined Monoclonal Antibodies of Werner DNA Helicases in the Nucleoplasm and Their Upregulation by Cell Transformation and Immortalization

1999 • 86 citations

Surface binding and interiorization of homologous and heterologous serum lipoproteins by rat aortic smooth muscle cells in culture

1975 • 77 citations

Localization of the bloom syndrome helicase to punctate nuclear structures and the nuclear matrix and regulation during the cell cycle: Comparison with the werner's syndrome helicase

1999 • 33 citations

The molecular structure of autoantigens

1990 • 23 citations

cDNA cloning of mouse BLM gene, the homologue to human Bloom’s syndrome gene, which is highly expressed in the testis at the mRNA level

1998 • 21 citations

Biological effects of a bifunctional DNA crosslinker

1999 • 10 citations