ALT-associated PML bodies are present in viable cells and are enriched in cells in the G2/M phase of the cell cycle

Specific Association of Human Telomerase Activity with Immortal Cells and Cancer

1994 • 7,043 citations

Extension of Life-Span by Introduction of Telomerase into Normal Human Cells

1998 • 4,845 citations

A survey of telomerase activity in human cancer

1997 • 2,747 citations

Use of all-trans retinoic acid in the treatment of acute promyelocytic leukemia

1988 • 2,380 citations

Telomere elongation in immortal human cells without detectable telomerase activity.

1995 • 1,249 citations

Evidence for an alternative mechanism for maintaining telomere length in human tumors and tumor-derived cell lines

1997 • 1,244 citations

Control of telomere length by the human telomeric protein TRF1

1997 • 1,197 citations

Inhibition of telomerase limits the growth of human cancer cells

1999 • 1,032 citations

Reconstitution of telomerase activity in normal human cells leads to elongation of telomeres and extended replicative life span

1998 • 1,001 citations

An alternative pathway for yeast telomere maintenance rescues est1− senescence

1993 • 916 citations

In vitro studies on cellular and molecular mechanisms of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia: As2O3 induces NB4 cell apoptosis with downregulation of Bcl-2 expression and modulation of PML-RAR alpha/PML proteins

1996 • 843 citations

Pml Is Critical for Nd10 Formation and Recruits the Pml-Interacting Protein Daxx to This Nuclear Structure When Modified by Sumo-1

1999 • 809 citations

A novel macromolecular structure is a target of the promyelocyte-retinoic acid receptor oncoprotein

1994 • 798 citations

Telomerase activity in normal and malignant hematopoietic cells.

1995 • 748 citations

Telomere shortening and apoptosis in telomerase-inhibited human tumor cells

1999 • 695 citations

A Human Telomeric Protein

1995 • 689 citations

Conjugation with the ubiquitin-related modifier SUMO-1 regulates the partitioning of PML within the nucleus

1998 • 676 citations

Retinoic acid regulates aberrant nuclear localization of PML-RARα in acute promyelocytic leukemia cells

1994 • 668 citations

Telomerase-negative immortalized human cells contain a novel type of promyelocytic leukemia (PML) body.

1999 • 659 citations

Dissociation among in vitro telomerase activity, telomere maintenance, and cellular immortalization

1998 • 629 citations

Pml is essential for multiple apoptotic pathways

1998 • 564 citations

Inhibition of human telomerase in immortal human cells leads to progressive telomere shortening and cell death

1999 • 545 citations

Role of PML in Cell Growth and the Retinoic Acid Pathway

1998 • 522 citations

RAD50 and RAD51 Define Two Pathways That Collaborate to Maintain Telomeres in the Absence of Telomerase

1999 • 396 citations

Detection of telomerase activity in human cells and tumors by a telomeric repeat amplification protocol (TRAP)

1995 • 395 citations

PML induces a novel caspase-independent death process

1998 • 384 citations

Sequestration and Inhibition of Daxx-Mediated Transcriptional Repression by PML

2000 • 357 citations

Human Daxx regulates Fas-induced apoptosis from nuclear PML oncogenic domains (PODs)

1999 • 273 citations

Structure, subnuclear distribution, and nuclear matrix association of the mammalian telomeric complex.

1996 • 230 citations

NBS1 and TRF1 Colocalize at Promyelocytic Leukemia Bodies during Late S/G2 Phases in Immortalized Telomerase-negative Cells

2000 • 210 citations

Cell cycle regulation of PML modification and ND10 composition

1999 • 190 citations

Telomerase Activation in Mouse Mammary Tumors: Lack of Detectable Telomere Shortening and Evidence for Regulation of Telomerase RNA with Cell Proliferation

1996 • 157 citations

Nuclear dots: Actors on Many Stages

1997 • 148 citations

Commentary on and reprint of Huang M-E, Ye Y-C, Chen S-R, Chai J-R, Lu J-X, Zhoa L, Gu L-J, Wang Z-Y, Use of all-trans-retinoic acid in the treatment of acute promyelocytic leukemia, in Blood (1988) 72:567–572

2000 • 128 citations

Immortalized cells with no detectable telomerase activity. A review.

1997 • 90 citations

Involvement of RB-1, p53, p16INK4 and telomerase in immortalisation of human cells.

1995 • 75 citations

Cooperation between the RING+B1-B2 and coiled-coil domains of PML is necessary for its effects on cell survival

1998 • 72 citations

Expression of two mucin antigens in cultured human ovarian surface epithelium: Influence of a family hostory of ovarian cancer

1995 • 53 citations