The promyelocytic leukemia protein PML has a pro‐apoptotic activity mediated through its RING domain

Antibodies, a laboratory manual

1989 • 12,929 citations

A Laboratory manual

1989 • 6,833 citations

Apoptosis in the Pathogenesis and Treatment of Disease

1995 • 6,610 citations

Social controls on cell survival and cell death

1992 • 2,641 citations

Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RARα with a novel putative transcription factor, PML

1991 • 1,463 citations

A novel macromolecular structure is a target of the promyelocyte-retinoic acid receptor oncoprotein

1994 • 798 citations

Bcl-2 blocks apoptosis in cells lacking mitochondrial DNA

1993 • 758 citations

Retinoic acid regulates aberrant nuclear localization of PML-RARα in acute promyelocytic leukemia cells

1994 • 668 citations

Does this have a familiar RING?

1996 • 632 citations

The t(15;17) translocation alters a nuclear body in a retinoic acid-reversible fashion.

1994 • 492 citations

The RING finger domain: a recent example of a sequence—structure family

1996 • 464 citations

Characterization of a Zinc Finger Gene Disrupted by the t(15;17) in Acute Promyelocytic Leukemia

1991 • 464 citations

Cell cycle and apoptosis: Common pathways to life and death

1995 • 404 citations

PIC 1, a novel ubiquitin-like protein which interacts with the PML component of a multiprotein complex that is disrupted in acute promyelocytic leukaemia.

1996 • 347 citations

The periphery of nuclear domain 10 (ND10) as site of DNA virus deposition.

1996 • 336 citations

The solution structure of the RING finger domain from the acute promyelocytic leukaemia proto-oncoprotein PML.

1995 • 324 citations

Adenovirus replication is coupled with the dynamic properties of the PML nuclear structure.

1996 • 307 citations

Structure and origin of the acute promyelocytic leukemia myl/RAR alpha cDNA and characterization of its retinoid-binding and transactivation properties.

1991 • 291 citations

Identification of a novel nuclear domain.

1991 • 285 citations

The nuclear location of PML, a cellular member of the C3HC4 zinc-binding domain protein family, is rearranged during herpes simplex virus infection by the C3HC4 viral protein ICP0

1994 • 281 citations

Nuclear Domain 10 as Preexisting Potential Replication Start Sites of Herpes Simplex Virus Type-1

1996 • 261 citations

A monoclonal antibody recognizing nuclear matrix-associated nuclear bodies

1992 • 258 citations

PML nuclear bodies are general targets for inflammation and cell proliferation.

1995 • 163 citations

Molecular characterization of NDP52, a novel protein of the nuclear domain 10, which is redistributed upon virus infection and interferon treatment.

1995 • 154 citations

Exclusion of Int-6 from PML Nuclear Bodies by Binding to the HTLV-I Tax Oncoprotein

1996 • 135 citations

Analysis of the Growth and Transformation Suppressor Domains of Promyelocytic Leukemia Gene, PML

1996 • 129 citations

The Epstein-Barr virus-encoded nuclear antigen EBNA-5 accumulates in PML-containing bodies

1996 • 119 citations

In vivo and in vitro characterization of the B1 and B2 zinc-binding domains from the acute promyelocytic leukemia protooncoprotein PML.

1996 • 116 citations

Disruption of PML-associated nuclear bodies during human cytomegalovirus infection

1995 • 96 citations

Adenovirus Infection Induces Rearrangements in the Intranuclear Distribution of the Nuclear Body-Associated PML Protein

1995 • 91 citations

The acute promyelocytic leukemia-specific PML/RAR alpha fusion protein reduces the frequency of commitment to apoptosis upon growth factor deprivation of GM-CSF-dependent myeloid cells.

1995 • 33 citations