Multifunctional regulatory proteins that control gene expression in both the nucleus and the cytoplasm

Nonsense-mediated mRNA decayin health and disease

1999 • 974 citations

The spliceosome deposits multiple proteins 20-24 nucleotides upstream of mRNA exon-exon junctions

2000 • 923 citations

A Perfect Message

1999 • 807 citations

Disruption of Splicing Regulated by a CUG-Binding Protein in Myotonic Dystrophy

1998 • 800 citations

hnRNP complexes: composition, structure, and function

1999 • 794 citations

Myotonic Dystrophy in Transgenic Mice Expressing an Expanded CUG Repeat

2000 • 688 citations

The SMN–SIP1 Complex Has an Essential Role in Spliceosomal snRNP Biogenesis

1997 • 650 citations

Extraribosomal functions of ribosomal proteins

1996 • 614 citations

A Novel Function for SMN, the Spinal Muscular Atrophy Disease Gene Product, in Pre-mRNA Splicing

1998 • 545 citations

When cells stop making sense: effects of nonsense codons on RNA metabolism in vertebrate cells.

1995 • 515 citations

FMRP Associates with Polyribosomes as an mRNP, and the I304N Mutation of Severe Fragile X Syndrome Abolishes This Association

1997 • 509 citations

La autoantigen enhances and corrects aberrant translation of poliovirus RNA in reticulocyte lysate

1993 • 485 citations

A specific subset of SR proteins shuttles continuously between the nucleus and the cytoplasm

1998 • 476 citations

The Skipping of Constitutive Exons in Vivo Induced by Nonsense Mutations

1993 • 440 citations

The CELF Family of RNA Binding Proteins Is Implicated in Cell-Specific and Developmentally Regulated Alternative Splicing

2001 • 420 citations

RNA surveillance: unforeseen consequences for gene expression, inherited genetic disorders and cancer

1999 • 400 citations

Binary specification of nonsense codons by splicing and cytoplasmic translation

1998 • 396 citations

Coupled Transcription and Translation Within Nuclei of Mammalian Cells

2001 • 379 citations

Protein Ligands to Hur Modulate Its Interaction with Target Mrnas in Vivo

2000 • 375 citations

Nonsense mutations in the dihydrofolate reductase gene affect RNA processing.

1989 • 367 citations

RNA recognition and translational regulation by a homeodomain protein

1996 • 343 citations

Internal initiation of translation in eukaryotes: the picornavirus paradigm and beyond.

1995 • 341 citations

Proofreading and Aminoacylation of tRNAs Before Export from the Nucleus

1998 • 316 citations

RNA binding and translational suppression by bicoid

1996 • 313 citations

Gene regulation by Y-box proteins: coupling control of transcription and translation

1998 • 299 citations

Why is Hu where? Shuttling of early-response-gene messenger RNA subsets

1999 • 294 citations

A splicing-dependent regulatory mechanism that detects translation signals.

1996 • 278 citations

Sex lethal controls dosage compensation in Drosophila by a non-splicing mechanism

1997 • 265 citations

The Double Lives of Shuttling mRNA Binding Proteins

2000 • 240 citations

The role of exportin-t in selective nuclear export of mature tRNAs

1998 • 224 citations

Formation of the 3′ end of histone mRNA

1999 • 221 citations

The Spinal Muscular Atrophy Disease Gene Product, Smn

1999 • 221 citations

Translational repressorbruno plays multiple roles in development and is widely conserved

1997 • 213 citations

The Regulation of the Drosophila Gene Reveals a Function for in Translational Control

1997 • 205 citations

A novel shuttling protein, 4E-T, mediates the nuclear import of the mRNA 5' cap-binding protein, eIF4E

2000 • 201 citations

Nuclear history of a pre-mRNA determines the translational activity of cytoplasmic mRNA

1998 • 200 citations

Nonsense Surveillance in Lymphocytes?

1998 • 200 citations

A novel gene, Translin, encodes a recombination hotspot binding protein associated with chromosomal translocations

1995 • 195 citations

The Y14 protein communicates to the cytoplasm the position of exon-exon junctions

2001 • 180 citations

Isolation of an FMRP-Associated Messenger Ribonucleoprotein Particle and Identification of Nucleolin and the Fragile X-Related Proteins as Components of the Complex

1999 • 179 citations

EDEN and EDEN-BP, a cis element and an associated factor that mediate sequence-specific mRNA deadenylation in Xenopus embryos

1998 • 175 citations

CUG repeat binding protein (CUGBP1) interacts with the 5' region of C/EBP mRNA and regulates translation of C/EBP isoforms

1999 • 170 citations

Was the nucleus the first endosymbiont?

1994 • 162 citations

The association of nonsense codons with exon skipping

1998 • 159 citations

Binding of a phosphoprotein to the 3' untranslated region of the mouse protamine 2 mRNA temporally represses its translation.

1993 • 157 citations

Activities of cold-shock domain proteins in translation control

1999 • 157 citations

Formation of the male-specific muscle in female Drosophila by ectopic fruitless expression

2000 • 155 citations

Maintenance of an open reading frame as an additional level of scrutiny during splice site selection

1994 • 146 citations

La autoantigen alleviates translational repression by the 5' leader sequence of the human immunodeficiency virus type 1 mRNA

1994 • 143 citations

Mammalian nonsense codons can be cis effectors of nuclear mRNA half-life.

1994 • 140 citations

Precursors to the U3 Small Nucleolar RNA Lack Small Nucleolar RNP Proteins but Are Stabilized by La Binding

2000 • 134 citations

Precursor RNAs Harboring Nonsense Codons Accumulate Near the Site of Transcription

2001 • 131 citations

Nonsense but not missense mutations can decrease the abundance of nuclear mRNA for the mouse major urinary protein, while both types of mutations can facilitate exon skipping.

1994 • 131 citations

Nuclear Eukaryotic Initiation Factor 4e (Eif4e) Colocalizes with Splicing Factors in Speckles

2000 • 130 citations

Orphan Receptor DAX-1 Is a Shuttling RNA Binding Protein Associated with Polyribosomes via mRNA

2000 • 122 citations

Modulation of AUUUA Response Element Binding by Heterogeneous Nuclear Ribonucleoprotein A1 in Human T Lymphocytes

1997 • 111 citations

Immunofluorescence studies of human fibroblasts demonstrate the presence of the complex of elongation factor-1βγd in the endoplasmic reticulum

1996 • 104 citations

Low cytoplasmic mRNA levels of immunoglobulin kappa light chain genes containing nonsense codons correlate with inefficient splicing.

1994 • 97 citations

mRNA quality control: Marking the message for life or death

2001 • 95 citations

The La Autoantigen Contains a Dimerization Domain That Is Essential for Enhancing Translation

1997 • 94 citations

The Drosophila splicing regulator sex-lethal directly inhibits translation of male-specific-lethal 2 mRNA.

1998 • 91 citations

The DNA/RNA-Binding Protein, TB-RBP, Moves from the Nucleus to the Cytoplasm and through Intercellular Bridges in Male Germ Cells

1998 • 91 citations

An AU-Rich Sequence Element (UUUN[A/U]U) Downstream of the Edited C in Apolipoprotein B mRNA Is a High-Affinity Binding Site for Apobec-1: Binding of Apobec-1 to This Motif in the 3′ Untranslated Region of c-myc Increases mRNA Stability

2000 • 89 citations

The RNA-binding protein, TB-RBP, is the mouse homologue of translin, a recombination protein associated with chromosomal translocations

1997 • 87 citations

U snRNP assembly in yeast involves the La protein

2000 • 86 citations

Problems and paradigms: Multifunctional proteins suggest connections between transcriptional and post‐transcriptional processes

1997 • 86 citations

T Cell Receptor (TCR) Mini-Gene mRNA Expression Regulated by Nonsense Codons: A Nuclear-associated Translation-like Mechanism

1997 • 76 citations

p53 Binds Selectively to the 5′ Untranslated Region of cdk4, an RNA Element Necessary and Sufficient for Transforming Growth Factor β- and p53-Mediated Translational Inhibition of cdk4

2000 • 69 citations

Homeodomain Position 54 Specifies Transcriptional versus Translational Control by Bicoid

2000 • 66 citations

Sequence interval within the PEST motif of Bicoid is important for translational repression of caudal mRNA in the anterior region of the Drosophila embryo

1999 • 61 citations

Human La Protein: a Stabilizer of Histone mRNA

1997 • 61 citations

METABOLIC PROPERTIES OF CELLS ISOLATED FROM ADULT MOUSE LIVER

1962 • 54 citations

Multiple Functions of an Evolutionarily Conserved RNA Binding Domain

2000 • 49 citations

Efficient Extraction and Partial Purification of the Polyribosome-Associated Stem−Loop Binding Protein Bound to the 3‘ End of Histone mRNA

1996 • 48 citations

Evidence for Involvement of trans-Acting Factors in Selection of the AUG Start Codon during Eukaryotic Translational Initiation

1996 • 46 citations

An N-Terminal Truncation Uncouples the Sex-Transforming and Dosage Compensation Functions of Sex-lethal

1999 • 45 citations

Coupling transcription to translation: A novel site for the regulation of eukaryotic gene expression

1996 • 43 citations

Embryo Deadenylation Element-Dependent Deadenylation Is Enhanced by a cis Element Containing AUU Repeats

1998 • 42 citations

Monoclonal antibody-aided characterization of cellular p220 in uninfected and poliovirus-infected HeLa cells: subcellular distribution and identification of conformers

1987 • 39 citations

TRA-1 regulates the cellular distribution of the tra-2 mRNA in C. elegans

1999 • 38 citations

A Premature Termination Codon Interferes with the Nuclear Function of an Exon Splicing Enhancer in an Open Reading Frame-Dependent Manner

1999 • 33 citations

Intracellular and intercellular transport of many germ cell mRNAs is mediated by the DNA- and RNA-binding protein, testis-brain-RNA-binding protein (TB-RBP)

2000 • 31 citations

Coupling of Transcription and Translation in Dictyostelium discoideum Nuclei

1999 • 18 citations

Novel functions for `nuclear factors' in the cytoplasm: theSex-lethalparadigm

1997 • 14 citations

Heterogeneous nuclear ribonucleoproteins (hnRNPs): an emerging family of autoantigens in rheumatic diseases.

1998 • 11 citations