Mechanisms of life span determination in Caenorhabditis elegans☆

Handbook of Physiology.

1960 • 10,428 citations

The serial cultivation of human diploid cell strains

1961 • 7,886 citations

The limited in vitro lifetime of human diploid cell strains

1965 • 5,595 citations

Oncogenic ras Provokes Premature Cell Senescence Associated with Accumulation of p53 and p16INK4a

1997 • 4,870 citations

Genome Sequence of the Nematode C. elegans : A Platform for Investigating Biology

1998 • 3,683 citations

Genome sequence of the nematode C-elegans: A platform for investigating biology

1998 • 3,265 citations

A C. elegans mutant that lives twice as long as wild type

1993 • 3,250 citations

Oxidative Stress, Caloric Restriction, and Aging

1996 • 3,136 citations

The Nematode Caenorhabditis elegans

1988 • 2,868 citations

daf-2 , an Insulin Receptor-Like Gene That Regulates Longevity and Diapause in Caenorhabditis elegans

1997 • 2,174 citations

The aging process.

1981 • 1,871 citations

AN UNSOLVED PROBLEM OF BIOLOGY

1953 • 1,832 citations

The retardation of aging and disease by dietary restriction

1989 • 1,494 citations

Longevity, senescence and the genome

1995 • 1,390 citations

The Retardation of Aging in Mice by Dietary Restriction: Longevity, Cancer, Immunity and Lifetime Energy Intake

1986 • 968 citations

A mutation in the age-1 gene in Caenorhabditis elegans lengthens life and reduces hermaphrodite fertility.

1988 • 958 citations

Signals from the reproductive system regulate the lifespan of C. elegans

1999 • 956 citations

The genetics of caloric restriction in Caenorhabditis elegans

1998 • 918 citations

Neurobiology of the Caenorhabditis elegans Genome

1998 • 912 citations

Molecular Biology of Aging

1999 • 877 citations

A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans

1996 • 870 citations

Thermotolerance and extended life-span conferred by single-gene mutations and induced by thermal stress.

1995 • 847 citations

Aging and resistance to oxidative damage in Caenorhabditis elegans.

1993 • 720 citations

Two Pleiotropic Classes of daf-2 Mutation Affect Larval Arrest, Adult Behavior, Reproduction and Longevity in Caenorhabditis elegans

1998 • 691 citations

Caenorhabditis elegans : modern biological analysis of an organism

1995 • 689 citations

Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor

1998 • 680 citations

A mutation in succinate dehydrogenase cytochrome b causes oxidative stress and ageing in nematodes

1998 • 676 citations

Longevity, senescence, and the genome

1992 • 609 citations

Genes that regulate both development and longevity in Caenorhabditis elegans.

1995 • 579 citations

Determination of Life-Span in Caenorhabditis elegans by Four Clock Genes

1996 • 529 citations

Handbook of Physiology. Section- 2

1967 • 520 citations

Mutation in the silencing gene S/R4 can delay aging in S. cerevisiae

1995 • 496 citations

Comparison of the Complete Protein Sets of Worm and Yeast: Orthology and Divergence

1998 • 447 citations

Genetic and Environmental Regulation of Dauer Larva Development

1997 • 446 citations

The age-1 and daf-2 genes function in a common pathway to control the lifespan of Caenorhabditis elegans.

1995 • 442 citations

The C. elegans PTEN Homolog, DAF-18, Acts in the Insulin Receptor-like Metabolic Signaling Pathway

1998 • 440 citations

Replicative Senescence: An Old Lives' Tale?

1996 • 429 citations

Mutations in the clk-1 gene of Caenorhabditis elegans affect developmental and behavioral timing.

1995 • 406 citations

A Genetic Pathway Conferring Life Extension and Resistance to UV Stress in Caenorhabditis elegans

1996 • 390 citations

Oxidative stress and ageing in Caenorhabditis elegans

1993 • 383 citations

Non-ageing developmental variant of Caenorhabditis elegans

1976 • 373 citations

Cell Nonautonomy of C. elegans daf-2 Function in the Regulation of Diapause and Life Span

1998 • 362 citations

Longevity, Genes, and Aging

1996 • 352 citations

An Insulin-like Signaling Pathway Affects Both Longevity and Reproduction in Caenorhabditis elegans

1998 • 347 citations

Luminol and lucigenin as detectors for O2ṡ−

1993 • 341 citations

THE LIMITED IN VITRO LIFETIME OF HUMAN DIPLOID CELL STRAINS

1964 • 339 citations

Structural and Functional Conservation of the Caenorhabditis elegans Timing Gene clk-1

1997 • 309 citations

The Taxonomy of Developmental Control in Caenorhabditis elegans

1998 • 304 citations

Production of sperm reduces nematode lifespan

1992 • 301 citations

Caenorhabditis elegans Is a Nematode

1998 • 281 citations

CLK-1 controls respiration, behavior and aging in the nematode Caenorhabditis elegans

1999 • 274 citations

Old Age and Natural Death

2019 • 266 citations

Das Problem der Lebensdauer und seine Beziehungen zu Wachstum und Ernährung

1908 • 256 citations

A cytosolic catalase is needed to extend adult lifespan in C. elegans daf-C and clk-1 mutants

1999 • 244 citations

Action of food restriction in delaying the aging process.

1982 • 243 citations

Three Mutants That Extend Both Mean and Maximum Life Span of the Nematode, Caenorhabditis Elegans, Define the Age-1 Gene

1988 • 239 citations

Bacterial senescence: stasis results in increased and differential oxidation of cytoplasmic proteins leading to developmental induction of the heat shock regulon

1998 • 225 citations

Lucigenin (Bis-N-methylacridinium) as a Mediator of Superoxide Anion Production

1997 • 220 citations

Biology of Aging: Observations and Principles

1998 • 220 citations

A methyl viologen-sensitive mutant of the nematode Caenorhabditis elegans

1990 • 212 citations

Thermotolerance of a Long-lived Mutant of Caenorhabditis elegans

1994 • 208 citations

Zinc Fingers in Caenorhabditis elegans : Finding Families and Probing Pathways

1998 • 200 citations

The Evolution of the Antiaging Action of Dietary Restriction: A Hypothesis

1996 • 196 citations

Divergent roles of RAS1 and RAS2 in yeast longevity

1994 • 191 citations

The COQ7 Gene Encodes a Protein in Saccharomyces cerevisiae Necessary for Ubiquinone Biosynthesis

1996 • 180 citations

Effects of Oxygen on Protein Carbonyl and Aging in Caenorhabditis elegans Mutants With Long (age-1) and Short (mev-1) Life Spans

1998 • 169 citations

The gerontogenes age‐1 and daf‐2 determine metabolic rate potential in aging Caenorhabditis elegans

1995 • 159 citations

Cloning, Expression, and Characterization of Two Manganese Superoxide Dismutases from Caenorhabditis elegans

1997 • 140 citations

Production of Age-Synchronous Mass Cultures of Caenorhabditis elegans

1994 • 137 citations

Hypothesis: Interventions That Increase the Response to Stress Offer the Potential for Effective Life Prolongation and Increased Health

1996 • 132 citations

Yeast Clk-1 Homologue (Coq7/Cat5) Is a Mitochondrial Protein in Coenzyme Q Synthesis

1998 • 131 citations

Quantitative measures of aging in the nematode Caenorhabditis elegans. I. Population and longitudinal studies of two behavioral parameters

1981 • 130 citations

Genetic Analysis of the Roles of daf28 and age-1 in Regulating Caenorhabditis elegans Dauer Formation

1996 • 129 citations

RADIATION-SENSITIVE MUTANTS OF CAENORHABDITIS ELEGANS

1982 • 127 citations

Apparent uncoupling of energy production and consumption in long-lived Clk mutants of Caenorhabditis elegans

1999 • 123 citations

Does growth hormone prevent or accelerate aging?

1998 • 121 citations

Rate of aerobic metabolism and superoxide production rate potential in the nematodeCaenorhabditis elegans

1996 • 115 citations

The Rate of Living Theory: A Contemporary Interpretation

1986 • 114 citations

Rapid accumulation of fluorescent material with aging in an oxygen-sensitive mutant mev-1 of Caenorhabditis elegans

1994 • 103 citations

Molecular genetics of life span in C. elegans: How much does it teach us?

1998 • 101 citations

Gene expression in the Caenorhabditis elegans dauer larva: Developmental regulation of Hsp90 and other genes

1992 • 97 citations

Intermediary metabolism in the dauer larva of the nematode Caenorhabditis elegans— 1. Glycolysis, gluconeogenesis, oxidative phosphorylation and the tricarboxylic acid cycle

1989 • 97 citations

Life extension and stress resistance in Caenorhabditis elegans. modulated by the tkr-1 gene

1998 • 88 citations

Intermediary metabolism in the dauer larva of the nematode Caenorhabditis elegans—II. The glyoxylate cycle and fatty-acid oxidation

1990 • 81 citations

Bifunctional Glyoxylate Cycle Protein of Caenorhabditis elegans: A Developmentally Regulated Protein of Intestine and Muscle

1995 • 79 citations

Dietary restriction

1995 • 78 citations

A Novel Superoxide Dismutase Gene Encoding Membrane-bound and Extracellular Isoforms by Alternative Splicing in Caenorhabditis elegans

1998 • 75 citations

Movement as an Index of Vitality:Comparing Wild Type and the age-1 Mutant of Caenorhabditis elegans

1995 • 72 citations

Responses of dauerlarvae of Caenorhabditis elegans (Nematoda: Rhabditidae) to thermal stress and oxygen deprivation

1978 • 66 citations

Immortality of the Germ-Line versus Disposability of the Soma

1987 • 64 citations

CAT5, a new gene necessary for derepression of gluconeogenic enzymes in Saccharomyces cerevisiae.

1995 • 63 citations

Ponce d'elegans: Genetic Quest for the Fountain of Youth

1996 • 59 citations

Superoxide dismutase activity in dauerlarvae of Caenorhabditis elegans (Nematoda: Rhabditidae)

1982 • 52 citations

The manganese superoxide dismutase gene of Caenorhabditis elegans.

1994 • 50 citations

Energy expenditure of adult male rhesus monkeys during the first 30 mo of dietary restriction

1997 • 49 citations

Evolution of Longevity in Animals

1987 • 49 citations

Aging, life span, and senescence

1998 • 49 citations

The copper/zinc superoxide dismutase gene of Caenorhabditis elegans.

1994 • 40 citations

Direct isolation of longevity mutants in the nematodeCaenorhabditis elegans

1996 • 40 citations

Cloning, Sequencing and Mapping of a Manganese Superoxide Dismutase Gene of the Nematode Caenorhabditis elegans

1996 • 38 citations

Aging of C. elegans

1998 • 36 citations

Nematode growth factor

1974 • 34 citations

Bioenergetics in the aging fischer 344 rat: Effects of exercise and food restriction

1987 • 32 citations

Quantitative measures of aging in the nematode caenorhabditis elegans: II. Lysosomal hydrolases as markers of senescence

1983 • 25 citations

Characterization of a Life-Extending Mutation in age-2, a New Aging Gene in Caenorhabditis elegans

1999 • 23 citations

The Effects of Temperature on the Longevity of a Radiation-Sensitive Mutant rad-8 of the Nematode Caenorhabditis elegans

1994 • 21 citations

The radiation-sensitive mutant RAD-8 of Caenorhabditis elegans is hypersensitive to the effects of oxygen on aging and development

1993 • 20 citations

Nematodes as Models to Study Aging

1980 • 19 citations

Age-specific Modulation of Light Production Potential, and Alkaline Phosphatase and Protein Tyrosine Kinase Activities in Various Age Mutants of Caenorhabditis elegans

1998 • 14 citations

Modulation of Kinase Activities in Dauers and in Long-lived Mutants of Caenorhabditis elegans

1997 • 11 citations

Preface

1995 • 2 citations