Central T Cell Tolerance in Lupus-Prone Mice: Influence of Autoimmune Background and the lpr Mutation

Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.

1992 • 9,540 citations

Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes

1988 • 1,711 citations

T Cell Activation Determined by T Cell Receptor Number and Tunable Thresholds

1996 • 1,038 citations

Detection of DNA strand breaks in individual apoptotic cells by the in situ terminal deoxynucleotidyl transferase and nick translation assays.

1993 • 997 citations

Positive and negative selection of an antigen receptor on T cells in transgenic mice

1988 • 758 citations

The fas antigen is involved in peripheral but not thymic deletion of T lymphocytes in T cell receptor transgenic mice

1994 • 708 citations

Selective development of CD4+ T cells in transgenic mice expressing a class II MHC-restricted antigen receptor

1989 • 646 citations

Models of T cell anergy: is there a common molecular mechanism?

1996 • 575 citations

Positive and Negative Thymocyte Selection Induced by Different Concentrations of a Single Peptide

1994 • 497 citations

In transgenic mice the introduced functional T cell receptor β gene prevents expression of endogenous β genes

1988 • 374 citations

Lymphoid Development in Mice Congenitally Lacking T Cell Receptor αβ-Expressing Cells

1992 • 371 citations

The Roles of Fas/APO-1 (CD95) and TNF in Antigen-Induced Programmed Cell Death in T Cell Receptor Transgenic Mice

1996 • 325 citations

Regulation of TCR α and β gene allelic exclusion during T-cell development

1992 • 284 citations

Negative Selection in the Thymus Includes Semimature T Cells

1997 • 224 citations

A T cell clone expresses two T cell receptor α genes but uses one αβ heterodimer for allorecognition and self MHC-restricted antigen recognition

1988 • 200 citations

Prevention of nephritis in major histocompatibility complex class II-deficient MRL-lpr mice.

1994 • 194 citations

Identification of a Naturally Occurring Ligand for Thymic Positive Selection

1997 • 193 citations

Binary and ternary complexes between T-cell receptor, class II MHC and superantigen in vitro

1994 • 182 citations

In vivo and in vitro clonal deletion of double-positive thymocytes.

1992 • 172 citations

Fas Modulation of Apoptosis during Negative Selection of Thymocytes

1996 • 162 citations

Selection of the T cell receptor repertoire in Lpr mice.

1993 • 155 citations

Murine lupus in the absence of alpha beta T cells.

1996 • 151 citations

Phenotypic differences between αβ versus β T-cell receptor transgenic mice undergoing negative selection

1989 • 147 citations

Two signals are required for negative selection of CD4+CD8+ thymocytes.

1993 • 143 citations

Murine lupus in MRL/lpr mice lacking CD4 or CD8 T cells

1995 • 141 citations

Studies of T cell deletion and T cell anergy following in vivo administration of SEB to normal and lupus-prone mice.

1993 • 125 citations

Upregulation of surface markers on dying thymocytes.

1995 • 122 citations

T Cell Receptor (TCR)-induced Death of Immature CD4+CD8+ Thymocytes by Two Distinct Mechanisms Differing in Their Requirement for CD28 Costimulation: Implications for Negative Selection in the Thymus

1997 • 118 citations

How do T-cell receptors, MHC molecules and superantigens get together?

1993 • 81 citations

Defective maintenance of T cell tolerance to a superantigen in MRL-lpr/lpr mice.

1992 • 71 citations

Anti-CD4 monoclonal antibody therapy suppresses autoimmune disease in MRL/Mp-lpr/lpr mice

1992 • 69 citations

Different superantigens interact with distinct sites in the Vbeta domain of a single T cell receptor.

1996 • 64 citations

Both intrathymic and peripheral selection modulate the differential expression of V beta 5 among CD4+ and CD8+ T cells.

1992 • 54 citations

Class I and class II MHC gene products differentially affect the fate of V beta 5 bearing thymocytes.

1990 • 44 citations

Induction of nonpathologic, humoral autoimmunity in lupus-prone mice by a class II-restricted, transgenic alpha beta T cell. Separation of autoantigen-specific and -nonspecific help.

1996 • 39 citations

T cells with gamma/delta T cell receptors (TCR) of intestinal type are preferentially expanded in TCR-alpha-deficient lpr mice.

1995 • 29 citations

PCR-RFLP Genotyping of Murine MHC Haplotypes

1996 • 16 citations

Self-Reactivity and the Expression of Memory Markers Vary Independently in MRL-Mp+/+ and MRL-Mp-lpr/lpr Mice

1992 • 7 citations

The CH Series of Murine B Cell Lymphomas: Identification of Cross-reactive Idiotypes and Restricted Antigen Specificities

1984 • 6 citations