In the Absence of Extrinsic Signals, Nutrient Utilization by Lymphocytes Is Insufficient to Maintain Either Cell Size or Viability

Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death

1990 • 3,817 citations

bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death

1993 • 3,111 citations

RAG-1-deficient mice have no mature B and T lymphocytes

1992 • 2,859 citations

Social controls on cell survival and cell death

1992 • 2,641 citations

Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes

1988 • 1,711 citations

Molecular thanatopsis: a discourse on the BCL2 family and cell death

1996 • 1,412 citations

PHOSPHOINOSITIDE KINASES

1998 • 1,321 citations

TUMOR NECROSIS FACTOR RECEPTOR AND Fas SIGNALING MECHANISMS

1999 • 1,309 citations

Mechanisms and consequences of activation of protein kinase B/Akt

1998 • 1,305 citations

Deregulated Bcl-2 gene expression selectively prolongs survival of growth factor-deprived hemopoietic cell lines.

1990 • 926 citations

Differential Requirements for Survival and Proliferation of CD8 Naïve or Memory T Cells

1997 • 875 citations

Coordination of Growth and Cell Division in the Drosophila Wing

1998 • 760 citations

Size Control in Animal Development

1999 • 742 citations

The Peptide Ligands Mediating Positive Selection in the Thymus Control T Cell Survival and Homeostatic Proliferation in the Periphery

1999 • 742 citations

TAP1 mutant mice are deficient in antigen presentation, surface class I molecules, and CD4−8+ T cells

1992 • 726 citations

Low-Affinity Ligands for the TCR Drive Proliferation of Mature CD8+ T Cells in Lymphopenic Hosts

1999 • 548 citations

Temporal analysis of events associated with programmed cell death (apoptosis) of sympathetic neurons deprived of nerve growth factor.

1993 • 535 citations

Bcl-xL Prevents Cell Death following Growth Factor Withdrawal by Facilitating Mitochondrial ATP/ADP Exchange

1999 • 496 citations

Outer mitochondrial membrane permeability can regulate coupled respiration and cell survival

2000 • 428 citations

Bcl-XL and Bcl-2 repress a common pathway of cell death.

1995 • 406 citations

Survival of Mature CD4 T Lymphocytes Is Dependent on Major Histocompatibility Complex Class II–expressing Dendritic Cells

1997 • 402 citations

Constitutive expression of the machinery for programmed cell death.

1996 • 386 citations

MHC Class II Molecules Are Not Required for Survival of Newly Generated CD4+ T Cells, but Affect Their Long-Term Life Span

1996 • 377 citations

Interleukin 3-dependent survival by the Akt protein kinase

1997 • 374 citations

Suppression of signalling through transcription factor NF-AT by interactions between calcineurin and Bcl-2

1997 • 368 citations

The Roles of Costimulation and Fas in T Cell Apoptosis and Peripheral Tolerance

1996 • 367 citations

Cross talk between cell death and cell cycle progression: BCL-2 regulates NFAT-mediated activation.

1996 • 344 citations

The anti-apoptosis function of Bcl-2 can be genetically separated from its inhibitory effect on cell cycle entry

1997 • 343 citations

Trophic regulation of nerve cell morphology and innervation in the autonomic nervous system

1988 • 342 citations

Programmed Cell Death in Neurons: Focus on the Pathway of Nerve Growth Factor Deprivation-Induced Death of Sympathetic Neurons

1997 • 220 citations

Long-term T cell memory requires the surface expression of self-peptide/major histocompatibility complex molecules

1998 • 186 citations

bcl-x exhibits regulated expression during B cell development and activation and modulates lymphocyte survival in transgenic mice.

1996 • 178 citations

Atrophy but not death of adult septal cholinergic neurons after ablation of target capacity to produce mRNAs for NGF, BDNF, and NT3

1993 • 170 citations

Growth responses of different subpopulations of adult sensory neurons to neurotrophic factors in vitro

1999 • 137 citations

Metabolic changes in activated T cells: An NMR study of human peripheral blood lymphocytes

1993 • 128 citations

Ligation of the T cell co‐stimulatory receptor CD28 activates the serine‐threonine protein kinase protein kinase B

1997 • 124 citations

MHC class I is required for peripheral accumulation of CD8+ thymic emigrants.

1998 • 112 citations

Survival of Naive CD4 T Cells: Roles of Restricting Versus Selecting MHC Class II and Cytokine Milieu

1999 • 105 citations

Regulation of D‐3 phosphoinositides during T cell activation via the T cell antigen receptor/CD3 complex and CD2 antigens

1992 • 103 citations

CD28 of T lymphocytes associates with phosphatidylinositol 3-kinase

1994 • 102 citations

MHC Class I Is Required for Peripheral Accumulation of CD8+ Thymic Emigrants

1998 • 100 citations

Effect of haematopoietic cell growth factor on intracellular ATP levels

1983 • 93 citations

T-cell survival

1998 • 90 citations

A method for size separation of murine spleen cells using counterflow centrifugation

1983 • 16 citations

Hemopoietic growth factor receptor abnormalities in leukemia

1998 • 15 citations