A transcription factor with SH2 and SH3 domains is directly activated by an interferon α-induced cytoplasmic protein tyrosine kinase(s)

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Antibodies, a laboratory manual

1989 • 12,929 citations

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

1983 • 11,902 citations

Signal transduction by receptors with tyrosine kinase activity

1990 • 5,528 citations

Atlas of protein sequence and structure

1965 • 4,462 citations

Genistein, a specific inhibitor of tyrosine-specific protein kinases.

1987 • 3,773 citations

The Leucine Zipper: A Hypothetical Structure Common to a New Class of DNA Binding Proteins

1988 • 3,479 citations

Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene

1984 • 3,150 citations

Oncogenes and signal transduction

1991 • 2,816 citations

Atlas of Protein Sequence and Structure, 1972.

1973 • 2,408 citations

PROTEIN-TYROSINE KINASES

1985 • 2,198 citations

How eukaryotic transcriptional activators work

1988 • 1,924 citations

INTERFERONS AND THEIR ACTIONS

1987 • 1,838 citations

The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck

1988 • 1,442 citations

[42] Detection and quantification of phosphotyrosine in proteins

1983 • 1,184 citations

PRIMARY RESPONSE GENES INDUCED BY GROWTH FACTORS AND TUMOR PROMOTERS

1991 • 1,078 citations

Regulated expression of a gene encoding a nuclear factor, IRF-1, that specifically binds to IFN-β gene regulatory elements

1988 • 984 citations

Phospholipase C-γ is a substrate for the PDGF and EGF receptor protein-tyrosine kinases in vivo and in vitro

1989 • 978 citations

Interferon-Dependent Tyrosine Phosphorylation of a Latent Cytoplasmic Transcription Factor

1992 • 906 citations

Cooperation between oncogenes

1991 • 792 citations

A novel viral oncogene with structural similarity to phospholipase C

1988 • 789 citations

Characterization of two 85 kd proteins that associate with receptor tyrosine kinases, middle-T/pp60c-src complexes, and PI3-kinase

1991 • 785 citations

EGF induces tyrosine phosphorylation of phospholipase C-II: A potential mechanism for EGF receptor signaling

1989 • 784 citations

Stimulation of Neuronal Acetylcholine Receptors Induces Rapid Gene Transcription

1986 • 761 citations

Transcriptional and posttranscriptional regulation of interferon-induced gene expression in human cells

1984 • 729 citations

Signal transduction through the CD4 receptor involves the activation of the internal membrane tyrosine-protein kinase p56lck

1989 • 671 citations

Signal Transduction by the Platelet-Derived Growth Factor Receptor

1989 • 653 citations

Association between the PDGF receptor and members of the src family of tyrosine kinases

1990 • 650 citations

Association of the fyn protein-tyrosine kinase with the T-cell antigen receptor.

1990 • 647 citations

Cloning of PI3 kinase-associated p85 utilizing a novel method for expression/cloning of target proteins for receptor tyrosine kinases

1991 • 641 citations

Interaction of the unique N-terminal region of tyrosine kinase p56lck with cytoplasmic domains of CD4 and CD8 is mediated by cysteine motifs

1990 • 629 citations

Binding of SH2 Domains of Phospholipase Cγ1, GAP, and Src to Activated Growth Factor Receptors

1990 • 608 citations

C. elegans cell-signalling gene sem-5 encodes a protein with SH2 and SH3 domains

1992 • 603 citations

cDNA cloning of a Novel 85 kd protein that has SH2 domains and regulates binding of PI3-kinase to the PDGF β-receptor

1991 • 585 citations

Interferon-induced nuclear factors that bind a shared promoter element correlate with positive and negative transcriptional control.

1988 • 583 citations

Genetic transfer of a functional human interferon α receptor into mouse cells: Cloning and expression of its c-DNA

1990 • 582 citations

Interaction of the IL-2 Receptor with thesrc-Family Kinase p56^lck: Identification of Novel Intermolecular Association

1991 • 576 citations

PDGF β-receptor stimulates tyrosine phosphorylation of GAP and association of GAP with a signaling complex

1990 • 561 citations

Sequence similarity of phospholipase C with the non-catalytic region of src

1988 • 541 citations

Peptides and Protein Phosphorylation

2018 • 525 citations

Autophosphorylation of the PDGF receptor in the kinase insert region regulates interactions with cell proteins

1989 • 524 citations

vav, a novel human oncogene derived from a locus ubiquitously expressed in hematopoietic cells.

1989 • 514 citations

Engagement of the high-affinity IgE receptor activates src protein-related tyrosine kinases

1992 • 503 citations

α-Interferon-induced transcription of HLA and metallothionein genes containing homologous upstream sequences

1985 • 498 citations

Cytoplasmic activation of ISGF3, the positive regulator of interferon-alpha-stimulated transcription, reconstituted in vitro.

1989 • 484 citations

Molecular cloning and expression of the human interferon-γ receptor

1988 • 481 citations

A Noncatalytic Domain Conserved among Cytoplasmic Protein-Tyrosine Kinases Modifies the Kinase Function and Transforming Activity of Fujinami Sarcoma Virus P130^gag-fps

1986 • 478 citations

ISGF3, the transcriptional activator induced by interferon alpha, consists of multiple interacting polypeptide chains.

1990 • 475 citations

Association of B Cell Antigen Receptor with Protein Tyrosine Kinase Lyn

1991 • 471 citations

T cell antigen receptor activation pathways: The tyrosine kinase connection

1991 • 442 citations

Binding of Transforming Protein, P47 ^gag-crk , to a Broad Range of Phosphotyrosine-containing Proteins

1990 • 433 citations

HEMOPOIETIC CELL GROWTH FACTORS AND THEIR RECEPTORS

1989 • 432 citations

Activation of T Cells by a Tyrosine Kinase Activation Domain in the Cytoplasmic Tail of CD3 ε

1992 • 430 citations

Interferons and other regulatory cytokines

1988 • 429 citations

Requirement for association of p56lck with CD4 in antigen-specific signal transduction in T cells

1991 • 417 citations

Cloning of an Interleukin-3 Receptor Gene: a Member of a Distinct Receptor Gene Family

1990 • 417 citations

Interferon-induced transcription of a gene encoding a 15-kDa protein depends on an upstream enhancer element.

1987 • 398 citations

Binding of GAP to Activated PDGF Receptors

1990 • 396 citations

Regulation of T cell receptor signaling by a src family protein-tyrosine kinase (p59fyn)

1991 • 395 citations

Subunit of an alpha-interferon-responsive transcription factor is related to interferon regulatory factor and Myb families of DNA-binding proteins.

1992 • 387 citations

Use of a selectable marker regulated by alpha interferon to obtain mutations in the signaling pathway.

1989 • 373 citations

An interferon gamma-regulated protein that binds the interferon-inducible enhancer element of major histocompatibility complex class I genes.

1990 • 368 citations

The Ick tyrosine protein kinase interacts with the cytoplasmic tail of the CD4 glycoprotein through its unique amino-terminal domain

1989 • 362 citations

Tyrosine phosphorylation of vav proto-oncogene product containing SH2 domain and transcription factor motifs

1992 • 361 citations

Evidence for a nuclear factor(s), IRF-1, mediating induction and silencing properties to human IFN-beta gene regulatory elements.

1988 • 342 citations

Commitment and activation at pol II promoters: A tail of protein-protein interactions

1990 • 332 citations

Purification and cloning of interferon-stimulated gene factor 2 (ISGF2): ISGF2 (IRF-1) can bind to the promoters of both beta interferon- and interferon-stimulated genes but is not a primary transcriptional activator of either.

1990 • 332 citations

Interferon-alpha regulates nuclear translocation and DNA-binding affinity of ISGF3, a multimeric transcriptional activator.

1990 • 321 citations

A noncatalytic domain conserved among cytoplasmic protein-tyrosine kinases modifies the kinase function and transforming activity of Fujinami sarcoma virus P130gag-fps.

1986 • 317 citations

Homology of a yeast actin-binding protein to signal transduction proteins and myosin-I

1990 • 315 citations

The tyrosine phosphorylated carboxyterminus of the EGF receptor is a binding site for GAP and PLC-gamma.

1990 • 314 citations

Interferons and other regulatory cytokines

1989 • 306 citations

Product of vav proto-oncogene defines a new class of tyrosine protein kinase substrates

1992 • 306 citations

Point mutations in the abl SH2 domain coordinately impair phosphotyrosine binding in vitro and transforming activity in vivo.

1992 • 295 citations

Interferon response element of the human gene 6-16.

1988 • 292 citations

A single DNA response element can confer inducibility by both alpha- and gamma-interferons.

1989 • 262 citations

Interferon response sequence potentiates activity of an enhancer in the promoter region of a mouse H–2 gene

1986 • 252 citations

Non-catalytic domains of cytoplasmic protein-tyrosine kinases: regulatory elements in signal transduction.

1988 • 250 citations

Transcriptional induction of two genes in human cells by beta interferon.

1984 • 236 citations

Platelet-derived growth factor (PDGF) binding promotes physical association of PDGF receptor with phospholipase C.

1989 • 235 citations

Two interferon-induced nuclear factors bind a single promoter element in interferon-stimulated genes.

1988 • 228 citations

Inositol phospholipid-specific phospholipase C: complete cDNA and protein sequences and sequence homology to tyrosine kinase-related oncogene products.

1988 • 223 citations

Rapid activation by interferon alpha of a latent DNA-binding protein present in the cytoplasm of untreated cells.

1989 • 218 citations

Oncogenic conversion by regulatory changes in transcription factors

1991 • 215 citations

Platelet-Derived Growth Factor (PDGF)-Dependent Association of Phospholipase C-γ with the PDGF Receptor Signaling Complex

1990 • 204 citations

Association of the v-crk oncogene product with phosphotyrosine-containing proteins and protein kinase activity.

1990 • 191 citations

Interferon-induced binding of nuclear factors to promoter elements of the 2-5A synthetase gene.

1988 • 190 citations

Enhancer-like interferon responsive sequences of the human and murine (2′-5′) oligoadenylate synthetase gene promoters.

1988 • 188 citations

Interferon-stimulated transcription: isolation of an inducible gene and identification of its regulatory region.

1986 • 185 citations

Transcriptional regulation of interferon‐stimulated genes

1991 • 184 citations

Interferon-induced transcription of a major histocompatibility class I gene accompanies binding of inducible nuclear factors to the interferon consensus sequence.

1988 • 170 citations

Interactions of alpha- and gamma-interferon in the transcriptional regulation of the gene encoding a guanylate-binding protein.

1989 • 159 citations

Cross-linking of T-cell surface molecules CD4 and CD8 stimulates phosphorylation of the lck tyrosine protein kinase at the autophosphorylation site.

1990 • 158 citations

Isolation and characterization of eight tumor necrosis factor-induced gene sequences from human fibroblasts.

1990 • 158 citations

Site-directed mutagenesis of the SH2- and SH3-coding domains of c-src produces varied phenotypes, including oncogenic activation of p60c-src.

1990 • 151 citations

Interleukin 2-induced tyrosine phosphorylation. Interleukin 2 receptor beta is tyrosine phosphorylated.

1990 • 149 citations

Functional equivalents of interferon-mediated signals needed for induction of an mRNA can be generated by double-stranded RNA and growth factors.

1987 • 141 citations

Overlapping sites for constitutive and induced DNA binding factors involved in interferon-stimulated transcription.

1989 • 134 citations

Purification and characterization of bovine brain type I phosphatidylinositol kinase

1990 • 129 citations

Alpha Interferon and Gamma Interferon Stimulate Transcription of a Single Gene through Different Signal Transduction Pathways

1989 • 112 citations

New inducers revealed by the promoter sequence analysis of two interferon-activated human genes

1987 • 110 citations

Phosphorylation-dependent activation of the adenovirus-inducible E2F transcription factor in a cell-free system.

1989 • 107 citations

Interferons increase transcription of a major histocompatibility class I gene via a 5' interferon consensus sequence.

1987 • 105 citations

Protein modification: phosphorylation on tyrosine residues

1989 • 96 citations

The common src homology region 2 domain of cytoplasmic signaling proteins is a positive effector of v-fps tyrosine kinase function.

1989 • 96 citations

Evidence for involvement of protein kinase C in the cellular response to interferon alpha.

1990 • 95 citations

Signal transduction and gene control

1991 • 94 citations

Characterization of the 47-Kilodalton Autosomal Chronic Granulomatous Disease Protein: Tissue-Specific Expression and Transcriptional Control by Retinoic Acid

1990 • 93 citations

Interferon-dependent transcriptional activation: signal transduction without second messenger involvement?

1990 • 90 citations

Interleukin 7 receptor ligation stimulates tyrosine phosphorylation, inositol phospholipid turnover, and clonal proliferation of human B-cell precursors.

1991 • 90 citations

Transmembrane signaling by interferon alpha involves diacylglycerol production and activation of the epsilon isoform of protein kinase C in Daudi cells.

1991 • 89 citations

Platelet-derived growth factor (PDGF)-dependent association of phospholipase C-gamma with the PDGF receptor signaling complex.

1990 • 86 citations

Cells resistant to interferon are defective in activation of a promoter-binding factor.

1988 • 83 citations

Transcription factors induced by interferons α and γ

1990 • 80 citations

Alpha interferon and gamma interferon stimulate transcription of a single gene through different signal transduction pathways.

1989 • 73 citations

Gene induction by interferons: functional complementation between trans-acting factors induced by alpha interferon and gamma interferon.

1990 • 70 citations

A Transcriptional Enhancer and an Interferon-Responsive Sequence in Major Histocompatibility Complex Class I Genes

1986 • 52 citations

Protein kinase activity required for an early step in interferon-alpha signaling.

1991 • 51 citations

Characterization of the 47-kilodalton autosomal chronic granulomatous disease protein: tissue-specific expression and transcriptional control by retinoic acid.

1990 • 50 citations

Growth factors and their receptors

1989 • 45 citations

[37] Purification of protein-tyrosine phosphatases from human placenta

1991 • 44 citations

Interferons as gene activators. Characteristics of an interferon-activatable enhancer.

1987 • 40 citations

[8] Generation of monoclonal antibodies against phosphotyrosine and their use for affinity purification of phosphotyrosine-containing proteins

1991 • 37 citations

The 75,000-Dalton Interleukin-2 Receptor Transmits a Signal for the Activation of a Tyrosine Protein Kinase

1989 • 32 citations

A transcriptional enhancer and an interferon-responsive sequence in major histocompatibility complex class I genes.

1986 • 27 citations

Induced factor binding to the interferon-stimulated response element. Interferon-alpha and platelet-derived growth factor utilize distinct signaling pathways

1991 • 13 citations

[9] Isolation of tyrosine-phosphorylated proteins and generation of monoclonal antibodies

1991 • 13 citations

[52] Expression and properties of epidermal growth factor receptor expressed from baculovirus vectors

1991 • 8 citations

Cell surface receptors for polypeptide hormones, growth factors and neuropeptides

1989 • 8 citations

Deleted Work

1955 • 0 citations