Mitochondrial contributions to cancer cell physiology: potential for drug development

On the Origin of Cancer Cells

1956 • 12,141 citations

Sequence and organization of the human mitochondrial genome

1981 • 9,348 citations

Mitochondria and Apoptosis

1998 • 8,909 citations

Caspases: Enemies Within

1998 • 6,923 citations

The Release of Cytochrome c from Mitochondria: A Primary Site for Bcl-2 Regulation of Apoptosis

1997 • 4,728 citations

Mechanisms Controlling Mitochondrial Biogenesis and Respiration through the Thermogenic Coactivator PGC-1

1999 • 3,923 citations

An Essential Role for NF-κB in Preventing TNF-α-Induced Cell Death

1996 • 3,094 citations

Mitochondrial Diseases in Man and Mouse

1999 • 3,008 citations

NF-κB: Ten Years After

1996 • 3,008 citations

TNF- and Cancer Therapy-Induced Apoptosis: Potentiation by Inhibition of NF-κB

1996 • 2,665 citations

Requirement for Generation of H ₂ O ₂ for Platelet-Derived Growth Factor Signal Transduction

1995 • 2,505 citations

Production of large amounts of hydrogen peroxide by human tumor cells.

1991 • 2,465 citations

Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis

1998 • 2,427 citations

The mitochondrial permeability transition pore and its role in cell death

1999 • 2,326 citations

Mitochondrial reactive oxygen species trigger hypoxia-induced transcription

1998 • 1,864 citations

Reactive Oxygen Species Generated at Mitochondrial Complex III Stabilize Hypoxia-inducible Factor-1α during Hypoxia

2000 • 1,860 citations

Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress

1997 • 1,762 citations

The p66shc adaptor protein controls oxidative stress response and life span in mammals

1999 • 1,688 citations

Cleavage of CAD inhibitor in CAD activation and DNA degradation during apoptosis

1998 • 1,651 citations

The cellular production of hydrogen peroxide

1972 • 1,526 citations

Mitochondrial transcription factor A is necessary for mtDNA maintance and embryogenesis in mice

1998 • 1,517 citations

Bax directly induces release of cytochrome c from isolated mitochondria

1998 • 1,514 citations

The antioxidant responsive element. Activation by oxidative stress and identification of the DNA consensus sequence required for functional activity

1991 • 1,432 citations

Bcl-xL Regulates the Membrane Potential and Volume Homeostasis of Mitochondria

1997 • 1,389 citations

The mitochondrial permeability transition in cell death: a common mechanism in necrosis, apoptosis and autophagy

1998 • 1,381 citations

Oxidative Phosphorylation at the fin de siècle

1999 • 1,256 citations

Mitochondrial cytochrome c release in apoptosis occurs upstream of DEVD-specific caspase activation and independently of mitochondrial transmembrane depolarization

1998 • 1,226 citations

Activation of Mitogen-activated Protein Kinase by H2O2

1996 • 1,202 citations

Superoxide and hydrogen peroxide in relation to mammalian cell proliferation

1995 • 1,185 citations

Bax and Adenine Nucleotide Translocator Cooperate in the Mitochondrial Control of Apoptosis

1998 • 1,183 citations

Redox Regulation of Cellular Signalling

1999 • 1,146 citations

Apoptosis signaling by death receptors

1998 • 976 citations

An essential role for free radicals and derived species in signal transduction

1997 • 909 citations

Somatic mutations of the mitochondrial genome in human colorectal tumours

1998 • 828 citations

Hypoxia-inducible factor-1alpha is a positive factor in solid tumor growth.

2000 • 784 citations

Mitochondria and cell death

1999 • 763 citations

Mitochondrial control of apoptosis: the role of cytochrome c

1998 • 751 citations

Functional antioxidant responsive elements

1997 • 702 citations

Role of redox potential and reactive oxygen species in stress signaling

1999 • 695 citations

Mammalian Peroxiredoxin Isoforms Can Reduce Hydrogen Peroxide Generated in Response to Growth Factors and Tumor Necrosis Factor-α

1998 • 672 citations

The mitochondrial permeability transition pore and its role in cell death

1999 • 670 citations

The stress-activated protein kinase pathways

1999 • 648 citations

Mitochondrial disease in mouse results in increased oxidative stress

1999 • 634 citations

Escaping Cell Death: Survival Proteins in Cancer

1999 • 629 citations

Random genetic drift in the female germline explains the rapid segregation of mammalian mitochondrial DNA

1996 • 580 citations

From calcium signaling to cell death: two conformations for the mitochondrial permeability transition pore. Switching from low- to high-conductance state

1998 • 568 citations

Essential cell biology

1998 • 568 citations

Nrf2 and Nrf1 in association with Jun proteins regulate antioxidant response element-mediated expression and coordinated induction of genes encoding detoxifying enzymes

1998 • 553 citations

Introduction of disease-related mitochondrial DNA deletions into HeLa cells lacking mitochondrial DNA results in mitochondrial dysfunction.

1991 • 548 citations

Expression of hypoxia-inducible factor 1: mechanisms and consequences

2000 • 504 citations

CROSSTALK BETWEEN NUCLEAR AND MITOCHONDRIAL GENOMES

1996 • 491 citations

Diphenyleneiodonium, an NAD(P)H Oxidase Inhibitor, also Potently Inhibits Mitochondrial Reactive Oxygen Species Production

1998 • 470 citations

Mice with a Homozygous Null Mutation for the Most Abundant Glutathione Peroxidase, Gpx1, Show Increased Susceptibility to the Oxidative Stress-inducing Agents Paraquat and Hydrogen Peroxide

1998 • 445 citations

Activation of an H2O2-generating NADH Oxidase in Human Lung Fibroblasts by Transforming Growth Factor β1

1995 • 426 citations

The Caspase-3 Precursor Has a Cytosolic and Mitochondrial Distribution: Implications for Apoptotic Signaling

1998 • 419 citations

Manganese superoxide dismutase (MnSOD) genetic polymorphisms, dietary antioxidants, and risk of breast cancer.

1999 • 407 citations

NF-κB as a primary regulator of the stress response

1999 • 407 citations

Antioxidant enzyme levels in cancer.

1997 • 396 citations

Targeting of Bcl-2 to the mitochondrial outer membrane by a COOH-terminal signal anchor sequence.

1993 • 390 citations

Bcl-2 family proteins and mitochondria

1998 • 374 citations

ERK activation upon hypoxia: involvement in HIF‐1 activation

2000 • 365 citations

Unusual retention of rhodamine 123 by mitochondria in muscle and carcinoma cells.

1982 • 356 citations

Stress Signals Utilize Multiple Pathways To Stabilize p53

2000 • 355 citations

Complexes between porin, hexokinase, mitochondrial creatine kinase and adenylate translocator display properties of the permeability transition pore. Implication for regulation of permeability transition by the kinases

1998 • 342 citations

Bcl-2 blocks loss of mitochondrial membrane potential while ICE inhibitors act at a different step during inhibition of death induced by respiratory chain inhibitors.

1996 • 300 citations

Redox Regulation of the Caspases during Apoptosis^a

1998 • 271 citations

Nuclear control of respiratory chain expression in mammalian cells.

1997 • 265 citations

Inhibition of anoxia-induced injury in heart myocytes by cyclosporin A

1991 • 261 citations

Aberrant glycolytic metabolism of cancer cells: a remarkable coordination of genetic, transcriptional, post-translational, and mutational events that lead to a critical role for type II hexokinase.

1997 • 244 citations

Hydrogen peroxide induces complex formation of SHC-Grb2-SOS with receptor tyrosine kinase and activates Ras and extracellular signal-regulated protein kinases group of mitogen-activated protein kinases.

1996 • 238 citations

Stable Overexpression of Manganese Superoxide Dismutase in Mitochondria Identifies Hydrogen Peroxide as a Major Oxidant in the AP-1-mediated Induction of Matrix-degrading Metalloprotease-1

1999 • 228 citations

Mitochondrial oxidative stress in mice lacking the glutathione peroxidase-1 gene

2000 • 222 citations

Stimulation of in vitro angiogenesis by hydrogen peroxide and the relation with Ets-1 in endothelial cells

1998 • 219 citations

Increased ROS levels contribute to elevated transcription factor and MAP kinase activities in malignantly progressed mouse keratinocyte cell lines

1999 • 206 citations

Covalent binding of polycyclic aromatic compounds to mitochondrial and nuclear DNA

1980 • 201 citations

Cellular Respiration during Hypoxia

1997 • 185 citations

Oxidative Stress and Upregulation of Mitochondrial Biogenesis Genes in Mitochondrial DNA-Depleted HeLa Cells

1999 • 166 citations

Overexpression of manganese superoxide dismutase in DU145 human prostate carcinoma cells has multiple effects on cell phenotype

1998 • 150 citations

Nucleo-Mitochondrial Interactions in Mitochondrial Gene Expression

1995 • 148 citations

Structural Organization and Transcription Regulation of Nuclear Genes Encoding the Mammalian Cytochrome c Oxidase Complex

1998 • 137 citations

Antioxidant Function of the Mitochondrial Protein SP-22 in the Cardiovascular System

1999 • 132 citations

Mutagenesis, tumorigenicity, and apoptosis: are the mitochondria involved?

1998 • 132 citations

Mitogen-activated Protein Kinase Phosphatase-1 (MKP-1) Expression Is Induced by Low Oxygen Conditions Found in Solid Tumor Microenvironments

1999 • 130 citations

Mitochondrial defects in cis-diamminedichloroplatinum(II)-resistant human ovarian carcinoma cells.

1992 • 120 citations

Mitochondria: beyond oxidative phosphorylation

1995 • 91 citations

Induction by carcinogens and chemoprevention by N-acetylcysteine of adducts to mitochondrial DNA in rat organs.

1996 • 89 citations

Oxidative phosphorylation enzymes in normal and neoplastic cell growth.

1997 • 79 citations

On the role of the general transcription factor Sp1 in the activation and repression of diverse mammalian oxidative phosphorylation genes.

1999 • 78 citations

Mitochondrial Injury Lessons from the Fialuridine Trial

1997 • 72 citations

Inhibition of cell growth in NIH/3T3 fibroblasts by overexpression of manganese superoxide dismutase: Mechanistic studies

1998 • 72 citations

A possible cellular mechanism of cisplatin-induced nephrotoxicity

1989 • 66 citations

Redox Regulation of GA-binding Protein-α DNA Binding Activity

1996 • 65 citations

Overexpression of Catalase in the Mitochondrial or Cytosolic Compartment Increases Sensitivity of HepG2 Cells to Tumor Necrosis Factor-α-induced Apoptosis

2000 • 65 citations

A Conserved Mechanism for Controlling the Translation of β-F1-ATPase mRNA between the Fetal Liver and Cancer Cells

2000 • 64 citations

Decreased mitochondrial function in quiescent cells isolated from multicellular tumor spheroids

1998 • 63 citations

Does the mitochondrial DNA play a role in the pathogenesis of diabetes?

1992 • 60 citations

Defective repair of oxidative damage in the mitochondrial DNA of a xeroderma pigmentosum group A cell line.

1996 • 60 citations

Increase in Intracellular Hydrogen Peroxide and Upregulation of a Nuclear Respiratory Gene Evoked by Impairment of Mitochondrial Electron Transfer in Human Cells

1998 • 56 citations

Mitochondria and apoptosis: HQ or high-security prison?

1999 • 53 citations

Upregulation of human heme oxygenase gene expression by Ets-family proteins

1999 • 51 citations

Thec-ets-1Proto-oncogene Is a New Early-Response Gene Differentially Regulated by Cytokines and Growth Factors in Human Fibroblasts

1996 • 50 citations

The α and β Subunits of the GA-binding Protein Form a Stable Heterodimer in Solution

2000 • 49 citations

Regulation of mitochondrial biogenesis in brown adipose tissue: nuclear respiratory factor-2/GA-binding protein is responsible for the transcriptional regulation of the gene for the mitochondrial ATP synthase β subunit

1998 • 48 citations

Hypoxia-induced bFGF gene expression is mediated through the JNK signal transduction pathway.

1999 • 47 citations

Genotoxicity and mitochondrial damage in human lymphocytic cells chronically exposed to 3′-azido-2′,3′-dideoxythymidine

1997 • 45 citations

ETS transcription factors regulate the expression of the gene for the human mitochondrial ATP synthase beta-subunit.

1994 • 44 citations

Up-regulation of nuclear genes in response to inhibition of mitochondrial DNA expression in chicken cells

1997 • 42 citations

Mitochondrial DNA damage by anticancer agents

1992 • 41 citations

Evidence for lack of mitochondrial DNA repair followingcis-dichlorodiammineplatinum treatment

1990 • 39 citations

Adaptive thermogenesis: Orchestrating mitochondrial biogenesis

1999 • 36 citations

Effects of modulators of the production and degradation of hydrogen peroxide on erythropoietin synthesis

1998 • 33 citations

On the tumorigenicity of mitochondrial DNA-depleted avian cells

1991 • 12 citations