Mitochondrial defects in cis-diamminedichloroplatinum(II)-resistant human ovarian carcinoma cells.

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

Ovarian Cancer

1993 • 3,213 citations

Monitoring of relative mitochondrial membrane potential in living cells by fluorescence microscopy.

1981 • 913 citations

Activation of programmed cell death (apoptosis) by cisplatin, other anticancer drugs, toxins and hyperthermia

1990 • 887 citations

Glucocorticoids activate a suicide process in thymocytes through an elevation of cytosolic Ca2+ concentration

1989 • 549 citations

Mitochondrial and plasma membrane potentials cause unusual accumulation and retention of rhodamine 123 by human breast adenocarcinoma-derived MCF-7 cells.

1985 • 398 citations

Cellular pharmacology of cisplatin: perspectives on mechanisms of acquired resistance.

1990 • 393 citations

Short-termcis-diamminedichloroplatinum(II) accumulation in sensitive and resistant human ovarian carcinoma cells

1990 • 357 citations

Oxidative stress in mitochondria: Its relationship to cellular Ca2+ homeostasis, cell death, proliferation, and differentiation

1991 • 307 citations

Use of a lipophilic cation for determination of membrane potential in neuroblastoma-glioma hybrid cell suspensions

1979 • 219 citations

Differential potentiation of alkylating and platinating agent cytotoxicity in human ovarian carcinoma cells by glutathione depletion.

1985 • 195 citations

Adverse effects of anti-tumor drug, cisplatin, on rat kidney mitochondria: Disturbances in glutathione peroxidase activity

1989 • 129 citations

Mitochondrial injury: an early event in cisplatin toxicity to renal proximal tubules

1990 • 127 citations

Factors determining the plasma-membrane potential of lymphocytes

1982 • 94 citations

Modulation of cis‐diamminedichloroplatinum(II) accumulation and sensitivity by forskolin and 3‐isobutyl‐1‐methylxanthine in sensitive and resistant human ovarian carcinoma cells

1991 • 93 citations

Involvement of protein kinase C in phorbol ester-induced sensitization of HeLa cells to cis-diamminedichloroplatinum(II).

1990 • 91 citations

Epidermal growth factor regulates the in vitro sensitivity of human ovarian carcinoma cells to cisplatin.

1990 • 89 citations

Role of the Na+, K(+)-adenosine triphosphatase in the accumulation of cis-diamminedichloroplatinum(II) in human ovarian carcinoma cells.

1991 • 88 citations

Increased sensitivity to cis-diamminedichloroplatinum(II) in human ovarian carcinoma cells in response to treatment with 12-O-tetradecanoylphorbol 13-acetate.

1990 • 86 citations

Mitochondrial myopathies and respiratory chain proteins

1988 • 78 citations

Comparison of indirect probes of membrane potential utilized in studies of human neutrophils

1983 • 68 citations

Function of the maize mitochondrial chaperonin hsp60: specific association between hsp60 and newly synthesized F1-ATPase alpha subunits.

1990 • 58 citations

Aberrant mitochondria in two human colon carcinoma cell lines.

1989 • 51 citations

ULTRASTRUCTURAL EFFECTS OF CISPLATIN

1980 • 51 citations

Loss of cis-diamminedichloroplatinum(II) resistance in human ovarian carcinoma cells selected for rhodamine 123 resistance.

1992 • 44 citations

Comparison of lipid content, surface membrane fluidity, and temperature dependence of cis-diamminedichloroplatinum(II) accumulation in sensitive and resistant human ovarian carcinoma cells.

1988 • 39 citations

Identification of a 66 KDa protein associated with yeast mitochondrial ATP synthase as heat shock protein hsp60

1990 • 25 citations

Effect of cisplatin on calcium uptake by rat kidney cortical mitochondria

1987 • 22 citations

Effect of membrane potential on the cellular uptake of 2-N-methyl-ellipticinium by L1210 cells

1984 • 21 citations

Ovarian cancer: where to next?

1991 • 20 citations

Differential effects of cisplatin on mouse hepatic and renal mitochrondrial DNA

1990 • 18 citations

Mitochondria in tumor cells effects of cytoskeleton on distribution and as targets for selective killing

1984 • 16 citations

Plasma membrane potential of murine erythroleukemia cells: Approach to measurement and evidence for cell‐density dependence

1986 • 15 citations