Hypoxia-induced bFGF gene expression is mediated through the JNK signal transduction pathway.

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

RNA molecular weight determinations by gel electrophoresis under denaturing conditions, a critical reexamination

1977 • 3,548 citations

JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

1994 • 3,219 citations

The stress-activated protein kinase subfamily of c-Jun kinases

1994 • 2,616 citations

ERKs: A family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF

1991 • 1,901 citations

Phosphorylation of c-jun mediated by MAP kinases

1991 • 1,495 citations

Transcription Factor ATF2 Regulation by the JNK Signal Transduction Pathway

1995 • 1,453 citations

The SRF accessory protein Elk-1 contains a growth factor-regulated transcriptional activation domain

1993 • 1,313 citations

The jun proto-oncogene is positively autoregulated by its product, Jun/AP-1

1988 • 1,256 citations

Requirement for integration of signals from two distinct phosphorylation pathways for activation of MAP kinase

1990 • 1,087 citations

Activation of protein kinase C decreases phosphorylation of c-Jun at sites that negatively regulate its DNA-binding activity

1991 • 1,071 citations

Phosphorylation of transcription factor p62TCF by MAP kinase stimulates ternary complex formation at c-fos promoter

1992 • 980 citations

Identification of a protein-binding site that mediates transcriptional response of the c-fos gene to serum factors

1986 • 883 citations

The mammalian ultraviolet response is triggered by activation of src tyrosine kinases

1992 • 874 citations

Oncogenic and transcriptional cooperation with Ha-Ras requires phosphorylation of c-Jun on serines 63 and 73

1991 • 800 citations

Characterization of SAP-1, a protein recruited by serum response factor to the c-fos serum response element

1992 • 688 citations

Transcriptional autoregulation of the proto-oncogene fos

1988 • 630 citations

Ha-Ras augments c-Jun activity and stimulates phosphorylation of its activation domain

1991 • 626 citations

Up-regulation of vascular endothelial growth factor and its cognate receptors in a rat glioma model of tumor angiogenesis.

1993 • 502 citations

The serum response element

1992 • 458 citations

Ets-related protein Elk-1 is homologous to the c-fos regulatory factor p62TCF

1991 • 447 citations

Heterodimer formation of cJun and ATF-2 is responsible for induction of c-jun by the 243 amino acid adenovirus E1A protein.

1993 • 380 citations

Hypoxic Induction of Endothelial Cell Growth Factors in Retinal Cells: Identification and Characterization of Vascular Endothelial Growth Factor (VEGF) as the Mitogen

1995 • 357 citations

JunB differs from c-Jun in its DNA-binding and dimerization domains, and represses c-Jun by formation of inactive heterodimers.

1993 • 323 citations

Ionizing radiation regulates expression of the c-jun protooncogene.

1990 • 297 citations

Protein kinase C mediates x-ray inducibility of nuclear signal transducers EGR1 and JUN.

1991 • 277 citations

The stress-activated protein kinases are major c-Jun amino-terminal kinases activated by ischemia and reperfusion

1994 • 266 citations

Hypoxia-mediated induction of acidic/basic fibroblast growth factor and platelet-derived growth factor in mononuclear phagocytes stimulates growth of hypoxic endothelial cells.

1995 • 252 citations

Induction of fos RNA by DNA-damaging agents.

1989 • 209 citations

Effects of irradiation on the release of growth factors from cultured bovine, porcine, and human endothelial cells.

1989 • 197 citations

Phosphorylation of the C terminus of Fos protein is required for transcriptional transrepression of the c-fos promoter

1990 • 189 citations

Autocrine effects of fibroblast growth factor in repair of radiation damage in endothelial cells.

1991 • 186 citations

c-fos transcriptional activation and repression correlate temporally with the phosphorylation status of TCF.

1993 • 153 citations

The Heat Shock Response in HeLa Cells is Accompanied by Elevated Expression of the c-fos Proto-Oncogene

1987 • 147 citations

Stimulation by hydrogen peroxide of DNA synthesis, competence family gene expression and phosphorylation of a specific protein in quiescent Balb/3T3 cells.

1990 • 139 citations

Pregrowth hormone messenger RNA: glucocorticoid induction and identification in rat pituitary cells.

1977 • 131 citations

ULTRAVIOLET‐RADIATION INDUCED c‐jun GENE TRANSCRIPTION: TWO AP‐1 LIKE BINDING SITES MEDIATE THE RESPONSE

1992 • 129 citations

Hypoxia and Hypoxia/Reoxygenation Activate p65PAK, p38Mitogen-Activated Protein Kinase (MAPK), and Stress-Activated Protein Kinase (SAPK) in Cultured Rat Cardiac Myocytes

1997 • 124 citations

Activating transcription factor-2 DNA-binding activity is stimulated by phosphorylation catalyzed by p42 and p54 microtubule-associated protein kinases.

1992 • 106 citations

Fos C-terminal mutations block down-regulation of c-fos transcription following serum stimulation.

1988 • 100 citations

Binding of promoter-associated AP-1 is not altered during induction and subsequent repression of the c-jun promoter by TPA and UV irradiation

1994 • 97 citations

Functional Characterization of the Human Basic Fibroblast Growth Factor Gene Promoter

1991 • 93 citations

Brief exposure to hypoxia induces bFGF mRNA and protein and protects rat cortical neurons from prolonged hypoxic stress

1995 • 70 citations

Fos is phosphorylated by p34cdc2, cAMP-dependent protein kinase and protein kinase C at multiple sites clustered within regulatory regions.

1991 • 70 citations

Effect of Ionizing Radiation on AP-1 Binding Activity and Basic Fibroblast Growth Factor Gene Expression in Drug-sensitive Human Breast Carcinoma MCF-7 and Multidrug-resistant MCF-7/ADR Cells

1995 • 60 citations

Alteration of a cyclic AMP-dependent protein kinase phosphorylation site in the c-Fos protein augments its transforming potential.

1992 • 57 citations

Basic fibroblast growth factor secreted by an animal tumor is detectable in urine.

1993 • 52 citations

The expression of c-fos, c-jun, and c-myc genes is regulated by heat shock in human lymphoid cells.

1990 • 47 citations

Hypoglycemia-induced c-Jun Phosphorylation Is Mediated by c-Jun N-terminal Kinase 1 and Lyn Kinase in Drug-resistant Human Breast Carcinoma MCF-7/ADR Cells

1997 • 44 citations

Cellular adaptive responses to low oxygen tension: apoptosis and resistance.

1997 • 34 citations

Host response in tumor growth and progression.

1996 • 24 citations

Hypoglycemia-induced AP-1 transcription factor and basic fibroblast growth factor gene expression in multidrug resistant human breast carcinoma MCF-7/ADR cells

1996 • 22 citations

Tumor promoters induce basic fibroblast growth factor gene expression in human dermal fibroblasts.

1992 • 18 citations

Alteration of a Cyclic AMP-Dependent Protein Kinase Phosphorylation Site in the c-Fos Protein Augments Its Transforming Potential

1992 • 17 citations