Mutagenesis, tumorigenicity, and apoptosis: are the mitochondria involved?

On the Origin of Cancer Cells

1956 • 12,141 citations

Prevention of Apoptosis by Bcl-2: Release of Cytochrome c from Mitochondria Blocked

1997 • 4,921 citations

The Release of Cytochrome c from Mitochondria: A Primary Site for Bcl-2 Regulation of Apoptosis

1997 • 4,728 citations

On Respiratory Impairment in Cancer Cells

1956 • 2,963 citations

Deletions of muscle mitochondrial DNA in patients with mitochondrial myopathies

1988 • 1,806 citations

Human cells lacking mtDNA: repopulation with exogenous mitochondria by complementation

1990 • 1,390 citations

Reduction in mitochondrial potential constitutes an early irreversible step of programmed lymphocyte death in vivo.

1995 • 1,179 citations

The biochemistry of programmed cell death

1995 • 997 citations

Mitochondrial permeability transition is a central coordinating event of apoptosis.

1996 • 857 citations

Bcl-xL forms an ion channel in synthetic lipid membranes

1997 • 817 citations

Identification of a p53-dependent negative response element in the bcl-2 gene.

1994 • 747 citations

Alterations in mitochondrial structure and function are early events of dexamethasone-induced thymocyte apoptosis.

1995 • 598 citations

Cell-free apoptosis in Xenopus egg extracts: Inhibition by Bcl-2 and requirement for an organelle fraction enriched in mitochondria

1994 • 577 citations

Programmed cell death and Bcl-2 protection in the absence of a nucleus.

1994 • 560 citations

On Respiratory Impairment in Cancer Cells

1956 • 511 citations

Ultrastructural analysis of the autophagic process in yeast: detection of autophagosomes and their characterization

1994 • 480 citations

Inhibitors of permeability transition interfere with the disruption of the mitochondrial transmembrane potential during apoptosis

1996 • 440 citations

Cell nucleus and DNA fragmentation are not required for apoptosis.

1994 • 436 citations

RNA-mediated transfer of the gene coxII from the mitochondrion to the nucleus during flowering plant evolution

1991 • 386 citations

Bcl-2 blocks p53-dependent apoptosis.

1994 • 371 citations

Über den Stoffwechsel von Tumoren im Körper

1926 • 337 citations

Circular Dimer and Catenate Forms of Mitochondrial DNA in Human Leukaemic Leucocytes

1967 • 323 citations

Bcl-2 and Bcl-XL antagonize the mitochondrial dysfunction preceding nuclear apoptosis induced by chemotherapeutic agents.

1997 • 302 citations

Protective Effect of N-Acetylcysteine in Tumor Necrosis Factor-α-Induced Apoptosis in U937 Cells: The Role of Mitochondria

1995 • 274 citations

The analysis of malignancy by cell fusion: I. hybrids between tumour cells and l cell derivatives

1971 • 251 citations

Escape of DNA from mitochondria to the nucleus in Saccharomyces cerevisiae

1990 • 249 citations

MMM1 encodes a mitochondrial outer membrane protein essential for establishing and maintaining the structure of yeast mitochondria.

1994 • 247 citations

Cell-free reconstitution of Fas-, UV radiation- and ceramide-induced apoptosis.

1995 • 243 citations

Apoptosis-associated derangement of mitochondrial function in cells lacking mitochondrial DNA.

1996 • 202 citations

Rearranged mitochondrial genes in the yeast nuclear genome

1983 • 196 citations

Ethidium Bromide-Induced Loss of Mitochondrial DNA from Primary Chicken Embryo Fibroblasts

1985 • 183 citations

Short-chain fatty acid-initiated cell cycle arrest and apoptosis of colonic epithelial cells is linked to mitochondrial function.

1997 • 181 citations

Regulated import and degradation of a cytosolic protein in the yeast vacuole

1991 • 174 citations

Induction of immortality is an early event in malignant transformation of mammalian cells by carcinogens

1982 • 174 citations

Oxidative Metabolism of Neoplastic Tissues

1955 • 165 citations

Nuclear mutations in Saccharomyces cerevisiae that affect the escape of DNA from mitochondria to the nucleus.

1993 • 158 citations

Mitochondrial perturbations define lymphocytes undergoing apoptotic depletion in vivo

1995 • 148 citations

Differential effects of ethidium bromide on mitochondrial and nuclear DNA synthesis in vivo in cultured mammalian cells

1972 • 139 citations

Ethidium bromide-induced loss of mitochondrial DNA from primary chicken embryo fibroblasts.

1985 • 138 citations

Tumor-forming ability in athymic nude mice of human cell lines devoid of mitochondrial DNA.

1994 • 110 citations

Mitochondrial morphological and functional defects in yeast caused by yme1 are suppressed by mutation of a 26S protease subunit homologue.

1994 • 109 citations

A COLLOQUIAL CONSIDERATION OF THE PASTEUR AND NEO-PASTEUR EFFECTS

1939 • 106 citations

New evidence for the insertion of mitochondrial DNA into the human genome: significance for cancer and aging

1992 • 104 citations

Bcl‐2 expression is associated with lymph node metastasis in human ductal breast carcinoma

1995 • 99 citations

Tumorigenicity and its suppression in cybrids of mouse and Chinese hamster cell lines.

1978 • 98 citations

Alteration of mitochondrial DNA in human oncocytomas

1989 • 96 citations

Complex Mitochondrial DNA

1968 • 95 citations

On Respiratory Impairment in Cancer Cells

1956 • 84 citations

The analysis of malignancy by cell fusion. VIII. evidence for the intervention of an extra-chromosomal element

1977 • 82 citations

p53 modulation of anchorage independent growth and experimental metastasis.

1996 • 80 citations

Gene Transfera

1987 • 75 citations

Mitochondrial-like DNA sequences flanked by direct and inverted repeats in the nuclear genome of Toxoplasma gondii

1991 • 73 citations

Mitochondrial D-loop sequences are integrated in the rat nuclear genome†

1991 • 62 citations

Development and characterization of continuous avian cell lines depleted of mitochondrial DNA

1988 • 59 citations

Role of mitochondria in carcinogenesis

1993 • 55 citations

Significant existence of deleted mitochondrial DNA in cirrhotic liver surrounding hepatic tumor

1992 • 53 citations

Mitochondria and the yeast cell surface: implications for carcinogenesis

1982 • 53 citations

Mitochondria, Cell Surface, and Carcinogenesis

1983 • 50 citations

Evidence for association of mitochondrial DNA sequence amplification and nuclear localization in human low-grade gliomas

1996 • 47 citations

Cytoplasmic suppression of malignancy

1987 • 43 citations

Increased level of the mitochondrial ND5 transcript in chemically induced rat hepatomas

1989 • 42 citations

HeLaTG cells have mitochondrial DNA inserted into the c-myc oncogene.

1991 • 39 citations

Tumor-associated mutations of rat mitochondrial transfer RNA genes

1983 • 36 citations

DNA sequences homologous to mitochondrial genes in nuclei from normal rat tissues and from rat hepatoma cells

1989 • 30 citations

On suppression of tumorigenicity in hybrid and cybrid mouse cells

1981 • 30 citations

Biochemical Properties of Neoplastic Cell Mitochondria2

1974 • 28 citations

Ultrastructure of Morris Renal Tumors2

1973 • 28 citations

Genetic analysis of tumorigenesis

1981 • 22 citations

The presence of intact mitochondrial DNA in HeLa cell nuclei

1986 • 20 citations

Abnormal Mitochondrial DNA in Acute Leukaemia and Lymphoma

1979 • 19 citations

Restriction enzyme analysis of human leukemic mitochondrial DNA

1980 • 16 citations

Mitochondrial D-loop sequences are integrated in the rat nuclear genome

1991 • 14 citations

Mitochondrial DNA modulation of the anchorage-independent phenotype of transformed avian cells.

1990 • 13 citations

On the tumorigenicity of mitochondrial DNA-depleted avian cells

1991 • 12 citations

rna12 +, a gene of Saccharomyces cerevisiae involved in pre-rRNA maturation. Characterization of a temperature-sensitive mutant, cloning and sequencing of the gene

1992 • 11 citations

Expression of six mitochondrial genes during Drosophila oogenesis: analysis by in situ hybridization

1990 • 10 citations

Giant mitochondria in acute lymphocytic leukemia

1987 • 10 citations