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Hydroperoxide metabolism in mammalian organs.

1979 • 5,821 citations

The Free Radical Theory of Aging Matures

1998 • 3,846 citations

Mitochondrial Diseases in Man and Mouse

1999 • 3,008 citations

The mitochondrial permeability transition

1995 • 2,412 citations

Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice

1991 • 2,028 citations

Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase

1995 • 1,761 citations

Mitochondrial control of apoptosis

1997 • 1,500 citations

Promoter traps in embryonic stem cells: a genetic screen to identify and mutate developmental genes in mice.

1991 • 1,358 citations

Bax and Adenine Nucleotide Translocator Cooperate in the Mitochondrial Control of Apoptosis

1998 • 1,183 citations

Membrane potential of mitochondria measured with an electrode sensitive to tetraphenyl phosphonium and relationship between proton electrochemical potential and phosphorylation potential in steady state

1979 • 954 citations

[5] Diversity of glutathione peroxidases

1995 • 835 citations

Oxidative damage, mitochondrial oxidant generation and antioxidant defenses during aging and in response to food restriction in the mouse

1994 • 785 citations

[42]Assessment of mitochondrial oxidative phosphorylation in patient muscle biopsies, lymphoblasts, and transmitochondrial cell lines

1996 • 746 citations

Mammalian Peroxiredoxin Isoforms Can Reduce Hydrogen Peroxide Generated in Response to Growth Factors and Tumor Necrosis Factor-α

1998 • 672 citations

The structure of the mouse glutathione peroxidase gene: the selenocysteine in the active site is encoded by the ‘termination’ codon, TGA.

1986 • 666 citations

The Fenton reagents

1993 • 646 citations

Mitochondrial disease in mouse results in increased oxidative stress

1999 • 634 citations

Oxidative Stress, Thiol Reagents, and Membrane Potential Modulate the Mitochondrial Permeability Transition by Affecting Nucleotide Binding to the Adenine Nucleotide Translocase

1997 • 588 citations

Mitochondrial disease in superoxide dismutase 2 mutant mice

1999 • 581 citations

Mice Deficient in Cellular Glutathione Peroxidase Develop Normally and Show No Increased Sensitivity to Hyperoxia

1997 • 558 citations

Detection of catalase in rat heart mitochondria.

1991 • 556 citations

Modulation of the Mitochondrial Permeability Transition Pore by Pyridine Nucleotides and Dithiol Oxidation at Two Separate Sites

1996 • 522 citations

Increased Oxidative Damage Is Correlated to Altered Mitochondrial Function in Heterozygous Manganese Superoxide Dismutase Knockout Mice

1998 • 454 citations

Mice with a Homozygous Null Mutation for the Most Abundant Glutathione Peroxidase, Gpx1, Show Increased Susceptibility to the Oxidative Stress-inducing Agents Paraquat and Hydrogen Peroxide

1998 • 445 citations

Superoxide Dismutases

1991 • 332 citations

A quantitative fluorimetric assay for the determination of oxidant production by polymorphonuclear leukocytes: Its use in the simultaneous fluorimetric assay of cellular activation processes

1984 • 322 citations

Regulation of the Permeability Transition Pore in Skeletal Muscle Mitochondria

1998 • 321 citations

Alterations of Antioxidant Enzymes and Oxidative Damage to Macromolecules in Different Organs of Rats During Aging

1998 • 298 citations

Mitochondrial Phospholipid Hydroperoxide Glutathione Peroxidase Plays a Major Role in Preventing Oxidative Injury to Cells

1999 • 296 citations

Recruitment of mitochondrial cyclophilin to the mitochondrial inner membrane under conditions of oxidative stress that enhance the opening of a calcium-sensitive non-specific channel

1994 • 245 citations

Substrate and Site Specificity of Hydrogen Peroxide Generation in Mouse Mitochondria

1998 • 237 citations

The Mitochondrial Permeability Transition Pore is Modulated by Oxidative Agents Through Both Pyridine Nucleotides and Glutathione at Two Separate Sites

1996 • 233 citations

Guide to techniques in mouse development

1993 • 220 citations

Membrane potential and surface potential in mitochondria: Uptake and binding of lipophilic cations

1984 • 213 citations

Tissue non-specific alkaline phosphatase is expressed in both embryonic and extraembryonic lineages during mouse embryogenesis but is not required for migration of primordial germ cells

1995 • 212 citations

Rat Phospholipid-hydroperoxide Glutathione Peroxidase

1995 • 198 citations

In vivo control of respiration by cytochrome c oxidase in wild-type and mitochondrial DNA mutation-carrying human cells

1997 • 189 citations

Import into Mitochondria of Phospholipid Hydroperoxide Glutathione Peroxidase Requires a Leader Sequence

1996 • 122 citations

Selenium-dependent glutathione peroxidase-GI is a major glutathione peroxidase activity in the mucosal epithelium of rodent intestine1Portions of this work were presented in the Selenium II minisymposia at Experimental Biology '96. Preliminary accounts of this work appear in the proceedings volumes of the Sixth International Symposium on Selenium in Biology and Medicine (ISSBM, 1996) and The Japanese Society of Chromatography (1996).1

1998 • 108 citations

Kinetic control of mitochondrial ATP synthesis

1986 • 103 citations

Mouse plasma glutathione peroxidase. cDNA sequence analysis and renal proximal tubular expression and secretion.

1994 • 80 citations

Immunocytochemical localization of seleno-glutathione peroxidase in the adult mouse brain

1996 • 70 citations

Distribution of phospholipid hydroperoxide glutathione peroxidase (PHGPx) in rat testis mitochondria

1994 • 67 citations

Changes in the levels of enzymes which modulate the antioxidant balance occur during aging and correlate with cellular damage

1995 • 59 citations

Immunohistochemical localization of glutathione-S-transferase and glutathione peroxidase in adult Syrian hamster tissues and during kidney development.

1991 • 34 citations

Mitochondrial membrane potential estimated with the correction of probe binding

1987 • 33 citations

Functional analysis of subunits III and IV of Bacillus subtilis aa3-600 quinol oxidase by in vitro mutagenesis and gene replacement

1995 • 23 citations