Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders

Naturally secreted oligomers of amyloid β protein potently inhibit hippocampal long-term potentiation in vivo

2002 • 4,135 citations

Alzheimer's Disease

2010 • 4,028 citations

Mechanisms Underlying Inflammation in Neurodegeneration

2010 • 3,161 citations

The Blood-Brain Barrier in Health and Chronic Neurodegenerative Disorders

2008 • 2,958 citations

Pericytes regulate the blood–brain barrier

2010 • 2,459 citations

Silent Brain Infarcts and the Risk of Dementia and Cognitive Decline

2003 • 2,195 citations

Neurovascular regulation in the normal brain and in Alzheimer's disease

2004 • 2,069 citations

Brain infarction and the clinical expression of Alzheimer disease. The Nun Study

1997 • 1,970 citations

RAGE and amyloid-β peptide neurotoxicity in Alzheimer's disease

1996 • 1,955 citations

Pericytes are required for blood–brain barrier integrity during embryogenesis

2010 • 1,848 citations

Decreased Clearance of CNS β-Amyloid in Alzheimer’s Disease

2010 • 1,835 citations

Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database

2006 • 1,815 citations

The Science of Stroke: Mechanisms in Search of Treatments

2010 • 1,736 citations

Onset and Progression in Inherited ALS Determined by Motor Neurons and Microglia

2006 • 1,540 citations

Brain Infarction and the Clinical Expression of Alzheimer Disease<subtitle>The Nun Study</subtitle>

1997 • 1,509 citations

The Role of Apolipoprotein E in Alzheimer's Disease

2009 • 1,475 citations

Clearance of Alzheimer’s amyloid-β1-40 peptide from brain by LDL receptor–related protein-1 at the blood-brain barrier

2000 • 1,296 citations

RAGE mediates amyloid-β peptide transport across the blood-brain barrier and accumulation in brain

2003 • 1,289 citations

Pericytes Control Key Neurovascular Functions and Neuronal Phenotype in the Adult Brain and during Brain Aging

2010 • 1,284 citations

Patterns of Brain Activation in People at Risk for Alzheimer's Disease

2000 • 1,282 citations

Ataxin-2 intermediate-length polyglutamine expansions are associated with increased risk for ALS

2010 • 1,208 citations

APP locus duplication causes autosomal dominant early-onset Alzheimer disease with cerebral amyloid angiopathy

2005 • 1,189 citations

Microglial Dysfunction and Defective β-Amyloid Clearance Pathways in Aging Alzheimer's Disease Mice

2008 • 1,166 citations

Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons

2007 • 1,160 citations

Alzheimer's disease: clinical trials and drug development

2010 • 1,152 citations

Blood–brain barrier delivery

2006 • 1,093 citations

Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis

2008 • 1,072 citations

Bidirectional control of CNS capillary diameter by pericytes

2006 • 1,042 citations

Cerebral microvascular pathology in aging and Alzheimer's disease

2001 • 1,041 citations

Deletion of the hypoxia-response element in the vascular endothelial growth factor promoter causes motor neuron degeneration

2001 • 1,012 citations

Non–cell autonomous toxicity in neurodegenerative disorders: ALS and beyond

2009 • 958 citations

CADASIL

2009 • 936 citations

Metabolic Regulation of Brain Aβ by Neprilysin

2001 • 918 citations

Neurovascular mechanisms of Alzheimer's neurodegeneration

2005 • 903 citations

VEGF is a modifier of amyotrophic lateral sclerosis in mice and humans and protects motoneurons against ischemic death

2003 • 858 citations

Age, Neuropathology, and Dementia

2009 • 848 citations

The amyloid hypothesis for Alzheimer’s disease: a critical reappraisal

2009 • 793 citations

Apolipoprotein E in Alzheimer's disease and other neurological disorders

2011 • 787 citations

Non–cell autonomous effect of glia on motor neurons in an embryonic stem cell–based ALS model

2007 • 777 citations

LRP/Amyloid β-Peptide Interaction Mediates Differential Brain Efflux of Aβ Isoforms

2004 • 769 citations

Brain oedema in focal ischaemia: molecular pathophysiology and theoretical implications

2007 • 732 citations

Wild-type microglia extend survival in PU.1 knockout mice with familial amyotrophic lateral sclerosis

2006 • 698 citations

Pericyte contraction induced by oxidative-nitrative stress impairs capillary reflow despite successful opening of an occluded cerebral artery

2009 • 696 citations

Review: Cerebral microvascular pathology in ageing and neurodegeneration

2010 • 693 citations

Cerebral hypoperfusion and clinical onset of dementia: The Rotterdam study

2005 • 693 citations

β-Amyloid-mediated vasoactivity and vascular endothelial damage

1996 • 686 citations

apoE isoform–specific disruption of amyloid β peptide clearance from mouse brain

2008 • 685 citations

Synchronous Hyperactivity and Intercellular Calcium Waves in Astrocytes in Alzheimer Mice

2009 • 673 citations

ANG mutations segregate with familial and 'sporadic' amyotrophic lateral sclerosis

2006 • 649 citations

Blood brain barrier: ageing and microvascular disease-systematic review and meta-analysis

2009 • 632 citations

Neuronal Death in the Hippocampus Is Promoted by Plasmin-Catalyzed Degradation of Laminin

1997 • 629 citations

Transport Pathways for Clearance of Human Alzheimer's Amyloid β-Peptide and Apolipoproteins E and J in the Mouse Central Nervous System

2006 • 610 citations

P-glycoprotein deficiency at the blood-brain barrier increases amyloid- deposition in an Alzheimer disease mouse model

2005 • 609 citations

The Cerebrospinal Fluid Provides a Proliferative Niche for Neural Progenitor Cells

2011 • 594 citations

SYMPOSIUM: Clearance of Aβ from the Brain in Alzheimer's Disease: Perivascular Drainage of Amyloid‐β Peptides from the Brain and Its Failure in Cerebral Amyloid Angiopathy and Alzheimer's Disease

2008 • 592 citations

VEGF delivery with retrogradely transported lentivector prolongs survival in a mouse ALS model

2004 • 591 citations

Relation of Diabetes to Mild Cognitive Impairment

2007 • 569 citations

Brain to Plasma Amyloid-β Efflux: a Measure of Brain Amyloid Burden in a Mouse Model of Alzheimer's Disease

2002 • 557 citations

Engaging neuroscience to advance translational research in brain barrier biology

2011 • 553 citations

Hypoxia facilitates Alzheimer's disease pathogenesis by up-regulating BACE1 gene expression

2006 • 547 citations

Matrix metalloproteinases and their multiple roles in neurodegenerative diseases

2009 • 543 citations

Cerebral amyloid angiopathy in the elderly

2011 • 540 citations

Peripherally Applied Aβ-Containing Inoculates Induce Cerebral β-Amyloidosis

2010 • 539 citations

Apolipoprotein E promotes astrocyte colocalization and degradation of deposited amyloid-β peptides

2004 • 530 citations

Proteomic analysis of active multiple sclerosis lesions reveals therapeutic targets

2008 • 509 citations

From angiogenesis to neuropathology

2005 • 505 citations

Insulin, insulin-degrading enzyme and amyloid-β peptide in Alzheimer's disease: review and hypothesis

2005 • 496 citations

Treatment of motoneuron degeneration by intracerebroventricular delivery of VEGF in a rat model of ALS

2004 • 494 citations

Hypertension and Cerebrovascular Dysfunction

2008 • 481 citations

RAGE, LRP-1, and amyloid-beta protein in Alzheimer’s disease

2006 • 454 citations

Microvascular injury and blood–brain barrier leakage in Alzheimer's disease

2006 • 447 citations

ALS-causing SOD1 mutants generate vascular changes prior to motor neuron degeneration

2008 • 447 citations

ApoE and Clusterin Cooperatively Suppress Aβ Levels and Deposition

2004 • 421 citations

APOE4 Allele Disrupts Resting State fMRI Connectivity in the Absence of Amyloid Plaques or Decreased CSF Aβ42

2010 • 419 citations

Role and Therapeutic Potential of VEGF in the Nervous System

2009 • 412 citations

Decreases in Regional Cerebral Blood Flow with Normal Aging

1991 • 400 citations

Neurovascular dysfunction, inflammation and endothelial activation: Implications for the pathogenesis of Alzheimer's disease

2011 • 400 citations

Hypoxia-inducible Factor 1α (HIF-1α)-mediated Hypoxia Increases BACE1 Expression and β-Amyloid Generation

2007 • 397 citations

SOD1 rescues cerebral endothelial dysfunction in mice overexpressing amyloid precursor protein

1999 • 393 citations

Clearance of amyloid-β by circulating lipoprotein receptors

2007 • 387 citations

Molecular biology of the blood-brain and the blood-cerebrospinal fluid barriers: similarities and differences

2011 • 374 citations

Minireview: Thyroid Hormone Transporters: The Knowns and the Unknowns

2010 • 359 citations

The RAGE Axis

2010 • 357 citations

The benefits and limitations of animal models for translational research in neurodegenerative diseases

2010 • 345 citations

Early-onset and Robust Cerebral Microvascular Accumulation of Amyloid β-Protein in Transgenic Mice Expressing Low Levels of a Vasculotropic Dutch/Iowa Mutant Form of Amyloid β-Protein Precursor

2004 • 338 citations

Hippocampal hypometabolism predicts cognitive decline from normal aging

2007 • 336 citations

Matrix Metalloproteinases Expressed by Astrocytes Mediate Extracellular Amyloid-β Peptide Catabolism

2006 • 331 citations

Neurovascular signalling defects in neurodegeneration

2008 • 331 citations

Blood—Brain Barrier Permeability Precedes Senile Plaque Formation in an Alzheimer Disease Model

2003 • 327 citations

Clusterin promotes amyloid plaque formation and is critical for neuritic toxicity in a mouse model of Alzheimer's disease

2002 • 325 citations

Novel Therapeutic Approach for the Treatment of Alzheimer's Disease by Peripheral Administration of Agents with an Affinity to β-Amyloid

2003 • 322 citations

Non-Fc-Mediated Mechanisms Are Involved in Clearance of Amyloid-βIn Vivoby Immunotherapy

2002 • 315 citations

Neuronal Activity Drives Localized Blood-Brain-Barrier Transport of Serum Insulin-like Growth Factor-I into the CNS

2010 • 314 citations

Fibrin deposition accelerates neurovascular damage and neuroinflammation in mouse models of Alzheimer's disease

2007 • 299 citations

Disruption of central nervous system barriers in multiple sclerosis

2010 • 298 citations

Amyloid-β Dynamics Correlate with Neurological Status in the Injured Human Brain

2008 • 289 citations

Vascular basis for brain degeneration: faltering controls and risk factors for dementia

2010 • 277 citations

Role of the MEOX2 homeobox gene in neurovascular dysfunction in Alzheimer disease

2005 • 272 citations

Na+-dependent Glutamate Transporters (EAAT1, EAAT2, and EAAT3) of the Blood-Brain Barrier

1999 • 269 citations

Hypometabolism exceeds atrophy in presymptomatic early-onset familial Alzheimer's disease.

2006 • 268 citations

Blood-brain barrier permeability is increased in normal-appearing white matter in patients with lacunar stroke and leucoaraiosis

2009 • 262 citations

Immunization with a Nontoxic/Nonfibrillar Amyloid-β Homologous Peptide Reduces Alzheimer's Disease-Associated Pathology in Transgenic Mice

2001 • 262 citations

Plaque‐associated disruption of CSF and plasma amyloid‐β (Aβ) equilibrium in a mouse model of Alzheimer's disease

2002 • 255 citations

Coupling of the NMDA receptor to neuroprotective and neurodestructive events

2009 • 247 citations

Lipopolysaccharide alters the blood–brain barrier transport of amyloid β protein: A mechanism for inflammation in the progression of Alzheimer’s disease

2009 • 242 citations

Activated protein C inhibits tissue plasminogen activator–induced brain hemorrhage

2006 • 241 citations

SRF and myocardin regulate LRP-mediated amyloid-β clearance in brain vascular cells

2008 • 241 citations

Decreased blood–brain barrier P-glycoprotein function in the progression of Parkinson’s disease, PSP and MSA

2008 • 239 citations

Low‐density lipoprotein receptor‐related protein‐1: a serial clearance homeostatic mechanism controlling Alzheimer’s amyloid β‐peptide elimination from the brain

2010 • 238 citations

Aβ1–40-related reduction in functional hyperemia in mouse neocortex during somatosensory activation

2000 • 237 citations

Human blood-brain barrier receptors for Alzheimer's amyloid-beta 1- 40. Asymmetrical binding, endocytosis, and transcytosis at the apical side of brain microvascular endothelial cell monolayer.

1998 • 232 citations

The up‐regulation of BACE1 mediated by hypoxia and ischemic injury: role of oxidative stress and HIF1α

2008 • 228 citations

Endothelial Smad4 Maintains Cerebrovascular Integrity by Activating N-Cadherin through Cooperation with Notch

2011 • 225 citations

Evidence of Compromised Blood-Spinal Cord Barrier in Early and Late Symptomatic SOD1 Mice Modeling ALS

2007 • 223 citations

The tissue plasminogen activator-plasminogen proteolytic cascade accelerates amyloid-beta (Abeta) degradation and inhibits Abeta-induced neurodegeneration.

2003 • 222 citations

Alzheimer's dementia begins as a disease of small blood vessels, damaged by oxidative‐induced inflammation and dysregulated amyloid metabolism: implications for early detection and therapy

2011 • 218 citations

A Histochemical and Ultrastructural Study

1983 • 218 citations

IgG Reactivity in the Spinal Cord and Motor Cortex in Amyotrophic Lateral Sclerosis

1990 • 215 citations

β-Amyloid-induced migration of monocytes across human brain endothelial cells involves RAGE and PECAM-1

2000 • 209 citations

Serum response factor and myocardin mediate arterial hypercontractility and cerebral blood flow dysregulation in Alzheimer's phenotype

2007 • 203 citations

Hypoxia increases Aβ generation by altering β- and γ-cleavage of APP

2007 • 202 citations

Altered brain activation in cognitively intact individuals at high risk for Alzheimer’s disease

1999 • 202 citations

The Tissue Plasminogen Activator-Plasminogen Proteolytic Cascade Accelerates Amyloid-β (Aβ) Degradation and Inhibits Aβ-Induced Neurodegeneration

2003 • 190 citations

APOE ε4 Genotype and Longitudinal Changes in Cerebral Blood Flow in Normal Aging

2010 • 189 citations

Common molecular signature in SOD1 for both sporadic and familial amyotrophic lateral sclerosis

2007 • 189 citations

GLUT-1 Expression in the Cerebra of Patients with Alzheimer’s Disease

1997 • 188 citations

Vascular risk factor detection and control may prevent Alzheimer's disease

2010 • 185 citations

Glial Nax Channels Control Lactate Signaling to Neurons for Brain [Na+] Sensing

2007 • 181 citations

Disruption of neurovascular unit prior to motor neuron degeneration in amyotrophic lateral sclerosis

2011 • 180 citations

Caffeine protects against MPTP‐induced blood‐brain barrier dysfunction in mouse striatum

2008 • 179 citations

A mouse model for Glut-1 haploinsufficiency

2006 • 176 citations

Control of Motoneuron Survival by Angiogenin

2008 • 175 citations

Activated protein C therapy slows ALS-like disease in mice by transcriptionally inhibiting SOD1 in motor neurons and microglia cells

2009 • 172 citations

Blood-Brain Barrier Transport of Circulating Alzheimer′s Amyloid β

1993 • 170 citations

TNF-α knockout and minocycline treatment attenuates blood–brain barrier leakage in MPTP-treated mice

2007 • 162 citations

Two‐Photon Imaging of Astrocytic Ca²⁺ Signaling and the Microvasculature in Experimental Mice Models of Alzheimer's Disease

2007 • 151 citations

Blood–brain barrier P-glycoprotein function decreases in specific brain regions with aging: A possible role in progressive neurodegeneration

2008 • 150 citations

Reduced basal ganglia blood flow and volume in pre-symptomatic, gene-tested persons at-risk for Huntington's disease

1999 • 138 citations

Update in the epidemiology of Parkinson's disease

2008 • 138 citations

Reduced cerebral glucose metabolism in patients at risk for Alzheimer's disease

2007 • 138 citations

Expanding the definition of the blood-brain barrier to protein.

1981 • 135 citations

Scavenger receptor CD36 is essential for the cerebrovascular oxidative stress and neurovascular dysfunction induced by amyloid-β

2011 • 135 citations

DECREASED mRNA EXPRESSION OF TIGHT JUNCTION PROTEINS IN LUMBAR SPINAL CORDS OF PATIENTS WITH ALS

2009 • 134 citations

Dysfunctional Cell-Cell Signaling in the Neurovascular Unit as a Paradigm for Central Nervous System Disease

2008 • 134 citations

Circulating amyloid-β peptide crosses the blood–brain barrier in aged monkeys and contributes to Alzheimer's disease lesions

2002 • 133 citations

Cerebrovascular Accumulation and Increased Blood‐Brain Barrier Permeability to Circulating Alzheimer's Amyloid β Peptide in Aged Squirrel Monkey with Cerebral Amyloid Angiopathy

1998 • 130 citations

Cytoprotective protein C pathways and implications for stroke and neurological disorders

2011 • 129 citations

Thrombin Mediates Severe Neurovascular Injury During Ischemia

2010 • 125 citations

Impaired angiogenesis in a transgenic mouse model of cerebral amyloidosis

2004 • 124 citations

Mesenchymal stem cell transplantation attenuates blood brain barrier damage and neuroinflammation and protects dopaminergic neurons against MPTP toxicity in the substantia nigra in a model of Parkinson's disease

2009 • 122 citations

Transport of Leucine‐Enkephalin Across the Blood‐Brain Barrier in the Perfused Guinea Pig Brain

1987 • 120 citations

Vascular Risk Factors: Imaging and Neuropathologic Correlates

2010 • 119 citations

Testing the Neurovascular Hypothesis of Alzheimer's Disease: LRP-1 Antisense Reduces Blood-brain Barrier Clearance, Increases Brain Levels of Amyloid-β Protein, and Impairs Cognition

2009 • 119 citations

Cerebral glucose metabolism in preclinical and prodromal Alzheimer’s disease

2010 • 119 citations

Oligemic Hypoperfusion Differentially Affects Tau and Amyloid-β

2010 • 118 citations

The effect of encapsulated VEGF-secreting cells on brain amyloid load and behavioral impairment in a mouse model of Alzheimer’s disease

2010 • 117 citations

Oxidative modification to LDL receptor-related protein 1 in hippocampus from subjects with Alzheimer disease: Implications for Aβ accumulation in AD brain

2010 • 117 citations

Prevalence and Impact of Cerebrovascular Lesions in Alzheimer and Lewy Body Diseases

2010 • 115 citations

Amyotrophic lateral sclerosis: A neurovascular disease

2011 • 112 citations

Blood-brain barrier permeability to leucine-enkephalin,d-Alanine2-d-leucine5-enkephalin and their N-terminal amino acid (tyrosine)

1985 • 112 citations

Hypoxia-Induced Down-Regulation of Neprilysin by Histone Modification in Mouse Primary Cortical and Hippocampal Neurons

2011 • 109 citations

Major Involvement of Low-Density Lipoprotein Receptor-Related Protein 1 in the Clearance of Plasma Free Amyloid β-Peptide by the Liver

2006 • 105 citations

The Low Density Lipoprotein Receptor-related Protein 1 Mediates Uptake of Amyloid β Peptides in an in Vitro Model of the Blood-Brain Barrier Cells

2008 • 104 citations

Peripheral reduction of β-amyloid is sufficient to reduce brain β-amyloid: Implications for Alzheimer's disease

2011 • 104 citations

Substitution at codon 22 reduces clearance of Alzheimer's amyloid-β peptide from the cerebrospinal fluid and prevents its transport from the central nervous system into blood

2002 • 103 citations

Thrombin, a mediator of neurotoxicity and memory impairment

2003 • 103 citations

Degeneration and repair in central nervous system disease

2010 • 103 citations

Reduction of Brain β-Amyloid (Aβ) by Fluvastatin, a Hydroxymethylglutaryl-CoA Reductase Inhibitor, through Increase in Degradation of Amyloid Precursor Protein C-terminal Fragments (APP-CTFs) and Aβ Clearance

2010 • 100 citations

Kinetics of arginine-vasopressin uptake at the blood-brain barrier

1990 • 98 citations

Brain Endothelial Cells Synthesize Neurotoxic Thrombin in Alzheimer’s Disease

2010 • 98 citations

Partial volume effect-corrected FDG PET and grey matter volume loss in patients with mild Alzheimer’s disease

2007 • 94 citations

Permeability of the blood-cerebrospinal fluid and blood-brain barriers to thyrotropin-releasing hormone

1985 • 93 citations

LRP promotes endocytosis and degradation, but not transcytosis, of the amyloid-β peptide in a blood–brain barrier in vitro model

2008 • 92 citations

Oxidative Stress and Altered Mitochondrial Function in Neurodegenerative Diseases: Lessons From Mouse Models

2010 • 90 citations

Brain Clearance of Alzheimer's Amyloid-β40 in the Squirrel Monkey: A SPECT Study in a Primate Model of Cerebral Amyloid Angiopathy

2002 • 89 citations

Kinetic Analysis of Leucine-Enkephalin Cellular Uptake at the Luminal Side of the Blood-Brain Barrier of an In Situ Perfused Guinea-Pig Brain

1989 • 86 citations

Glut1 deficiency: Inheritance pattern determined by haploinsufficiency

2010 • 86 citations

Microvessels from Alzheimer's Disease Brains Kill Neurons in Vitro

1999 • 84 citations

Blood-brain barrier uptake of the 40 and 42 amino acid sequences of circulating Alzheimer's amyloid β in guinea pigs

1996 • 82 citations

Disturbed Cross Talk between Insulin-Like Growth Factor I and AMP-Activated Protein Kinase as a Possible Cause of Vascular Dysfunction in the Amyloid Precursor Protein/Presenilin 2 Mouse Model of Alzheimer's Disease

2007 • 81 citations

Isolation of Peptide Transport System-6 from Brain Endothelial Cells: Therapeutic Effects with Antisense Inhibition in Alzheimer and Stroke Models

2008 • 80 citations

Cerebrovascular Hypoperfusion Induces Spatial Memory Impairment, Synaptic Changes, and Amyloid-β Oligomerization in Rats

2010 • 79 citations

Age-related changes in choroid plexus and blood–cerebrospinal fluid barrier function in the sheep

2008 • 78 citations

Gray matter perfusion correlates with disease severity in ALS

2010 • 77 citations

Differential activation of mitochondrial apoptotic pathways by vasculotropic amyloid‐β variants in cells composing the cerebral vessel walls

2009 • 75 citations

Role of mitochondrial-mediated signaling pathways in Alzheimer disease and hypoxia

2009 • 70 citations

Blood-Brain Barrier as a Regulatory Interface

2009 • 68 citations

Expression of Neprilysin in Skeletal Muscle Reduces Amyloid Burden in a Transgenic Mouse Model of Alzheimer Disease

2009 • 68 citations

Endothelial Protein C Receptor-Assisted Transport of Activated Protein C across the Mouse Blood—Brain Barrier

2008 • 67 citations

Circulating neprilysin clears brain amyloid

2010 • 67 citations

Impaired Lipoprotein Receptor-Mediated Peripheral Binding of Plasma Amyloid-β is an Early Biomarker for Mild Cognitive Impairment Preceding Alzheimer's Disease

2011 • 66 citations

Permeability and Residual Plasma Volume of Human, Dutch Variant, and Rat Amyloid β-Protein 1-40 at the Blood–Brain Barrier

1997 • 56 citations

Transgenic Mice Overexpressing APP and Transforming Growth Factor-β1 Feature Cognitive and Vascular Hallmarks of Alzheimer's Disease

2010 • 54 citations

Mitochondria: The Missing Link Between Preconditioning and Neuroprotection

2010 • 53 citations

Intra-arterial infusion of [125l]Aβ 1–40 labels amyloid deposits in the aged primate brain in vivo

1996 • 52 citations

Acute hypoxia promote the phosphorylation of tau via ERK pathway

2010 • 44 citations

Vascular Parkinsonism: A Clinical Review

2008 • 43 citations

Differential Changes in Phosphorylation of Tau at PHF-1 and 12E8 Epitopes During Brain Ischemia and Reperfusion in Gerbils

2006 • 40 citations

ATP-Binding Cassette Transporters and Their Roles in Protecting the Brain

2011 • 39 citations

Lead-induced accumulation of β-amyloid in the choroid plexus: Role of low density lipoprotein receptor protein-1 and protein kinase C

2010 • 39 citations

Brain microbleeds: more evidence, but still a clinical dilemma

2010 • 38 citations

Chemical preconditioning-induced reactive astrocytosis contributes to the reduction of post-ischemic edema through aquaporin-4 downregulation

2010 • 32 citations

Hypoxia suppresses astrocyte glutamate transport independently of amyloid formation

2007 • 26 citations

Blood-brain barrier disruption in the striatum of rats treated with 3-nitropropionic acid

2008 • 23 citations

Vasomotor hyporeactivity in the anterior cerebral artery during motor activation in Huntington’s disease patients

2000 • 23 citations

Amyloid angiopathy in idiopathic Parkinson’s disease. Immunohistochemical and ultrastructural study

2008 • 23 citations

Cholinergic neurons degenerate when exposed to conditioned medium of primary rat brain capillary endothelial cells: Counteraction by NGF, MK-801 and inflammation

2006 • 19 citations

The future of genetic research on neurodegeneration

2010 • 18 citations

Chemical Hypoxia Facilitates Alternative Splicing of EAAT2 in Presymptomatic APP23 Transgenic Mice

2007 • 13 citations

Neurometabolic Coupling in the Lateral Geniculate Nucleus Changes With Extended Age

2010 • 12 citations

Deleted Work

1955 • 0 citations