Major Involvement of Low-Density Lipoprotein Receptor-Related Protein 1 in the Clearance of Plasma Free Amyloid β-Peptide by the Liver

The carboxy terminus of the .beta. amyloid protein is critical for the seeding of amyloid formation: Implications for the pathogenesis of Alzheimer's disease

1993 • 1,951 citations

Hydrodynamics-based transfection in animals by systemic administration of plasmid DNA

1999 • 1,702 citations

Isolation and quantification of soluble Alzheimer's β-peptide from biological fluids

1992 • 1,701 citations

Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease.

1993 • 1,329 citations

Clearance of Alzheimer’s amyloid-β1-40 peptide from brain by LDL receptor–related protein-1 at the blood-brain barrier

2000 • 1,296 citations

RAGE mediates amyloid-β peptide transport across the blood-brain barrier and accumulation in brain

2003 • 1,289 citations

Peripheral anti-Aβ antibody alters CNS and plasma Aβ clearance and decreases brain Aβ burden in a mouse model of Alzheimer's disease

2001 • 1,264 citations

LRP: a multifunctional scavenger and signaling receptor

2001 • 975 citations

LRP: a multifunctional scavenger and signaling receptor

2001 • 856 citations

LRP/Amyloid β-Peptide Interaction Mediates Differential Brain Efflux of Aβ Isoforms

2004 • 769 citations

Alzheimer's beta-amyloid peptides compete for insulin binding to the insulin receptor.

2002 • 497 citations

Inducible inactivation of hepatic LRP gene by cre-mediated recombination confirms role of LRP in clearance of chylomicron remnants.

1998 • 454 citations

Amyloid-β immunotherapy for Alzheimer's disease: the end of the beginning

2002 • 437 citations

Distribution of the ?2-macroglobulin receptor/low density lipoprotein receptor-related protein in human tissues

1992 • 385 citations

Passive immunotherapy against Abeta in aged APP-transgenic mice reverses cognitive deficits and depletes parenchymal amyloid deposits in spite of increased vascular amyloid and microhemorrhage.

2004 • 352 citations

Modulation of amyloid β-protein clearance and Alzheimer’s disease susceptibility by the LDL receptor–related protein pathway

2000 • 335 citations

Amyloid β-Peptide Is Transported on Lipoproteins and Albumin in Human Plasma

1996 • 316 citations

Evidence that the 42- and 40-amino acid forms of amyloid β protein are generated from the β-amyloid precursor protein by different protease activities

1996 • 291 citations

RAP, a specialized chaperone, prevents ligand-induced ER retention and degradation of LDL receptor-related endocytic receptors.

1996 • 274 citations

Functional expression of low density lipoprotein receptor-related protein is controlled by receptor-associated protein in vivo.

1995 • 270 citations

Biomarkers of Alzheimer disease in plasma

2004 • 268 citations

Alzheimer's β-Amyloid Peptides Compete for Insulin Binding to the Insulin Receptor

2002 • 264 citations

Human blood-brain barrier receptors for Alzheimer's amyloid-beta 1- 40. Asymmetrical binding, endocytosis, and transcytosis at the apical side of brain microvascular endothelial cell monolayer.

1998 • 232 citations

Advanced glycation end product ligands for the receptor for advanced glycation end products: biochemical characterization and formation kinetics

2003 • 178 citations

Systemic Catabolism of Alzheimer's Aβ40 and Aβ42

2004 • 176 citations

Fusogenic Properties of the C-terminal Domain of the Alzheimer β-Amyloid Peptide

1996 • 148 citations

Circulating amyloid-β peptide crosses the blood–brain barrier in aged monkeys and contributes to Alzheimer's disease lesions

2002 • 133 citations

Cerebrovascular Accumulation and Increased Blood‐Brain Barrier Permeability to Circulating Alzheimer's Amyloid β Peptide in Aged Squirrel Monkey with Cerebral Amyloid Angiopathy

1998 • 130 citations

The roles of receptor-associated protein (RAP) as a molecular chaperone for members of the LDL receptor family

2001 • 119 citations

Amyloid-beta peptide, substance P, and bombesin bind to the serpin-enzyme complex receptor.

1991 • 102 citations

The α5β1 Integrin Mediates Elimination of Amyloid-β Peptide and Protects Against Apoptosis

1998 • 97 citations

The length of Amyloid-β in Hereditary Cerebral Hemorrhage with Amyloidosis, Dutch Type

1996 • 91 citations

Localization of norepinephrine and serotonin transporter in mouse brain capillary endothelial cells

2002 • 85 citations

Transport of protein-bound steroid hormones into liver in vivo.

1979 • 79 citations

Carotid Artery Injection Technique: Bounds for Bolus Mixing by Plasma and by Brain

1985 • 73 citations

Apolipoprotein E influences amyloid-beta clearance from the murine periphery

2003 • 65 citations

Kinetics of Neutral Amino Acid Transport Through the Blood‐Brain Barrier of the Newborn Rabbit

1982 • 61 citations

Pharmacokinetic Analysis of the Blood-Brain Barrier Transport of¹²⁵I-Amyloid β Protein 40 in Wild-Type and Alzheimer's Disease Transgenic Mice (APP,PS1) and Its Implications for Amyloid Plaque Formation

2005 • 58 citations

Permeability and Residual Plasma Volume of Human, Dutch Variant, and Rat Amyloid β-Protein 1-40 at the Blood–Brain Barrier

1997 • 56 citations

Cohort movement of different ligands and receptors in the intracellular endocytic pathway of alveolar macrophages

1989 • 45 citations

Plasma β-amyloid (Aβ) 40 concentration, lipid status and age in humans

2004 • 18 citations

The rate of internalization of different receptor–ligand complexes in alveolar macrophages is receptor-specific

1990 • 13 citations

Blood flow rate and cellular influx of glucose and arginine in mouse liver in vivo

1980 • 13 citations

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