Amyotrophic lateral sclerosis: A neurovascular disease

Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

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Astrocyte–endothelial interactions at the blood–brain barrier

2005 • 4,950 citations

Structure and function of the blood–brain barrier

2009 • 4,310 citations

Getting to the site of inflammation: the leukocyte adhesion cascade updated

2007 • 3,957 citations

How Matrix Metalloproteinases Regulate Cell Behavior

2001 • 3,860 citations

Pericytes regulate the blood–brain barrier

2010 • 2,459 citations

The Blood-Brain Barrier/Neurovascular Unit in Health and Disease

2005 • 2,454 citations

Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

1994 • 2,255 citations

The blood–brain barrier: an overview

2004 • 2,040 citations

Amyotrophic Lateral Sclerosis

2001 • 1,664 citations

Onset and Progression in Inherited ALS Determined by Motor Neurons and Microglia

2006 • 1,540 citations

UNRAVELING THE MECHANISMS INVOLVED IN MOTOR NEURON DEGENERATION IN ALS

2004 • 1,362 citations

Astrocyte–endothelial interactions and blood–brain barrier permeability*

2002 • 1,098 citations

Molecular biology of amyotrophic lateral sclerosis: insights from genetics

2006 • 1,071 citations

Cellular actions of beta-amyloid precursor protein and its soluble and fibrillogenic derivatives

1997 • 991 citations

Signalling to and from tight junctions

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Matrix Metalloproteinases and TIMPs Are Associated With Blood-Brain Barrier Opening After Reperfusion in Rat Brain

1998 • 847 citations

Matrix metalloproteinases in neuroinflammation

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Neurovascular mechanisms and blood–brain barrier disorder in Alzheimer’s disease

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A cell culture model of the blood-brain barrier.

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Pericytes in the microvasculature

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Cytokine regulation of endothelial cell function

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Natural history of amyotrophic lateral sclerosis in a database population Validation of a scoring system and a model for survival prediction

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Developing nervous tissue induces formation of blood-brain barrier characteristics in invading endothelial cells: A study using quail-chick transplantation chimeras

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Current hypotheses for the underlying biology of amyotrophic lateral sclerosis

2009 • 673 citations

Chronic cerebrospinal venous insufficiency in patients with multiple sclerosis

2008 • 664 citations

Shedding of the Matrix Metalloproteinases MMP-2, MMP-9, and MT1-MMP as Membrane Vesicle-Associated Components by Endothelial Cells

2002 • 557 citations

Tight junctions and the modulation of barrier function in disease

2008 • 552 citations

Pericytes. Morphofunction, interactions and pathology in a quiescent and activated mesenchymal cell niche.

2009 • 533 citations

Amyotrophic lateral sclerosis

2007 • 528 citations

Presence of dendritic cells, MCP‐1, and activated microglia/macrophages in amyotrophic lateral sclerosis spinal cord tissue

2003 • 519 citations

Microglia, macrophages, perivascular macrophages, and pericytes: a review of function and identification

2003 • 517 citations

Diverse roles of matrix metalloproteinases and tissue inhibitors of metalloproteinases in neuroinflammation and cerebral ischemia

2008 • 506 citations

Dystroglycan is selectively cleaved at the parenchymal basement membrane at sites of leukocyte extravasation in experimental autoimmune encephalomyelitis

2006 • 502 citations

Inflammatory processes in amyotrophic lateral sclerosis

2002 • 460 citations

Relationship of microglial and astrocytic activation to disease onset and progression in a transgenic model of familial ALS

1998 • 456 citations

The role of excitotoxicity in the pathogenesis of amyotrophic lateral sclerosis

2006 • 449 citations

ALS-causing SOD1 mutants generate vascular changes prior to motor neuron degeneration

2008 • 447 citations

Impairment of Glucose and Glutamate Transport and Induction of Mitochondrial Oxidative Stress and Dysfunction in Synaptosomes by Amyloid β‐Peptide: Role of the Lipid Peroxidation Product 4‐Hydroxynonenal

1997 • 440 citations

Blood-brain barrier biology and methodology

1999 • 436 citations

Transporting therapeutics across the blood-brain barrier

1996 • 429 citations

Involvement of ROS in BBB dysfunction

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Immune reactivity in a mouse model of familial ALS correlates with disease progression

2001 • 424 citations

The blood-brain barrier in neuroinflammatory diseases.

1997 • 406 citations

Brain endothelial cells and the glio-vascular complex

2008 • 404 citations

Circulating endothelial cells

2005 • 381 citations

A prospective open-label study of endovascular treatment of chronic cerebrospinal venous insufficiency

2009 • 372 citations

Cell cycle inhibition provides neuroprotection and reduces glial proliferation and scar formation after traumatic brain injury

2005 • 367 citations

Tight junctional abnormality in multiple sclerosis white matter affects all calibres of vessel and is associated with blood–brain barrier leakage and active demyelination

2003 • 365 citations

Junctional complexes of the blood–brain barrier: permeability changes in neuroinflammation

2002 • 352 citations

Pericytes from Brain Microvessels Strengthen the Barrier Integrity in Primary Cultures of Rat Brain Endothelial Cells

2007 • 346 citations

Glial cell influence on the human blood‐brain barrier

2001 • 322 citations

The extracellular matrix of the central and peripheral nervous systems: structure and function

1988 • 313 citations

Matrix Metalloproteinase-9 Mediates Hypoxia-Induced Vascular Leakage in the Brain via Tight Junction Rearrangement

2009 • 305 citations

Lymphocytic Infiltrates in the Spinal Cord in Amyotrophic Lateral Sclerosis

1993 • 295 citations

In Search of the Astrocytic Factor(s) Modulating Blood–Brain Barrier Functions in Brain Capillary Endothelial Cells In Vitro

2005 • 292 citations

Increased expression of the pro-inflammatory enzyme cyclooxygenase-2 in amyotrophic lateral sclerosis

2001 • 270 citations

Differential expression of inflammation‐ and apoptosis‐related genes in spinal cords of a mutant SOD1 transgenic mouse model of familial amyotrophic lateral sclerosis

2001 • 268 citations

Focal Cerebral Ischemia Induces Active Proteases That Degrade Microvascular Matrix

2004 • 265 citations

Reperfusion and Neurovascular Dysfunction in Stroke: from Basic Mechanisms to Potential Strategies for Neuroprotection

2010 • 248 citations

Molecular Anatomy of the Blood-Brain Barrier as Defined by Immunocytochemistry

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Possible involvement of gap junctions in the barrier function of tight junctions of brain and lung endothelial cells

2006 • 238 citations

Physiology and pharmacological role of the blood-brain barrier.

2008 • 229 citations

The Membranes of Cells

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Induction of blood–brain barrier properties in immortalized bovine brain endothelial cells by astrocytic factors

1999 • 223 citations

Evidence of Compromised Blood-Spinal Cord Barrier in Early and Late Symptomatic SOD1 Mice Modeling ALS

2007 • 223 citations

Oxidative Stress and Motor Neurone Disease

1999 • 220 citations

IgG Reactivity in the Spinal Cord and Motor Cortex in Amyotrophic Lateral Sclerosis

1990 • 215 citations

Ultrastructure of blood–brain barrier and blood–spinal cord barrier in SOD1 mice modeling ALS

2007 • 214 citations

Circulating endothelial cells, von Willebrand factor, interleukin-6, and prognosis in patients with acute coronary syndromes

2004 • 213 citations

Diapedesis of mononuclear cells across cerebral venules during experimental autoimmune encephalomyelitis leaves tight junctions intact

2004 • 210 citations

Endothelial cell tube formation depends on cadherin 5 and CD31 interactions with filamentous actin.

1997 • 209 citations

The Pathobiology of Amyotrophic Lateral Sclerosis: A Proteinopathy?

2005 • 202 citations

Protein Kinase C Regulates the Phosphorylation and Cellular Localization of Occludin

2001 • 199 citations

Temporal patterns of cytokine and apoptosis‐related gene expression in spinal cords of the G93A‐SOD1 mouse model of amyotrophic lateral sclerosis

2002 • 196 citations

Mast Cells as Early Responders in the Regulation of Acute Blood–Brain Barrier Changes after Cerebral Ischemia and Hemorrhage

2010 • 185 citations

The blood-brain barrier. Transport across the cerebral endothelium.

1985 • 184 citations

Cytokine upregulation in a murine model of familial amyotrophic lateral sclerosis

2001 • 182 citations

Disruption of neurovascular unit prior to motor neuron degeneration in amyotrophic lateral sclerosis

2011 • 180 citations

Glial cells and neurons induce blood-brain barrier related enzymes in cultured cerebral endothelial cells

1991 • 180 citations

Protein Kinase Cα-RhoA Cross-talk in CCL2-induced Alterations in Brain Endothelial Permeability

2006 • 180 citations

Blood–brain barrier alterations in both focal and diffuse abnormalities on postmortem MRI in multiple sclerosis

2005 • 176 citations

Perivascular cells act as scavengers in the cerebral perivascular spaces and remain distinct from pericytes, microglia and macrophages

1993 • 174 citations

Trans-cellular migration: cell–cell contacts get intimate

2008 • 173 citations

Expression of immunologically relevant endothelial cell activation antigens on isolated central neurvous system microvessels from patients with multiple sclerosis

1994 • 170 citations

Properties of an immortalised vascular endothelial/glioma cell co-culture model of the blood-brain barrier

1996 • 161 citations

The Tight Junction Protein, Occludin, Regulates the Directional Migration of Epithelial Cells

2010 • 161 citations

BARRIER MECHANISMS IN THE BRAIN, I. ADULT BRAIN

1999 • 158 citations

Impaired blood–brain and blood–spinal cord barriers in mutant SOD1-linked ALS rat

2009 • 156 citations

Tumor Necrosis Factor-α Mediates the Blood–Brain Barrier Dysfunction Induced by Activated Microglia in Mouse Brain Microvascular Endothelial Cells

2010 • 154 citations

Tissue inhibitors of matrix metalloproteinases are elevated in cerebrospinal fluid of neurodegenerative diseases

2003 • 154 citations

The pericyte: Cellular regulator of microvascular blood flow

2009 • 153 citations

Neuroinflammation, COX-2, and ALS—a dual role?

2004 • 150 citations

Inhibition of MMP‐3 or ‐9 suppresses lipopolysaccharide‐induced expression of proinflammatory cytokines and iNOS in microglia

2008 • 150 citations

H2O2 induces paracellular permeability of porcine brain-derived microvascular endothelial cells by activation of the p44/42 MAP kinase pathway

2005 • 145 citations

Meningeal and Perivascular Macrophages of the Central Nervous System Play a Protective Role During Bacterial Meningitis

2001 • 144 citations

Reciprocal Regulation of the Junctional Proteins Claudin-1 and Connexin43 by Interleukin-1β in Primary Human Fetal Astrocytes

2000 • 139 citations

Transforming Growth Factor-β Signaling Alters Substrate Permeability and Tight Junction Protein Expression at the Blood-Brain Barrier during Inflammatory Pain

2009 • 136 citations

DECREASED mRNA EXPRESSION OF TIGHT JUNCTION PROTEINS IN LUMBAR SPINAL CORDS OF PATIENTS WITH ALS

2009 • 134 citations

Agrin, Aquaporin-4, and Astrocyte Polarity as an Important Feature of the Blood-Brain Barrier

2009 • 132 citations

Altered blood–brain barrier integrity in adult aquaporin-4 knockout mice

2008 • 132 citations

Loss of astrocyte polarity marks blood–brain barrier impairment during experimental autoimmune encephalomyelitis

2009 • 129 citations

Matrix metalloproteinase-9 is elevated in serum of patients with amyotrophic lateral sclerosis

2000 • 127 citations

Matrix Metalloproteinases and Neuroinflammation in Multiple Sclerosis

2002 • 125 citations

Redox-Linked Signal Transduction Pathways for Protein Tyrosine Kinase Activation

2002 • 125 citations

Neural induction of the blood-brain barrier: still an enigma.

2000 • 124 citations

Oxidative stress in amyotrophic lateral sclerosis

2000 • 113 citations

Deposits of IgG and C3 in the spinal cord and motor cortex of ALS patients

1984 • 111 citations

Serum and CSF immunological findings in ALS

1991 • 110 citations

Blood-brain barrier disruption highly induces aquaporin-4 mRNA and protein in perivascular and parenchymal astrocytes: Protective effect by estradiol treatment in ovariectomized animals

2005 • 109 citations

Redox-control of matrix metalloproteinase-1: A critical link between free radicals, matrix remodeling and degenerative disease

2010 • 102 citations

Glutamate up-regulates P-glycoprotein expression in rat brain microvessel endothelial cells by an NMDA receptor-mediated mechanism

2004 • 102 citations

The severity of chronic cerebrospinal venous insufficiency in patients with multiple sclerosis is related to altered cerebrospinal fluid dynamics.

2009 • 102 citations

Matrix metalloproteinases and diseases of the central nervous system with a special emphasis on ischemic brain

2006 • 100 citations

Morphology and Molecular Properties of Cellular Components of Normal Cerebral Vessels

2003 • 92 citations

Antibodies to calcium channels from ALS patients passively transferred to mice selectively increase intracellular calcium and induce ultrastructural changes in motoneurons

1995 • 91 citations

Cyclic Strain–Mediated Regulation of Vascular Endothelial Occludin and ZO-1

2005 • 87 citations

Metalloproteinases are enriched in microglia compared with leukocytes and they regulate cytokine levels in activated microglia

2007 • 85 citations

Serum MMP-9/TIMP-1 and MMP-2/TIMP-2 ratios in multiple sclerosis: relationships with different magnetic resonance imaging measures of disease activity during IFN-beta-1a treatment

2005 • 83 citations

Matrix metalloproteinases and their tissue inhibitors in serum and cerebrospinal fluid of patients with amyotrophic lateral sclerosis

2009 • 82 citations

Mechanisms of Endothelial Growth Control

1992 • 81 citations

Circulating endothelial cells in acute ischaemic stroke

2005 • 77 citations

Gray matter perfusion correlates with disease severity in ALS

2010 • 77 citations

Activation of PKC modulates blood-brain barrier endothelial cell permeability changes induced by hypoxia and posthypoxic reoxygenation

2005 • 76 citations

Cerebrospinal fluid (CSF) findings in amyotrophic lateral sclerosis

1984 • 76 citations

The pro and the active form of matrix metalloproteinase-9 is increased in serum of patients with amyotrophic lateral sclerosis

2004 • 73 citations

Comparison of the growth hormone, IGF‐1 and insulin in cerebrospinal fluid and serum between patients with motor neuron disease and healthy controls

2006 • 70 citations

Targeting the neurovascular unit for treatment of neurological disorders

2010 • 70 citations

BLOOD-BRAIN BARRIER TRANSPORT OF NUTRIENTS

2009 • 68 citations

MMP-2 and MMP-9 are elevated in spinal cord and skin in a mouse model of ALS

2010 • 67 citations

Linking neuron and skin: Matrix metalloproteinases in amyotrophic lateral sclerosis (ALS)

2009 • 66 citations

High levels of C3c in the cerebrospinal fluid from amyotrophic lateral sclerosis patients

2009 • 64 citations

Glucocorticoid effects on endothelial barrier function in the murine brain endothelial cell line cEND incubated with sera from patients with multiple sclerosis

2010 • 61 citations

The Complementary Membranes Forming the Blood‐Brain Barrier

2002 • 59 citations

Membrane Trafficking of Aquaporin 1 Is Mediated by Protein Kinase C via Microtubules and Regulated by Tonicity

2010 • 56 citations

Aquaporin‐4 Overexpression in Rat ALS Model

2008 • 56 citations

P-glycoprotein expression and function are increased in an animal model of amyotrophic lateral sclerosis

2010 • 55 citations

New aspects of the molecular constituents of tissue barriers

2010 • 52 citations

Nordihydroguaiaretic acid increases glutamate uptake in vitro and in vivo: Therapeutic implications for amyotrophic lateral sclerosis

2008 • 52 citations

Loss of flow induces leukocyte-mediated MMP/TIMP imbalance in dynamic in vitro blood-brain barrier model: role of pro-inflammatory cytokines

2006 • 48 citations

Receptor-Mediated Therapeutic Transport Across the Blood–Brain Barrier

2009 • 47 citations

Tissue Inhibitor of Metalloproteinase-3 is Associated with Neuronal Death in Reperfusion Injury

2002 • 44 citations

Increased circulating endothelial cells in acute heart failure: Comparison with von Willebrand factor and soluble E‐selectin

2005 • 44 citations

Collagen abnormalities in the spinal cord from patients with amyotrophic lateral sclerosis

1998 • 43 citations

Cerebrospinal fluid insulin-like growth factor-1, insulin growth factor binding protein-2 or nitric oxide are not increased in MS or ALS

2004 • 37 citations

Reduction of Circulating Endothelial Cells in Peripheral Blood of ALS Patients

2010 • 37 citations

Regulation of endothelial cell functions by basement membrane‐ and arachidonic acid‐derived products

2009 • 36 citations

The immunophenotype of perivascular cells in the human brain

1996 • 35 citations

An Inhibitory Role of Nitric Oxide in the Dynamic Regulation of the Blood-Brain Barrier Function

2007 • 35 citations

The blood-brain barrier : biology and research protocols

2003 • 34 citations

Decreased type IV collagen of skin and serum in patients with amyotrophic lateral sclerosis

1998 • 33 citations

Evaluation of humoral immune response in adaptive immunity in ALS patients during disease progression

2009 • 31 citations

Metalloproteinase alterations in the bone marrow of ALS patients

2010 • 30 citations

Different activation forms of MMP-2 oppositely affect the fate of endothelial cells

2010 • 30 citations

No evidence of microbleeds in ALS patients at 7 Tesla MRI

2010 • 28 citations

Neuroimmune Pharmacology

2008 • 28 citations

Serum matrix metalloproteinase-9 activity is dysregulated with disease progression in the mutant SOD1 transgenic mice

2010 • 27 citations

The blood–brain barrier. Biology and research protocols

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A possible haemodynamic mechanism for Amyotrophic Lateral Sclerosis

2010 • 17 citations

Increased Expression of Laminin 1 in the Skin of Amyotrophic Lateral Sclerosis

2000 • 14 citations

The Blood Brain Barrier

2008 • 13 citations

[Exchanges through the blood-brain barrier].

2002 • 8 citations

Processus de transport à travers la barrière hémato-encéphalique

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