Insulin, insulin-degrading enzyme and amyloid-β peptide in Alzheimer's disease: review and hypothesis

Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

1984 • 5,166 citations

Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease.

1993 • 4,145 citations

Naturally secreted oligomers of amyloid β protein potently inhibit hippocampal long-term potentiation in vivo

2002 • 4,135 citations

Diabetes mellitus and the risk of dementia

1999 • 2,031 citations

Oligomeric and Fibrillar Species of Amyloid-β Peptides Differentially Affect Neuronal Viability

2002 • 1,405 citations

Insulin-degrading enzyme regulates the levels of insulin, amyloid β-protein, and the β-amyloid precursor protein intracellular domain in vivo

2003 • 1,393 citations

Diabetes Mellitus and Risk of Alzheimer Disease and Decline in Cognitive Function

2004 • 1,200 citations

Type 2 Diabetes, APOE Gene, and the Risk for Dementia and Related Pathologies

2002 • 1,166 citations

Increased Risk of Type 2 Diabetes in Alzheimer Disease

2004 • 872 citations

Alzheimer Disease as a Vascular Disorder

2002 • 834 citations

Insulin-degrading Enzyme Regulates Extracellular Levels of Amyloid β-Protein by Degradation

1998 • 783 citations

How Good a Marker Is Insulin Level for Insulin Resistance?

1993 • 750 citations

Brain insulin and insulin receptors in aging and sporadic Alzheimer's disease

1998 • 728 citations

Enhanced Proteolysis of β-Amyloid in APP Transgenic Mice Prevents Plaque Formation, Secondary Pathology, and Premature Death

2003 • 678 citations

Diabetes Mellitus and Risk of Alzheimer's Disease and Dementia with Stroke in a Multiethnic Cohort

2001 • 671 citations

Hyperinsulinemia and risk of Alzheimer disease

2004 • 666 citations

Association of diabetes mellitus and dementia: The Rotterdam Study

1996 • 650 citations

Identification of insulin in rat brain.

1978 • 599 citations

Cerebrospinal fluid and plasma insulin levels in Alzheimer's disease

1998 • 550 citations

Type 2 diabetes mellitus, cognitive impairment and dementia

1999 • 550 citations

Brain Insulin Receptors and Spatial Memory

1999 • 516 citations

Evidence for Genetic Linkage of Alzheimer's Disease to Chromosome 10q

2000 • 513 citations

Alzheimer's beta-amyloid peptides compete for insulin binding to the insulin receptor.

2002 • 497 citations

Islet amyloid: a long-recognized but underappreciated pathological feature of type 2 diabetes.

1999 • 483 citations

Stimulation of β-Amyloid Precursor Protein Trafficking by Insulin Reduces Intraneuronal β-Amyloid and Requires Mitogen-Activated Protein Kinase Signaling

2001 • 479 citations

New Frontiers in Alzheimer's Disease Genetics

2001 • 470 citations

Neurons Regulate Extracellular Levels of Amyloid β-Protein via Proteolysis by Insulin-Degrading Enzyme

2000 • 466 citations

Association between features of the insulin resistance syndrome and alzheimer's disease independently of apolipoprotein e4 phenotype: cross sectional population based study

1997 • 427 citations

Diabetes mellitus and risk of dementia in the Kungsholmen project

2004 • 404 citations

Susceptibility Locus for Alzheimer's Disease on Chromosome 10

2000 • 386 citations

Alzheimer's β‐amyloid peptide specifically interacts with and is degraded by insulin degrading enzyme

1994 • 385 citations

Cognitive dysfunction in older subjects with diabetes mellitus: impact on diabetes self-management and use of care services

2000 • 344 citations

Linkage of Type 2 Diabetes Mellitus and of Age at Onset to a Genetic Location on Chromosome 10q in Mexican Americans

1999 • 340 citations

Reduced Hippocampal Insulin-Degrading Enzyme in Late-Onset Alzheimer's Disease Is Associated with the Apolipoprotein E-ε4 Allele

2003 • 321 citations

Age at Onset in Two Common Neurodegenerative Diseases Is Genetically Controlled

2002 • 316 citations

Does insulin dysfunction play a role in Alzheimer's disease?

2002 • 315 citations

Amyloid-β peptide levels in brain are inversely correlated with insulysin activity levels in vivo

2003 • 285 citations

A high fasting plasma insulin concentration predicts type 2 diabetes independent of insulin resistance: evidence for a pathogenic role of relative hyperinsulinemia.

2000 • 285 citations

Insulin increases CSF Aβ42 levels in normal older adults

2003 • 260 citations

Partial Loss-of-Function Mutations in Insulin-Degrading Enzyme that Induce Diabetes also Impair Degradation of Amyloid β-Protein

2004 • 249 citations

Degradation of soluble amyloid beta-peptides 1-40, 1-42, and the Dutch variant 1-40Q by insulin degrading enzyme from Alzheimer disease and control brains.

2000 • 233 citations

Type 2 Diabetes and Cognitive Function in Community-Dwelling Elderly Women

2001 • 223 citations

Insulin and Cognitive Function in an Elderly Population: The Rotterdam Study

1997 • 209 citations

Amyloid precursor protein (APP) and the biology of proteolytic processing: relevance to Alzheimer’s disease

2003 • 206 citations

The brain insulin signal transduction system and sporadic (type II) Alzheimer disease: an update

2002 • 201 citations

Insulin Effects on Glucose Metabolism, Memory, and Plasma Amyloid Precursor Protein in Alzheimer's Disease Differ According to Apolipoprotein‐E Genotype

2000 • 188 citations

Cognitive Function in an Elderly Population With Persistent Impaired Glucose Tolerance

1998 • 187 citations

Degradation of Alzheimer's beta-amyloid protein by human and rat brain peptidases: involvement of insulin-degrading enzyme.

1997 • 180 citations

Insulin regulates soluble amyloid precursor protein release via phosphatidyl inositol 3 kinase‐dependent pathway

2000 • 175 citations

Insulin-degrading enzyme: embarking on amyloid destruction

2001 • 174 citations

Tracking Insulin to the Mind

1998 • 171 citations

Insulin-degrading enzyme.

1996 • 167 citations

Degradation of Amyloid β-Protein by a Metalloprotease Secreted by Microglia and Other Neural and Non-neural Cells

1997 • 166 citations

Degradation of Amylin by Insulin-degrading Enzyme

2000 • 159 citations

A Major Locus for Fasting Insulin Concentrations and Insulin Resistance on Chromosome 6q with Strong Pleiotropic Effects on Obesity-Related Phenotypes in Nondiabetic Mexican Americans

2001 • 156 citations

Insulin-degrading enzyme identified as a candidate diabetes susceptibility gene in GK rats

2000 • 153 citations

Dementia: The leading predictor of death in a defined elderly population

2004 • 152 citations

Insulin Metabolism in Alzheimer’s Disease Differs According to Apolipoprotein E Genotype and Gender

1999 • 151 citations

The Risk of Dementia among Persons with Diabetes Mellitus: A Population‐Based Cohort Study^a

1997 • 150 citations

Human Insulin-Degrading Enzyme Shares Structural and Functional Homologies with E. coli Protease III

1988 • 141 citations

Insulysin Hydrolyzes Amyloid β Peptides to Products That Are Neither Neurotoxic Nor Deposit on Amyloid Plaques

2000 • 124 citations

Hyperinsulinaemia and Alzheimer's Disease

1994 • 122 citations

Substrate Activation of Insulin-degrading Enzyme (Insulysin)

2003 • 119 citations

Inhibition of insulin degradation by hepatoma cells after microinjection of monoclonal antibodies to a specific cytosolic protease.

1986 • 118 citations

Insulin-degrading enzyme is differentially expressed and developmentally regulated in various rat tissues.

1993 • 113 citations

Increased insulin levels after OGTT load in peripheral blood and cerebrospinal fluid of patients with dementia of Alzheimer type

1991 • 110 citations

Polymorphisms in the Insulin-Degrading Enzyme Gene Are Associated With Type 2 Diabetes in Men From the NHLBI Framingham Heart Study

2003 • 108 citations

Substantial linkage disequilibrium across the insulin-degrading enzyme locus but no association with late-onset Alzheimer's disease

2001 • 98 citations

Genetic variation in a haplotype block spanningIDE influences Alzheimer disease

2003 • 98 citations

Genetic variants in a haplotype block spanningIDE are significantly associated with plasma A?42 levels and risk for Alzheimer disease

2004 • 97 citations

A high molecular weight metalloendoprotease from the cytosol of mammalian cells.

1983 • 93 citations

The genetics of late-onset Alzheimerʼs disease

2001 • 90 citations

Aging, amyloid, and Alzheimer's disease: a perspective in honor of Carl Cotman.

2003 • 90 citations

Differential Degradation of Amyloid β Genetic Variants Associated with Hereditary Dementia or Stroke by Insulin-degrading Enzyme

2003 • 80 citations

The rat insulin‐degrading enzyme

1993 • 74 citations

Apolipoprotein‐E Genotyping of Diabetic Dementia Patients: Is Diabetes Rare in Alzheimer's Disease?

1996 • 73 citations

Polymorphisms of insulin degrading enzyme gene are not associated with Alzheimer's disease

2002 • 68 citations

Insulin degrading enzyme (IDE) genetic variants and risk of Alzheimer's disease: evidence of effect modification by apolipoprotein E (APOE)

2003 • 64 citations

IN VIVO ASSOCIATION OF [¹²⁵I]-INSULIN WITH A CYTOSOLIC INSULIN-DEGRADING ENZYME: DETECTION BY COVALENT CROSS-LINKING AND IMMUNOPRECIPITATION WITH A MONOCLONAL ANTIBODY

1987 • 60 citations

Quantitative Trait Loci Near the Insulin-Degrading Enzyme (IDE) Gene Contribute to Variation in Plasma Insulin Levels

2004 • 58 citations

[44] Insulysin and pitrilysin: Insulin-degrading enzymes of mammals and bacteria

1995 • 56 citations

Association and Haplotype Analysis of the Insulin-Degrading Enzyme (IDE) Gene, a Strong Positional and Biological Candidate for Type 2 Diabetes Susceptibility

2003 • 55 citations

Diabetes and Dementia in Long-Term Care

1999 • 52 citations

Inducible expression and cellular localization of insulin-degrading enzyme in a stably transfected cell line.

1994 • 50 citations

Insulin-Degrading Enzyme, Apolipoprotein E, and Alzheimer's Disease

2004 • 50 citations

The effect of insulin and glucose on the plasma concentration of Alzheimer's amyloid precursor protein

1999 • 46 citations

Alzheimer Disease and Vascular Dementia: Relationships with Fasting Glucose and Insulin Levels

2000 • 45 citations

Cerebrospinal fluid levels of insulin in patients with Alzheimer's disease

2002 • 43 citations

Affinity purification of insulin-degrading enzyme and its endogenous inhibitor from rat liver.

1992 • 37 citations

Confirmation of association between D10S583 and Alzheimer's disease in a case–control sample

2002 • 37 citations

Identification and Isolation of a Cytosolic Proteolytic Complex Containing Insulin Degrading Enzyme and the Multicatalytic Proteinase

1994 • 35 citations

The Effect of Age on Insulin-degrading Activity in Rat Tissue

1979 • 34 citations

Degradation of Insulin and Insulin-Like Growth Factors by Enzyme Purified From Human Erythrocytes: Comparison of Degradation Products Observed With A14- and B26-[125I]monoiodoinsulin

1989 • 32 citations

Non-covalent interaction of ubiquitin with insulin-degrading enzyme

2003 • 29 citations

p25 protein in neurodegeneration

2001 • 23 citations

An Elderly Patient with an Insulinoma Who Had Prolonged Dementia-like Symptoms.

1998 • 4 citations