Matrix Metalloproteinases Expressed by Astrocytes Mediate Extracellular Amyloid-β Peptide Catabolism

Amyloid Oligomers Exacerbate Tau Pathology in a Mouse Model of Tauopathy

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Inflammation and Alzheimer's disease

2000 • 4,315 citations

Correlative Memory Deficits, Aβ Elevation, and Amyloid Plaques in Transgenic Mice

1996 • 4,118 citations

MMP-9/Gelatinase B Is a Key Regulator of Growth Plate Angiogenesis and Apoptosis of Hypertrophic Chondrocytes

1998 • 1,753 citations

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2003 • 1,393 citations

Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes

1998 • 1,336 citations

Clearance of Alzheimer’s amyloid-β1-40 peptide from brain by LDL receptor–related protein-1 at the blood-brain barrier

2000 • 1,296 citations

Inflammation in Neurodegenerative Disease—A Double-Edged Sword

2002 • 1,167 citations

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2005 • 1,164 citations

Age-Dependent Changes in Brain, CSF, and Plasma Amyloid β Protein in the Tg2576 Transgenic Mouse Model of Alzheimer's Disease

2001 • 990 citations

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2003 • 941 citations

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2001 • 918 citations

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2002 • 901 citations

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2003 • 850 citations

Insulin-degrading Enzyme Regulates Extracellular Levels of Amyloid β-Protein by Degradation

1998 • 783 citations

Insulin Degradation: Progress and Potential*

1998 • 772 citations

Recombinant AAV Viral Vectors Pseudotyped with Viral Capsids from Serotypes 1, 2, and 5 Display Differential Efficiency and Cell Tropism after Delivery to Different Regions of the Central Nervous System

2004 • 715 citations

Enhanced Proteolysis of β-Amyloid in APP Transgenic Mice Prevents Plaque Formation, Secondary Pathology, and Premature Death

2003 • 678 citations

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1998 • 646 citations

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2002 • 567 citations

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2000 • 466 citations

Mechanisms for pro matrix metalloproteinase activation

1999 • 436 citations

Physiological production of the β-amyloid protein and the mechanism of Alzheimer's disease

1993 • 423 citations

In vivo assessment of brain interstitial fluid with microdialysis reveals plaque-associated changes in amyloid-beta metabolism and half-life.

2003 • 422 citations

Alzheimer's disease, normal‐pressure hydrocephalus, and senescent changes in CSF circulatory physiology: a hypothesis

2003 • 404 citations

Rapid Communication: Characterization of β‐Amyloid Peptide from Human Cerebrospinal Fluid

1993 • 383 citations

Neprilysin Gene Transfer Reduces Human Amyloid Pathology in Transgenic Mice

2003 • 379 citations

In VivoAssessment of Brain Interstitial Fluid with Microdialysis Reveals Plaque-Associated Changes in Amyloid-β Metabolism and Half-Life

2003 • 363 citations

Unaltered Secretion of β-Amyloid Precursor Protein in Gelatinase A (Matrix Metalloproteinase 2)-deficient Mice

1997 • 352 citations

Insulin Degradation: Progress and Potential

1998 • 346 citations

Matrix metalloproteinase-9 (MMP-9) is synthesized in neurons of the human hippocampus and is capable of degrading the amyloid-beta peptide (1-40).

1996 • 341 citations

Angiotensin-converting Enzyme Degrades Alzheimer Amyloid β-Peptide (Aβ); Retards Aβ Aggregation, Deposition, Fibril Formation; and Inhibits Cytotoxicity

2001 • 339 citations

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2004 • 326 citations

Degradation of the Alzheimer's Amyloid β Peptide by Endothelin-converting Enzyme

2001 • 325 citations

Extracellular proteolysis in brain injury and inflammation: Role for plasminogen activators and matrix metalloproteinases

2002 • 313 citations

The Profile of Soluble Amyloid β Protein in Cultured Cell Media

1996 • 293 citations

Matrix Metalloproteinase-9 (MMP-9) Is Synthesized in Neurons of the Human Hippocampus and Is Capable of Degrading the Amyloid-β Peptide (1–40)

1996 • 293 citations

The Plasmin System Is Induced by and Degrades Amyloid-β Aggregates

2000 • 289 citations

Highly Selective and Orally Active Inhibitors of Type IV Collagenase (MMP-9 and MMP-2): N-Sulfonylamino Acid Derivatives

1998 • 278 citations

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1996 • 262 citations

β‐Amyloid catabolism: roles for neprilysin (NEP) and other metallopeptidases?

2002 • 255 citations

Alzheimer's Disease β-Amyloid Peptide Is Increased in Mice Deficient in Endothelin-converting Enzyme

2003 • 252 citations

Expression and Activation of Matrix Metalloproteinase-2 and -9 in Rat Brain after Transient Focal Cerebral Ischemia

2001 • 234 citations

Immune reactive cells in senile plaques and cognitive decline in Alzheimer’s disease

2002 • 228 citations

Blood-Brain Barrier Disruption and Matrix Metalloproteinase-9 Expression During Reperfusion Injury

2002 • 205 citations

Human endothelin-converting enzyme (ECE-1): three isoforms with distinct subcellular localizations

1997 • 204 citations

Matrix metalloproteases and their inhibitors are produced by overlapping populations of activated astrocytes

2002 • 198 citations

Insulin-degrading enzyme: embarking on amyloid destruction

2001 • 174 citations

Degradation of Amyloid β-Protein by a Metalloprotease Secreted by Microglia and Other Neural and Non-neural Cells

1997 • 166 citations

Low Molecular Weight Inhibitors in Corneal Ulceration^a

1994 • 159 citations

Degradation of Amylin by Insulin-degrading Enzyme

2000 • 159 citations

Increased production of gelatinase B (matrix metalloproteinase‐9) and interleukin‐6 by activated rat microglia in culture

1995 • 154 citations

Increased Production of Matrix Metalloproteinases in Enriched Astrocyte and Mixed Hippocampal Cultures Treated with β‐Amyloid Peptides

1996 • 153 citations

Preparation and characterization of type 1 astrocytes cultured from adult rat cortex, cerebellum, and striatum

1992 • 139 citations

Alzheimer’s Disease as Proteolytic Disorders: Anabolism and Catabolism of β-Amyloid

1998 • 136 citations

Matrix Metalloproteinase Inhibition: From The Jurassic To The Third Millennium

1999 • 134 citations

Proteolysis of Aβ Peptide from Alzheimer Disease Brain by Gelatinase A

1994 • 129 citations

Selective distribution of matrix metalloproteinase-3 (MMP-3) in Alzheimer’s disease brain

2000 • 123 citations

Zymographic measurement of gelatinase activity in brain tissue after detergent extraction and affinity-support purification

1997 • 117 citations

Microglial cells are the driving force in fibrillar plaque formation, whereas astrocytes are a leading factor in plaque degradation

2000 • 116 citations

Plasmin Cleavage of the Amyloid β-Protein: Alteration of Secondary Structure and Stimulation of Tissue Plasminogen Activator Activity

1999 • 113 citations

Amyloid-β Induces Smac Release via AP-1/Bim Activation in Cerebral Endothelial Cells

2002 • 112 citations

Matrix metalloproteinase–9 and spontaneous hemorrhage in an animal model of cerebral amyloid angiopathy

2003 • 103 citations

Molecular characterization of mouse gastric epithelial progenitor cells

2002 • 97 citations

Increased Extracellular Amyloid Deposition and Neurodegeneration in Human Amyloid Precursor Protein Transgenic Mice Deficient in Receptor-Associated Protein

2002 • 89 citations

β-Amyloid induces the production of active, matrix-degrading proteases in cultured rat astrocytes

2003 • 81 citations

Overexpression of Insulin Degrading Enzyme: Cellular Localization and Effects on Insulin Signaling

1997 • 80 citations

Quantitation of matrix metalloproteinases in cultured rat astrocytes using the polymerase chain reaction with a multi-competitor cDNA standard

1996 • 70 citations

Protein Phosphatase 2A RegulatesbimExpression via the Akt/FKHRL1 Signaling Pathway in Amyloid-β Peptide-Induced Cerebrovascular Endothelial Cell Death

2006 • 64 citations

Membrane Localization of Endopeptidase‐24.11 and Peptidyl Dipeptidase A (Angiotensin Converting Enzyme) in the Pig Brain: A Study Using Subcellular Fractionation and Electron Microscopic Immunocytochemistry

1992 • 62 citations

Immunohistochemical analysis of reactive astrocytes around glioblastoma: an immunohistochemical study of postmortem glioblastoma cases

2002 • 61 citations

Engineering of Selective TIMPs

1999 • 57 citations

Alzheimer's Disease, Neuropeptides, Neuropeptidase, and Amyloid-β Peptide Metabolism

2003 • 53 citations

Characterization of amyloid β peptides from brain extracts of transgenic mice overexpressing the London mutant of human amyloid precursor protein

2003 • 47 citations

Laser microdissection of immunolabeled astrocytes allows quantification of astrocytic gene expression

2004 • 44 citations

Inhibition of Gelatinase A by Oleic Acid

1999 • 41 citations

Laser microdissection reveals regional and cellular differences in GFAP mRNA upregulation following brain injury, axonal denervation, and amyloid plaque deposition

2004 • 35 citations

Molecular Characterization of Mouse Gastric Zymogenic Cells

2003 • 34 citations

LRP: a bright beacon at the blood-brain barrier

2003 • 4 citations