The tissue plasminogen activator-plasminogen proteolytic cascade accelerates amyloid-beta (Abeta) degradation and inhibits Abeta-induced neurodegeneration.

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Tissue-plasminogen activator is induced as an immediate–early gene during seizure, kindling and long-term potentiation

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Excitotoxin-induced neuronal degeneration and seizure are mediated by tissue plasminogen activator

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Tissue plasminogen activator (tPA) increase neuronal damage after focal cerebral ischemia in wild-type and tPA-deficient mice

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Neuronal Death in the Hippocampus Is Promoted by Plasmin-Catalyzed Degradation of Laminin

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Presenilins are required for γ-secretase cleavage of β-APP and transmembrane cleavage of Notch-1

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Tissue Plasminogen Activator Contributes to the Late Phase of LTP and to Synaptic Growth in the Hippocampal Mossy Fiber Pathway

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The Plasmin System Is Induced by and Degrades Amyloid-β Aggregates

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Brain plasmin enhances APP α‐cleavage and Aβ degradation and is reduced in Alzheimer's disease brains

2000 • 206 citations

Are Presenilins Intramembrane-Cleaving Proteases? Implications for the Molecular Mechanism of Alzheimer's Disease

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The γ-secretase-generated intracellular domain of β-amyloid precursor protein binds Numb and inhibits Notch signaling

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Fibrin Inhibits Peripheral Nerve Remyelination by Regulating Schwann Cell Differentiation

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Tissue Plasminogen Activator (tPA) Deficiency Exacerbates Cerebrovascular Fibrin Deposition and Brain Injury in a Murine Stroke Model

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Tissue Plasminogen Activator Requires Plasminogen to Modulate Amyloid‐β Neurotoxicity and Deposition

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Ham-Wasserman Lecture: Role of the Plasminogen System in Fibrin-Homeostasis and Tissue Remodeling

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Amyloid β-Protein (Aβ) 1–40 But Not Aβ1–42 Contributes to the Experimental Formation of Alzheimer Disease Amyloid Fibrils in Rat Brain

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