Hypoxia-Induced Down-Regulation of Neprilysin by Histone Modification in Mouse Primary Cortical and Hippocampal Neurons

DNA Methyltransferases Dnmt3a and Dnmt3b Are Essential for De Novo Methylation and Mammalian Development

1999 • 5,748 citations

Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex

1998 • 3,363 citations

DNMT1 forms a complex with Rb, E2F1 and HDAC1 and represses transcription from E2F-responsive promoters

2000 • 938 citations

Inhibitors of Class 1 Histone Deacetylases Reverse Contextual Memory Deficits in a Mouse Model of Alzheimer's Disease

2009 • 666 citations

Inactivation of the tumor suppressor PTEN/MMAC1 in advanced human prostate cancer through loss of expression

1998 • 640 citations

Age-Specific Epigenetic Drift in Late-Onset Alzheimer's Disease

2008 • 455 citations

Hypomethylation of MB-COMT promoter is a major risk factor for schizophrenia and bipolar disorder

2006 • 452 citations

Hypoxia-inducible Factor 1α (HIF-1α)-mediated Hypoxia Increases BACE1 Expression and β-Amyloid Generation

2007 • 397 citations

Histone H3-lysine 9 methylation is associated with aberrant gene silencing in cancer cells and is rapidly reversed by 5-aza-2'-deoxycytidine.

2002 • 383 citations

Neprilysin Gene Transfer Reduces Human Amyloid Pathology in Transgenic Mice

2003 • 379 citations

DNA (cytosine-5)-methyltransferases in mouse cells and tissues. studies with a mechanism-based probe

1997 • 353 citations

Dependence of histone modifications and gene expression on DNA hypermethylation in cancer.

2002 • 351 citations

Valproic acid inhibits Aβ production, neuritic plaque formation, and behavioral deficits in Alzheimer's disease mouse models

2008 • 343 citations

The Roles of Cyclin-dependent Kinase 5 and Glycogen Synthase Kinase 3 in Tau Hyperphosphorylation

2006 • 333 citations

Relation of cerebral infarctions to dementia and cognitive function in older persons

2003 • 290 citations

Atherosclerosis and AD

2005 • 281 citations

β‐Amyloid catabolism: roles for neprilysin (NEP) and other metallopeptidases?

2002 • 255 citations

Hypoxic Stress Induces Dimethylated Histone H3 Lysine 9 through Histone Methyltransferase G9a in Mammalian Cells

2006 • 210 citations

Hypoxia increases Aβ generation by altering β- and γ-cleavage of APP

2007 • 202 citations

Presenilin 1 gene silencing by S‐adenosylmethionine: a treatment for Alzheimer disease?

2003 • 188 citations

Pathological role of hypoxia in Alzheimer's disease

2009 • 173 citations

Amyloid-Degrading Enzymes as Therapeutic Targets in Alzheimers Disease

2008 • 172 citations

Neprilysin gene expression requires binding of the amyloid precursor protein intracellular domain to its promoter: implications for Alzheimer disease

2008 • 165 citations

Neprilysin Regulates Amyloid β Peptide Levels

2004 • 154 citations

Oxidative Stress Modulates DNA Methylation during Melanocyte Anchorage Blockade Associated with Malignant Transformation

2007 • 154 citations

Role of microglial IKKβ in kainic acid-induced hippocampal neuronal cell death

2008 • 151 citations

Decreased Expression and Activity of Neprilysin in Alzheimer Disease Are Associated With Cerebral Amyloid Angiopathy

2006 • 144 citations

Hypoxic silencing of tumor suppressor RUNX3 by histone modification in gastric cancer cells

2008 • 139 citations

Oxidative stress induced by lead, cadmium and arsenic mixtures: 30-day, 90-day, and 180-day drinking water studies in rats: An overview

2004 • 134 citations

The epigenetic effects of amyloid-β1–40 on global DNA and neprilysin genes in murine cerebral endothelial cells

2008 • 132 citations

Enhanced clearance of Aβ in brain by sustaining the plasmin proteolysis cascade

2008 • 129 citations

Neprilysin and Amyloid Beta Peptide Degradation

2008 • 120 citations

Dopamine D3 receptor‐preferring agonists induce neurotrophic effects on mesencephalic dopamine neurons

2005 • 118 citations

Pharmacogenomics in Alzheimer's Disease

2008 • 108 citations

Effects of Hypoxia and Oxidative Stress on Expression of Neprilysin in Human Neuroblastoma Cells and Rat Cortical Neurones and Astrocytes

2007 • 102 citations

Hypoxic regulation of telomerase gene expression by transcriptional and post-transcriptional mechanisms

2005 • 95 citations

Cerebrospinal fluid neprilysin is reduced in prodromal Alzheimer's disease

2005 • 94 citations

Hypoxia and nickel inhibit histone demethylase JMJD1A and repress Spry2 expression in human bronchial epithelial BEAS-2B cells

2010 • 90 citations

Histone deacetylases: Focus on the nervous system

2007 • 81 citations

Role of microglial IKKbeta in kainic acid-induced hippocampal neuronal cell death

2008 • 69 citations

Tissue-specific Expression of Rat Neutral Endopeptidase (Neprilysin) mRNAs

1995 • 66 citations

Etiology of sporadic Alzheimer’s disease: Somatostatin, neprilysin, and amyloid β peptide

2005 • 56 citations

Expression of amyloid precursor protein (β‐APP) in the neonatal brain following hypoxic ischaemic injury

1998 • 47 citations

Analysis of the human CD10/neutral endopeptidase 24.11 promoter region: two separate regulatory elements

1995 • 42 citations

5-Aza-2′-deoxycytidine Induces Histone Hyperacetylation of Mouse Centromeric Heterochromatin by a Mechanism Independent of DNA Demethylation

2001 • 36 citations

Lack of hepatocellular CD10 along bile canaliculi is physiologic in early childhood and persistent in Alagille syndrome

2007 • 30 citations