Transport Pathways for Clearance of Human Alzheimer's Amyloid β-Peptide and Apolipoproteins E and J in the Mouse Central Nervous System

The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics

2002 • 13,092 citations

Amyloid Oligomers Exacerbate Tau Pathology in a Mouse Model of Tauopathy

2012 • 10,051 citations

Clearance of Alzheimer’s amyloid-β1-40 peptide from brain by LDL receptor–related protein-1 at the blood-brain barrier

2000 • 1,296 citations

RAGE mediates amyloid-β peptide transport across the blood-brain barrier and accumulation in brain

2003 • 1,289 citations

Metabolic Regulation of Brain Aβ by Neprilysin

2001 • 918 citations

Neurovascular mechanisms of Alzheimer's neurodegeneration

2005 • 903 citations

Adult mouse astrocytes degrade amyloid-β in vitro and in situ

2003 • 850 citations

Identification of the major Aβ1–42-degrading catabolic pathway in brain parenchyma: Suppression leads to biochemical and pathological deposition

2000 • 837 citations

LRP/Amyloid β-Peptide Interaction Mediates Differential Brain Efflux of Aβ Isoforms

2004 • 769 citations

Clearing the Brain's Amyloid Cobwebs

2001 • 538 citations

Apolipoprotein E promotes astrocyte colocalization and degradation of deposited amyloid-β peptides

2004 • 530 citations

In vivo assessment of brain interstitial fluid with microdialysis reveals plaque-associated changes in amyloid-beta metabolism and half-life.

2003 • 422 citations

ApoE and Clusterin Cooperatively Suppress Aβ Levels and Deposition

2004 • 421 citations

Glycoprotein 330/megalin: probable role in receptor-mediated transport of apolipoprotein J alone and in a complex with Alzheimer disease amyloid beta at the blood-brain and blood-cerebrospinal fluid barriers.

1996 • 414 citations

Clearance of Alzheimer's Aβ Peptide

2004 • 411 citations

In VivoAssessment of Brain Interstitial Fluid with Microdialysis Reveals Plaque-Associated Changes in Amyloid-β Metabolism and Half-Life

2003 • 363 citations

Clearing amyloid through the blood–brain barrier

2004 • 326 citations

Clusterin promotes amyloid plaque formation and is critical for neuritic toxicity in a mouse model of Alzheimer's disease

2002 • 325 citations

Reply to: 'Clearance of amyloid β-peptide from brain: transport or metabolism?'

2000 • 285 citations

A 70-kDa apolipoprotein designated ApoJ is a marker for subclasses of human plasma high density lipoproteins.

1990 • 260 citations

Apolipoprotein J (clusterin) and Alzheimer's disease

2000 • 243 citations

Human blood-brain barrier receptors for Alzheimer's amyloid-beta 1- 40. Asymmetrical binding, endocytosis, and transcytosis at the apical side of brain microvascular endothelial cell monolayer.

1998 • 232 citations

IgG-Assisted Age-Dependent Clearance of Alzheimer's Amyloid β Peptide by the Blood–Brain Barrier Neonatal Fc Receptor

2005 • 225 citations

Fate of Cerebrospinal Fluid‐Borne Amyloid β‐Peptide: Rapid Clearance into Blood and Appreciable Accumulation by Cerebral Arteries

1996 • 223 citations

Blood-Brain Barrier Transport of Circulating Alzheimer′s Amyloid β

1993 • 170 citations

Isoform‐Specific Effects of Apolipoproteins E2, E3, and E4 on Cerebral Capillary Sequestration and Blood‐Brain Barrier Transport of Circulating Alzheimer's Amyloid β

1997 • 144 citations

Cerebrovascular Accumulation and Increased Blood‐Brain Barrier Permeability to Circulating Alzheimer's Amyloid β Peptide in Aged Squirrel Monkey with Cerebral Amyloid Angiopathy

1998 • 130 citations

The Low Density Lipoprotein Receptor Regulates the Level of CentralNervous System Human and Murine Apolipoprotein E but Does Not Modify AmyloidPlaque Pathology in PDAPPMice

2005 • 129 citations

Production and characterization of astrocyte-derived human apolipoprotein E isoforms from immortalized astrocytes and their interactions with amyloid-β

2005 • 121 citations

Passage of human amyloid β-protein 1–40 across the murine blood-brain barrier

1994 • 109 citations

Neurovascular Pathways and Alzheimer Amyloid β-peptide

2006 • 106 citations

Quantitative Measurement of Changes in Amyloid-β(40) in the Rat Brain and Cerebrospinal Fluid following Treatment with the γ-Secretase Inhibitor LY-411575 [N²-[(2S)-2-(3,5-Difluorophenyl)-2-hydroxyethanoyl]-N¹-[(7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-l-alaninamide]

2005 • 101 citations

Lack of LDL receptor aggravates learning deficits and amyloid deposits in Alzheimer transgenic mice

2005 • 97 citations

Efflux of human and mouse amyloid β proteins 1–40 and 1–42 from brain: impairment in a mouse model of alzheimer's disease

2003 • 88 citations

ELISA Method for Measurement of Amyloid-β Levels

2005 • 74 citations

Glycoprotein 330/Megalin (LRP-2) Has Low Prevalence as mRNA and Protein in Brain Microvessels and Choroid Plexus

1999 • 74 citations

Permeability and Residual Plasma Volume of Human, Dutch Variant, and Rat Amyloid β-Protein 1-40 at the Blood–Brain Barrier

1997 • 56 citations

Method for measurement of the blood–brain barrier permeability in the perfused mouse brain: application to amyloid-β peptide in wild type and Alzheimer’s Tg2576 mice

2004 • 54 citations

Intra-arterial infusion of [125l]Aβ 1–40 labels amyloid deposits in the aged primate brain in vivo

1996 • 52 citations

Quantitative analysis of amyloid- peptides in cerebrospinal fluid using immunoprecipitation and MALDI-Tof mass spectrometry

2007 • 42 citations

Alzheimer'S Disease: Advances In Genetics, Molecular And Cellular Biology

2007 • 27 citations

Role of A β Transport and Clearance in the Pathogenesis and Treatment of Alzheimer’s Disease

2007 • 13 citations