Thrombin, a mediator of neurotoxicity and memory impairment

Microglia in degenerative neurological disease

1993 • 594 citations

Head Trauma as a Risk Factor for Alzheimer's Disease: A Collaborative Re-Analysis of Case-Control Studies

1991 • 582 citations

Immunohistochemical evidence for apoptosis in Alzheimerʼs disease

1994 • 569 citations

Experimental Brain Injury Induces Regionally Distinct Apoptosis during the Acute and Delayed Post-Traumatic Period

1998 • 532 citations

Mechanisms of edema formation after intracerebral hemorrhage: effects of thrombin on cerebral blood flow, blood-brain barrier permeability, and cell survival in a rat model

1997 • 364 citations

Edema from intracerebral hemorrhage: the role of thrombin

1996 • 353 citations

Cognitive correlates of ventricular enlargement and cerebral white matter lesions on magnetic resonance imaging. The Rotterdam Study.

1994 • 351 citations

Repetitive Mild Brain Trauma Accelerates Aβ Deposition, Lipid Peroxidation, and Cognitive Impairment in a Transgenic Mouse Model of Alzheimer Amyloidosis

2002 • 335 citations

Erythrocytes and delayed brain edema formation following intracerebral hemorrhage in rats

1998 • 322 citations

Thrombin modulates and reverses neuroblastoma neurite outgrowth.

1988 • 318 citations

Chronic traumatic brain injury in professional soccer players

1998 • 316 citations

Thrombin Induces Apoptosis in Cultured Neurons and Astrocytes via a Pathway Requiring Tyrosine Kinase and RhoA Activities

1997 • 303 citations

Traumatic Brain Injury and Time to Onset of Alzheimer's Disease: A Population-based Study

1999 • 292 citations

Self-assembly in vitro of the 68,000 molecular weight component of the mammalian neurofilament triplet proteins into intermediate-sized filaments

1981 • 288 citations

The protease thrombin is an endogenous mediator of hippocampal neuroprotection against ischemia at low concentrations but causes degeneration at high concentrations

2000 • 287 citations

Prefrontal cortex dysfunction mediates deficits in working memory and prepotent responding in schizophrenia

2002 • 280 citations

The morphological phenotype of β-amyloid plaques and associated neuritic changes in Alzheimer’s disease

2001 • 266 citations

Molecular signatures of brain injury after intracerebral hemorrhage

2002 • 266 citations

Potentiation of NMDA Receptor Function by the Serine Protease Thrombin

2000 • 225 citations

Thrombin May Contribute to the Pathophysiology of Central Nervous System Injury

1993 • 218 citations

Attenuation of Thrombin-Induced Brain Edema by Cerebral Thrombin Preconditioning

1999 • 203 citations

Re-examination of ex-boxers' brains using immunohistochemistry with antibodies to amyloid ?-protein and tau protein

1991 • 200 citations

Reciprocal Modulation of Astrocyte Stellation by Thrombin and Protease Nexin‐1

1990 • 198 citations

Thrombin accumulation in brains of patients with Alzheimer's disease

1992 • 172 citations

Impaired learning in a spatial working memory version and in a cued version of the water maze in rats with MPTP-induced mesencephalic dopaminergic lesions

2002 • 159 citations

Frontal cortex BDNF levels correlate with working memory in an animal model of Down syndrome

2003 • 154 citations

Neurochemical Diversity of Dystrophic Neurites in the Early and Late Stages of Alzheimer's Disease

1999 • 136 citations

Intracerebral infusion of thrombin as a cause of brain edema

1995 • 127 citations

Prefrontal–posterior parietal networks in schizophrenia: primary dysfunctions and secondary compensations

2002 • 123 citations

Acute Tissue Damage After Injections of Thrombin and Plasmin into Rat Striatum

2001 • 120 citations

Protease nexin-1 and thrombin modulate neuronal Ca2+ homeostasis and sensitivity to glucose deprivation-induced injury

1995 • 114 citations

Pro‐ and anti‐inflammatory actions of thrombin: a distinct role for proteinase‐activated receptor‐1 (PAR₁)

1999 • 110 citations

A thrombin cleavage fragment of apolipoprotein E exhibits isoform-specific neurotoxicity

1996 • 100 citations

Brain Damage in Boxers

1969 • 91 citations

Thrombin-Receptor Activation and Thrombin-Induced Brain Tolerance

2002 • 91 citations

Thrombin and its inhibitors regulate morphological and biochemical differentiation of astrocytes in vitro

1990 • 87 citations

Differential phenotypic expression induced in cultured rat astroblasts by acidic fibroblast growth factor, epidermal growth factor, and thrombin

1989 • 87 citations

Mechanisms of cell death in primary cortical neurons and PC12 cells

2001 • 87 citations

Protease nexin-1, a potent thrombin inhibitor, is reduced around cerebral blood vessels in Alzheimer's disease

1994 • 77 citations

Neurologic aspects of boxing.

1987 • 74 citations

Modulation of morphological differentiation of human neuroepithelial cells by serine proteases: independence from blood coagulation.

1989 • 72 citations

Neutral proteases and disruption of the blood–brain barrier in rat

1997 • 70 citations

Neurologic Aspects of Boxing

1987 • 66 citations

Cerebral arterial contractions induced by human and bovine thrombin.

1980 • 59 citations

Motor Neuron Cell Death in Wobbler Mutant Mice Follows Overexpression of the G-protein-coupled, Protease-activated Receptor for Thrombin

2000 • 59 citations

Neural Thrombin and Protease Nexin I Kinetics After Murine Peripheral Nerve Injury

1996 • 54 citations

Proteolytic processing of amyloid β protein precursor (APP) by thrombin

1992 • 52 citations

Bacterial expression, purification of full length and carboxyl terminal fragment of alzheimer amyloid precursor protein and their proteolytic processing by thrombin

1994 • 51 citations

Effects of hippocampal lesions on patterned motor learning in the rat

2002 • 48 citations

Thrombin induced inhibition of neurite outgrowth from dorsal root ganglion neurons

1998 • 41 citations

Thrombin Induces Surface and Intracellular Secretion of Amyloid Precursor Protein from Human Endothelial Cells

1999 • 35 citations

Inhibition of Thrombin-induced Neuronal Cell Death by Recombinant Thrombomodulin and E5510, a Synthetic Thrombin Receptor Signaling Inhibitor

1999 • 33 citations

Effects of Lesions of Hippocampal Fields CA1 and CA3 on Acquisition of Inhibitory Avoidance

2002 • 31 citations

Intracerebral Hemorrhage: Pathology of Selected Topics

1994 • 30 citations

Thrombin-soaked gelatin sponge and brain edema in rats

1996 • 17 citations

Prevention of thrombin-induced motoneuron degeneration with different neurotrophic factors in highly enriched cultures

1999 • 13 citations