Rapamycin Blocks IL-2-Driven T Cell Cycle Progression While Preserving T Cell Survival

Cluster analysis and display of genome-wide expression patterns

1998 • 16,410 citations

A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry

1991 • 4,682 citations

A mammalian protein targeted by G1-arresting rapamycin–receptor complex

1994 • 1,954 citations

RAFT1: A mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs

1994 • 1,470 citations

The Pezcoller lecture: cancer cell cycles revisited.

2000 • 1,208 citations

Contingent Genetic Regulatory Events in T Lymphocyte Activation

1989 • 1,108 citations

lnterleukin-2 programs mouse αβ T lymphocytes for apoptosis

1991 • 1,027 citations

Homeostasis and Self-Tolerance in the Immune System: Turning Lymphocytes off

1998 • 989 citations

Phosphorylation of the Translational Repressor PHAS-I by the Mammalian Target of Rapamycin

1997 • 953 citations

lnterleukin-2-mediated elimination of the p27Kipl cyclin-dependent kinase inhibitor prevented by rapamycin

1994 • 903 citations

Betaglycan presents ligand to the TGFβ signaling receptor

1993 • 887 citations

Isolation of a Protein Target of the FKBP12-Rapamycin Complex in Mammalian Cells

1995 • 859 citations

Blocking both signal 1 and signal 2 of T-cell activation prevents apoptosis of alloreactive T cells and induction of peripheral allograft tolerance

1999 • 762 citations

Making and reading microarrays

1999 • 681 citations

IMMUNOPHARMACOLOGY OF RAPAMYCIN

1996 • 651 citations

Degradation of the cyclin-dependent-kinase inhibitor p27Kip1 is instigated by Jab1

1999 • 624 citations

Requirement for T-cell apoptosis in the induction of peripheral transplantation tolerance

1999 • 621 citations

Functional Activation of Jak1 and Jak3 by Selective Association with IL-2 Receptor Subunits

1994 • 581 citations

Regulation of eIF-4E BP1 Phosphorylation by mTOR

1997 • 511 citations

Phosphatidylinositol 3-Kinase Couples the Interleukin-2 Receptor to the Cell Cycle Regulator E2F

1997 • 411 citations

Three distinct IL-2 signaling pathways mediated by bcl-2, c-myc, and lck cooperate in hematopoietic cell proliferation

1995 • 372 citations

The Cyclins and Cyclin-Dependent Kinase Inhibitors in Hormonal Regulation of Proliferation and Differentiation*

1999 • 358 citations

Mechanism of TGFβ receptor inhibition by FKBP12

1997 • 342 citations

Rapamycin Inhibition of the G1 to S Transition Is Mediated by Effects on Cyclin D1 mRNA and Protein Stability

1998 • 338 citations

Sequential expression of genes involved in human T lymphocyte growth and differentiation.

1985 • 291 citations

Inactivation of a Cdk2 inhibitor during interleukin 2-induced proliferation of human T lymphocytes.

1994 • 289 citations

Crystal Structure and Mutational Analysis of the Human CDK2 Kinase Complex with Cell Cycle–Regulatory Protein CksHs1

1996 • 236 citations

Overexpression of Stra13, a novel retinoic acid-inducible gene of the basic helix–loop–helix family, inhibits mesodermal and promotes neuronal differentiation of P19 cells

1997 • 236 citations

Alloreactive cloned T cell lines. I. Interactions between cloned amplifier and cytolytic T cell lines.

1980 • 235 citations

Transcript imaging of the development of human T helper cells using oligonucleotide arrays

2000 • 230 citations

Activation changes the spectrum but not the diversity of genes expressed by T cells

1999 • 227 citations

Rapamycin Resistance Tied to Defective Regulation of p27^Kip1

1996 • 213 citations

Rapamycin-induced inhibition of p34cdc2 kinase activation is associated with G1/S-phase growth arrest in T lymphocytes.

1993 • 182 citations

Cell Cycle-Dependent Regulation of FLIP Levels and Susceptibility to Fas-Mediated Apoptosis

1999 • 173 citations

Implication of eIF2B Rather Than eIF4E in the Regulation of Global Protein Synthesis by Amino Acids in L6 Myoblasts

1998 • 166 citations

The regulation and function of p21ras during T-cell activation and growth

1995 • 160 citations

Requirement of Nuclear Prolactin for Interleukin-2—Stimulated Proliferation of T Lymphocytes

1991 • 156 citations

rpt-1, an intracellular protein from helper/inducer T cells that regulates gene expression of interleukin 2 receptor and human immunodeficiency virus type 1.

1988 • 150 citations

Interleukin-2 Triggers a Novel Phosphatidylinositol 3-Kinase-Dependent MEK Activation Pathway

1995 • 145 citations

Alloreactive cloned T cell lines. VI. Multiple lymphokine activities secreted by helper and cytolytic cloned T lymphocytes.

1982 • 145 citations

Regulation of E2F transcription by cyclin E–Cdk2 kinase mediated through p300/CBP co-activators

2000 • 144 citations

p70^s6k Integrates Phosphatidylinositol 3-Kinase and Rapamycin-Regulated Signals for E2F Regulation in T Lymphocytes

1999 • 138 citations

The zinc finger protein A20 interacts with a novel anti-apoptotic protein which is cleaved by specific caspases

1999 • 134 citations

Requirement of Protein Kinase Cζ for Stimulation of Protein Synthesis by Insulin

1997 • 127 citations

Identification of STRAP, a Novel WD Domain Protein in Transforming Growth Factor-β Signaling

1998 • 123 citations

The Upregulation of p27Kip1 by Rapamycin Results in G1 Arrest in Exponentially Growing T-Cell Lines

1998 • 117 citations

Cloning and characterization of hTAFII18, hTAFII20 and hTAFII28: three subunits of the human transcription factor TFIID.

1995 • 114 citations

Molecular Cloning of a Novel Member of the Eukaryotic Polypeptide Chain-Releasing Factors (eRF)

1998 • 107 citations

Transforming growth factor β from multiple myeloma cells inhibits proliferation and IL-2 responsiveness in T lymphocytes

1999 • 104 citations

Ubiquitination of RNA polymerase II large subunit signaled by phosphorylation of carboxyl-terminal domain

1999 • 99 citations

Identification of an NTF2-Related Factor That Binds Ran-GTP and Regulates Nuclear Protein Export

1999 • 91 citations

Recombinant interleukin 2 regulates levels of c-myc mRNA in a cloned murine T lymphocyte.

1985 • 80 citations

cDNA cloning and characterization of interleukin 2-induced genes in a cloned T helper lymphocyte.

1990 • 77 citations

The Murine Antiapoptotic Protein A1 Is Induced in Inflammatory Macrophages and Constitutively Expressed in Neutrophils

1999 • 70 citations

A rough guide to a smooth brain

2000 • 64 citations

Cell Cycle Progression Out of G1 Sensitizes Primary-Cultured Nontransformed T Cells to TCR-Mediated Apoptosis

1996 • 51 citations

The immunosuppressant rapamycin blocks in vitro responses to hematopoietic cytokines and inhibits recovering but not steady-state hematopoiesis in vivo

1994 • 51 citations

Bax-mediated cell death by the Gax homeoprotein requires mitogen activation but is independent of cell cycle activity

1998 • 49 citations

Rapamycin Selectively Blocks Interleukin-2-induced Proliferating Cell Nuclear Antigen Gene Expression in T Lymphocyte

1995 • 47 citations

Cloning, Expression, and Characterization of Human Metalloprotease 1: A Novel Member of the Pitrilysin Family of Metalloendoproteases

1999 • 45 citations

Promoter activity of the proliferating-cell nuclear antigen gene is associated with inducible CRE-binding proteins in interleukin 2-stimulated T lymphocytes.

1994 • 44 citations

Interleukin-2 expression in human carcinoma cell lines and its role in cell cycle progression

2000 • 34 citations

Identification of an Essential Cis-Element Near the Transcription Start Site for Transcriptional Activation of the Proliferating Cell Nuclear Antigen Gene

1996 • 22 citations

RAPAMYCIN BUT NOT FK506 INHIBITS THE PROLIFERATION OF MONONUCLEAR PHAGOCYTES INDUCED BY COLONY-STIMULATING FACTORS

1994 • 22 citations

Review: Role of Transforming Growth Factor Beta (TGFβ) in Systemic Autoimmunity

1993 • 21 citations

Murine TRAIL (TNF-Related Apoptosis Inducing Ligand) Expression Induced by T Cell Activation Is Blocked by Rapamycin, Cyclosporin A, and Inhibitors of Phosphatidylinositol 3-Kinase, Protein Kinase C, and Protein Tyrosine Kinases: Evidence for TRAIL Induction via the T Cell Receptor Signaling Pathway

1999 • 21 citations

Three Distinct IL-2 Signaling Pathways Mediated by bcl-2, c-myc, and lck Cooperate in Hematopoietic Cell Proliferation.

1996 • 20 citations

Dexamethasone induces apoptosis in human T cell clones expressing low levels of Bcl-2

1999 • 15 citations

Murine betaglycan primary structure, expression and glycosaminoglycan attachment sites

1998 • 14 citations

Requirement of PI3-kinase activity for the nuclear transport of prolactin in cloned murine T lymphocytes

1999 • 13 citations

Expression of a Novel Isoform of Cyclin I in Human Testis

1998 • 12 citations

Isolation and Analysis of a T Cell Clone Variant Exhibiting Constitutively Phosphorylated Ser133 cAMP Response Element-Binding Protein

1998 • 11 citations

T-cell growth factors in allograft rejection and tolerance

1999 • 10 citations