A novel cytokine-inducible gene CIS encodes an SH2-containing protein that binds to tyrosine-phosphorylated interleukin 3 and erythropoietin receptors.

Jak-STAT Pathways and Transcriptional Activation in Response to IFNs and Other Extracellular Signaling Proteins

1994 • 5,932 citations

A conserved AU sequence from the 3′ untranslated region of GM-CSF mRNA mediates selective mRNA degradation

1986 • 4,200 citations

Amino Acid Sequences Common to Rapidly Degraded Proteins: The PEST Hypothesis

1986 • 2,566 citations

Structural design and molecular evolution of a cytokine receptor superfamily.

1990 • 2,104 citations

The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling

1992 • 1,636 citations

Cytokine signal transduction

1994 • 1,358 citations

CYTOKINES: COORDINATORS OF IMMUNE AND INFLAMMATORY RESPONSES

1990 • 1,304 citations

JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin

1993 • 1,223 citations

Binding of a high affinity phosphotyrosyl peptide to the Src SH2 domain: Crystal structures of the complexed and peptide-free forms

1993 • 758 citations

Signaling by the cytokine receptor superfamily: JAKs and STATs

1994 • 659 citations

Interleukin-3, granulocyte-macrophage colony stimulating factor and interleukin-5 transduce signals through two STAT5 homologs.

1995 • 641 citations

Involvement of the Jak-3 Janus kinase in signalling by interleukins 2 and 4 in lymphoid and myeloid cells

1994 • 618 citations

Organization, distribution, and stability of endogenous ecotropic murine leukemia virus DNA sequences in chromosomes of Mus musculus

1982 • 611 citations

Cytokine Receptors and Signal Transduction

1992 • 607 citations

Phosphorylation and activation of the Jak-3 Janus kinase in response to interleukin-2

1994 • 598 citations

Phosphorylation at threonine-235 by a ras-dependent mitogen-activated protein kinase cascade is essential for transcription factor NF-IL6.

1993 • 587 citations

JAK2 associates with the beta c chain of the receptor for granulocyte-macrophage colony-stimulating factor, and its activation requires the membrane-proximal region.

1994 • 506 citations

[24] Rapid amplification of complementary DNA ends for generation of full-length complementary DNAs: Thermal race

1993 • 501 citations

Development and applications of a molecular genetic linkage map of the mouse genome

1991 • 427 citations

Truncated erythropoietin receptor causes dominantly inherited benign human erythrocytosis.

1993 • 404 citations

Signal transduction by the high-affinity GM-CSF receptor: two distinct cytoplasmic regions of the common beta subunit responsible for different signaling.

1993 • 383 citations

A restricted cytoplasmic region of IL-2 receptor β chain is essential for growth signal transduction but not for ligand binding and internalization

1989 • 370 citations

Critical cytoplasmic domains of the common beta subunit of the human GM-CSF, IL-3 and IL-5 receptors for growth signal transduction and tyrosine phosphorylation.

1992 • 365 citations

Hematopoietic Cell Phosphatase Associates with the Interleukin-3 (IL-3) Receptor β Chain and Down-Regulates IL-3-Induced Tyrosine Phosphorylation and Mitogenesis

1993 • 340 citations

Point mutation in the exoplasmic domain of the erythropoietin receptor resulting in hormone-independent activation and tumorigenicity

1990 • 325 citations

Suppression of apoptotic death in hematopoietic cells by signalling through the IL-3/GM-CSF receptors.

1995 • 321 citations

Establishment of an interleukin 6 (IL 6)/B cell stimulatory factor 2‐dependent cell line and preparation of anti‐IL 6 monoclonal antibodies

1988 • 308 citations

Growth and differentiation signals mediated by different regions in the cytoplasmic domain of granulocyte colony-stimulating factor receptor

1993 • 283 citations

Linkage, recombination and mapping

1981 • 279 citations

Friend spleen focus-forming virus glycoprotein gp55 interacts with the erythropoietin receptor in the endoplasmic reticulum and affects receptor metabolism.

1990 • 244 citations

IL-2 and EGF receptors stimulate the hematopoietic cell cycle via different signaling pathways: Demonstration of a novel role for c-myc

1992 • 242 citations

Multiple cytokines induce the tyrosine phosphorylation of Shc and its association with Grb2 in hemopoietic cells.

1993 • 238 citations

Activation of the mitogen-activated protein kinase pathway by the erythropoietin receptor.

1994 • 220 citations

Hematopoietic cell phosphatase associates with the interleukin-3 (IL-3) receptor beta chain and down-regulates IL-3-induced tyrosine phosphorylation and mitogenesis.

1993 • 204 citations

The adapter protein Shc interacts with the interleukin-2 (IL-2) receptor upon IL-2 stimulation.

1994 • 149 citations

A detailed deletion mapping of the short arm of chromosome 3 in sporadic renal cell carcinoma.

1991 • 145 citations

Erythropoietin-dependent association of phosphatidylinositol 3-kinase with tyrosine-phosphorylated erythropoietin receptor.

1994 • 133 citations

In vitro phosphorylation of the erythropoietin receptor and an associated protein, pp130.

1992 • 127 citations

Deletion mapping on the short arm of chromosome 3 in squamous cell carcinoma and adenocarcinoma of the lung.

1992 • 107 citations

Multiple hemopoietins, with the exception of interleukin-4, induce modification of Shc and mSos1, but not their translocation.

1994 • 102 citations

JAK2 Associates with the β_c Chain of the Receptor for Granulocyte-Macrophage Colony-Stimulating Factor, and Its Activation Requires the Membrane-Proximal Region

1994 • 85 citations

Ligand-induced activation of chimeric receptors between the erythropoietin receptor and receptor tyrosine kinases.

1994 • 85 citations

Multimeric cytokine receptors: common versus specific functions

1994 • 82 citations

Cytokines: Coordinators Of Immune And Inflammatory Responses

1990 • 81 citations

Interleukin-4-dependent proliferation dissociates p44erk-1, p42erk-2, and p21ras activation from cell growth.

1994 • 78 citations

Proliferation and erythroid differentiation through the cytoplasmic domain of the erythropoietin receptor.

1994 • 56 citations

Inhibition of p21ras activation blocks proliferation but not differentiation of interleukin-3-dependent myeloid cells.

1994 • 46 citations

Cytokine Receptors And Signal Transduction

1992 • 45 citations

Erythropoietin and interleukin-3 induce distinct events in erythropoietin receptor-expressing BA/F3 cells

1995 • 43 citations

Characterization of cell phenotype by a novel cDNA library subtraction system: expression of CD8 alpha in a mast cell-derived interleukin-4- dependent cell line

1994 • 37 citations

Ligand-induced phosphorylation of the murine interleukin 3 receptor signals its cleavage.

1992 • 29 citations

Monoclonal antibodies specific for low-affinity interleukin-3 (IL-3) binding protein AIC2A: evidence that AIC2A is a component of a high- affinity IL-3 receptor

1992 • 28 citations

In Vitro Phosphorylation of the Erythropoietin Receptor and an Associated Protein, pp130

1992 • 24 citations

cDNA Cloning and Chromosomal Mapping of the Mouse Type VII Collagen Gene (Col7a1): Evidence for Rapid Evolutionary Divergence of the Gene

1993 • 23 citations

Monoclonal antibodies specific for low-affinity interleukin-3 (IL-3) binding protein AIC2A: evidence that AIC2A is a component of a high- affinity IL-3 receptor

1992 • 18 citations