The Jak-STAT pathway

Jak-STAT Pathways and Transcriptional Activation in Response to IFNs and Other Extracellular Signaling Proteins

1994 • 5,932 citations

STATs and Gene Regulation

1997 • 3,927 citations

Stat3 as an Oncogene

1999 • 2,770 citations

A family of cytokine-inducible inhibitors of signalling

1997 • 2,055 citations

Maximal activation of transcription by statl and stat3 requires both tyrosine and serine phosphorylation

1995 • 1,960 citations

JAKS AND STATS: Biological Implications

1998 • 1,788 citations

Targeted Disruption of the Stat1 Gene in Mice Reveals Unexpected Physiologic Specificity in the JAK–STAT Signaling Pathway

1996 • 1,648 citations

Stat6 Is Required for Mediating Responses to IL-4 and for the Development of Th2 Cells

1996 • 1,618 citations

Essential role of Stat6 in IL-4 signalling

1996 • 1,563 citations

Targeted Disruption of the Mouse Stat1 Gene Results in Compromised Innate Immunity to Viral Disease

1996 • 1,560 citations

STATs: Signal Transducers and Activators of Transcription

1996 • 1,414 citations

A new protein containing an SH2 domain that inhibits JAK kinases

1997 • 1,413 citations

Interleukin-2 receptor γ chain mutation results in X-linked severe combined immunodeficiency in humans

1993 • 1,317 citations

Stat5a and Stat5b Proteins Have Essential and Nonessential, or Redundant, Roles in Cytokine Responses

1998 • 1,316 citations

Structure and function of a new STAT-induced STAT inhibitor

1997 • 1,308 citations

Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality

1997 • 1,306 citations

Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted State6 gene

1996 • 1,304 citations

Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice

1996 • 1,277 citations

Cytokine receptor signalling

1995 • 1,242 citations

Enhanced Th1 Activity and Development of Chronic Enterocolitis in Mice Devoid of Stat3 in Macrophages and Neutrophils

1999 • 1,228 citations

JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin

1993 • 1,223 citations

Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells

1996 • 1,182 citations

Jak2 Is Essential for Signaling through a Variety of Cytokine Receptors

1998 • 1,155 citations

Interleukin-2 Receptor γ Chain: a Functional Component of the Interleukin-7 Receptor

1993 • 1,128 citations

Stat5a is mandatory for adult mammary gland development and lactogenesis.

1997 • 1,106 citations

Defective lymphoid development in mice lacking expression of the common cytokine receptor γ chain

1995 • 1,024 citations

Fundamental Immunology

1999 • 1,011 citations

Requirement of STAT5b for sexual dimorphism of body growth rates and liver gene expression

1997 • 989 citations

Identification of JAK2 as a growth hormone receptor-associated tyrosine kinase

1993 • 988 citations

Specific Inhibition of Stat3 Signal Transduction by PIAS3

1997 • 971 citations

Specific recruitment of SH-PTP1 to the erythropoietin receptor causes inactivation of JAK2 and termination of proliferative signals

1995 • 956 citations

Enhanced DNA-Binding Activity of a Stat3-Related Protein in Cells Transformed by the Src Oncoprotein

1995 • 945 citations

Jak2 Deficiency Defines an EssentialDevelopmental Checkpoint in DefinitiveHematopoiesis

1998 • 904 citations

Lymphoid development in mice with a targeted deletion of the interleukin 2 receptor gamma chain.

1995 • 881 citations

A protein tyrosine kinase in the interferon αβ signaling pathway

1992 • 876 citations

Mutations of Jak-3 gene in patients with autosomal severe combined immune deficiency (SCID)

1995 • 875 citations

Serine phosphorylation of STATs

2000 • 873 citations

Disruption of the Jak1 Gene Demonstrates Obligatory and Nonredundant Roles of the Jaks in Cytokine-Induced Biologic Responses

1998 • 827 citations

Defective IL7R expression in T-B+NK+ severe combined immunodeficiency

1998 • 805 citations

Mutation of Jak3 in a Patient with SCID: Essential Role of Jak3 in Lymphoid Development

1995 • 800 citations

SOCS1 Is a Critical Inhibitor of Interferon γ Signaling and Prevents the Potentially Fatal Neonatal Actions of this Cytokine

1999 • 767 citations

The protein tyrosine kinase JAK1 complements defects in interferon-α/β and -γ signal transduction

1993 • 766 citations

A novel cytokine-inducible gene CIS encodes an SH2-containing protein that binds to tyrosine-phosphorylated interleukin 3 and erythropoietin receptors.

1995 • 761 citations

Inhibition of Stat1-mediated gene activation by PIAS1

1998 • 760 citations

Twenty proteins containing a C-terminal SOCS box form five structural classes

1998 • 735 citations

Functional interactions between Stat5 and the glucocorticoid receptor

1996 • 681 citations

Defective Lymphoid Development in Mice Lacking Jak3

1995 • 650 citations

Interaction of IL-2Rβ and γ _c Chains with Jak1 and Jak3: Implications for XSCID and XCID

1994 • 647 citations

Interleukin-3, granulocyte-macrophage colony stimulating factor and interleukin-5 transduce signals through two STAT5 homologs.

1995 • 641 citations

Negative Regulation of Cytokine Signaling Pathways

2000 • 607 citations

IL-13, IL-4Rα, and Stat6 Are Required for the Expulsion of the Gastrointestinal Nematode Parasite Nippostrongylus brasiliensis

1998 • 582 citations

Requirement of Serine Phosphorylation for Formation of STAT-Promoter Complexes

1995 • 578 citations

Constitutively Activated Jak-STAT Pathway in T Cells Transformed with HTLV-I

1995 • 571 citations

Stat3 Activation Is Responsible for IL-6-Dependent T Cell Proliferation Through Preventing Apoptosis: Generation and Characterization of T Cell-Specific Stat3-Deficient Mice

1998 • 571 citations

Cloning and expression of Stat5 and an additional homologue (Stat5b) involved in prolactin signal transduction in mouse mammary tissue.

1995 • 556 citations

Stat5 Is Required for IL-2-Induced Cell Cycle Progression of Peripheral T Cells

1999 • 554 citations

Defects in B Lymphocyte Maturation and T Lymphocyte Activation in Mice Lacking Jak3

1995 • 551 citations

Requirement for MAP Kinase (ERK2) Activity in Interferon α- and Interferon β-Stimulated Gene Expression Through STAT Proteins

1995 • 549 citations

Complementation by the protein tyrosine kinase JAK2 of a mutant cell line defective in the interferon-& gamma; signal transduction pathway

1993 • 548 citations

CIS, a Cytokine Inducible SH2 Protein, Is a Target of the JAK-STAT5 Pathway and Modulates STAT5 Activation

1997 • 538 citations

Cutting Edge: The Common γ-Chain Is an Indispensable Subunit of the IL-21 Receptor Complex

2001 • 535 citations

SOCS1 Deficiency Causes a Lymphocyte-Dependent Perinatal Lethality

1999 • 531 citations

A STAT protein domain that determines DNA sequence recognition suggests a novel DNA-binding domain.

1995 • 531 citations

Developmental defects of lymphoid cells in Jak3 kinase-deficient mice

1995 • 493 citations

Cooperation of Stat2 and p300/CBP in signalling induced by interferon-α

1996 • 492 citations

Two contact regions between Stat1 and CBP/p300 in interferon γ signaling

1996 • 486 citations

Cooperative DNA Binding and Sequence-Selective Recognition Conferred by the STAT Amino-Terminal Domain

1996 • 483 citations

Signal Transducer and Activator of Transcription Factor 6 (Stat6)-deficient Mice Are Protected from Antigen-induced Airway Hyperresponsiveness and Mucus Production

1998 • 458 citations

Liver degeneration and lymphoid deficiencies in mice lacking suppressor of cytokine signaling-1

1998 • 433 citations

Partial Impairment of Cytokine Responses in Tyk2-Deficient Mice

2000 • 412 citations

Regulation of Interferon-γ-Activated STAT1 by the Ubiquitin-Proteasome Pathway

1996 • 405 citations

Immune Response in Stat2 Knockout Mice

2000 • 399 citations

Identification of a Stat Gene That Functions in Drosophila Development

1996 • 397 citations

Jaks, STATs, Cytokine Signal Transduction, and Immunoregulation: Are We There Yet?

1997 • 381 citations

STAT3β, a Splice Variant of Transcription Factor STAT3, Is a Dominant Negative Regulator of Transcription

1996 • 378 citations

marelle Acts Downstream of the Drosophila HOP/JAK Kinase and Encodes a Protein Similar to the Mammalian STATs

1996 • 375 citations

p38 MAP kinase is required for STAT1 serine phosphorylation and transcriptional activation induced by interferons

1999 • 373 citations

SOCS3 Is Essential in the Regulation of Fetal Liver Erythropoiesis

1999 • 372 citations

Modulation of STAT signaling by STAT-interacting proteins

2000 • 372 citations

Cooperative transcriptional activity of Jun and Stat3 beta, a short form of Stat3.

1995 • 363 citations

Functional Participation of the IL-2 Receptor γ Chain in IL-7 Receptor Complexes

1994 • 342 citations

Jak-STAT Signaling Induced by the v- abl oncogene

1995 • 341 citations

Roles of STAT3 defined by tissue-specific gene targeting

2000 • 341 citations

Transcriptional regulation of the cyclin D1 promoter by STAT5: its involvement in cytokine-dependent growth of hematopoietic cells

1999 • 341 citations

Stat5b Is Essential for Natural Killer Cell–mediated Proliferation and Cytolytic Activity

1998 • 323 citations

Cloning of a type I cytokine receptor most related to the IL-2 receptor β chain

2000 • 322 citations

Constitutive activation of STAT proteins in primary lymphoid and myeloid leukemia cells and in Epstein-Barr virus (EBV)-related lymphoma cell lines

1996 • 318 citations

Abrogation of Bronchial Eosinophilic Inflammation and Airway Hyperreactivity in Signal Transducers and Activators of Transcription (STAT)6-deficient Mice

1998 • 314 citations

STAT-related transcription factors are constitutively activated in peripheral blood cells from acute leukemia patients

1996 • 312 citations

Tyk2 Plays a Restricted Role in IFNα Signaling, Although It Is Required for IL-12-Mediated T Cell Function

2000 • 310 citations

DNA binding of in vitro activated Stat1 alpha, Stat1 beta and truncated Stat1: interaction between NH2-terminal domains stabilizes binding of two dimers to tandem DNA sites.

1996 • 302 citations

Functional Association of Nmi with Stat5 and Stat1 in IL-2- and IFN γ-Mediated Signaling

1999 • 297 citations

Accelerated apoptosis of lymphocytes by augmented induction of Bax in SSI-1 (STAT-induced STAT inhibitor-1) deficient mice

1998 • 290 citations

Constitutive activation of JAKs and STATs in BCR-Abl-expressing cell lines and peripheral blood cells derived from leukemic patients.

1997 • 283 citations

Overlapping elements in the guanylate-binding protein gene promoter mediate transcriptional induction by alpha and gamma interferons.

1991 • 278 citations

Proliferation of adult T cell leukemia/lymphoma cells is associated with the constitutive activation of JAK/STAT proteins

1997 • 278 citations

An Indirect Effect of Stat5a in IL-2–Induced Proliferation: A Critical Role for Stat5a in IL-2–Mediated IL-2 Receptor α Chain Induction

1997 • 275 citations

Stat1 Depends on Transcriptional Synergy with Sp1

1995 • 272 citations

Naturally Occurring Dominant Negative Variants of Stat5

1996 • 270 citations

Suppression of STAT5 Functions in Liver, Mammary Glands, and T Cells in Cytokine-Inducible SH2-Containing Protein 1 Transgenic Mice

1999 • 269 citations

Structure of the Amino-Terminal Protein Interaction Domain of STAT-4

1998 • 267 citations

Cloning and Characterization of Novel CIS Family Genes

1997 • 259 citations

Requirement for Ras/Rac1-Mediated p38 and c-Jun N-Terminal Kinase Signaling in Stat3 Transcriptional Activity Induced by the Src Oncoprotein

1999 • 259 citations

Components of a stat recognition code: Evidence for two layers of molecular selectivity

1995 • 254 citations

STAT3 Acts as a Co-activator of Glucocorticoid Receptor Signaling

1997 • 236 citations

SH2 Signaling in a Lower Eukaryote: A STAT Protein That Regulates Stalk Cell Differentiation in Dictyostelium

1997 • 230 citations

A null mutation in the perforin gene impairs cytolytic T lymphocyte- and natural killer cell-mediated cytotoxicity.

1994 • 224 citations

Ser727-dependent recruitment of MCM5 by Stat1α in IFN-γ-induced transcriptional activation

1998 • 220 citations

p300/CREB-Binding Protein Enhances the Prolactin-Mediated Transcriptional Induction through Direct Interaction with the Transactivation Domain of Stat5, but Does Not Participate in the Stat5-Mediated Suppression of the Glucocorticoid Response

1998 • 217 citations

The Significance of Tetramerization in Promoter Recruitment by Stat5

1999 • 213 citations

The state of the STATs: recent developments in the study of signal transduction to the nucleus

1997 • 212 citations

Cloning of Human Stat5B

1996 • 210 citations

Distribution of the Mammalian Stat Gene Family in Mouse Chromosomes

1995 • 195 citations

DNA Binding Site Selection of Dimeric and Tetrameric Stat5 Proteins Reveals a Large Repertoire of Divergent Tetrameric Stat5a Binding Sites

2000 • 187 citations

STAT5A-Deficient Mice Demonstrate a Defect in Granulocyte-Macrophage Colony-Stimulating Factor–Induced Proliferation and Gene Expression

1997 • 180 citations

Blastocyst formation is blocked in mouse embryos lacking the splicing factor SRp20

1999 • 170 citations

THE MOLECULAR BASIS OF X-LINKED SEVERE COMBINED IMMUNODEFICIENCY: Defective Cytokine Receptor Signaling

1996 • 168 citations

Characterization of Stat5a and Stat5b Homodimers and Heterodimers and Their Association with the Glucocortiocoid Receptor in Mammary Cells

1998 • 164 citations

An alternative pathway for STAT activation that is mediated by the direct interaction between JAK and STAT

1997 • 158 citations

Functionally Distinct Isoforms of STAT5 Are Generated by Protein Processing

1997 • 155 citations

An IL-2 response element in the human IL-2 receptor alpha chain promoter is a composite element that binds Stat5, Elf-1, HMG-I(Y) and a GATA family protein.

1996 • 152 citations

Distinct Domains of the Protein Tyrosine Kinase tyk2 Required for Binding of Interferon-α/β and for Signal Transduction

1995 • 148 citations

STAT3 Is a Serine Kinase Target in T Lymphocytes

1997 • 139 citations

Signaling via IL-2 and IL-4 in JAK3-Deficient Severe Combined Immunodeficiency Lymphocytes: JAK3-Dependent and Independent Pathways

1996 • 129 citations

Interaction of the growth hormone receptor cytoplasmic domain with the JAK2 tyrosine kinase.

1994 • 127 citations

p300/CBP is required for transcriptional induction by interleukin-4 and interacts with Stat6

1999 • 126 citations

Elf-1 and Stat5 Bind to a Critical Element in a New Enhancer of the Human Interleukin-2 Receptor α Gene

1996 • 117 citations

CIS Associates with the Interleukin-2 Receptor β Chain and Inhibits Interleukin-2-dependent Signaling

1999 • 116 citations

Extracellular Signal-Regulated Kinase (ERK) Interacts with Signal Transducer and Activator of Transcription (STAT) 5a

1999 • 104 citations

CIS3 and JAB have different regulatory roles in interleukin-6 mediated differentiation and STAT3 activation in M1 leukemia cells

1998 • 93 citations

Defective IL-2-mediated IL-2 receptor alpha chain expression in Stat3- deficient T lymphocytes

1998 • 92 citations

Both Stat5a and Stat5b are required for antigen-induced eosinophil and T-cell recruitment into the tissue

2000 • 84 citations

Cleavage Plane Specification in C. elegans: How to Divide the Spoils

1996 • 76 citations

Role of a STAT Binding Site in the Regulation of the Human Perforin Promoter

1999 • 76 citations

Cooperation of the Transcriptional Coactivators CBP and p300 with Stat6

1999 • 75 citations

Mouse Interleukin-2 Receptor α Gene Expression

1995 • 62 citations

Preface: STAT signaling

2000 • 58 citations

Mutational Analysis of the STAT6 SH2 Domain

1998 • 57 citations

Cytokine signaling: Inhibitors keep cytokines in check

1999 • 52 citations

STATs and cytokine specificity

1996 • 45 citations

p300/CREB-Binding Protein Enhances the Prolactin-Mediated Transcriptional Induction through Direct Interaction with the Transactivation Domain of Stat5, but Does Not Participate in the Stat5-Mediated Suppression of the Glucocorticoid Response

1998 • 44 citations

Interaction of the growth hormone receptor cytoplasmic domain with the JAK2 tyrosine kinase

1994 • 37 citations

Extracellular Signal-Regulated Kinase (ERK) Interacts with Signal Transducer and Activator of Transcription (STAT) 5a

1999 • 25 citations