Requirement for Ras/Rac1-Mediated p38 and c-Jun N-Terminal Kinase Signaling in Stat3 Transcriptional Activity Induced by the Src Oncoprotein

Jak-STAT Pathways and Transcriptional Activation in Response to IFNs and Other Extracellular Signaling Proteins

1994 • 5,932 citations

STATs and Gene Regulation

1997 • 3,927 citations

A synthetic inhibitor of the mitogen-activated protein kinase cascade.

1995 • 2,723 citations

Interleukin-3-Induced Phosphorylation of BAD Through the Protein Kinase Akt

1997 • 2,245 citations

Stat3: a STAT Family Member Activated by Tyrosine Phosphorylation in Response to Epidermal Growth Factor and Interleukin-6

1994 • 2,037 citations

Maximal activation of transcription by statl and stat3 requires both tyrosine and serine phosphorylation

1995 • 1,960 citations

TRANSCRIPTIONAL RESPONSES TO POLYPEPTIDE LIGANDS: The JAK-STAT Pathway

1995 • 1,826 citations

Constitutive Activation of Stat3 Signaling Confers Resistance to Apoptosis in Human U266 Myeloma Cells

1999 • 1,655 citations

Selective activation of the JNK signaling cascadeand c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs

1995 • 1,499 citations

Liver Failure and Defective Hepatocyte Regeneration in Interleukin-6-Deficient Mice

1996 • 1,498 citations

Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality

1997 • 1,306 citations

Transcriptional Regulation by Extracellular signals: Mechanisms and Specificity

1995 • 1,287 citations

The Rho family GTPases RhoA, Racl , and CDC42Hsregulate transcriptional activation by SRF

1995 • 1,280 citations

Differential Activation of ERK and JNK Mitogen-Activated Protein Kinases by Raf-1 and MEKK

1994 • 1,092 citations

Role of Phosphoinositide 3-OH Kinase in Cell Transformation and Control of the Actin Cytoskeleton by Ras

1997 • 1,064 citations

Complexes of Ras⋅GTP with Raf-1 and Mitogen-Activated Protein Kinase Kinase

1993 • 987 citations

Enhanced DNA-Binding Activity of a Stat3-Related Protein in Cells Transformed by the Src Oncoprotein

1995 • 945 citations

Inhibition of histamine secretion by wortmannin through the blockade of phosphatidylinositol 3-kinase in RBL-2H3 cells.

1993 • 738 citations

Activation of Rac1, RhoA, and Mitogen-Activated Protein Kinases Is Required for Ras Transformation

1995 • 683 citations

Stat3 Activation by Src Induces Specific Gene Regulation and Is Required for Cell Transformation

1998 • 666 citations

Two Signals Are Necessary for Cell Proliferation Induced by a Cytokine Receptor gp130: Involvement of STAT3 in Anti-Apoptosis

1996 • 661 citations

A Mammalian Scaffold Complex That Selectively Mediates MAP Kinase Activation

1998 • 653 citations

Stat3 Activation Is Required for Cellular Transformation by v-src

1998 • 624 citations

The SIF binding element confers sis/PDGF inducibility onto the c-fos promoter.

1990 • 615 citations

STAT3 Serine Phosphorylation by ERK-Dependent and -Independent Pathways Negatively Modulates Its Tyrosine Phosphorylation

1997 • 612 citations

Constitutively Activated Jak-STAT Pathway in T Cells Transformed with HTLV-I

1995 • 571 citations

Requirement for MAP Kinase (ERK2) Activity in Interferon α- and Interferon β-Stimulated Gene Expression Through STAT Proteins

1995 • 549 citations

Selective Activation of p38 Mitogen-activated Protein (MAP) Kinase Isoforms by the MAP Kinase Kinases MKK3 and MKK6

1998 • 531 citations

Transcriptionally active Stat1 is required for the antiproliferative effects of both interferon alpha and interferon gamma.

1996 • 529 citations

Requirement of Stat3 but not Stat1 activation for epidermal growth factor receptor- mediated cell growth In vitro.

1998 • 508 citations

Role of p38 and JNK Mitogen-Activated Protein Kinases in the Activation of Ternary Complex Factors

1997 • 467 citations

Structural basis of inhibitor selectivity in MAP kinases

1998 • 408 citations

STAT3β, a Splice Variant of Transcription Factor STAT3, Is a Dominant Negative Regulator of Transcription

1996 • 378 citations

Activation and Association of Stat3 with Src in v-Src-Transformed Cell Lines

1996 • 372 citations

Constitutive activation of Stat3 in fibroblasts transformed by diverse oncoproteins and in breast carcinoma cells.

1997 • 370 citations

Jak-STAT Signaling Induced by the v- abl oncogene

1995 • 341 citations

Requirement of p38 Mitogen-activated Protein Kinase for Neuronal Differentiation in PC12 Cells

1998 • 340 citations

Mapping of Stat3 serine phosphorylation to a single residue (727) and evidence that serine phosphorylation has no influence on DNA binding of Stat1 and Stat3

1997 • 325 citations

Constitutive activation of STAT proteins in primary lymphoid and myeloid leukemia cells and in Epstein-Barr virus (EBV)-related lymphoma cell lines

1996 • 318 citations

MEKKs, GCKs, MLKs, PAKs, TAKs, and Tpls: upstream regulators of the c-Jun amino-terminal kinases?

1997 • 318 citations

MLK-3 activates the SAPK/JNK and p38/RK pathways via SEK1 and MKK3/6.

1996 • 314 citations

Regulation of Phosphorylation Pathways by p21 GTPases

1996 • 300 citations

Constitutive activation of JAKs and STATs in BCR-Abl-expressing cell lines and peripheral blood cells derived from leukemic patients.

1997 • 283 citations

Proliferation of adult T cell leukemia/lymphoma cells is associated with the constitutive activation of JAK/STAT proteins

1997 • 278 citations

Rho family GTPases: the cytoskeleton and beyond

1996 • 262 citations

B lymphocytes from patients with chronic lymphocytic leukemia contain signal transducer and activator of transcription (STAT) 1 and STAT3 constitutively phosphorylated on serine residues.

1997 • 248 citations

Megakaryocytic Differentiation Induced by Constitutive Activation of Mitogen-Activated Protein Kinase Kinase

1997 • 237 citations

Activation of Jak/STAT proteins involved in signal transduction pathway mediated by receptor for interleukin 2 in malignant T lymphocytes derived from cutaneous anaplastic large T-cell lymphoma and Sezary syndrome.

1996 • 232 citations

Rapid inhibition of interleukin-6 signaling and Stat3 activation mediated by mitogen-activated protein kinases

1998 • 227 citations

Differential activation of c-fos promoter elements by serum, lysophosphatidic acid, G proteins and polypeptide growth factors.

1995 • 226 citations

STAT3 activation by cytokines utilizing gp130 and related transducers involves a secondary modification requiring an H7-sensitive kinase.

1995 • 211 citations

Activation of STAT transcription factors in oncogenic tyrosine kinase signaling

1998 • 206 citations

Repression of Stat3 activity by activation of mitogen-activated protein kinase (MAPK)

1998 • 198 citations

MKK7 Is A Stress-activated Mitogen-activated Protein Kinase Kinase Functionally Related to hemipterous

1997 • 182 citations

Overexpressed pp60c-src can induce focus formation without complete transformation of NIH 3T3 cells.

1985 • 171 citations

Interleukin-2 activation of STAT5 requires the convergent action of tyrosine kinases and a serine/threonine kinase pathway distinct from the Raf1/ERK2 MAP kinase pathway.

1996 • 167 citations

Identification and characterization of a new mammalian mitogen-activated protein kinase kinase, MKK2.

1993 • 152 citations

Phosphatidylinositol 3-kinase functions upstream of Ras and Raf in mediating insulin stimulation of c-fos transcription

1993 • 146 citations

The Functional Synergy Between IL-12 and IL-2 Involves p38 Mitogen-Activated Protein Kinase and Is Associated with the Augmentation of STAT Serine Phosphorylation

1999 • 142 citations

Dual Leucine Zipper-bearing Kinase (DLK) Activates p46SAPK and p38 but Not ERK2

1996 • 140 citations

STAT3 Is a Serine Kinase Target in T Lymphocytes

1997 • 139 citations

AKT2, a member of the protein kinase B family, is activated by growth factors, v-Ha-ras, and v-src through phosphatidylinositol 3-kinase in human ovarian epithelial cancer cells.

1998 • 130 citations

A Single Amino Acid Substitution in the v-Eyk Intracellular Domain Results in Activation of Stat3 and Enhances Cellular Transformation

1999 • 121 citations

Dual phosphorylation and autophosphorylation in mitogen-activated protein (MAP) kinase activation

1993 • 118 citations

Abrogation of Interleukin-3 Dependence of Myeloid Cells by the v-src Oncogene Requires SH2 and SH3 Domains Which Specify Activation of STATs

1997 • 108 citations

Activation of Stress-activated Protein Kinases/c-Jun N-terminal Protein Kinases (SAPKs/JNKs) by a Novel Mitogen-activated Protein Kinase Kinase (MKK7)

1997 • 100 citations

Activation of STAT transcription factors by herpesvirus Saimiri Tip-484 requires p56lck

1997 • 95 citations

Dominant inhibitory Ras mutants demonstrate the requirement for Ras activity in the action of tyrosine kinase oncogenes.

1991 • 94 citations

Signal Transducer and Activator of Transcription-3 Serine Phosphorylation by Insulin Is Mediated by a Ras/Raf/MEK-Dependent Pathway*

1997 • 64 citations

Phosphatidylinositol-3 kinase is activated in v-src, v-yes, and v-fps transformed chicken embryo fibroblasts.

1991 • 60 citations

Mek1 Phosphorylation Site Mutants Activate Raf-1 in NIH 3T3 Cells

1996 • 53 citations

Raf-1 N-Terminal Sequences Necessary for Ras-Raf Interaction and Signal Transduction

1995 • 50 citations

STAT3 activation accompanies keratinocyte differentiation.

1998 • 50 citations

Ras-independent transformation by v-Src

1997 • 50 citations

Fibroblast Transformation by Fps/Fes Tyrosine Kinases Requires Ras, Rac, and Cdc42 and Induces Extracellular Signal-regulated and c-Jun N-terminal Kinase Activation

1998 • 45 citations

Evidence that Ha-Ras mediates two distinguishable intracellular signals activated by v-Src.

1992 • 42 citations

Activation of extracellular signal-regulated kinase (ERK) by mitogenic stimuli is repressed in v-Src-transformed cells.

1997 • 28 citations

Delay in serum stimulation of Erk activity caused by oncogenic transformation.

1996 • 15 citations