Reactive Oxygen Species as Mediators of Signal Transduction in Ischemic Preconditioning

Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium.

1986 • 7,740 citations

Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide.

1990 • 7,068 citations

Oxygen-Derived Free Radicals in Postischemic Tissue Injury

1985 • 5,488 citations

STATs and Gene Regulation

1997 • 3,927 citations

Apaf-1, a Human Protein Homologous to C. elegans CED-4, Participates in Cytochrome c–Dependent Activation of Caspase-3

1997 • 3,130 citations

The mitochondrial generation of hydrogen peroxide. General properties and effect of hyperbaric oxygen

1973 • 2,608 citations

Regulation of Neuronal Survival by the Serine-Threonine Protein Kinase Akt

1997 • 2,442 citations

Pro-inflammatory Cytokines and Environmental Stress Cause p38 Mitogen-activated Protein Kinase Activation by Dual Phosphorylation on Tyrosine and Threonine

1995 • 2,238 citations

Prostaglandin Endoperoxide H Synthases (Cyclooxygenases)-1 and −2

1996 • 1,987 citations

THE MITOCHONDRIAL DEATH/LIFE REGULATOR IN APOPTOSIS AND NECROSIS

1998 • 1,982 citations

PI3K: Downstream AKTion Blocks Apoptosis

1997 • 1,693 citations

Generation of superoxide anion by the NADH dehydrogenase of bovine heart mitochondria

1980 • 1,609 citations

Dystrophin protects the sarcolemma from stresses developed during muscle contraction.

1993 • 1,444 citations

STATs: Signal Transducers and Activators of Transcription

1996 • 1,414 citations

MKK3- and MKK6-Regulated Gene Expression Is Mediated by the p38 Mitogen-Activated Protein Kinase Signal Transduction Pathway

1996 • 1,286 citations

Biochemical, physiological and medical aspects of ubiquinone function

1995 • 1,210 citations

Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB

1997 • 1,162 citations

SIGNALLING BY RECEPTOR TYROSINE KINASES

1993 • 1,098 citations

Apoptotic and necrotic myocyte cell deaths are independent contributing variables of infarct size in rats.

1996 • 1,045 citations

Cardioprotective Effect of Diazoxide and Its Interaction With Mitochondrial ATP-Sensitive K ⁺ Channels

1997 • 1,032 citations

Molecular and Cellular Mechanisms of Myocardial Stunning

1999 • 1,023 citations

Cardiac stress protein elevation 24 hours after brief ischemia or heat stress is associated with resistance to myocardial infarction.

1993 • 1,005 citations

Phosphorylation of transcription factor p62TCF by MAP kinase stimulates ternary complex formation at c-fos promoter

1992 • 980 citations

The respiratory burst of phagocytes.

1984 • 914 citations

Nitric Oxide: Pathophysiological Mechanisms

1995 • 876 citations

Interleukin-1 activates a novel protein kinase cascade that results in the phosphorylation of hsp27

1994 • 866 citations

Cardiac Muscle Cell Hypertrophy and Apoptosis Induced by Distinct Members of the p38 Mitogen-activated Protein Kinase Family

1998 • 855 citations

Production of superoxide radicals and hydrogen peroxide by NADH-ubiquinone reductase and ubiquinol-cytochrome c reductase from beef-heart mitochondria

1977 • 854 citations

Mitochondrial permeability transition and oxidative stress

2001 • 842 citations

Mitochondrial non-specific pores remain closed during cardiac ischaemia, but open upon reperfusion

1995 • 830 citations

Activation of the β1 isozyme of phospholipase C by α subunits of the Gq class of G proteins

1991 • 774 citations

The Late Phase of Preconditioning

2000 • 753 citations

Ghrelin and des-acyl ghrelin inhibit cell death in cardiomyocytes and endothelial cells through ERK1/2 and PI 3-kinase/AKT

2002 • 734 citations

Nitric Oxide and Cardiac Function

1996 • 721 citations

Reactive Oxygen Species Released from Mitochondria during Brief Hypoxia Induce Preconditioning in Cardiomyocytes

1998 • 715 citations

Mitochondrial calcium transport: physiological and pathological relevance

1994 • 702 citations

The permeability transition pore complex: another view

2002 • 702 citations

Role of redox potential and reactive oxygen species in stress signaling

1999 • 695 citations

Regulation of tyrosine kinase cascades by G-protein-coupled receptors

1999 • 688 citations

Intracellular Signaling by Reactive Oxygen Species during Hypoxia in Cardiomyocytes

1998 • 684 citations

Hypoxia Induces Cyclooxygenase-2 via the NF-κB p65 Transcription Factor in Human Vascular Endothelial Cells

1997 • 673 citations

Opening of Mitochondrial K _ATP Channels Triggers the Preconditioned State by Generating Free Radicals

2000 • 666 citations

Insulin-like Growth Factor 1 Inhibits Apoptosis Using the Phosphatidylinositol 3′-Kinase and Mitogen-activated Protein Kinase Pathways

1997 • 662 citations

Role of ubiquinone in the mitochondrial generation of hydrogen peroxide

1976 • 656 citations

Complex I-mediated reactive oxygen species generation: modulation by cytochrome c and NAD(P)+ oxidation–reduction state

2002 • 656 citations

Isozyme-selective stimulation of phospholipase C-β2 by G protein βγ-subunits

1992 • 630 citations

Delayed effects of sublethal ischemia on the acquisition of tolerance to ischemia.

1993 • 629 citations

Multiple pathways control protein kinase C phosphorylation

2000 • 598 citations

Activation of NF-?B protects hippocampal neurons against oxidative stress-induced apoptosis: Evidence for induction of manganese superoxide dismutase and suppression of peroxynitrite production and protein tyrosine nitration

1997 • 572 citations

Oxidative Stress-Induced Actin Reorganization Mediated by the p38 Mitogen-Activated Protein Kinase/Heat Shock Protein 27 Pathway in Vascular Endothelial Cells

1997 • 569 citations

Activation of the JAK-STAT pathway by reactive oxygen species

1998 • 566 citations

Reactive Oxygen Species Mediate the Activation of Akt/Protein Kinase B by Angiotensin II in Vascular Smooth Muscle Cells

1999 • 563 citations

Mechanisms of lipid peroxidation

1985 • 542 citations

Stimulation of the Stress-Activated Mitogen-Activated Protein Kinase Subfamilies in Perfused Heart

1996 • 531 citations

Deleterious effects of oxygen radicals in ischemia/reperfusion. Resolved and unresolved issues.

1989 • 518 citations

Evidence that mitochondrial respiration is a source of potentially toxic oxygen free radicals in intact rabbit hearts subjected to ischemia and reflow.

1993 • 518 citations

Inhibition of p38 Mitogen-Activated Protein Kinase Decreases Cardiomyocyte Apoptosis and Improves Cardiac Function After Myocardial Ischemia and Reperfusion

1999 • 504 citations

Mitochondrial oxygen radical generation and leak: sites of production in states 4 and 3, organ specificity, and relation to aging and longevity.

1999 • 492 citations

Pro-Leu-Ser/Thr-Pro is a consensus primary sequence for substrate protein phosphorylation. Characterization of the phosphorylation of c-myc and c-jun proteins by an epidermal growth factor receptor threonine 669 protein kinase

1991 • 491 citations

Oxygen Radicals Released During Ischemic Preconditioning Contribute to Cardioprotection in the Rabbit Myocardium

1997 • 490 citations

Sarcolemmal Versus Mitochondrial ATP-Sensitive K ⁺ Channels and Myocardial Preconditioning

1999 • 484 citations

Nitric Oxide Mediates the Antiapoptotic Effect of Insulin in Myocardial Ischemia-Reperfusion

2002 • 480 citations

ATP-regulated K+ channels protect the myocardium against ischemia/reperfusion damage.

1991 • 479 citations

The regulation of the matrix volume of mammalian mitochondria in vivo and in vitro and its role in the control of mitochondrial metabolism

1989 • 443 citations

Subcellular and submitochondrial mode of action of Bcl-2-like oncoproteins

1998 • 421 citations

Inhibition of Extracellular Signal–Regulated Kinase Enhances Ischemia/Reoxygenation–Induced Apoptosis in Cultured Cardiac Myocytes and Exaggerates Reperfusion Injury in Isolated Perfused Heart

2000 • 419 citations

Cellular mechanisms of cardiac hypertrophy

1998 • 409 citations

The Dystrophin Complex Forms a Mechanically Strong Link between the Sarcolemma and Costameric Actin

2000 • 402 citations

Cardiotrophin 1 (CT-1) Inhibition of Cardiac Myocyte Apoptosis via a Mitogen-activated Protein Kinase-dependent Pathway

1997 • 399 citations

Diazoxide-Induced Cardioprotection Requires Signaling Through a Redox-Sensitive Mechanism

2001 • 396 citations

Role of Troponin I Proteolysis in the Pathogenesis of Stunned Myocardium

1997 • 392 citations

Src Family Tyrosine Kinases and Growth Factor Signaling

2000 • 391 citations

Cyclooxygenase-2 mediates the cardioprotective effects of the late phase of ischemic preconditioning in conscious rabbits

2000 • 389 citations

The late phase of ischemic preconditioning is abrogated by targeted disruption of the inducible NO synthase gene

1999 • 389 citations

Oxidative Damage of Cardiomyocytes Is Limited by Extracellular Regulated Kinases 1/2-mediated Induction of Cyclooxygenase-2

1999 • 382 citations

Why are mitochondria involved in apoptosis? Permeability transition pores and apoptosis as selective mechanisms to eliminate superoxide‐producing mitochondria and cell

1996 • 376 citations

Bcl-2 family proteins and mitochondria

1998 • 374 citations

Phosphatidylinositol 3-Kinase Is an Early Intermediate in the Gβγ-mediated Mitogen-activated Protein Kinase Signaling Pathway

1996 • 372 citations

Activation and Association of Stat3 with Src in v-Src-Transformed Cell Lines

1996 • 372 citations

The Phosphatidylinositol 3-Kinase (PI3K)-Akt Pathway Suppresses Bax Translocation to Mitochondria

2002 • 369 citations

Modulation of Mitochondrial ATP-Dependent K ⁺ Channels by Protein Kinase C

1998 • 368 citations

Ischemic Preconditioning Activates Phosphatidylinositol-3-Kinase Upstream of Protein Kinase C

2000 • 362 citations

Mitochondrial ATP-Sensitive Potassium Channels Attenuate Matrix Ca ²⁺ Overload During Simulated Ischemia and Reperfusion

2001 • 362 citations

Bioenergetic consequences of opening the ATP-sensitive K⁺channel of heart mitochondria

2001 • 355 citations

Small Heat Shock Proteins and Protection Against Ischemic Injury in Cardiac Myocytes

1997 • 345 citations

Direct Activation of Mitochondrial Apoptosis Machinery by c-Jun N-terminal Kinase in Adult Cardiac Myocytes

2002 • 342 citations

Preconditioning causes improved wall motion as well as smaller infarcts after transient coronary occlusion in rabbits.

1991 • 329 citations

Mitochondrial implication in accidental and programmed cell death: apoptosis and necrosis.

1997 • 326 citations

K_ATP channel‐independent targets of diazoxide and 5‐hydroxydecanoate in the heart

2002 • 323 citations

Leukocytes and Ischemia-Induced Myocardial Injury

1986 • 321 citations

The Protective Effect of Late Preconditioning Against Myocardial Stunning in Conscious Rabbits Is Mediated by Nitric Oxide Synthase

1997 • 316 citations

Troponin I Degradation and Covalent Complex Formation Accompanies Myocardial Ischemia/Reperfusion Injury

1999 • 315 citations

Mitochondrial ATP-sensitive K⁺channels modulate cardiac mitochondrial function

1998 • 313 citations

Preconditioning in Cardiomyocytes Protects by Attenuating Oxidant Stress at Reperfusion

2000 • 311 citations

Free radicals and myocardial ischemia and reperfusion injury.

1987 • 307 citations

Nuclear Factor-κB Plays an Essential Role in the Late Phase of Ischemic Preconditioning in Conscious Rabbits

1999 • 302 citations

On the involvement of a cyclosporin A sensitive mitochondrial pore in myocardial reperfusion injury

1993 • 295 citations

Oxygen Radicals Can Induce Preconditioning in Rabbit Hearts

1997 • 294 citations

Mitochondrial ATP-Sensitive Potassium Channels Inhibit Apoptosis Induced by Oxidative Stress in Cardiac Cells

2001 • 281 citations

An essential role of the JAK-STAT pathway in ischemic preconditioning

2001 • 280 citations

Differential regulation of protein kinase C isoforms in isolated neonatal and adult rat cardiomyocytes

1994 • 280 citations

The nitric oxide hypothesis of late preconditioning

1998 • 274 citations

Role of NAD(P)H Oxidase in Angiotensin II–Induced JAK/STAT Signaling and Cytokine Induction

2000 • 273 citations

Mitochondrial oxidative stress and cell death in astrocytes —requirement for stored Ca2+ and sustained opening of the permeability transition pore

2002 • 265 citations

Rapid expression of heat shock protein in the rabbit after brief cardiac ischemia.

1991 • 265 citations

The Jak-Stat Pathway: Cytokine Signalling from the Receptor to the Nucleus

1999 • 263 citations

Effects of the KATP channel opener bimakalim on coronary blood flow, monophasic action potential duration, and infarct size in dogs.

1994 • 259 citations

Myeloperoxidase-dependent effect of amines on functions of isolated neutrophils.

1983 • 257 citations

Evidence That Late Preconditioning Against Myocardial Stunning in Conscious Rabbits Is Triggered by the Generation of Nitric Oxide

1997 • 255 citations

Nitric Oxide Synthase Is the Mediator of Late Preconditioning Against Myocardial Infarction in Conscious Rabbits

1998 • 254 citations

Characterization of protein kinase C isotype expression in adult rat heart. Protein kinase C-epsilon is a major isotype present, and it is activated by phorbol esters, epinephrine, and endothelin.

1993 • 252 citations

Determination of the mechanism of free radical generation in human aortic endothelial cells exposed to anoxia and reoxygenation.

1994 • 251 citations

Evidence for an essential role of reactive oxygen species in the genesis of late preconditioning against myocardial stunning in conscious pigs.

1996 • 244 citations

Redox modification of sodium-calcium exchange activity in cardiac sarcolemmal vesicles.

1986 • 242 citations

Breakdown and Release of Myofilament Proteins During Ischemia and Ischemia/Reperfusion in Rat Hearts

1998 • 240 citations

Preconditioning of the ischaemic myocardium; involvement of the <scp>l</scp>‐arginine nitric oxide pathway

1992 • 238 citations

Differential regulation of endothelial cell adhesion molecule expression by nitric oxide donors and antioxidants

1998 • 233 citations

Ischemic preconditioning in rats: role of mitochondrial K_ATPchannel in preservation of mitochondrial function

2000 • 228 citations

MAP kinase-mediated signalling to nucleosomes and immediate-early gene induction

1999 • 226 citations

Hydrogen peroxide and hydroxyl radical mediation of activated leukocyte depression of cardiac sarcoplasmic reticulum. Participation of the cyclooxygenase pathway.

1983 • 222 citations

Activation of JAK/STAT pathway transduces cytoprotective signal in rat acute myocardial infarction

2000 • 221 citations

Peptide modulators of protein–protein interactions in intracellular signaling

1998 • 216 citations

Interferon-gamma induces tyrosine phosphorylation of interferon-gamma receptor and regulated association of protein tyrosine kinases, Jak1 and Jak2, with its receptor.

1994 • 213 citations

Ischemia-induced STAT-1 Expression and Activation Play a Critical Role in Cardiomyocyte Apoptosis

2000 • 208 citations

The mitochondrial site of superoxide formation

1986 • 208 citations

Activation of Bcl-2-Associated Death Protein and Counter-Response of Akt within Cell Populations during Seizure-Induced Neuronal Death

2002 • 204 citations

Potassium channel openers protect cardiac mitochondria by attenuating oxidant stress at reoxygenation

2002 • 202 citations

Activation of Mitochondrial ATP-Sensitive K ⁺ Channel for Cardiac Protection Against Ischemic Injury Is Dependent on Protein Kinase C Activity

1999 • 202 citations

Signals through gp130 upregulate bcl-x gene expression via STAT1-binding cis-element in cardiac myocytes.

1997 • 201 citations

Preconditioning does not attenuate myocardial stunning.

1992 • 194 citations

Phosphorylation of Protein Kinase C-α on Serine 657 Controls the Accumulation of Active Enzyme and Contributes to Its Phosphatase-resistant State

1997 • 194 citations

Activation of JAK-STAT and MAP Kinases by Leukemia Inhibitory Factor Through gp130 in Cardiac Myocytes

1996 • 192 citations

p38 Mitogen-Activated Protein Kinase Mediates a Negative Inotropic Effect in Cardiac Myocytes

2002 • 190 citations

Opening mitochondrial K ATP in the heart - what happens, and what does not happen

2000 • 188 citations

Activation of Src family kinase activity by the G protein-coupled thrombin receptor in growth-responsive fibroblasts.

1994 • 186 citations

Direct Evidence That Initial Oxidative Stress Triggered by Preconditioning Contributes to Second Window of Protection by Endogenous Antioxidant Enzyme in Myocytes

1996 • 184 citations

Mammalian TOR Controls One of Two Kinase Pathways Acting upon nPKCδ and nPKCε

1999 • 182 citations

Evidence That Phospholipase δ1 Is the Effector in the Gh (Transglutaminase II)-mediated Signaling

1996 • 180 citations

Ischemic Preconditioning Activates MAPKAPK2 in the Isolated Rabbit Heart

2000 • 177 citations

Synergistic Modulation of ATP-Sensitive K ⁺ Currents by Protein Kinase C and Adenosine

1996 • 175 citations

In Cardiomyocyte Hypoxia, Insulin-Like Growth Factor-I-Induced Antiapoptotic Signaling Requires Phosphatidylinositol-3-OH-Kinase-Dependent and Mitogen-Activated Protein Kinase-Dependent Activation of the Transcription Factor cAMP Response Element-Binding Protein

2001 • 174 citations

Reperfusion injury: laboratory artifact or clinical dilemma?

1986 • 174 citations

Role of Protein Kinase C in Mitochondrial K _ATP Channel–Mediated Protection Against Ca ²⁺ Overload Injury in Rat Myocardium

1999 • 165 citations

Oxidative stress in Ca²⁺‐induced membrane permeability transition in brain mitochondria

2001 • 164 citations

Depression of heart sarcolemmal Ca2+-pump activity by oxygen free radicals

1989 • 164 citations

Effect of electron transfer inhibitors on superoxide generation in the cytochrome bc₁ site of the mitochondrial respiratory chain

1983 • 164 citations

Regulation of novel protein kinase C ε by phosphorylation

2002 • 164 citations

Are mitochondria a permanent source of reactive oxygen species?

2000 • 163 citations

Ca²⁺-Induced Increased Lipid Packing and Domain Formation in Submitochondrial Particles. A Possible Early Step in the Mechanism of Ca²⁺-Stimulated Generation of Reactive Oxygen Species by the Respiratory Chain

1999 • 163 citations

Inducible Nitric Oxide Synthase Modulates Cyclooxygenase-2 Activity in the Heart of Conscious Rabbits During the Late Phase of Ischemic Preconditioning

2002 • 159 citations

Activation of c-Jun N-terminal kinase promotes survival of cardiac myocytes after oxidative stress

2002 • 158 citations

Hibernation during Hypoxia in Cardiomyocytes

1998 • 158 citations

The Mitochondrial Permeability Transition Mediates Both Necrotic and Apoptotic Death of Hepatocytes Exposed to Br-A23187

1999 • 157 citations

Mimicking Phosphorylation of αB-Crystallin on Serine-59 Is Necessary and Sufficient to Provide Maximal Protection of Cardiac Myocytes From Apoptosis

2003 • 156 citations

Opening of ATP-sensitive potassium channels causes generation of free radicals in vascular smooth muscle cells

2002 • 154 citations

Differential activation of extracellular signal regulated kinase isoforms in preconditioning and opioid-induced cardioprotection.

2001 • 153 citations

p38 MAP Kinase Mediates Nitric Oxide-induced Apoptosis of Neural Progenitor Cells

2001 • 152 citations

Differential Activation of Mitogen-Activated Protein Kinase Cascades and Apoptosis by Protein Kinase C ε and δ in Neonatal Rat Ventricular Myocytes

2001 • 152 citations

Cardioprotection with the KATP Opener Cromakalim Is Not Correlated with Ischemic Myocardial Action Potential Duration

1995 • 148 citations

Ischemic preconditioning translocates PKC-δ and -ε, which mediate functional protection in isolated rat heart

1998 • 146 citations

Interleukin-1β Regulation of Inducible Nitric Oxide Synthase and Cyclooxygenase-2 Involves the p42/44 and p38 MAPK Signaling Pathways in Cardiac Myocytes

1999 • 146 citations

Lactate and P <scp>o</scp> ₂ Modulate Superoxide Anion Production in Bovine Cardiac Myocytes

1997 • 146 citations

Essential activation of PKC-δ in opioid-initiated cardioprotection

2001 • 141 citations

A Redox-Based Mechanism for Cardioprotection Induced by Ischemic Preconditioning in Perfused Rat Heart

1995 • 141 citations

SAPKs regulation of ischemic preconditioning

2000 • 139 citations

Ischaemic preconditioning in a model of global ischaemia: Infarct size limitation, but no reduction of stunning

1995 • 138 citations

In vitro study on contribution of oxidative metabolism of isolated rabbit heart mitochondria to myocardial reperfusion injury.

1984 • 136 citations

Cellular Mechanisms in Ischemic Preconditioning: The Role of Adenosine and Protein Kinase C a

1994 • 134 citations

ACh and adenosine activate PI3-kinase in rabbit hearts through transactivation of receptor tyrosine kinases

2002 • 133 citations

Activation of nuclear factor-κB is necessary for myotrophin-induced cardiac hypertrophy

2002 • 130 citations

Whole-Body Hyperthermia Provides Biphasic Cardioprotection Against Ischemia/Reperfusion Injury in the Rat

1998 • 127 citations

Xanthine oxidase is not a source of free radicals in the ischemic rabbit heart

1987 • 127 citations

Aldose Reductase Is an Obligatory Mediator of the Late Phase of Ischemic Preconditioning

2002 • 125 citations

c-Src-dependent Tyrosine Phosphorylation of IKKβ Is Involved in Tumor Necrosis Factor-α-induced Intercellular Adhesion Molecule-1 Expression

2003 • 125 citations

Redox-Linked Signal Transduction Pathways for Protein Tyrosine Kinase Activation

2002 • 125 citations

Effect of β-Blockers on Free Radical–Induced Cardiac Contractile Dysfunction

1999 • 124 citations

Mitochondrial KATP channel opening protects a human atrial-derived cell line by a mechanism involving free radical generation

2001 • 123 citations

Role of ATP dependent potassium channels in myocardial ischaemia

1992 • 123 citations

The Type I Angiotensin II Receptor Couples to Stat1 and Stat3 Activation Through Jak2 Kinase in Neonatal Rat Cardiac Myocytes

1997 • 122 citations

Myocardial release of malondialdehyde and purine compounds during coronary bypass surgery.

1994 • 122 citations

The early and late phases of preconditioning against myocardial stunning and the essential role of oxyradicals in the late phase: an overview

1996 • 122 citations

Marked reduction in myocardial infarct size due to prolonged infusion of an antioxidant during reperfusion.

1994 • 121 citations

Phosphorylation State of hsp27 and p38 MAPK During Preconditioning and Protein Phosphatase Inhibitor Protection of Rabbit Cardiomyocytes

1999 • 119 citations

Pathophysiology of superoxide radical as potential mediator of reperfusion injury in pig heart

1986 • 117 citations

The p38 MAPK inhibitor, SB203580, abrogates ischaemic preconditioning in rat heart but timing of administration is critical

2000 • 113 citations

Morphine Mimics Preconditioning via Free Radical Signals and Mitochondrial K _ATP Channels in Myocytes

2001 • 111 citations

Characterization of the Mitogen-activated Protein Kinase Kinase 4 (MKK4)/c-Jun NH2-terminal kinase 1 and MKK3/p38 Pathways Regulated by MEK Kinases 2 and 3

1997 • 110 citations

Perfusate sodium during ischemia modifies post-ischemic functional and metabolic recovery in the rabbit heart*

1984 • 109 citations

Src-family Tyrosine Kinases in Activation of ERK-1 and p85/p110-phosphatidylinositol 3-Kinase by G/CCKBReceptors

1999 • 108 citations

Suppression of Stress Kinase JNK Is Involved in HSP72-mediated Protection of Myogenic Cells from Transient Energy Deprivation

2000 • 107 citations

Mechanism for depression of heart sarcolemmal Ca2+ pump by oxygen free radicals

1989 • 107 citations

Activation of p38 MAPK Induced by a Multi-cycle Ischaemic Preconditioning Protocol is Associated with Attenuated p38 MAPK Activity During Sustained Ischaemia and Reperfusion

2001 • 106 citations

Dual roles of mitochondrial K_ATP channels in diazoxide-mediated protection in isolated rabbit hearts

2001 • 104 citations

Studies on the phosphorylation of protein kinase C-α

1992 • 103 citations

Nitric oxide: a trigger for classic preconditioning?

2000 • 103 citations

Protein Kinase C ε–Src Modules Direct Signal Transduction in Nitric Oxide–Induced Cardioprotection

2001 • 101 citations

Insulin-induced hyperpolarization in mammalian skeletal muscle

1989 • 100 citations

Human Mitogen-activated Protein Kinase Kinase 7 (MKK7) Is a Highly Conserved c-Jun N-terminal Kinase/Stress-activated Protein Kinase (JNK/SAPK) Activated by Environmental Stresses and Physiological Stimuli

1998 • 100 citations

Dual Requirement for Rho and Protein Kinase C in Direct Activation of Phospholipase D1 Through G Protein-coupled Receptor Signaling

2000 • 100 citations

Phospholipase D Plays a Role in Ischemic Preconditioning in Rabbit Heart

1996 • 97 citations

Basic fibroblast growth factor is cardioprotective in ischemia-reperfusion injury

1995 • 97 citations

Role of protein kinase C as a cellular mediator of ischemic preconditioning: a critical review

1998 • 96 citations

Ischemic Preconditioning Upregulates Inducible Nitric Oxide Synthase in Cardiac Myocyte

2002 • 96 citations

A Novel Mechanism for Myocardial Stunning Involving Impaired Ca ²⁺ Handling

2001 • 96 citations

Canine myocardial reperfusion injury: protection by a free radical scavenger, N-2-mercaptopropionyl glycine.

1986 • 95 citations

Stress-activated protein kinase phosphorylation during cardioprotection in the ischemic myocardium

2001 • 95 citations

Inhibition of p38 MAPK α/β reduces ischemic injury and does not block protective effects of preconditioning

2001 • 94 citations

Alterations in cardiac contractile proteins due to oxygen free radicals

1991 • 92 citations

The importance of manganese superoxide dismutase in delayed preconditioning Involvement of reactive oxygen species and cytokines

2002 • 90 citations

Distinct myoprotective roles of cardiac sarcolemmal and mitochondrial K _ATP channels during metabolic inhibition and recovery

2001 • 90 citations

β‐Oxidation of 5‐hydroxydecanoate, a Putative Blocker of Mitochondrial ATP‐Sensitive Potassium Channels

2003 • 88 citations

Adenosine A1Receptor Activation Reduces Reactive Oxygen Species and Attenuates Stunning in Ventricular Myocytes

2001 • 88 citations

Sulfhydryl oxidation down-regulates T-cell signaling and inhibits tyrosine phosphorylation of phospholipase C gamma 1.

1992 • 88 citations

Protection of Ischemic Preconditioning is Dependent upon a Critical Timing Sequence of Protein Kinase C Activation

1997 • 87 citations

Death by Dozens of Cuts

1998 • 87 citations

Stunning: A Radical Re-view

1992 • 85 citations

Differential Actions of Cardioprotective Agents on the Mitochondrial Death Pathway

2003 • 84 citations

Myocardial adaptation to ischemia by oxidative stress induced by endotoxin

1995 • 84 citations

Protective Effects of ATP-Sensitive Potassium-Channel Openers in Experimental Myocardial Ischemia

1994 • 83 citations

Ischemia/Reperfusion Impairs Mitochondrial Energy Conservation and Triggers O₂⁻Release as a Byproduct of Respiration

1993 • 82 citations

Evaluation of leukocyte-depleted terminal blood cardioplegic solution in patients undergoing elective and emergency coronary artery bypass grafting

1994 • 82 citations

Absence of Troponin I Degradation or Altered Sarcoplasmic Reticulum Uptake Protein Expression After Reversible Ischemia in Swine

1999 • 81 citations

The contribution of endothelial nitric oxide synthase to early ischaemic preconditioning: the lowering of the preconditioning threshold. An investigation in eNOS knockout mice

2001 • 81 citations

Causative role of oxyradicals in myocardial stunning: A proven hypothesis

1998 • 78 citations

Canine Myocardial Reperfusion Injury

1986 • 78 citations

Energy dependence of contraction band formation in perfused hearts and isolated adult myocytes.

1986 • 77 citations

Mitochondrial KATPChannel Opening is Important During Index Ischemia and Following Myocardial Reperfusion in Ischemic Preconditioned Rat Hearts

2001 • 76 citations

Depression of peak force without altering calcium sensitivity by the superoxide anion in chemically skinned cardiac muscle of rat.

1992 • 76 citations

No Involvement of Endogenous Nitric Oxide In Classical Ischemic Preconditioning in Swine

2000 • 75 citations

Acetylcholine but not adenosine triggers preconditioning through PI3-kinase and a tyrosine kinase

2003 • 74 citations

Leukocyte Depletion Attenuates Reperfusion Injury in Patients With Left Ventricular Hypertrophy

1996 • 74 citations

Glyburide-reversible cardioprotective effect of BMS-180448 is independent of action potential shortening

1995 • 73 citations

The cellular basis of angiotensin converting enzyme mRNA expression in rat heart

1996 • 72 citations

Neutrophil-derived, oxygen free radical-mediated cardiovascular dysfunction*

1984 • 72 citations

Microtubule Disruption by Colchicine Reversibly Enhances Calcium Signaling in Intact Rat Cardiac Myocytes

2001 • 71 citations

Distinct Effects of N-Acetylcysteine and Nitric Oxide on Angiotensin II-induced Epidermal Growth Factor Receptor Phosphorylation and Intracellular Ca2+ Levels

2000 • 70 citations

Signal Transduction by the Phosphatidylinositol Cycle in Myocardium

1995 • 69 citations

Preconditioning is not abolished by the delayed rectifier K+ blocker dofetilide

1996 • 69 citations

Enhanced phosphodiesteratic breakdown and turnover of phosphoinositides during reperfusion of ischemic rat heart.

1988 • 67 citations

Stunning: A radical re-view

1991 • 66 citations

Hypoxia and Hypoxia/Reoxygenation Activate Src Family Tyrosine Kinases and p21 in Cultured Rat Cardiac Myocytes

1996 • 66 citations

Differential role of K_ATP channels in late preconditioning against myocardial stunning and infarction in rabbits

2000 • 66 citations

Preconditioning induced protection against post-ischaemic contractile dysfunction: Characteristics and mechanisms

1995 • 64 citations

Quantification of hydroxyl radical and its lack of relevance to myocardial injury during early reperfusion after graded ischemia in rat hearts.

1992 • 63 citations

Intramyocardial Infusion of FGF-1 Mimics Ischemic Preconditioning in Pig Myocardium

1998 • 63 citations

Implication of Protein Kinase C- , , and Isoforms in Ischemic Preconditioning in Perfused Rat Hearts

1997 • 62 citations

Continuous synthesis of two protein-kinase-C-related proteins after down-regulation by phorbol esters.

1988 • 62 citations

Opposing Effects of δ and ξ PKC in Ethanol-induced Cardioprotection

2001 • 59 citations

Involvement of a p38 Mitogen-activated Protein Kinase Phosphatase in Protecting Neonatal Rat Cardiac Myocytes from Ischemia

2000 • 58 citations

Prevention of the oxygen paradox in hypoxic-reoxygenated hearts

1991 • 58 citations

A novel cardioprotective role of RhoA: new signaling mechanism for adenosine

2001 • 58 citations

Myocardial ischemia and reperfusion: The role of oxygen radicals in tissue injury

1989 • 57 citations

Src tyrosine kinase is the trigger but not the mediator of ischemic preconditioning

2001 • 57 citations

Contribution of both the sarcolemmal K ATP and mitochondrial K ATP channels to infarct size limitation by K ATP channel openers: differences from preconditioning in the role of sarcolemmal K ATP channels

2001 • 56 citations

Ubisemiquinones of the Mitochondrial Respiratory Chain Do not Interact with Molecular Oxygen

1992 • 54 citations

Xanthine oxidase contributes to preconditioning's preservation of left ventricular developed pressure in isolated rat heart: developed pressure may not be an appropriate end-point for studies of preconditioning

2002 • 53 citations

Thrombin-mediated phosphoinositide hydrolysis in Chinese hamster ovary cells overexpressing phospholipase C-delta 1.

1994 • 53 citations

p38 mitogen-activated protein kinase inhibits calcium-dependent chloride secretion in T₈₄ colonic epithelial cells

2003 • 52 citations

Block of Cardiac ATP-Sensitive K+ Channels Reduces Hydroxyl Radicals in the Rat Myocardium

2000 • 51 citations

Monophosphoryl lipid A induces pharmacologic ?preconditioning? in rabbit hearts without concomitant expression of 70-kDa heat shock protein

1996 • 51 citations

Src Family Kinase and Adenosine Differentially Regulate Multiple MAP Kinases in Ischemic Myocardium: Modulation of MAP Kinases Activation by Ischemic Preconditioning

2001 • 51 citations

Activation of βγ Subunits of Gi2 and Gi3 Proteins by Basic Secretagogues Induces Exocytosis Through Phospholipase Cβ and Arachidonate Release Through Phospholipase Cγ in Mast Cells

2001 • 51 citations

Does the Antiarrhythmic Effect of Ischemie Preconditioning in Rats Involve the L-Arginine Nitric Oxide Pathway?

1995 • 49 citations

Nitric oxide mediates protein kinase C isoform translocation in rat heart during postischemic reperfusion

1999 • 48 citations

Dissociation of Heat Shock Proteins Expression with Ischemic Tolerance by Whole Body Hyperthermia in Rat Heart

1998 • 47 citations

Insulin-like growth factor-II delays myocardial infarction in experimental coronary artery occlusion

1997 • 46 citations

Regulation of mitochondrial KATP channel by redox agents

1999 • 46 citations

Protective Effects of ATP-Sensitive Potassium-Channel Openers in Experimental Myocardial Ischemia

1994 • 44 citations

Molecular conformation dictates signaling module formation: example of PKCε and Src tyrosine kinase

2002 • 43 citations

Cross-talk Between Receptor-mediated Phospholipase C-βand D via Protein Kinase C as Intracellular Signal Possibly Leading to Hypertrophy in Serum-free Cultured Cardiomyocytes

1997 • 43 citations

Comparison ofIn VitroPreconditioning Responses of Isolated Pig and Rabbit Cardiomyocytes: Effects of a Protein Phosphatase Inhibitor, Fostriecin

1997 • 42 citations

Sulfhydryl Redox State Affects Susceptibility to Ischemia and Sarcoplasmic Reticulum Ca ²⁺ Release in Rat Heart

1998 • 42 citations

Oxidative stress modifies the activity of cardiac sarcolemmal phospholipase C

1994 • 41 citations

Protein kinase C mediates Ca2(+)-induced cardioadaptation to ischemia-reperfusion injury

1996 • 41 citations

Protein Kinase C Isoform Diversity in Preconditioning

1997 • 40 citations

Induction of 72-kDa heat shock protein does not produce second window of ischemic preconditioning in rat heart

1999 • 40 citations

Dual Involvement of Coenzyme Q₁₀in Redox Signaling and Inhibition of Death Signaling in the Rat Heart Mitochondria

2001 • 39 citations

Ischemic Preconditioning Decreases Oxidative Stress during Reperfusion: A Chemiluminescence Study

1996 • 38 citations

Biochemical mechanism(s) of stunning in conscious dogs

2000 • 37 citations

p38 MAPK Activity is Not Increased Early During Sustained Coronary Artery Occlusion in Preconditioned Versus Control Rabbit Heart

2001 • 37 citations

Sarcoplasmic reticulum Ca2+ pump in pig coronary artery smooth muscle is regulated by a novel pathway

1996 • 36 citations

Protection of ischemic myocardium by inhibition of contracture in isolated rat heart

1996 • 35 citations

Protection against oxygen-induced reperfusion injury of the isolated canine heart by superoxide dismutase and catalase

1986 • 34 citations

Protein kinase C isoform–dependent myocardial protection by ischemic preconditioning and potassium cardioplegia

2001 • 28 citations

Glyburide-reversible cardioprotective effect of BMS-180448 is independent of action potential shortening

1995 • 28 citations

Superoxide radical and xanthine oxidoreductase activity in the human heart during cardiac operations

1995 • 26 citations

Role of mitochondrial K_ATP channels and protein kinase C in ischaemic preconditioning

2003 • 25 citations

Monophosphoryl lipid A induces pharmacologic ?preconditioning? in rabbit hearts without concomitant expression of 70-kDa heat shock protein

1996 • 23 citations

Brief rapid pacing depresses contractile function via Ca²⁺/PKC-dependent signaling in cat ventricular myocytes

2001 • 23 citations

Preservation of myofilament calcium responsiveness underlies protection against myocardial stunning by ischemic preconditioning

1999 • 21 citations

Integrated pharmacological preconditioning in combination with adenosine, a mitochondrial KATP channel opener and a nitric oxide donor

2003 • 21 citations

Depression of heart sarcolemmal Ca[2+]-pump activity by oxygen free radicals

1991 • 19 citations

Involvement of Reactive Oxygen Intermediates in Lectin-Induced Protein-Tyrosine Phosphorylation of Syk in THP-1 Cells

1998 • 17 citations

Activation of phospholipase D in porcine tracheal smooth muscle: role of phosphatidylinositol 3-kinase and RhoA activation

2001 • 8 citations