Troponin I Degradation and Covalent Complex Formation Accompanies Myocardial Ischemia/Reperfusion Injury

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa

1987 • 11,491 citations

Apoptosis in Ischemic and Reperfused Rat Myocardium

1996 • 801 citations

Calpain: new perspectives in molecular diversity and physiological‐pathological involvement

1994 • 673 citations

G _h : a GTP-Binding Protein with Transglutaminase Activity and Receptor Signaling Function

1994 • 550 citations

Thin Filament-Mediated Regulation of Cardiac Contraction

1996 • 516 citations

Characterization of cardiac troponin subunit release into serum after acute myocardial infarction and comparison of assays for troponin T and I

1998 • 392 citations

Role of Troponin I Proteolysis in the Pathogenesis of Stunned Myocardium

1997 • 392 citations

MASS SPECTROMETRY OF PEPTIDES AND PROTEINS

1992 • 390 citations

Bcl-2 expression prevents activation of the ICE protease cascade.

1996 • 254 citations

Breakdown and Release of Myofilament Proteins During Ischemia and Ischemia/Reperfusion in Rat Hearts

1998 • 240 citations

Molecular Basis of Human Cardiac Troponin T Isoforms Expressed in the Developing, Adult, and Failing Heart

1995 • 236 citations

Relationship Between Intracellular Calcium and Contractile Force in Stunned Myocardium

1995 • 219 citations

The interaction of the calcium-binding protein (troponin C) with bivalent cations and the inhibitory protein (troponin I)

1974 • 218 citations

Mapping of a second actin-tropomyosin and a second troponin C binding site within the C terminus of troponin I, and their importance in the Ca2+-dependent regulation of muscle contraction

1997 • 203 citations

Modulation of the in Situ Activity of Tissue Transglutaminase by Calcium and GTP

1998 • 201 citations

Phosphorylation by cAMP-dependent protein kinase inhibits the degradation of tau by calpain.

1992 • 196 citations

A truncated cardiac troponin T molecule in transgenic mice suggests multiple cellular mechanisms for familial hypertrophic cardiomyopathy.

1998 • 194 citations

The expression of "tissue" transglutaminase in two human cancer cell lines is related with the programmed cell death (apoptosis).

1991 • 183 citations

Specific degradation of troponin T and I by μ-calpain and its modulation by substrate phosphorylation

1995 • 165 citations

Calpain: A Cytosolic Proteinase Active at the Membranes

1997 • 154 citations

Different Molecular Mechanisms for Rho Family GTPase-dependent, Ca2+-independent Contraction of Smooth Muscle

1998 • 143 citations

Altered Interactions Among Thin Filament Proteins Modulate Cardiac Function,

1996 • 134 citations

Apoptosis in the heart: when and why?

1996 • 125 citations

Ischemia induces early changes to cytoskeletal and contractile proteins in diseased human myocardium

1995 • 118 citations

The C Terminus of Cardiac Troponin I Is Essential for Full Inhibitory Activity and Ca2+ Sensitivity of Rat Myofibrils

1997 • 106 citations

Regulatory Properties of the NH2- and COOH-terminal Domains of Troponin T

1998 • 106 citations

Transglutaminase II: A New Class of GTP-Binding Protein with New Biological Functions

1997 • 105 citations

Role of Calcium-Activated Neutral Protease (Calpain) in Cell Death in Cultured Neonatal Rat Cardiomyocytes During Metabolic Inhibition

1995 • 98 citations

Isopeptidase: a novel eukaryotic enzyme that cleaves isopeptide bonds.

1982 • 92 citations

Phosphorylation of connexin-32 by protein kinase C prevents its proteolysis by mu-calpain and m-calpain

1993 • 89 citations

Alterations in myofibrillar function and protein profiles after complete global ischemia in rat hearts.

1992 • 89 citations

Binding of Cytosolic Proteins to Myofibrils in Ischemic Rat Hearts

1996 • 89 citations

Genes from the medicinal leech (Hirudo medicinalis) coding for unusual enzymes that specifically cleave endo-ɛ(γ-Glu)-Lys isopeptide bonds and help to dissolve blood clots

1996 • 89 citations

Inhomogeneous Disappearance of Myofilament-Related Cytoskeletal Proteins in Stunned Myocardium of Guinea Pig

1996 • 89 citations

Hydrolysis of γ:ϵ Isopeptides by Cytosolic Transglutaminases and by Coagulation Factor XIIIa

1997 • 77 citations

Reperfusion after brief ischemia disrupts the microtubule network in canine hearts.

1993 • 65 citations

Destabilase, the novel ϵ-(??-Glu)-Lys isopeptidase with thrombolytic activity

1991 • 62 citations

PEST Sequences Do Not Influence Substrate Susceptibility to Calpain Proteolysis

1995 • 61 citations

α ₁ -Adrenergic Receptor Coupling With G _h in the Failing Human Heart

1996 • 59 citations

Phosphorylation of τ In Situ: Inhibition of Calcium‐Dependent Proteolysis

1995 • 56 citations

Cardiomyocyte Troponin T Immunoreactivity Is Modified by Cross-linking Resulting From Intracellular Calcium Overload

1996 • 56 citations

PEST sequences in calmodulin-binding proteins

1995 • 55 citations

Effects of calcium and subunit interactions on surface accessibility of cysteine residues in cardiac troponin

1988 • 51 citations

Myocardial infarction alters myofilament calcium sensitivity and mechanical behavior of myocytes

1997 • 49 citations

Protective Effect of the Protease Inhibitor Leupeptin Against Myocardial Stunning

1993 • 47 citations

Transglutaminases: purification and actuivity assays

1996 • 44 citations

Strategic utilization of cardiac markers for the diagnosis of acute myocardial infarction.

1996 • 43 citations

Platelet factor XIII is activated by calpain

1987 • 42 citations

Time-resolved tryptophan emission study of cardiac troponin I

1992 • 41 citations

The binding sites of rabbit skeletal troponin-I on troponin-T

1980 • 40 citations

The Ordered Phosphorylation of Cardiac Troponin I by the cAMP‐Dependent Protein Kinase Structural Consequences and Functional Implications

1997 • 37 citations

Tissue Transglutaminase Is an In Situ Substrate of Calpain: Regulation of Activity

1998 • 37 citations

Enzyme from the medicinal leech (Hirudo medicinalis) that specifically splits endo‐ϵ(‐γ‐Glu)‐Lys isopeptide bonds: cDNA cloning and protein primary structure

1996 • 36 citations

Troponin T cross-linking in human apoptotic cardiomyocytes.

1997 • 35 citations

Structural and Functional Domains of the Troponin Complex Revealed by Limited Digestion

1997 • 34 citations

The Effects of Phosphorylation of Cardiac Troponin-I on Its Interactions with Actin and Cardiac Troponin-C

1995 • 31 citations

Incorporation of the Troponin Regulatory Complex of Post-ischemic Stunned Porcine Myocardium Reduces Myofilament Calcium Sensitivity in Rabbit Psoas Skeletal Muscle Fibers

1998 • 30 citations

The Effects of Phosphorylation of Cardiac Troponin-I on Its Interactions with Actin and Cardiac Troponin-C

1995 • 28 citations

Transglutaminase-Catalyzed Polymerization of Troponin in Vitro

1995 • 28 citations

Apoptosis in experimental myocardial infarction in situ and in the perfused heart in vitro

1997 • 27 citations

A Novel Calcium-Independent Enzyme Capable of Incorporating Putrescine into Proteins

1998 • 7 citations

Prevention of hypoxic liver injury by in vivo transfection of the human bcl-2 gene

1997 • 4 citations