Adenosine A1Receptor Activation Reduces Reactive Oxygen Species and Attenuates Stunning in Ventricular Myocytes

Cardioprotective Effect of Diazoxide and Its Interaction With Mitochondrial ATP-Sensitive K ⁺ Channels

1997 • 1,032 citations

Molecular and Cellular Mechanisms of Myocardial Stunning

1999 • 1,023 citations

Mitochondrial ATP-Dependent Potassium Channels

1998 • 825 citations

Marked reduction of free radical generation and contractile dysfunction by antioxidant therapy begun at the time of reperfusion. Evidence that myocardial "stunning" is a manifestation of reperfusion injury.

1989 • 580 citations

Adenosine as an adjunct to thrombolytic therapy for acute myocardial infarction

1999 • 535 citations

Direct evidence that oxygen-derived free radicals contribute to postischemic myocardial dysfunction in the intact dog.

1989 • 467 citations

Medical and Cellular Implications of Stunning, Hibernation, and Preconditioning

1998 • 441 citations

Coupling of ATP-sensitive K+ channels to A1 receptors by G proteins in rat ventricular myocytes

1990 • 409 citations

Significant Levels of Oxidants are Generated by Isolated Cardiomyocytes During Ischemia Prior to Reperfusion

1997 • 391 citations

Preconditioning in Cardiomyocytes Protects by Attenuating Oxidant Stress at Reperfusion

2000 • 311 citations

Adenosine A1 receptors, KATP channels, and ischemic preconditioning in dogs

1993 • 291 citations

A physiological role of the adenosine A ₃ receptor: Sustained cardioprotection

1998 • 196 citations

Pharmacological plasticity of cardiac ATP-sensitive potassium channels toward diazoxide revealed by ADP

1999 • 183 citations

Mitochondrial Electron Transport can Become a Significant Source of Oxidative Injury in Cardiomyocytes

1997 • 161 citations

Cardioprotection provided by adenosine receptor activation is abolished by blockade of the KATP channel

1994 • 158 citations

Signal Transduction in Ischemic Preconditioning:

1999 • 154 citations

Selective Effects of Oxygen Free Radicals on Excitation-Contraction Coupling in Ventricular Muscle

1996 • 146 citations

Pharmacological and Histochemical Distinctions Between Molecularly Defined Sarcolemmal K_ATPChannels and Native Cardiac Mitochondrial K_ATPChannels

1999 • 132 citations

Use of aromatic hydroxylation of phenylalanine to measure production of hydroxyl radicals after myocardial ischemia in vivo. Direct evidence for a pathogenetic role of the hydroxyl radical in myocardial stunning.

1993 • 122 citations

Visualization of doxorubicin-induced oxidative stress in isolated cardiac myocytes

1996 • 121 citations

Roles of mitochondrial ATP-sensitive K channels and PKC in anti-infarct tolerance afforded by adenosine A1receptor activation

2000 • 117 citations

Glibenclamide antagonizes adenosine A1 receptor-mediated cardioprotection in stunned canine myocardium.

1993 • 105 citations

Localization of dichlorofluorescin in cardiac myocytes: implications for assessment of oxidative stress

2000 • 103 citations

Adenosine Deaminase Inhibition Prevents Free Radical-mediated Injury in the Postischemic Heart

1996 • 102 citations

Delayed ischemic preconditioning is mediated by opening of ATP-sensitive potassium channels in the rabbit heart

1999 • 101 citations

Adenosine Myocardial Protection

1999 • 99 citations

Protective effects of adenosine in the perfused rat heart: changes in metabolism and intracellular ion homeostasis

1993 • 92 citations

Nicorandil Attenuates Myocardial Dysfunction Associated with Transient Ischemia by Opening ATP-Dependent Potassium Channels

1992 • 92 citations

Direct preconditioning of cardiac ventricular myocytes via adenosine A1 receptor and KATP channel

1996 • 87 citations

Adenosine-induced activation of ATP-sensitive K⁺channels in excised membrane patches is mediated by PKC

1999 • 47 citations

Nicorandil Attenuates Myocardial Dysfunction Associated with Transient Ischemia by Opening ATP-Dependent Potassium Channels

1992 • 35 citations

Phosphatase inhibitor cantharidin blocks adenosine A₁receptor anti-adrenergic effect in rat cardiac myocytes

2000 • 31 citations

5-hydroxydecanoate inhibits ATP-sensitive K+ channel currents in guinea-pig single ventricular myocytes

1992 • 31 citations

Modulation of ATP-sensitive K+ channels in rabbit ventricular myocytes by adenosine A1 receptor activation

1997 • 25 citations

Onset of Reduced Ca2+Sensitivity of Tension During Stunning in Porcine Myocardium

1996 • 25 citations

Metabolic and antioxidant effects of R(±)-N6-(2-phenylisopropyl)-adenosine following regional ischemia and reperfusion in canine myocardium

1997 • 18 citations

The effect of hypoxia on glycolytic ATP production

1972 • 17 citations

Chemiluminescence measurements of xanthine oxidase and xanthine dehydrogenase activity in four types of cardiovascular cell

1988 • 15 citations

Effects of diazoxide and glyburide on ATP-sensitive K+ channels from hypertrophied ventricular myocytes.

1992 • 14 citations