Biochemical mechanism(s) of stunning in conscious dogs

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

Molecular and Cellular Mechanisms of Myocardial Stunning

1999 • 1,023 citations

Regional myocardial functional and electrophysiological alterations after brief coronary artery occlusion in conscious dogs.

1975 • 1,004 citations

Targeted ablation of the phospholamban gene is associated with markedly enhanced myocardial contractility and loss of beta-agonist stimulation.

1994 • 696 citations

Direct evidence that oxygen-derived free radicals contribute to postischemic myocardial dysfunction in the intact dog.

1989 • 467 citations

Pathophysiology and pathogenesis of stunned myocardium. Depressed Ca2+ activation of contraction as a consequence of reperfusion-induced cellular calcium overload in ferret hearts.

1987 • 424 citations

Targeted ablation of the phospholamban gene is associated with markedly enhanced myocardial contractility and loss of beta-agonist stimulation.

1994 • 407 citations

Role of Troponin I Proteolysis in the Pathogenesis of Stunned Myocardium

1997 • 392 citations

Adenosine 3′:5′-Monophosphate-dependent Protein Kinase-catalyzed Phosphorylation Reaction and Its Relationship to Calcium Transport in Cardiac Sarcoplasmic Reticulum

1974 • 382 citations

Oxygen-derived free radicals and postischemic myocardial dysfunction (“stunned myocardium”)

1988 • 349 citations

beta-Adrenergic stimulation of phospholamban phosphorylation and Ca2+-ATPase activity in guinea pig ventricles.

1983 • 348 citations

Overexpression of the rat sarcoplasmic reticulum Ca2+ ATPase gene in the heart of transgenic mice accelerates calcium transients and cardiac relaxation.

1997 • 326 citations

Limitation of experimental infarct size by an angiotensin-converting enzyme inhibitor.

1982 • 321 citations

Cardiac-specific overexpression of phospholamban alters calcium kinetics and resultant cardiomyocyte mechanics in transgenic mice.

1996 • 319 citations

Cardiac Troponin I Phosphorylation Increases the Rate of Cardiac Muscle Relaxation

1995 • 314 citations

Identification of the major protein phosphatases in mammalian cardiac muscle which dephosphorylate phospholamban

1991 • 226 citations

Troponin I Phosphorylation in the Normal and Failing Adult Human Heart

1997 • 225 citations

Alterations in cardiac sarcoplasmic reticulum calcium transport in the postischemic "stunned" myocardium.

1989 • 204 citations

Studies on the phosphorylation of the inhibitory subunit of troponin during modification of contraction in perfused rat heart

1976 • 192 citations

Reperfusion of Rat Heart After Brief Ischemia Induces Proteolysis of Calspectin (Nonerythroid Spectrin or Fodrin) by Calpain

1995 • 170 citations

Reversibly injured, postischemic canine myocardium retains normal contractile reserve.

1987 • 164 citations

Functional Co-expression of the Canine Cardiac Ca2+Pump and Phospholamban in Spodoptera frugiperda (Sf21) Cells Reveals New Insights on ATPase Regulation

1997 • 162 citations

Comparative studies of cardiac and skeletal sarcoplasmic reticulum ATPases. Effect of a phospholamban antibody on enzyme activation by Ca2+

1993 • 161 citations

Alpha 1-receptor-independent activation of protein kinase C in acute myocardial ischemia. Mechanisms for sensitization of the adenylyl cyclase system.

1992 • 144 citations

The role of heat shock proteins in the heart

1995 • 120 citations

Attenuation of myocardial stunning by the ACE inhibitor ramiprilat through a signal cascade of bradykinin and prostaglandins but not nitric oxide.

1994 • 115 citations

Demonstration of free radical generation in the "stunned" myocardium in the conscious dog and identification of major differences between conscious and open-chest dogs.

1993 • 109 citations

Postischemic myocardial "stunning". Identification of major differences between the open-chest and the conscious dog and evaluation of the oxygen radical hypothesis in the conscious dog.

1991 • 109 citations

Calcium Responsiveness in Regional Myocardial Short-term Hibernation and Stunning in the In Situ Porcine Heart

1996 • 108 citations

Stimulation of 3′,5′-cyclic AMP formation in dog myocardium following arrest of blood flow

1969 • 101 citations

Direct evidence that the hydroxyl radical plays a pathogenetic role in myocardial "stunning" in the conscious dog and demonstration that stunning can be markedly attenuated without subsequent adverse effects.

1993 • 94 citations

Differential sensitivity to isoprenaline of troponin I and phospholamban phosphorylation in isolated rat hearts

1990 • 89 citations

Inhibition of endothelium-derived relaxing factor enhances myocardial stunning in conscious dogs.

1993 • 83 citations

Absence of Troponin I Degradation or Altered Sarcoplasmic Reticulum Uptake Protein Expression After Reversible Ischemia in Swine

1999 • 81 citations

Cardiac protein phosphorylation: functional and pathophysiological correlates

1998 • 78 citations

Validation of a single crystal for measurement of transmural and epicardial thickening

1986 • 73 citations

A1-adenosine receptor-mediated inhibition of isoproterenol-stimulated protein phosphorylation in ventricular myocytes. Evidence against a cAMP-dependent effect.

1993 • 54 citations

Postnatal changes in contractile time parameters, calcium regulatory proteins, and phosphatases

1998 • 51 citations

Receptor mechanisms involved in the 5‐HT‐induced inotropic action in the rat isolated atrium

1998 • 49 citations

Enhanced gene expression of calcium regulatory proteins in stunned porcine myocardium

1993 • 49 citations

Changes in gene expression following short coronary occlusions studied in porcine hearts with run-on assays

1994 • 45 citations

Myocardial stunning in dogs: Preconditioning effect and influence of coronary collateral flow

1990 • 43 citations

Acidemia and hypernatremia enhance postischemic recovery of excitation-contraction coupling.

1994 • 41 citations

Expression of calcium regulatory proteins in short-term hibernation and stunning in the in situ porcine heart1

1998 • 40 citations

“Myocardial stunning”

1998 • 36 citations

The effect of ischaemia and reperfusion on sarcolemmal inositol phospholipid and cytosolic inositol phosphate metabolism in the isolated perfused rat heart

1991 • 21 citations

Stunning - great paradigmatic, but little clinical importance

1998 • 18 citations

A chronically implantable catheter-tip micromanometer (JSI 0400) that can be calibrated after implantation

1979 • 17 citations

The Effects of Thoracic Epidural Anesthesia on Functional Recovery from Myocardial Stunning in Propofol-Anesthetized Dogs

1997 • 15 citations

The Effects of Thoracic Epidural Anesthesia on Functional Recovery from Myocardial Stunning in Propofol-Anesthetized Dogs

1997 • 12 citations