Small Heat Shock Proteins and Protection Against Ischemic Injury in Cardiac Myocytes

Small heat shock proteins are molecular chaperones.

1993 • 1,376 citations

Cardiac stress protein elevation 24 hours after brief ischemia or heat stress is associated with resistance to myocardial infarction.

1993 • 1,005 citations

Overexpression of the rat inducible 70-kD heat stress protein in a transgenic mouse increases the resistance of the heart to ischemic injury.

1995 • 859 citations

Heat shock resistance conferred by expression of the human HSP27 gene in rodent cells.

1989 • 699 citations

A simple technique for the rescue of early region I mutations into infectious human adenovirus type 5

1988 • 606 citations

Transgenic mice expressing the human heat shock protein 70 have improved post-ischemic myocardial recovery.

1995 • 558 citations

Modulation of actin microfilament dynamics and fluid phase pinocytosis by phosphorylation of heat shock protein 27.

1993 • 544 citations

Alpha B-crystallin is a small heat shock protein.

1991 • 526 citations

Induction of Chinese hamster HSP27 gene expression in mouse cells confers resistance to heat shock. HSP27 stabilization of the microfilament organization.

1993 • 494 citations

HSP27 phosphorylation-mediated resistance against actin fragmentation and cell death induced by oxidative stress.

1996 • 471 citations

Structural and functional similarities of bovine alpha-crystallin and mouse small heat-shock protein. A family of chaperones.

1993 • 375 citations

Rapid purification of mammalian 70,000-dalton stress proteins: affinity of the proteins for nucleotides.

1985 • 365 citations

Heat shock protein induction in rat hearts. A role for improved myocardial salvage after ischemia and reperfusion?

1992 • 323 citations

Alpha B-crystallin in cardiac tissue. Association with actin and desmin filaments.

1992 • 302 citations

Expression of inducible stress protein 70 in rat heart myogenic cells confers protection against simulated ischemia-induced injury.

1994 • 285 citations

Heat-shock response and limitation of tissue necrosis during occlusion/reperfusion in rabbit hearts.

1993 • 278 citations

Overexpression of Heat Shock Protein 72 in Transgenic Mice Decreases Infarct Size In Vivo

1996 • 220 citations

Tissue distribution and developmental profiles of immunoreactive αB crystallin in the rat determined with a sensitive immunoassay system

1991 • 193 citations

Induction of HSP70 in cultured rat neonatal cardiomyocytes by hypoxia and metabolic stress.

1993 • 176 citations

Heat shock protein 27 and alpha B-crystallin can form a complex, which dissociates by heat shock.

1992 • 151 citations

Ischaemia and the myocyte cytoskeleton: review and speculation

1993 • 143 citations

Molecular cloning of sequences encoding the human heat-shock proteins and their expression during hyperthermia

1986 • 129 citations

Enhanced constitutive expression of the 27‐kDa heat shock proteins in heat‐resistant variants from chinese hamster cells

1988 • 128 citations

αB-Crystallin Expression in Mouse NIH 3T3 Fibroblasts: Glucocorticoid Responsiveness and Involvement in Thermal Protection

1993 • 126 citations

Endothelin inhibits adenylate cyclase and stimulates phosphoinositide hydrolysis in adult cardiac myocytes.

1992 • 123 citations

Coordinate and independent regulation of αB‐crystallin and HSP27 expression in response to physiological stress

1994 • 119 citations

Characterization of an inhibitor of actin polymerization in vinculin‐rich fraction of turkey gizzard smooth muscle

1988 • 117 citations

Sense and antisense modification of glial alpha B-crystallin production results in alterations of stress fiber formation and thermoresistance.

1994 • 97 citations

Heat‐induced changes in the conformation of α‐ and β‐crystalline: Unique thermal stability of α‐crystallin

1988 • 95 citations

Binding of Cytosolic Proteins to Myofibrils in Ischemic Rat Hearts

1996 • 89 citations

Temporospatial expression of the small HSP/αB-crystallin in cardiac and skeletal muscle during mouse development

1997 • 88 citations

Adenovirus-mediated Gene Transfer of a Heat Shock Protein 70 (hsp70i) Protects Against Simulated Ischemia

1996 • 88 citations

Alpha B-crystallin expression in mouse NIH 3T3 fibroblasts: glucocorticoid responsiveness and involvement in thermal protection.

1993 • 79 citations

Multiple mRNAs of rat brain alpha-crystallin B chain result from alternative transcriptional initiation.

1990 • 59 citations

Thermal response in murine L929 cells lacking ?B-crystallin expression and ?B-crystallin expressing L929 transfectants

1996 • 38 citations