Microtubule Disruption by Colchicine Reversibly Enhances Calcium Signaling in Intact Rat Cardiac Myocytes

PKA Phosphorylation Dissociates FKBP12.6 from the Calcium Release Channel (Ryanodine Receptor)

2000 • 1,940 citations

Calcium Sparks: Elementary Events Underlying Excitation-Contraction Coupling in Heart Muscle

1993 • 1,917 citations

Excitation-Contraction Coupling and Cardiac Contractile Force

2010 • 1,661 citations

Excitation-Contraction Coupling and Cardiac Contractile Force

1993 • 765 citations

Defective Excitation-Contraction Coupling in Experimental Cardiac Hypertrophy and Heart Failure

1997 • 754 citations

Rates of diffusional exchange between small cells and a measuring patch pipette

1988 • 712 citations

Simulated calcium current can both cause calcium loading in and trigger calcium release from the sarcoplasmic reticulum of a skinned canine cardiac Purkinje cell.

1985 • 445 citations

Rapid Adaptation of Cardiac Ryanodine Receptors: Modulation by Mg ²⁺ and Phosphorylation

1995 • 349 citations

Cytoskeletal Role in the Contractile Dysfunction of Hypertrophied Myocardium

1993 • 273 citations

Structure, Mechanism, and Regulation of Mammalian Adenylyl Cyclase

1999 • 235 citations

Contraction due to microtubule disruption is associated with increased phosphorylation of myosin regulatory light chain.

1995 • 229 citations

Mechanism of action of acetylcholine on calcium current in single cells from frog ventricle.

1986 • 214 citations

Tubulin binds specifically to the signal-transducing proteins, Gs alpha and Gi alpha 1.

1990 • 204 citations

Cytoskeletal Mechanics in Pressure-Overload Cardiac Hypertrophy

1997 • 180 citations

Identification and Subcellular Localization of the Subunits of L-type Calcium Channels and Adenylyl Cyclase in Cardiac Myocytes

1997 • 178 citations

Modulation of Cardiac Ryanodine Receptors by Sorcin

1997 • 160 citations

Heterogeneity of the early outward current in ventricular cells isolated from normal and hypertrophied rat hearts.

1993 • 141 citations

Cytoskeletal Role in the Transition From Compensated to Decompensated Hypertrophy During Adult Canine Left Ventricular Pressure Overloading

1998 • 131 citations

Regional contributions ofKv1.4,Kv4.2, andKv4.3to transient outward K⁺current in rat ventricle

1999 • 113 citations

Inactivation of L-type Ca channels in embryonic chick ventricle cells: dependence on the cytoskeletal agents colchicine and taxol

1994 • 113 citations

The Role of the Cytoskeleton in Left Ventricular Pressure Overload Hypertrophy and Failure

1996 • 105 citations

Ca2+ diffusion and sarcoplasmic reticulum transport both contribute to [Ca2+]i decline during Ca2+ sparks in rat ventricular myocytes.

1996 • 105 citations

G protein binding and G protein activation by nucleotide transfer involve distinct domains on tubulin: Regulation of signal transduction by cytoskeletal elements

1993 • 97 citations

Microtubule Disruption Modulates Ca ²⁺ Signaling in Rat Cardiac Myocytes

2000 • 93 citations

Tubulin, Gq, and Phosphatidylinositol 4,5-Bisphosphate Interact to Regulate Phospholipase Cβ1 Signaling

1997 • 90 citations

Calcium entry via L-type calcium channels acts as a negative regulator of adenylyl cyclase activity and cyclic AMP levels in cardiac myocytes.

1993 • 85 citations

Microtubules in Cardiac Myocytes

1988 • 73 citations

Effect of the microtubule polymerizing agent taxol on contraction, Ca²⁺ transient and L‐type Ca²⁺ current in rat ventricular myocytes

1999 • 67 citations

Cellular Basis of Contractile Derangements of Hypertrophied Feline Ventricular Myocytes

1997 • 66 citations

Direct Effects of Colchicine on Myocardial Function

1999 • 57 citations

Insulin stimulation of rat ventricular K⁺ currents depends on the integrity of the cytoskeleton

1999 • 55 citations

Insulin stimulates the L-type Ca2+ current in rat cardiac myocytes

1999 • 55 citations

Effects of microtubule disruption on force, velocity, stiffness and [Ca²⁺]_iin porcine coronary arteries

2000 • 54 citations

Role of microtubules in myocyte contractile dysfunction during cardiac hypertrophy in the rat

1996 • 50 citations

Cardiostimulatory and antiarrhythmic activity of tubulin-binding agents.

1992 • 50 citations

Ca2+, Sr2+, and Ba2+ Identify Distinct Regulatory Sites on Adenylyl Cyclase (AC) Types VI and VIII and Consolidate the Apposition of Capacitative Cation Entry Channels and Ca2+-sensitive ACs

2000 • 44 citations

Modulation of Ca ²⁺ Signaling by Microtubule Disruption in Rat Ventricular Myocytes and Its Dependence on the Ruptured Patch-Clamp Configuration

2001 • 37 citations

Postnatal Changes in the G-Proteins, Cyclic Nucleotides and Adenylyl Cyclase Activity in Rabbit Heart Cells

1994 • 35 citations

Beating rate of isolated neonatal cardiomyocytes is regulated by the stable microtubule subset

2000 • 35 citations

Immunological quantitation and localization of tubulin in adult rat heart isolated myocytes.

1983 • 31 citations

Microtubule cytoskeleton involvement in muscarinic suppression of voltage‐gated calcium channel current in guinea‐pig ileal smooth muscle

1999 • 28 citations

Specific associations between tubulin and G proteins: participation of cytoskeletal elements in cellular signal transduction.

1990 • 22 citations

Microtubules modulate cardiomyocyte β-adrenergic response in cardiac hypertrophy

1998 • 21 citations

Effects of colchicine on cardiac cell function indicate possible role for membrane surface tubulin

1986 • 17 citations

Tubulin stimulates adenylyl cyclase activity in rat striatal membranes via transfer of guanine nucleotide to Gs protein

1995 • 14 citations

Myocardial colchicine-binding proteins: Possible relation to DNA synthesis initiation

1979 • 7 citations

Terminal Warm Blood Cardioplegia Improves Cardiac Function Through Microtubule Repolymerization

1998 • 5 citations

Tubulin Binding Agent CI-980 Has Positive Inotropic and Local Anesthetic Actions

1994 • 4 citations

Disparate effects of colchicine on thyroxine-induced cardiac hypertrophy and adrenoceptor changes.

1991 • 3 citations