Human Mitogen-activated Protein Kinase Kinase 7 (MKK7) Is a Highly Conserved c-Jun N-terminal Kinase/Stress-activated Protein Kinase (JNK/SAPK) Activated by Environmental Stresses and Physiological Stimuli

Pro-inflammatory Cytokines and Environmental Stress Cause p38 Mitogen-activated Protein Kinase Activation by Dual Phosphorylation on Tyrosine and Threonine

1995 • 2,238 citations

The mitogen-activated protein kinase signal transduction pathway

1993 • 2,174 citations

Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain.

1993 • 1,902 citations

The small GTP-binding proteins Rac1 and Cdc42regulate the activity of the JNK/SAPK signaling pathway

1995 • 1,653 citations

Independent Human MAP-Kinase Signal Transduction Pathways Defined by MEK and MKK Isoforms

1995 • 1,562 citations

Selective activation of the JNK signaling cascadeand c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs

1995 • 1,499 citations

2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans

1994 • 1,472 citations

Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun

1994 • 978 citations

JNK is involved in signal integration during costimulation of T lymphocytes

1994 • 929 citations

Identification of a Dual Specificity Kinase That Activates the Jun Kinases and p38-Mpk2

1995 • 775 citations

IMMUNE REGULATION BY CD40 AND ITS LIGAND GP39

1996 • 653 citations

Cdc42 and PAK-mediated Signaling Leads to Jun Kinase and p38 Mitogen-activated Protein Kinase Activation

1995 • 639 citations

An Osmosensing Signal Transduction Pathway in Mammalian Cells

1994 • 584 citations

Requirement for CD40 Ligand in Costimulation Induction, T Cell Activation, and Experimental Allergic Encephalomyelitis

1996 • 425 citations

A JNK signal transduction pathway that mediates morphogenesis and an immune response in Drosophila.

1996 • 407 citations

Mitogen-activated protein kinase kinase 7 is an activator of the c-Jun NH ₂ -terminal kinase

1997 • 382 citations

Involvement of ras p21 protein in signal-transduction pathways from interleukin 2, interleukin 3, and granulocyte/macrophage colony-stimulating factor, but not from interleukin 4.

1991 • 351 citations

The complexity of signaling pathways activated by the BCR

1997 • 333 citations

hemipterous encodes a novel drosophila MAP kinase kinase, required for epithelial cell sheet movement

1995 • 331 citations

Stress-signalling kinase Sek1 protects thymocytes from apoptosis mediated by CD95 and CD3

1997 • 330 citations

The Drosophila Jun-N-terminal kinase is required for cell morphogenesis but not for DJun-dependent cell fate specification in the eye.

1996 • 310 citations

Targeted disruption of the MKK4 gene causes embryonic death, inhibition of c-Jun NH ₂ -terminal kinase activation, and defects in AP-1 transcriptional activity

1997 • 266 citations

A novel SAPK/JNK kinase, MKK7, stimulated by TNFalpha and cellular stresses

1997 • 258 citations

Differential activation of the ERK, JNK, and p38 mitogen-activated protein kinases by CD40 and the B cell antigen receptor.

1996 • 237 citations

p21ras activation via hemopoietin receptors and c-kit requires tyrosine kinase activity but not tyrosine phosphorylation of p21ras GTPase-activating protein.

1992 • 213 citations

MKK7 Is A Stress-activated Mitogen-activated Protein Kinase Kinase Functionally Related to hemipterous

1997 • 182 citations

Cross-linking CD40 on B cells preferentially induces stress-activated protein kinases rather than mitogen-activated protein kinases.

1996 • 175 citations

Hemopoietic Growth Factors with the Exception of Interleukin-4 Activate the p38 Mitogen-activated Protein Kinase Pathway

1997 • 172 citations

Fas Induces Cytoplasmic Apoptotic Responses and Activation of the MKK7-JNK/SAPK and MKK6-p38 Pathways Independent of CPP32-like Proteases

1997 • 154 citations

Mast cell tumor necrosis factor α production is regulated by MEK kinases

1997 • 152 citations

Multiple hemopoietic growth factors stimulate activation of mitogen-activated protein kinase family members.

1992 • 147 citations

ERKs, extracellular signal-regulated MAP-2 kinases

1991 • 145 citations

Use of human universally antigenic tetanus toxin T cell epitopes as carriers for human vaccination.

1992 • 135 citations

Impaired CD28-mediated Interleukin 2 Production and Proliferation in Stress Kinase SAPK/ERK1 Kinase (SEK1)/Mitogen-activated Protein Kinase Kinase 4 (MKK4)-deficient T Lymphocytes

1997 • 128 citations

Cellular Stresses and Cytokines Activate Multiple Mitogen‐Activated‐Protein Kinase Kinase Homologues in PC12 and KB Cells

1996 • 123 citations

Identification of c-Jun NH2-terminal Protein Kinase (JNK)-activating Kinase 2 as an Activator of JNK but Not p38

1997 • 120 citations

Evidence for Multiple Activators for Stress-activated Protein Kinases/c-Jun Amino-terminal Kinases.

1995 • 114 citations

Activation of JNK Signaling Pathway by Erythropoietin, Thrombopoietin, and Interleukin-3

1997 • 110 citations

Molecular Cloning and Characterization of Human JNKK2, a Novel Jun NH₂-Terminal Kinase-Specific Kinase

1997 • 108 citations

Fc gamma receptor cross-linking activates p42, p38, and JNK/SAPK mitogen-activated protein kinases in murine macrophages: role for p42MAPK in Fc gamma receptor-stimulated TNF-alpha synthesis.

1997 • 104 citations

Activation of Stress-activated Protein Kinases/c-Jun N-terminal Protein Kinases (SAPKs/JNKs) by a Novel Mitogen-activated Protein Kinase Kinase (MKK7)

1997 • 100 citations

The p38 mitogen-activated protein kinase is activated by ligation of the T or B lymphocyte antigen receptors, Fas or CD40, but suppression of kinase activity does not inhibit apoptosis induced by antigen receptors.

1997 • 91 citations

Tyrosine 763 of the Murine Granulocyte Colony-Stimulating Factor Receptor Mediates Ras-Dependent Activation of the JNK/SAPK Mitogen-Activated Protein Kinase Pathway

1997 • 86 citations

Activation of the Stress-Activated Protein Kinases by Multiple Hematopoietic Growth Factors With the Exception of Interleukin-4

1997 • 81 citations

Activation of p38mapk, MKK3, and MKK4 by TNF-alpha in mouse bone marrow-derived macrophages.

1997 • 75 citations

SKK4, a novel activator of stress‐activated protein kinase‐1 (SAPK1/JNK)

1997 • 52 citations

Ras-dependent Activation of c-Jun N-terminal Kinase/Stress-activated Protein Kinase in Response to Interleukin-3 Stimulation in Hematopoietic BaF3 Cells

1997 • 49 citations

Multiple Loss of Effector Cell Functions in FcRγ-Deficient Mice

1996 • 29 citations

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