Ischemic preconditioning translocates PKC-δ and -ε, which mediate functional protection in isolated rat heart

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

1979 • 54,907 citations

Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium.

1986 • 7,740 citations

Intracellular Signaling by Hydrolysis of Phospholipids and Activation of Protein Kinase C

1992 • 4,480 citations

The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C

1991 • 2,499 citations

Protein Kinase C: Structure, Function, and Regulation

1995 • 1,640 citations

Protection against infarction afforded by preconditioning is mediated by A1 adenosine receptors in rabbit heart.

1991 • 1,346 citations

Chelerythrine is a potent and specific inhibitor of protein kinase C

1990 • 1,208 citations

Preconditioning protects ischemic rabbit heart by protein kinase C activation

1994 • 603 citations

Ischemic preconditioning reduces infarct size in swine myocardium.

1990 • 560 citations

Isoenzyme specificity of bisindolylmaleimides, selective inhibitors of protein kinase C

1993 • 523 citations

Ischemic Preconditioning Induces Selective Translocation of Protein Kinase C Isoforms ε and η in the Heart of Conscious Rabbits Without Subcellular Redistribution of Total Protein Kinase C Activity

1997 • 491 citations

Preconditioning of Isolated Rat Heart Is Mediated by Protein Kinase C

1995 • 424 citations

Preconditioning against myocardial dysfunction after ischemia and reperfusion by an alpha 1-adrenergic mechanism.

1993 • 409 citations

Signal transduction pathways of angiotensin II--induced c-fos gene expression in cardiac myocytes in vitro. Roles of phospholipid-derived second messengers.

1993 • 389 citations

A Selective ε-Protein Kinase C Antagonist Inhibits Protection of Cardiac Myocytes from Hypoxia-induced Cell Death

1997 • 386 citations

Protein kinase C. Its role in ischemic preconditioning in the rat.

1994 • 362 citations

Evidence that Translocation of Protein Kinase C is a Key Event During Ischemic Preconditioning of Rabbit Myocardium

1994 • 310 citations

Does Ischemic Preconditioning in the Human Involve Protein Kinase C and the ATP-Dependent K ⁺ Channel?

1995 • 293 citations

Role of myocardial ATP-sensitive potassium channels in mediating preconditioning in the dog heart and their possible interaction with adenosine A1-receptors.

1992 • 255 citations

Preconditioning rabbit cardiomyocytes: role of pH, vacuolar proton ATPase, and apoptosis.

1996 • 233 citations

Synergistic Modulation of ATP-Sensitive K ⁺ Currents by Protein Kinase C and Adenosine

1996 • 175 citations

Reperfusion of Rat Heart After Brief Ischemia Induces Proteolysis of Calspectin (Nonerythroid Spectrin or Fodrin) by Calpain

1995 • 170 citations

Protein Kinase C–Induced Changes in the Stoichiometry of ATP Binding Activate Cardiac ATP-Sensitive K ⁺ Channels

1996 • 148 citations

Mechanisms of Ischemic Preconditioning in Rat Hearts

1995 • 126 citations

Role of Activation of Protein Kinase C in the Infarct SizeLimiting Effect of Ischemic Preconditioning Through Activation of Ecto-5′-nucleotidase

1996 • 122 citations

Calcium Preconditioning Elicits Strong Protection Against Ischemic Injury via Protein Kinase C Signaling Pathway

1996 • 96 citations

Role of protein kinase C in the phosphorylation of cardiac myosin light chain 2

1993 • 94 citations

Protein kinase C enhances myosin light-chain kinase effects on force development and ATPase activity in rat single skinned cardiac cells

1992 • 84 citations

Cardioprotection in an In Vitro model of Hypoxic Preconditioning

1995 • 64 citations

Nuclear translocation of PKCζ during ischemia and its inhibition by wortmannin, an inhibitor of phosphatidylinositol 3‐kinase

1997 • 63 citations

Effects of carbachol and (−)‐N⁶‐phenylisopropyladenosine on myocardial inositol phosphate content and force of contraction

1990 • 52 citations

Antiplatelet effects of chelerythrine chloride isolated from Zanthoxylum simulans

1990 • 49 citations

Calcium and the Endothelin-1 and α1-Adrenergic Stimulated Phosphatidylinositol Cycle in Cultured Rat Cardiomyocytes

1994 • 32 citations

PKC-lambda is the atypical protein kinase C isoform expressed by immature ventricle

1997 • 28 citations