Interleukin 1 in the brain: biology, pathology and therapeutic target

Positional cloning of the mouse obese gene and its human homologue

1994 • 12,975 citations

Leptin and the regulation of body weight in mammals

1998 • 5,366 citations

Receptors for Purines and Pyrimidines

2012 • 4,065 citations

A novel heterodimeric cysteine protease is required for interleukin-1βprocessing in monocytes

1992 • 2,495 citations

A cytokine-responsive IκB kinase that activates the transcription factor NF-κB

1997 • 2,137 citations

Small Differences in Intraischemic Brain Temperature Critically Determine the Extent of Ischemic Neuronal Injury

1987 • 1,821 citations

Arthritis and anti-inflammatory agents as possible protective factors for Alzheimer's disease

1996 • 1,371 citations

Regulation of the Hypothalamic-Pituitary-Adrenal Axis by Cytokines: Actions and Mechanisms of Action

1999 • 1,254 citations

Fever: Role of Pyrogens and Cryogens

1991 • 1,240 citations

Interleukin-1 receptor antagonist activity of a human interleukin-1 inhibitor

1990 • 1,143 citations

NF-kB: a crucial transcription factor for glial and neuronal cell function

1997 • 1,005 citations

Cytokines and the nervous system II: actions and mechanisms of action

1995 • 928 citations

cDNA Expression Cloning of the IL-1 Receptor, a Member of the Immunoglobulin Superfamily

1988 • 896 citations

Cytokines and the nervous system I: expression and recognition

1995 • 745 citations

Rho Family GTPases Regulate p38 Mitogen-activated Protein Kinase through the Downstream Mediator Pak1

1995 • 733 citations

Functional Role of Caspase-1 and Caspase-3 in an ALS Transgenic Mouse Model

2000 • 700 citations

A novel IL-1 receptor, cloned from B cells by mammalian expression, is expressed in many cell types.

1991 • 677 citations

Molecular Cloning and Characterization of a Second Subunit of the Interleukin 1 Receptor Complex

1995 • 634 citations

Interleukin 1 signaling occurs exclusively via the type I receptor.

1993 • 609 citations

Production of Mice Deficient in Genes for Interleukin (IL)-1α, IL-1β, IL-1α/β, and IL-1 Receptor Antagonist Shows that IL-1β Is Crucial in Turpentine-induced Fever Development and Glucocorticoid Secretion

1998 • 604 citations

Interleukin 1 regulates synthesis of amyloid beta-protein precursor mRNA in human endothelial cells.

1989 • 586 citations

Signal transduction pathways activated by the IL-1 receptor family: ancient signaling machinery in mammals, insects, and plants

1998 • 573 citations

“Inflammatory” Cytokines

2000 • 499 citations

Interleukin‐1β, Interleukin‐18, and the Interleukin‐1β Converting Enzyme^a

1998 • 495 citations

Inflammatory cytokines and related genes are induced in the rat hippocampus by limbic status epilepticus

2000 • 494 citations

Toll‐like receptor 4: the missing link of the cerebral innate immune response triggered by circulating gram‐negative bacterial cell wall components

2001 • 494 citations

A neuromodulatory role of interleukin-1β in the hippocampus

1998 • 481 citations

Type 1 interleukin‐1 receptor in the rat brain: Distribution, regulation, and relationship to sites of IL‐1–induced cellular activation

1995 • 470 citations

Interleukin-18 and interleukin-1 beta: two cytokine substrates for ICE (caspase-1).

1999 • 462 citations

A randomized controlled trial of prednisone in Alzheimer’s disease

2000 • 452 citations

Visualization and characterization of interleukin 1 receptors in brain.

1987 • 451 citations

Further studies of the role of hyperthermia in methamphetamine neurotoxicity.

1994 • 401 citations

The IL-1 receptor/toll-like receptor superfamily: crucial receptors for inflammation and host defense

2000 • 396 citations

Lipocortin-1: cellular mechanisms and clinical relevance

1994 • 383 citations

Phenotypic and functional characterization of mice that lack the type I receptor for IL-1.

1997 • 370 citations

Neural-immune interactions in health and disease.

1997 • 364 citations

Leptin actions on food intake and body temperature are mediated by IL-1

1999 • 364 citations

Association of interleukin-1 gene polymorphisms with Alzheimer's disease

2000 • 358 citations

Identification and Initial Characterization of Four Novel Members of the Interleukin-1 Family

2000 • 357 citations

Genetic Classification of Primary Neurodegenerative Disease

1998 • 337 citations

Genetic dissection of Alzheimer's disease and related dementias: amyloid and its relationship to tau

1998 • 336 citations

Four New Members Expand the Interleukin-1 Superfamily

2000 • 333 citations

Association of early-onset Alzheimer's disease with an interleukin-1? gene polymorphism

2000 • 331 citations

Interleukin-1β inhibits long-term potentiation in the CA3 region of mouse hippocampal slices

1990 • 326 citations

Psychoneuroimmunology and the cytokine action in the CNS: Implications for psychiatric disorders

1998 • 302 citations

Interleukin-1 Receptors in Mouse Brain:Characterization and Neuronal Localization

1990 • 302 citations

A new member of the IL-1 receptor family highly expressed in hippocampus and involved in X-linked mental retardation

1999 • 300 citations

Cerebral Hypoxia-Ischemia Stimulates Cytokine Gene Expression in Perinatal Rats

1995 • 282 citations

An Essential Role of Interleukin-1β in Mediating NF-κB Activity and COX-2 Transcription in Cells of the Blood–Brain Barrier in Response to a Systemic and Localized Inflammation But Not During Endotoxemia

1999 • 279 citations

Kinetics and Mechanism of ATP-Dependent IL-1β Release from Microglial Cells

2000 • 277 citations

Enhanced Expression of Interleukin (IL)-1 and IL-6 Messenger RNA and Bioactive Protein after Hypoxia-Ischemia in Neonatal Rats

1996 • 273 citations

The role of interleukin 1 in acute neurodegeneration and stroke: pathophysiological and therapeutic implications.

1997 • 271 citations

Receptors for interleukin-1 (α and β) in mouse brain: Mapping and neuronal localization in hippocampus

1991 • 269 citations

Is amyloidogenesis during Alzheimer's disease due to an IL-1-/IL-6-mediated ‘acute phase response’ in the brain?

1991 • 267 citations

Interleukin (IL)-1?, IL-1?, and IL-1 receptor antagonist gene polymorphisms in patients with temporal lobe epilepsy

2000 • 267 citations

Inhibition of p38 mitogen-activated protein kinase provides neuroprotection in cerebral focal ischemia

2001 • 261 citations

Cytokines ‐ killers in the brain?

1999 • 251 citations

Interleukin-1 receptor antagonist decreases the number of necrotic neurons in rats with middle cerebral artery occlusion.

1995 • 238 citations

Potential mechanisms of interleukin-1 involvement in cerebral ischaemia

1999 • 232 citations

Cytokines and their receptors in the central nervous system: Physiology, pharmacology, and pathology

1996 • 229 citations

The Progression and Topographic Distribution of Interleukin-1β Expression after Permanent Middle Cerebral Artery Occlusion in the Rat

1999 • 228 citations

Recruitment of IRAK to the interleukin 1 receptor complex requires interleukin 1 receptor accessory protein

1997 • 227 citations

Reduced prevalence of AD in users of NSAIDs and H2 receptor antagonists

2000 • 224 citations

Genetic susceptibility and head injury as risk factors for Alzheimer's disease among community‐dwelling elderly persons and their first‐degree relatives

1993 • 221 citations

Caspase-1 is activated in neural cells and tissue with amyotrophic lateral sclerosis-associated mutations in copper-zinc superoxide dismutase

1998 • 218 citations

Inflammation of the brain in Alzheimer's disease: implications for therapy

1999 • 216 citations

Interleukin-1 beta attenuates excitatory amino acid-induced neurodegeneration in vitro: involvement of nerve growth factor

1995 • 214 citations

Increased Neuronal β‐Amyloid Precursor Protein Expression in Human Temporal Lobe Epilepsy: Association with Interleukin‐1α Immunoreactivity

1994 • 196 citations

Sleep: A Physiologic Role for IL‐1β and TNF‐α^a

1998 • 193 citations

The contrasting roles of ICE family proteases and interleukin-1beta in apoptosis induced by trophic factor withdrawal and by copper/zinc superoxide dismutase down-regulation.

1996 • 190 citations

Cultures of astrocytes and microglia express interleukin 18

1999 • 184 citations

Microglial inter leukin‐1α expression in brain regions in Alzheimer's disease: correlation with neuritic plaque distribution

1995 • 181 citations

Mice Deficient in Interleukin-1 Converting Enzyme are Resistant to Neonatal Hypoxic-Ischemic Brain Damage

1999 • 169 citations

IL-1 Receptor Accessory Protein Is an Essential Component of the IL-1 Receptor

1998 • 169 citations

Excitotoxic brain damage in the rat induces interleukin-1? protein in microglia and astrocytes: Correlation with the progression of cell death

1999 • 166 citations

Cytokines in neurodegeneration and repair

1995 • 165 citations

Hematolymphopoietic and inflammatory cytokines in neural development

1997 • 162 citations

Chapter 53: Role of the OVLT in the febrile response to circulating pyrogens

1992 • 158 citations

Murine Microglial Cells Produce and Respond to Interleukin‐18

1999 • 153 citations

Interleukin-6 is a centrally acting endogenous pyrogen in the rat

1991 • 152 citations

Interleukin 1-receptor antagonist blocks interleukin 1-induced sleep and fever

1991 • 149 citations

Expression of type I and type II interleukin-1 receptors in mouse brain

1994 • 147 citations

Interleukin-1 Promotes Expression and Phosphorylation of Neurofilament and tau Proteins in Vivo

2000 • 145 citations

Effects of interleukin-1β on sleep are mediated by the type I receptor

1998 • 144 citations

Endogenous Interleukin-1 Receptor Antagonist is Neuroprotective

1997 • 139 citations

ATP Treatment of Human Monocytes Promotes Caspase-1 Maturation and Externalization

1999 • 138 citations

Protective effect of the interleukin-1 receptor antagonist (IL-1ra) on experimental allergic encephalomyelitis in rats

1995 • 136 citations

CRF is involved in the pyrogenic and thermogenic effects of interleukin 1 beta in the rat

1989 • 134 citations

Brain sites of action of endogenous interleukin‐1 in the febrile response to localized inflammation in the rat

1999 • 132 citations

Interleukin‐1 receptors on rat brain endothelial cells: a role in neuroimmune interaction?

1996 • 129 citations

Towards an understanding of the signal transduction pathways for interleukin 1

1995 • 123 citations

IL-10 as a mediator in the HPA axis and brain

1999 • 121 citations

Effects of interleukin-1 and arachiodonate on the preoptic and anterior hypothalamic neurons

1988 • 118 citations

Expression and localization of p80 and p68 interleukin-1 receptor proteins in the brain of adult mice

1999 • 118 citations

The pyrogenic and mitogenic actions of interleukin-1 are related

1983 • 116 citations

Distribution of interleukin‐1‐immunoreactive microglia in cerebral cortical layers: implications for neuritic plaque formation in Alzheimer’s disease

1998 • 115 citations

Interleukin-1 binding sites on astrocytes

1993 • 96 citations

The Differential Production of Three Forms of IL-1 Receptor Antagonist by Human Neutrophils and Monocytes

1998 • 95 citations

Differential induction of interleukin-12, interleukin-18, and interleukin-1β converting enzyme mRNA in experimental autoimmune encephalomyelitis of the Lewis rat

1998 • 93 citations

Roles of Bcl-2 and caspases in hypoxia-induced neuronal cell death: a possible neuroprotective mechanism of peptide growth factors

1998 • 93 citations

IL-1 type I receptor mediates acute phase response to turpentine, but not lipopolysaccharide, in mice

1996 • 93 citations

Cloning of rat brain interleukin-18 cDNA

1998 • 92 citations

Central Nervous System IL-1β System and Neuropeptide Y mRNAs During IL-1β-induced Anorexia in Rats

1997 • 91 citations

Cortical cell death induced by IL-1 is mediated via actions in the hypothalamus of the rat

2000 • 91 citations

Quantitative changes in interleukin proteins following focal stroke in the rat

2000 • 90 citations

Chapter 16 Molecular pathology of head trauma: altered βAPP metabolism and the aetiology of Alzheimer's disease

1993 • 89 citations

Corticotrophin-releasing factor antagonist inhibits neuronal damage induced by focal cerebral ischaemia or activation of NMDA receptors in the rat brain

1994 • 89 citations

Relevance of interleukin 1 receptor antagonist intron 2 polymorphism in Italian MS patients

1999 • 87 citations

Polymorphisms in IL-1β and IL-1 receptor antagonist genes are associated with myasthenia gravis

1998 • 84 citations

Interleukin-4 and interleukin-10 regulate IL1-? induced mouse primary astrocyte activation: A comparative study

1999 • 79 citations

Progressive Neuronal Injury Associated with Amyloid Plaque Formation in Alzheimer Disease

1998 • 78 citations

Interleukin‐1 System: Receptors, Ligands, and ICE in the Brain and Their Involvement in the Fever Response

1998 • 78 citations

Acute-phase cytokines IL-1β and TNF-α in brain development

2000 • 72 citations

Interleukin-1 induces slow-wave sleep at the prostaglandin D2-sensitive sleep-promoting zone in the rat brain.

1998 • 67 citations

Regulation of cytokine gene expression in the central nervous system by glucocorticoids: Mechanisms and functional consequences

1997 • 64 citations

Interleukin-1 receptors: cloning studies and role in central nervous system disorders1Published on the World Wide Web on 24 October 1997.1

1998 • 61 citations

Rat homolog of mouse interleukin-1 receptor accessory protein: cloning, localization and modulation studies

1996 • 61 citations

Mechanisms of the Behavioral Effects of Interleukin 1 Role of Prostaglandins and CRFa

1992 • 59 citations

Alzheimer's disease: pathology to potential treatments?

1992 • 59 citations

Central action sites of interleukin‐1 beta for inducing fever in rabbits.

1990 • 58 citations

Detection of the interleukin 18 family in rat brain by RT-PCR

2000 • 56 citations

Mechanisms Mediating the Effects of Cytokines on Neuroendocrine Functions in the Rat

2007 • 55 citations

The possible role of the immune system in Alzheimer’s disease

1998 • 52 citations

Gram-negative and gram-positive bacterial products induce differential cytokine profiles in the brain: analysis using an integrative molecular-behavioral in vivo model.

1998 • 51 citations

Cytokine interactions and cytokine balance in the brain: relevance to neurology and psychiatry

1999 • 42 citations

Effects of lipopolysaccharide and glucocorticoids on expression of interleukin-1β converting enzyme in the pituitary and brain of mice

1996 • 40 citations

Constitutive Expression of Interleukin-1beta (IL-1beta) in Rat Oligodendrocytes

1999 • 40 citations

Induction of interleukin-1β-converting enzyme (ICE) in murine microglia by lipopolysaccharide

1997 • 35 citations

Constitutive and Cytokine-inducible Expression of Prion Protein Gene in Human Neural Cell Lines

1998 • 35 citations

The contribution of inflammation to acute and chronic neurodegeneration

1998 • 34 citations

Autoregulation of the interleukin-1 system and cytokine–cytokine interactions in primary human astrocytoma cells

2000 • 34 citations

Demonstration of the presence of an interleukin-1 receptor on the surface of murine astrocytes and its regulation by cytokines and Theiler's virus.

1994 • 27 citations

Blockade of brain type II interleukin-1 receptors potentiates IL1β-induced anorexia in mice

1998 • 26 citations

Interleukin-1 Receptor Type I mRNA Levels in Brain Regions From Male and Female Rats

1997 • 22 citations

IL-1β induced changes in hypothalamic IL-1R1 and IL-1R2 mRNA expression in the rat

2000 • 18 citations

Involvement of caspase-1 proteases in hypoxic brain injury. Effects of their inhibitors in developing neurons

1999 • 17 citations

Dissociation between the effects of interleukin-1 on excitotoxic brain damage and body temperature in the rat

1999 • 17 citations

Effects of an interleukin-1β analogue [Lys-d-Pro-Thr], on incomplete cerebral ischemia-induced inhibition of long-term potentiation in rat hippocampal neurons in vivo

1999 • 14 citations

Regulation of ICE activity and ICE isoforms by LPS

1997 • 12 citations

Dual Specificity of the Interleukin 1- and Tumor Necrosis Factor-activated β Casein Kinase

1997 • 12 citations

Deleted Work

1955 • 0 citations