The contribution of inflammation to acute and chronic neurodegeneration

Tissue Plasminogen Activator for Acute Ischemic Stroke

1995 • 10,997 citations

Microglia: a sensor for pathological events in the CNS

1996 • 4,309 citations

Activation of microglial cells by β-amyloid protein and interferon-γ

1995 • 1,298 citations

Matrix Metalloproteinase Expression Increases After Cerebral Focal Ischemia in Rats

1998 • 731 citations

Excitotoxin-induced neuronal degeneration and seizure are mediated by tissue plasminogen activator

1995 • 659 citations

Microglia in degenerative neurological disease

1993 • 594 citations

MUTANT GENES IN FAMILIAL ALZHEIMER'S DISEASE AND TRANSGENIC MODELS

1998 • 576 citations

Role of microglia and host prion protein in neurotoxicity of a prion protein fragment

1996 • 506 citations

An Extracellular Proteolytic Cascade Promotes Neuronal Degeneration in the Mouse Hippocampus

1997 • 421 citations

Anti‐inflammatory agents as a therapeutic approach to Alzheimer's disease

1992 • 396 citations

Loss of the tight junction proteins occludin and zonula occludens-1 from cerebral vascular endothelium during neutrophil-induced blood–brain barrier breakdown in vivo

1998 • 354 citations

Differential matrix metalloproteinase expression in cases of multiple sclerosis and stroke

1997 • 265 citations

Molecular and Cellular Characterization of the Membrane Attack Complex, C5b-9, in Alzheimer’s Disease

1997 • 254 citations

The kinetics and morphological characteristics of the macrophage-microglial response to kainic acid-induced neuronal degeneration

1991 • 252 citations

Age-related effects of interleukin-1 beta on polymorphonuclear neutrophil-dependent increases in blood-brain barrier permeability in rats

1997 • 244 citations

Intercellular adhesion molecule 1 activation induces tyrosine phosphorylation of the cytoskeleton-associated protein cortactin in brain microvessel endothelial cells.

1994 • 241 citations

Expression of endothelial adhesion molecules and recruitment of neutrophils after traumatic brain injury in rats

1997 • 233 citations

Inflammation in the nervous system

1995 • 223 citations

EVIDENCE FOR AN EARLY INFLAMMATORY RESPONSE IN THE CENTRAL NERVOUS SYSTEM OF MICE WITH SCRAPIE

1996 • 192 citations

OVERRIDING THE BRAIN'S INTRINSIC RESISTANCE TO LEUKOCYTE RECRUITMENT WITH INTRAPARENCHYMAL INJECTIONS OF RECOMBINANT CHEMOKINES

1996 • 181 citations

The Prion Diseases

1995 • 174 citations

Inflammatory processes and antiinflammatory drugs in Alzheimer's disease: A current appraisal

1996 • 158 citations

Characterization of the microglial response in murine scrapie

1994 • 144 citations

Scrapie in Immunologically Deficient Mice

1971 • 88 citations

Adhesion molecule expression on murine cerebral endothelium following the injection of a proinflammagen or during acute neuronal degeneration

1995 • 69 citations

Antibodies against Mac-1 Attenuate Neutrophil Accumulation after Traumatic Brain Injury in Rats

1996 • 62 citations

Alzheimerʼs disease and Creutzfeldt-Jakob disease

1993 • 56 citations

The acute inflammatory response in CNS following injection of prion brain homogenate or normal brain homogenate

1999 • 51 citations

Lymphocyte Recruitment Following Spinal Cord Injury in Mice is Altered by Prior Viral Exposure

1997 • 49 citations

Behavioral consequences of prion disease targeted to the hippocampus in a mouse model of scrapie

1999 • 41 citations

Monocyte recruitment into the scrapie-affected brain

1995 • 24 citations

Swing Wide of that One

1995 • 18 citations

The Excitotoxic Concept

1997 • 17 citations

Stroke: A double-edged sword for cleaving clots?

1998 • 10 citations

Cerebrovascular Diseases

1992 • 9 citations

Anti-Adhesion Molecule Monoclonal Antibodies

1996 • 4 citations

Loss of the tight junction proteins occludin and ZO-1 from cerebral vascular endothelium during neutrophil-induced blood-brain barrier breakdown in vivo.

1998 • 1 citations