Mice Deficient in Interleukin-1 Converting Enzyme are Resistant to Neonatal Hypoxic-Ischemic Brain Damage

Biologic basis for interleukin-1 in disease

1996 • 4,324 citations

Comparative aspects of the brain growth spurt

1979 • 2,491 citations

The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzyme

1993 • 2,484 citations

The influence of immaturity on hypoxic‐ischemic brain damage in the rat

1981 • 2,073 citations

Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice

1996 • 1,902 citations

Altered Cytokine Export and Apoptosis in Mice Deficient in Interleukin-1β Converting Enzyme

1995 • 1,625 citations

Mice deficient in IL-1β-converting enzyme are defective in production of mature IL-1β and resistant to endotoxic shock

1995 • 1,413 citations

Induction of apoptosis in fibroblasts by IL-1β-converting enzyme, a mammalian homolog of the C. elegans cell death gene ced-3

1993 • 1,387 citations

Inhibition of interleukin 1β converting enzyme family proteases reduces ischemic and excitotoxic neuronal damage

1997 • 835 citations

Biochemistry and the central nervous system

1986 • 794 citations

Amniotic fluid inflammatory cytokines (interleukin-6, interleukin-1β, and tumor necrosis factor-α), neonatal brain white matter lesions, and cerebral palsy

1997 • 763 citations

Induction of Caspase-3-Like Protease May Mediate Delayed Neuronal Death in the Hippocampus after Transient Cerebral Ischemia

1998 • 706 citations

Very Delayed Infarction after Mild Focal Cerebral Ischemia: A Role for Apoptosis?

1996 • 613 citations

Human copper-zinc superoxide dismutase transgenic mice are highly resistant to reperfusion injury after focal cerebral ischemia.

1994 • 571 citations

Attenuation of Delayed Neuronal Death after Mild Focal Ischemia in Mice by Inhibition of the Caspase Family

1998 • 554 citations

At what age is the developing cerebral cortex of the rat comparable to that of the full-term newborn human baby?

1991 • 535 citations

Caspase inhibitor affords neuroprotection with delayed administration in a rat model of neonatal hypoxic-ischemic brain injury.

1998 • 514 citations

Intraischemic but Not Postischemic Brain Hypothermia Protects Chronically following Global Forebrain Ischemia in Rats

1993 • 481 citations

High expression of tumor necrosis factor-α and interleukin-6 in periventricular leukomalacia

1997 • 376 citations

Expression of a Dominant Negative Mutant of Interleukin-1β Converting Enzyme in Transgenic Mice Prevents Neuronal Cell Death Induced by Trophic Factor Withdrawal and Ischemic Brain Injury

1997 • 345 citations

Excitotoxic neuronal death in the immature brain is an apoptosis-necrosis morphological continuum

1997 • 333 citations

Reduced Ischemic Brain Injury in Interleukin-1β Converting Enzyme—Deficient Mice

1998 • 302 citations

Mouse Strain Differences in Susceptibility to Cerebral Ischemia are Related to Cerebral Vascular Anatomy

1993 • 290 citations

Cerebral Hypoxia-Ischemia Stimulates Cytokine Gene Expression in Perinatal Rats

1995 • 282 citations

Enhanced Expression of Interleukin (IL)-1 and IL-6 Messenger RNA and Bioactive Protein after Hypoxia-Ischemia in Neonatal Rats

1996 • 273 citations

Effect of Ibotenate on Brain Development

1995 • 256 citations

Prenatal and perinatal factors and cerebral palsy in very low birth weight infants

1996 • 238 citations

Attenuation of Transient Focal Cerebral Ischemic Injury in Transgenic Mice Expressing a Mutant ICE Inhibitory Protein

1997 • 237 citations

C57BL/6 strain is most susceptible to cerebral ischemia following bilateral common carotid occlusion among seven mouse strains: selective neuronal death in the murine transient forebrain ischemia

1997 • 235 citations

Response to local inflammation of IL-1 beta-converting enzyme- deficient mice.

1997 • 235 citations

Procedural and Strain-related Variables Significantly Affect Outcome in a Murine Model of Focal Cerebral Ischemia

1996 • 220 citations

Basic Fibroblast Growth Factor Protects against Hypoxia-Ischemia and NMDA Neurotoxicity in Neonatal Rats

1993 • 218 citations

Interleukin-1 beta attenuates excitatory amino acid-induced neurodegeneration in vitro: involvement of nerve growth factor

1995 • 214 citations

Cytokine Regulation of Neuronal Survival

1992 • 209 citations

Selective Glial Vulnerability following Transient Global Ischemia in Rat Brain

1998 • 206 citations

Brain Injury after Perinatal Hypoxia-Ischemia Is Exacerbated in Copper/Zinc Superoxide Dismutase Transgenic Mice

1996 • 193 citations

Neonatal Mice Lacking Neuronal Nitric Oxide Synthase Are Less Vulnerable to Hypoxic–Ischemic Injury

1996 • 192 citations

The Role of Neutrophils in the Production of Hypoxic-Ischemic Brain Injury in the Neonatal Rat

1997 • 186 citations

Identification of necrotic cell death by the TUNEL assay in the hypoxic-ischemic neonatal rat brain

1997 • 173 citations

Neuropathology of remote hypoxic-ischemic damage in the immature rat

1991 • 168 citations

CYTOKINES AND PERINATAL BRAIN INJURY

1997 • 167 citations

Allopurinol Administered after Inducing Hypoxia-Ischemia Reduces Brain Injury in 7-Day-Old Rats

1993 • 166 citations

Transient Global Forebrain Ischemia Induces a Prolonged Expression of the Caspase-3 mRNA in Rat Hippocampal CA1 Pyramidal Neurons

1998 • 164 citations

Influence of Mild Hypothermia on Hypoxic-Ischemic Brain Damage in the Immature Rat

1993 • 164 citations

The Interleukin-1 Receptor Antagonist (rhIL-1ra) Protects against Cerebral Infarction in a Rat Model of Hypoxia-Ischemia

1994 • 161 citations

Hypoxic-Ischemic Brain Injury Induces an Acute Microglial Reaction in Perinatal Rats1

1996 • 158 citations

Brief post-hypoxic-ischemic hypothermia markedly delays neonatal brain injury

1997 • 158 citations

Nerve growth factor protects the neonatal brain against hypoxic–ischemic injury

1996 • 154 citations

Increased Expression of IL-1β Converting Enzyme in Hippocampus after Ischemia: Selective Localization in Microglia

1996 • 149 citations

Interleukin-6 in the Cerebrospinal Fluid After Perinatal Asphyxia Is Related to Early and Late Neurological Manifestations

1997 • 140 citations

DNA fragmentation indicative of apoptosis following unilateral cerebral hypoxia-ischemia in the neonatal rat

1995 • 135 citations

Neuroprotective effects of NG-nitro-L-arginine in focal stroke in the 7-day old rat

1992 • 133 citations

Immunohistochemical expression of tumor necrosis factor α in neonatal leukomalacia

1996 • 127 citations

Cold thoughts of death: the role of ICE proteases in neuronal cell death

1996 • 118 citations

Cerebral Blood Flow and Edema in Perinatal Hypoxic-Ischemic Brain Damage

1990 • 105 citations

Quantitative assessment of neuroprotection against NMDA-induced brain injury

1989 • 102 citations

The Platelet-Activating Factor Antagonist BN 52021 Attenuates Hypoxic-Ischemic Brain Injury in the Immature Rat

1996 • 73 citations

gp120, an HIV-1 protein, increases susceptibility to hypoglycemic and ischemic brain injury in perinatal rats

1995 • 56 citations

Pathogenesis of hypoxic-ischemic brain injury in a perinatal rodent model

1984 • 48 citations

Regional cerebral blood flow during hypoxia-ischemia in the immature rat: comparison of iodoantipyrine and iodoamphetamine as radioactive tracers

1991 • 41 citations

Brain injury and protective effects of hypothermia using triphenyltetrazolium chloride in neonatal rat

1993 • 31 citations