Cytokines in neurodegeneration and repair

A novel heterodimeric cysteine protease is required for interleukin-1βprocessing in monocytes

1992 • 2,495 citations

The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzyme

1993 • 2,484 citations

The Role of Glutamate Neurotoxicity in Hypoxic-Ischemic Neuronal Death

1990 • 2,204 citations

Mechanisms of nitric oxide-mediated neurotoxicity in primary brain cultures

1993 • 1,024 citations

Interleukin-1 regulates synthesis of nerve growth factor in non-neuronal cells of rat sciatic nerve

1987 • 1,000 citations

Interleukin-1 Stimulation of Astroglial Proliferation After Brain Injury

1985 • 855 citations

Interleukin-1 Immunoreactive Innervation of the Human Hypothalamus

1988 • 771 citations

Blocking IL-1: interleukin 1 receptor antagonist in vivo and in vitro

1991 • 729 citations

Prevention of Vertebrate Neuronal Death by the crmA Gene

1994 • 618 citations

Interleukin-1 receptor antagonist inhibits ischaemic and excitotoxic neuronal damage in the rat

1992 • 547 citations

Increase in IL-6, IL-1 and TNF levels in rat brain following traumatic lesion

1993 • 517 citations

Induction of Neuronal Differentiation in PC12 Cells by B-Cell Stimulatory Factor 2/Interleukin 6

1988 • 402 citations

Recombinant human interleukin-1 induces meningitis and blood-brain barrier injury in the rat. Characterization and comparison with tumor necrosis factor.

1991 • 375 citations

Immunoreactive interleukin-1β localization in the rat forebrain

1990 • 343 citations

Appearance of interleukin-1 in macrophages and in ramified microglia in the brain of endotoxin-treated rats: a pathway for the induction of non-specific symptoms of sickness?

1992 • 337 citations

Induction of Interleukin‐1β mRNA in Rat Brain After Transient Forebrain Ischemia

1992 • 336 citations

Interleukin-1 beta mRNA expression in ischemic rat cortex.

1993 • 335 citations

Bidirectional transport of interleukin-1 alpha across the blood-brain barrier

1989 • 323 citations

Cytokine regulation of neuronal differentiation of hippocampal progenitor cells

1993 • 307 citations

Protection against ischaemic neuronal damage by drugs acting on excitatory neurotransmission.

1990 • 298 citations

Induction of neuronal differentiation in PC12 cells by B-cell stimulatory factor 2/interleukin 6.

1988 • 295 citations

Interleukin-1 receptor antagonist inhibits neuronal damage caused by fluid percussion injury in the rat

1995 • 252 citations

Trophic effects of interleukin-4, -7 and -8 on hippocampal neuronal cultures: potential involvement of glial-derived factors

1993 • 244 citations

Interleukin-1 beta attenuates excitatory amino acid-induced neurodegeneration in vitro: involvement of nerve growth factor

1995 • 214 citations

Cytokine Regulation of Neuronal Survival

1992 • 209 citations

Cooperative regulation of nerve growth factor synthesis and secretion in fibroblasts and astrocytes by fibroblast growth factor and other cytokines

1992 • 207 citations

Cholinergic sprouting in the hippocampus: A proposed role for IL-1

1990 • 187 citations

Interleukin 3 as a trophic factor for central cholinergic neurons in vitro and in vivo

1990 • 184 citations

Interleukin‐1‐like activity in rat brain: Sources, targets, and effects of injury

1987 • 180 citations

Involvement of cytokines in acute neurodegeneration in the CNS

1993 • 169 citations

Ventricular fluid interleukin-1 activity in patients with head injury.

1987 • 164 citations

Neurotrophic effects of basic and acidic fibroblast growth factors are not mediated through glial cells

1988 • 156 citations

Regulation by Interleukin‐1 of Nerve Growth Factor Secretion and Nerve Growth Factor mRNA Expression in Rat Primary Astroglial Cultures

1991 • 153 citations

Interleukin-1β inhibits Ca2+ channel currents in hippocampal neurons through protein kinase C

1994 • 136 citations

The Two Interleukin-1 Receptors Play Different Roles in IL-1 Actions

1994 • 123 citations

Interferon-γ and interleukin-1β induce nitric oxide formation from primary mouse astrocytes

1993 • 115 citations

Possible involvement of interleukin-1 in ischemic brain edema formation

1992 • 108 citations

The role of glutamate antagonists for the treatment of CNS injury.

1992 • 108 citations

Regulation of β‐nerve growth factor expression by inflammatory mediators in hippocampal cultures

1990 • 99 citations

Pharmacology of Interleukin-1 Actions in the Brain

1994 • 75 citations

Interleukin-2 promotes survival and neurite extension of cultured neurons from fetal rat brain

1993 • 72 citations

Cytokine Regulation of Nerve Growth Factor‐Mediated Cholinergic Neurotrophic Activity Synthesized by Astrocytes and Fibroblasts

1992 • 68 citations

Stimulation of neuron survival by basic FGF and CNTF is a direct effect and not mediated by non-neuronal cells: evidence from single cell cultures

1992 • 66 citations

Interleukin‐2 enhances chick and rat sympathetic, but not sensory, neurite outgrowth

1990 • 65 citations

Peripheral endotoxin induces hypothalamic immunoreactive interleukin‐1β in the rat

1993 • 64 citations

Protective effect of nerve growth factor against glutamate-induced neurotoxicity in cultured cortical neurons

1993 • 63 citations

Contrasting Effects of Specific Lymphokines on the Survival of Hippocampal Neurons in Culture

1992 • 19 citations

Metabolic responses to interleukin-1

1992 • 10 citations

Treatment of Dementias

1992 • 9 citations