Signal transduction pathways activated by the IL-1 receptor family: ancient signaling machinery in mammals, insects, and plants

A human homologue of the Drosophila Toll protein signals activation of adaptive immunity

1997 • 5,522 citations

Biologic basis for interleukin-1 in disease

1996 • 4,324 citations

The Dorsoventral Regulatory Gene Cassette spätzle/Toll/cactus Controls the Potent Antifungal Response in Drosophila Adults

1996 • 3,854 citations

A cytokine-responsive IκB kinase that activates the transcription factor NF-κB

1997 • 2,137 citations

IKK-1 and IKK-2: Cytokine-Activated IκB Kinases Essential for NF-κB Activation

1997 • 2,048 citations

MAP3K-related kinase involved in NF-KB induction by TNF, CD95 and IL-1

1997 • 1,294 citations

TRAF6 is a signal transducer for interleukin-1

1996 • 1,287 citations

IκB Kinase-β: NF-κB Activation and Complex Formation with IκB Kinase-α and NIK

1997 • 1,198 citations

IRAK (Pelle) Family Member IRAK-2 and MyD88 as Proximal Mediators of IL-1 Signaling

1997 • 1,159 citations

Interleukin-1 Type II Receptor: A Decoy Target for IL-1 That Is Regulated by IL-4

1993 • 972 citations

cDNA Expression Cloning of the IL-1 Receptor, a Member of the Immunoglobulin Superfamily

1988 • 896 citations

IRAK: A Kinase Associated with the Interleukin-1 Receptor

1996 • 894 citations

Signaling in Plant-Microbe Interactions

2013 • 764 citations

IGIF Does Not Drive Th1 Development but Synergizes with IL-12 for Interferon-γ Production and Activates IRAK and NFκB

1997 • 726 citations

A novel IL-1 receptor, cloned from B cells by mammalian expression, is expressed in many cell types.

1991 • 677 citations

Molecular Cloning and Characterization of a Second Subunit of the Interleukin 1 Receptor Complex

1995 • 634 citations

Tumor necrosis factor (TNF)-mediated kinase cascades: Bifurcation of Nuclear Factor-κB and c-jun N-terminal kinase (JNK/SAPK) pathways at TNF receptor-associated factor 2

1997 • 552 citations

The search for physiological substrates of MAP and SAP kinases in mammalian cells

1997 • 544 citations

Purification and Characterization of the Human Interleukin-18 Receptor

1997 • 471 citations

The Interleukin-1 Receptor Accessory Protein (IL-1RAcP) Is Essential for IL-1-induced Activation of Interleukin-1 Receptor-associated Kinase (IRAK) and Stress-activated Protein Kinases (SAP Kinases)

1997 • 311 citations

Actions of IL-1 are selectively controlled by p38 mitogen-activated protein kinase: regulation of prostaglandin H synthase-2, metalloproteinases, and IL-6 at different levels.

1997 • 288 citations

The Interleukin-1 Receptor-associated Kinase Is Degraded by Proteasomes following Its Phosphorylation

1997 • 281 citations

The 18-wheeler mutation reveals complex antibacterial gene regulation in Drosophila host defense

1997 • 277 citations

Recruitment of IRAK to the interleukin 1 receptor complex requires interleukin 1 receptor accessory protein

1997 • 227 citations

IL-1Rrp Is a Novel Receptor-like Molecule Similar to the Type I Interleukin-1 Receptor and Its Homologues T1/ST2 and IL-1R AcP

1996 • 225 citations

T1/ST2 Signaling Establishes It as a Member of an Expanding Interleukin-1 Receptor Family

1996 • 212 citations

Ras, Rap, and Rac Small GTP-binding Proteins Are Targets for Clostridium sordellii Lethal Toxin Glucosylation

1996 • 206 citations

Towards an understanding of the signal transduction pathways for interleukin 1

1995 • 123 citations

Chromosomal Localization ofTIL,a Gene Encoding a Protein Related to theDrosophilaTransmembrane Receptor Toll, to Human Chromosome 4p14

1996 • 109 citations

Activation of the HIV-1 Long Terminal Repeat by Cytokines and Environmental Stress Requires an Active CSBP/p38 MAP Kinase

1996 • 103 citations

Interleukin‐1‐induced activation of a protein kinase co‐precipitating with the type I interleukin‐1 receptor in T cells

1994 • 76 citations

Signaling in Plant-Microbe Interactions

1997 • 72 citations

Interleukin-1 signal transduction. Increased GTP binding and hydrolysis in membranes of a murine thymoma line (EL4).

1990 • 68 citations

Interleukin 1 alpha activates two forms of p54 alpha mitogen-activated protein kinase in rabbit liver.

1994 • 51 citations

Human Mitogen-activated Protein Kinase CSBP1, but Not CSBP2, Complements a hog1 Deletion in Yeast

1995 • 49 citations

Evidence from sequence information that the interleukin-1 receptor is a transmembrane GTPase

1995 • 17 citations

Dual Specificity of the Interleukin 1- and Tumor Necrosis Factor-activated β Casein Kinase

1997 • 12 citations