Regulation of cytokine gene expression in the central nervous system by glucocorticoids: Mechanisms and functional consequences

Sickness behavior as a new target for drug development

1992 • 866 citations

Inflammatory mediator-induced hypothalamic-pituitary-adrenal axis activation is defective in streptococcal cell wall arthritis-susceptible Lewis rats.

1989 • 723 citations

A central nervous system defect in biosynthesis of corticotropin-releasing hormone is associated with susceptibility to streptococcal cell wall-induced arthritis in Lewis rats.

1989 • 579 citations

Glucocorticoids selectively inhibit the transcription of the interleukin 1 beta gene and decrease the stability of interleukin 1 beta mRNA.

1988 • 510 citations

Peripheral administration of lipopolysaccharide induces the expression of cytokine transcripts in the brain and pituitary of mice

1994 • 502 citations

Exposure to physical and psychological stressors elevates plasma interleukin 6: relationship to the activation of hypothalamic-pituitary-adrenal axis.

1993 • 488 citations

Differential regulation of lipopolysaccharide‐induced interleukin 1 and tumor necrosis factor synthesis: effects of endogenous and exogenous glucocorticoids and the role of the pituitary‐adrenal axis

1989 • 328 citations

The effects of psychological stress on plasma interleukin-6 activity in rats

1990 • 315 citations

Adrenalectomy sensitizes mice to the lethal effects of interleukin 1 and tumor necrosis factor.

1988 • 295 citations

Immobilization stress induces interleukin-1β mRNA in the rat hypothalamus

1991 • 258 citations

Glucocorticoids alter fever and IL-6 responses to psychological stress and to lipopolysaccharide

1993 • 168 citations

Expression of type I and type II interleukin-1 receptors in mouse brain

1994 • 147 citations

Adrenalectomy enhances pro-inflammatory cytokines gene expression, in the spleen, pituitary and brain of mice in response to lipopolysaccharide

1996 • 126 citations

Stress Downregulates Lipopolysaccharide-Induced Expression of Proinflammatory Cytokines in the Spleen, Pituitary, and Brain of Mice

1995 • 105 citations

How do cytokines say hello to the brain? Neural versus humoral mediation.

1994 • 101 citations

Interleukin 1: a regulatory role in glucocorticoid-regulated hepatic metabolism.

1986 • 95 citations

Endotoxin-induced fever is modulated by endogenous glucocorticoids in rats

1992 • 95 citations

Neuro-hormonal host defence in endotoxin shock

1992 • 76 citations

Stress, the immune system, and psychiatry /

1995 • 56 citations

Regulation of lnterleukin-1 Receptor Expression in Mouse Brain and Pituitary by Lipopolysaccharide and Glucocorticoids

1993 • 53 citations

Endogenous glucocorticoids down regulate central effects of interleukin-1 β on body temperature and behaviour in mice

1995 • 48 citations

Effect of Interleukin-1 on ACTH and Corticosterone Secretion in Dexamethasone and Adrenalectomized Pretreated Male Rats

1989 • 48 citations

Molecular Identification of Two Types of lnterleukin‐1 Receptors in the Murine Pituitary Gland

1993 • 47 citations

Central effects of glucocorticoid receptor antagonist RU-38486 on lipopolysaccharide and stress-induced fever

1994 • 45 citations

Effects of lipopolysaccharide and glucocorticoids on expression of interleukin-1β converting enzyme in the pituitary and brain of mice

1996 • 40 citations

Corticosteroid Regulation of IL-1 Receptors in the Mouse Hippocampus: Effects of Glucocorticoid Treatment, Stress, and Adrenalectomy

1994 • 30 citations

Psychoneuroimmunology of stress

1995 • 18 citations