Interleukin-1 receptors: cloning studies and role in central nervous system disorders1Published on the World Wide Web on 24 October 1997.1
Data up to Jan 2025
Total Citations Per Year
Abstract
References (178)
LIGAND: A versatile computerized approach for characterization of ligand-binding systems
1980 • 8,534 citations
FLICE, A Novel FADD-Homologous ICE/CED-3–like Protease, Is Recruited to the CD95 (Fas/APO-1) Death-Inducing Signaling Complex
1996 • 3,065 citations
Excitatory Amino Acids as a Final Common Pathway for Neurologic Disorders
1994 • 2,668 citations
A novel heterodimeric cysteine protease is required for interleukin-1βprocessing in monocytes
1992 • 2,495 citations
Induction by IL 1 and interferon-gamma: tissue distribution, biochemistry, and function of a natural adherence molecule (ICAM-1).
1986 • 2,490 citations
The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzyme
1993 • 2,484 citations
Involvement of MACH, a Novel MORT1/FADD-Interacting Protease, in Fas/APO-1- and TNF Receptor–Induced Cell Death
1996 • 2,306 citations
Interleukin-1 and interleukin-1 antagonism
1991 • 2,276 citations
Excitatory amino acid neurotoxicity and neurodegenerative disease
1990 • 1,781 citations
Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease.
1989 • 1,752 citations
The Role of the Hippocampus in Feedback Regulation of the Hypothalamic-Pituitary-Adrenocortical Axis*
1991 • 1,690 citations
Altered Cytokine Export and Apoptosis in Mice Deficient in Interleukin-1β Converting Enzyme
1995 • 1,625 citations
Effects of Cerebral Ischemia in Mice Deficient in Neuronal Nitric Oxide Synthase
1994 • 1,578 citations
Biology of interleukin 1
1988 • 1,547 citations
Interleukin-1 Stimulates the Secretion of Hypothalamic Corticotropin-Releasing Factor
1987 • 1,512 citations
Overlapping patterns of activation of human endothelial cells by interleukin 1, tumor necrosis factor, and immune interferon.
1986 • 1,439 citations
Mice deficient in IL-1β-converting enzyme are defective in production of mature IL-1β and resistant to endotoxic shock
1995 • 1,413 citations
Induction of apoptosis in fibroblasts by IL-1β-converting enzyme, a mammalian homolog of the C. elegans cell death gene ced-3
1993 • 1,387 citations
There is more than one interleukin 1
1986 • 1,226 citations
Corticosteroid Inhibition of ACTH Secretion*
1984 • 1,212 citations
Corticotropin-Releasing Factor-Producing Neurons in the Rat Activated by Interleukin-1
1987 • 1,152 citations
Molecular Cloning of the Interleukin-1β Converting Enzyme
1992 • 1,115 citations
Cytotoxicity of microglia
1993 • 1,042 citations
Interleukin-1 Type II Receptor: A Decoy Target for IL-1 That Is Regulated by IL-4
1993 • 972 citations
POTENTIATION OF THE T-LYMPHOCYTE RESPONSE TO MITOGENS
1972 • 921 citations
cDNA Expression Cloning of the IL-1 Receptor, a Member of the Immunoglobulin Superfamily
1988 • 896 citations
IRAK: A Kinase Associated with the Interleukin-1 Receptor
1996 • 894 citations
Interleukin 1 of the central nervous system is produced by ameboid microglia.
1986 • 858 citations
Role of Ca2+ in toxic cell killing
1989 • 856 citations
Interleukin-1 Stimulation of Astroglial Proliferation After Brain Injury
1985 • 855 citations
Ich-1, an Ice/ced-3-related gene, encodes both positive and negative regulators of programmed cell death
1994 • 843 citations
Structure and mechanism of interleukin-lβ converting enzyme
1994 • 842 citations
Inhibition of interleukin 1β converting enzyme family proteases reduces ischemic and excitotoxic neuronal damage
1997 • 835 citations
Endothelial Cell Gene Expression of a Neutrophil Chemotactic Factor by TNF-α, LPS, and IL-1β
1989 • 785 citations
Interleukin-1 Immunoreactive Innervation of the Human Hypothalamus
1988 • 771 citations
Involvement of an ICE-like protease in Fas-mediated apoptosis
1995 • 757 citations
Production of prostaglandin E and an interleukin-1 like factor by cultured astrocytes and C6 glioma cells.
1982 • 754 citations
Cytokines and the nervous system I: expression and recognition
1995 • 745 citations
In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains.
1996 • 731 citations
A novel IL-1 receptor, cloned from B cells by mammalian expression, is expressed in many cell types.
1991 • 677 citations
Molecular Cloning and Characterization of a Second Subunit of the Interleukin 1 Receptor Complex
1995 • 634 citations
Prevention of Vertebrate Neuronal Death by the crmA Gene
1994 • 618 citations
Requirement of an ICE/CED-3 protease for Fas/APO-1-mediated apoptosis
1995 • 616 citations
Interleukin 1 signaling occurs exclusively via the type I receptor.
1993 • 609 citations
Fas- and Tumor Necrosis Factor-induced Apoptosis Is Inhibited by the Poxvirus crmA Gene Product
1995 • 604 citations
Induction of apoptosis by the mouse Nedd2 gene, which encodes a protein similar to the product of the Caenorhabditis elegans cell death gene ced-3 and the mammalian IL-1 beta-converting enzyme.
1994 • 596 citations
Interleukin-1 injected into mammalian brain stimulates astrogliosis and neovascularization
1988 • 587 citations
Detection of interleukin-1 and interleukin-6 in adult rat brain, following mechanical injury, by in vivo microdialysis: evidence of a role for microglia in cytokine production
1991 • 579 citations
Interleukin-1 as a Pathogenetic Mediator of Ischemic Brain Damage in Rats
1995 • 572 citations
Crystal structure of the cysteine protease interleukin-1β-converting enzyme: A (p20/p10)2 homodimer
1994 • 567 citations
Interleukin-1 receptor antagonist inhibits ischaemic and excitotoxic neuronal damage in the rat
1992 • 547 citations
Increase in IL-6, IL-1 and TNF levels in rat brain following traumatic lesion
1993 • 517 citations
Identification of a monocyte specific pre-interleukin 1 beta convertase activity.
1989 • 501 citations
The role of glutamate in epilepsy and other CNS disorders.
1994 • 476 citations
A soluble receptor for interleukin-1β encoded by vaccinia virus: A novel mechanism of virus modulation of the host response to infection
1992 • 475 citations
Endothelial Cell Production of Nitrogen Oxides in Response to Interferon in Combination With Tumor Necrosis Factor, Interleukin-1, or Endotoxin
1990 • 474 citations
Type 1 interleukin‐1 receptor in the rat brain: Distribution, regulation, and relationship to sites of IL‐1–induced cellular activation
1995 • 470 citations
Local production of tumor necrosis factor alpha, interleukin 1, and interleukin 6 in meningococcal meningitis. Relation to the inflammatory response.
1989 • 461 citations
Neuroprotective Effects of Human Recombinant Interleukin-1 Receptor Antagonist in Focal Cerebral Ischaemia in the Rat
1996 • 456 citations
Visualization and characterization of interleukin 1 receptors in brain.
1987 • 451 citations
Sleep-promoting effects of endogenous pyrogen (interleukin-1)
1984 • 450 citations
Interleukin-1 is an astroglial growth factor in the developing brain
1988 • 442 citations
ICE Family Proteases: Mediators of All Apoptotic Cell Death?
1996 • 440 citations
Brain glia release factors with opposing actions upon neuronal survival
1993 • 437 citations
Activation of the Sphingomyelin Signaling Pathway in Intact EL4 Cells and in a Cell-Free System By IL-1β
1993 • 433 citations
Mch2, a new member of the apoptotic Ced-3/Ice cysteine protease gene family.
1995 • 407 citations
Mch3, a novel human apoptotic cysteine protease highly related to CPP32.
1995 • 391 citations
Recombinant human interleukin-1 induces meningitis and blood-brain barrier injury in the rat. Characterization and comparison with tumor necrosis factor.
1991 • 375 citations
Regulation of Nerve Growth Factor (NGF) Synthesis in the Rat Central Nervous System: Comparison between the Effects of Interleukin‐1 and Various Growth Factors in Astrocyte Cultures and in vivo
1990 • 369 citations
The Baculovirus p35 Protein Inhibits Fas- and Tumor Necrosis Factor-induced Apoptosis
1995 • 366 citations
HIV‐1, macrophages, glial cells, and cytokines in AIDS nervous system disease
1991 • 359 citations
Anti–Intercellular Adhesion Molecule–1 Antibody Reduces Ischemic Cell Damage After Transient But Not Permanent Middle Cerebral Artery Occlusion in the Wistar Rat
1995 • 346 citations
Immunoreactive interleukin-1β localization in the rat forebrain
1990 • 343 citations
INTERLEUKIN-1 STIMULATES ACTH RELEASE BY AN INDIRECT ACTION WHICH REQUIRES ENDOGENOUS CORTICOTROPIN RELEASING FACTOR
1987 • 340 citations
A monoclonal antibody that detects a novel antigen on endothelial cells that is induced by tumor necrosis factor, IL-1, or lipopolysaccharide.
1990 • 339 citations
Induction of Interleukin‐1β mRNA in Rat Brain After Transient Forebrain Ischemia
1992 • 336 citations
In situ histochemical localization of type I interleukin-1 receptor messenger RNA in the central nervous system, pituitary, and adrenal gland of the mouse
1992 • 335 citations
Interleukin-1 beta mRNA expression in ischemic rat cortex.
1993 • 335 citations
Interleukins-1 and -6 Stimulate the Release of Corticotropin-Releasing Hormone-41 from Rat Hypothalamusin Vitrovia the Eicosanoid Cyclooxygenase Pathway*
1991 • 331 citations
ICE-LAP3, a Novel Mammalian Homologue of the Caenorhabditis elegans Cell Death Protein Ced-3 Is Activated during Fas- and Tumor Necrosis Factor-induced Apoptosis
1996 • 327 citations
A novel human protease similar to the interleukin-1 beta converting enzyme induces apoptosis in transfected cells.
1995 • 313 citations
Cytokines and the nervous system I: expression and recognition
1995 • 307 citations
ICE-LAP6, a Novel Member of the ICE/Ced-3 Gene Family, Is Activated by the Cytotoxic T Cell Protease Granzyme B
1996 • 304 citations
Interleukin-1 Receptors in Mouse Brain:Characterization and Neuronal Localization
1990 • 302 citations
Alternative promoter usage of the Fos-responsive gene Fit-1 generates mRNA isoforms coding for either secreted or membrane-bound proteins related to the IL-1 receptor.
1994 • 295 citations
Excitatory amino acid receptors, neural membrane phospholipid metabolism and neurological disorders
1991 • 286 citations
Brain macrophages synthesize interleukin‐1 and interleukin‐1 mRNAs in vitro
1988 • 286 citations
Molecular Cloning and Pro-apoptotic Activity of ICErelII and ICErelIII, Members of the ICE/CED-3 Family of Cysteine Proteases
1995 • 281 citations
Synthesis of interleukin 1/endogenous pyrogen in the brain of endotoxin-treated mice: a step in fever induction?
1984 • 279 citations
Correlation of interleukin-1β and cachectin concentrations in cerebrospinal fluid and outcome from bacterial meningitis
1989 • 278 citations
Concomitant cortical expression of TNF-α and IL-1β mRNAs follows early response gene expression in transient focal ischemia
1994 • 278 citations
The interleukins 1
1989 • 276 citations
Characterization of microglial reaction after middle cerebral artery occlusion in rat brain
1993 • 274 citations
Interleukin-1 Costimulatory Activity on the Interleukin-2 Promoter Via AP-1
1989 • 271 citations
Cloning the interleukin 1 receptor from human T cells.
1989 • 267 citations
Cerebral Infarction
1974 • 266 citations
Identification and Characterization of ICH-2, a Novel Member of the Interleukin-1β-converting Enzyme Family of Cysteine Proteases
1995 • 262 citations
Development of tissue damage, inflammation and resolution following stroke: An immunohistochemical and quantitative planimetric study
1993 • 262 citations
Interleukin-1 receptor antagonist inhibits neuronal damage caused by fluid percussion injury in the rat
1995 • 252 citations
Attenuation of Stroke Size in Rats Using an Adenoviral Vector to Induce Overexpression of Interleukin-1 Receptor Antagonist in Brain
1995 • 245 citations
Interleukin-1 receptor antagonist decreases the number of necrotic neurons in rats with middle cerebral artery occlusion.
1995 • 238 citations
Induction of interleukin-1β mRNA after focal cerebral ischaemia in the rat
1994 • 236 citations
Identification and Characterization of Ich-3, a Member of the Interleukin-1β Converting Enzyme (ICE)/Ced-3 Family and an Upstream Regulator of ICE
1996 • 231 citations
The Progression and Topographic Distribution of Interleukin-1β Expression after Permanent Middle Cerebral Artery Occlusion in the Rat
1999 • 228 citations
Interleukin 1 signaling occurs exclusively via the typeI receptor
1993 • 228 citations
Identification and Characterization of CPP32/Mch2 Homolog 1, a Novel Cysteine Protease Similar to CPP32
1996 • 223 citations
In the Rat, Interleukin- 1α Acts at the Level of the Brain and the Gonads to Interfere with Gonadotropin and Sex Steroid Secretion*
1989 • 215 citations
Presence of a novel primary response gene ST2L, encoding a product highly similar to the interleukin 1 receptor type 1
1993 • 214 citations
pelle encodes a protein kinase required to establish dorsoventral polarity in the Drosophila embryo
1993 • 210 citations
An ICE inhibitor, z-VAD-DCB attenuates ischaemic brain damage in the rat
1996 • 207 citations
Peripheral Administration of Interleukin-1 Receptor Antagonist Inhibits Brain Damage after Focal Cerebral Ischemia in the Rat
1996 • 206 citations
Monocyte adherence to human vascular endothelium
1993 • 205 citations
Suppression of food intake during infection: is interleukin-1 involved?
1985 • 199 citations
Interleukin-1 Directly Stimulates the Release of Corticotrophin Releasing Factor from Rat Hypothalamus
1989 • 198 citations
Tumor Necrosis Factor-α is a Potent ACTH Secretagogue: Comparison to Interleukin-1β
1989 • 196 citations
Expression of interleukin (IL)‐1β, IL‐6 and their respective receptors in the normal rat brain and after injury
1992 • 191 citations
Cholinergic sprouting in the hippocampus: A proposed role for IL-1
1990 • 187 citations
Evidence for different interleukin 1 receptors in murine B- and T-cell lines.
1989 • 186 citations
Localization of type I interleukin-1 receptor mRNA in the rat brain
1994 • 183 citations
The Immune Logical Brain
1987 • 175 citations
Cytokines in neurodegeneration and repair
1995 • 165 citations
Growth-promoting effect of recombinant interleukin 1 and tumor necrosis factor for a human astrocytoma cell line.
1987 • 165 citations
The Interleukin-1 Receptor Antagonist (rhIL-1ra) Protects against Cerebral Infarction in a Rat Model of Hypoxia-Ischemia
1994 • 161 citations
Identification of a high-affinity receptor for interleukin-1 beta in rat brain
1988 • 160 citations
Convulsants induce interleukin-1β messenger RNA in rat brain
1990 • 158 citations
Brain IL-1-induced immunosuppression occurs through activation of both pituitary-adrenal axis and sympathetic nervous system by corticotropin- releasing factor
1990 • 157 citations
Intracerebral injection of proinflammatory cytokines or leukocyte chemotaxins induces minimal myelomonocytic cell recruitment to the parenchyma of the central nervous system.
1992 • 156 citations
Interleukin-1 derived from astrocytes enhances slow wave activity in sleep EEG of the rat
1984 • 154 citations
Expression of transforming growth factor-?1 and interleukin-1? mRNA in rat brain following transient forebrain ischemia
1993 • 150 citations
Increased Expression of IL-1β Converting Enzyme in Hippocampus after Ischemia: Selective Localization in Microglia
1996 • 149 citations
Interleukin-1 Receptor and Receptor Antagonist Gene Expression After Focal Stroke in Rats
1997 • 148 citations
Cytokines: Influence on Glial Cell Gene Expression and Function
1997 • 145 citations
Endogenous Interleukin-1 Receptor Antagonist is Neuroprotective
1997 • 139 citations
The Numerous Postulated Biological Manifestations of Interleukin-1
1984 • 136 citations
Transient Increase of Cytokine-Induced Neutrophil Chemoattractant, a Member of the Interleukin-8 Family, in Ischemic Brain Areas After Focal Ischemia in Rats
1995 • 132 citations
Neutrophil as a mediator of ischemic edema formation in the brain
1991 • 131 citations
Interferon-γ and interleukin-1β induce nitric oxide formation from primary mouse astrocytes
1993 • 115 citations
In situ hybridization study of interleukin-1β mRNA induced by kainic acid in the rat brain
1993 • 114 citations
Sleep and Cerebrospinal Fluid Interleukin-1-Like Activity in the Cat
1988 • 113 citations
Genetic and molecular characterization of tube, a Drosophila gene maternally required for embryonic dorsoventral polarity.
1991 • 113 citations
An in situ hybridization study on interleukin-1β mRNA induced by transient forebrain ischemia in the rat brain
1994 • 109 citations
Possible involvement of interleukin-1 in ischemic brain edema formation
1992 • 108 citations
Interleukin-1 induces analgesia in mice by a central action
1988 • 97 citations
An mRNA homologous to interleukin-1 receptor type I is expressed in cultured rat sympathetic ganglia
1993 • 94 citations
Cytokines and transcription factors
1990 • 91 citations
DNA Damage and Repair in Central Nervous System Injury
1996 • 88 citations
Interleukin-1 receptor antagonist attenuates the heat stroke-induced neuronal damage by reducing the cerebral ischemia in rats
1995 • 86 citations
Cloning and Characterization of an Alternatively Processed Human Type II Interleukin-1 Receptor mRNA
1996 • 86 citations
Astroglial and microglial reactions in the gerbil hippocampus with induced ischemic tolerance
1994 • 83 citations
Cloning of a cDNA encoding a novel interleukin-1 receptor related protein (IL1R-rp2)
1996 • 79 citations
Central activation of thermogenesis and fever by interleukin-1β and interleukin-1α involves different mechanisms
1989 • 74 citations
Interleukin 1 induction of the c-jun promoter.
1993 • 73 citations
Type I interleukin-1 receptors in the mouse brain-endocrine-immune axis labelled with [125I]recombinant human interleukin-1 receptor antagonist
1992 • 69 citations
Molecular cloning of the murine IL-1 beta converting enzyme cDNA.
1992 • 65 citations
Interleukin 1 beta (IL-1 beta) processing in murine macrophages requires a structurally conserved homologue of human IL-1 beta converting enzyme.
1993 • 61 citations
Rat homolog of mouse interleukin-1 receptor accessory protein: cloning, localization and modulation studies
1996 • 61 citations
Localization of lnterleukln-1 Receptor Messenger RNA in Murlne Hippocampus
1991 • 58 citations
Neural Mechanisms in the Pyrogenic and Acute-Phase Responses to Interleukin-1
1988 • 58 citations
Responses of thermosensitive preoptic and septal neurons to hippocampal and brain stem stimulation
1977 • 57 citations
Low Affinity Binding of Interleukin-1β and Intracellular Signaling via NF-κB Identify Fit-1 as a Distant Member of the Interleukin-1 Receptor Family
1995 • 51 citations
Chapter 1 Mechanisms of Nerve Cell Death: Apoptosis or Necrosis After Cerebral Ischaemia
1996 • 50 citations
Localization of Interleukin-1βP Converting Enzyme mRNA in Rat Brain Vasculature: Evidence that the Genes Encoding the Interleukin-1 System Are Constitutively Expressed in Brain Blood Vessels
1995 • 49 citations
Importance of brain IL-1 type II receptors in fever and thermogenesis in the rat
1993 • 45 citations
Murine ST2 gene is a member of the primary response gene family induced by growth factors
1992 • 44 citations
Immunoregulation of cells within the central nervous system
1988 • 41 citations
Interleukin-1 stimulates the expression of type I and type II interleukin-1 receptors in the rat insulinoma cell line Rinm5F; sequencing a rat type II interleukin-1 receptor cDNA.
1994 • 40 citations
Interleukin-1 induced gene expression of neutrophil activating protein (interleukin-8) and monocyte chemotactic peptide in human synovial cells
1991 • 38 citations
Cloning, Tissue Expression and Regulation of Rat Interleukin 1β Converting Enzyme
1995 • 34 citations
Impaired effects of interleukin-1 beta on fever and thermogenesis in genetically obese rats.
1989 • 31 citations
Regionally specific induction of ICE mRNA and enzyme activity in the rat brain and adrenal gland by LPS
1996 • 30 citations
Cytokines: Influence on Glial Cell Gene Expression and Function (Part 1 of 2)
1992 • 20 citations
Species differences in [125I]interleukin-1 binding in brain, endocrine and immune tissues
1993 • 20 citations
Contrasting Effects of Specific Lymphokines on the Survival of Hippocampal Neurons in Culture
1992 • 19 citations
Macrophages in the Brain: Friends or Enemies?
1994 • 18 citations
Evidence that the interleukin-1β-induced prostaglandin E2 release from rat hypothalamus is mediated by type I and type II interleukin-1 receptors
1995 • 18 citations
Hippocampal input to preoptic thermosensitive neurons in the rat
1982 • 17 citations
Leukocyte Adhesion to Endothelium
1993 • 17 citations
Cytokines and neurodegeneration
1997 • 7 citations