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Interleukin-1 receptors: cloning studies and role in central nervous system disorders1Published on the World Wide Web on 24 October 1997.1

Data up to Jan 2025

Published1998
Citations61
References178

Total Citations Per Year

Abstract

References (178)

LIGAND: A versatile computerized approach for characterization of ligand-binding systems

1980 • 8,534 citations

FLICE, A Novel FADD-Homologous ICE/CED-3–like Protease, Is Recruited to the CD95 (Fas/APO-1) Death-Inducing Signaling Complex

1996 • 3,065 citations

Excitatory Amino Acids as a Final Common Pathway for Neurologic Disorders

1994 • 2,668 citations

A novel heterodimeric cysteine protease is required for interleukin-1βprocessing in monocytes

1992 • 2,495 citations

Induction by IL 1 and interferon-gamma: tissue distribution, biochemistry, and function of a natural adherence molecule (ICAM-1).

1986 • 2,490 citations

The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzyme

1993 • 2,484 citations

Involvement of MACH, a Novel MORT1/FADD-Interacting Protease, in Fas/APO-1- and TNF Receptor–Induced Cell Death

1996 • 2,306 citations

Interleukin-1 and interleukin-1 antagonism

1991 • 2,276 citations

Excitatory amino acid neurotoxicity and neurodegenerative disease

1990 • 1,781 citations

Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease.

1989 • 1,752 citations

The Role of the Hippocampus in Feedback Regulation of the Hypothalamic-Pituitary-Adrenocortical Axis*

1991 • 1,690 citations

Altered Cytokine Export and Apoptosis in Mice Deficient in Interleukin-1β Converting Enzyme

1995 • 1,625 citations

Effects of Cerebral Ischemia in Mice Deficient in Neuronal Nitric Oxide Synthase

1994 • 1,578 citations

Biology of interleukin 1

1988 • 1,547 citations

Interleukin-1 Stimulates the Secretion of Hypothalamic Corticotropin-Releasing Factor

1987 • 1,512 citations

Overlapping patterns of activation of human endothelial cells by interleukin 1, tumor necrosis factor, and immune interferon.

1986 • 1,439 citations

Mice deficient in IL-1β-converting enzyme are defective in production of mature IL-1β and resistant to endotoxic shock

1995 • 1,413 citations

Induction of apoptosis in fibroblasts by IL-1β-converting enzyme, a mammalian homolog of the C. elegans cell death gene ced-3

1993 • 1,387 citations

There is more than one interleukin 1

1986 • 1,226 citations

Corticosteroid Inhibition of ACTH Secretion*

1984 • 1,212 citations

Corticotropin-Releasing Factor-Producing Neurons in the Rat Activated by Interleukin-1

1987 • 1,152 citations

Molecular Cloning of the Interleukin-1β Converting Enzyme

1992 • 1,115 citations

Cytotoxicity of microglia

1993 • 1,042 citations

Interleukin-1 Type II Receptor: A Decoy Target for IL-1 That Is Regulated by IL-4

1993 • 972 citations

POTENTIATION OF THE T-LYMPHOCYTE RESPONSE TO MITOGENS

1972 • 921 citations

cDNA Expression Cloning of the IL-1 Receptor, a Member of the Immunoglobulin Superfamily

1988 • 896 citations

IRAK: A Kinase Associated with the Interleukin-1 Receptor

1996 • 894 citations

Interleukin 1 of the central nervous system is produced by ameboid microglia.

1986 • 858 citations

Role of Ca2+ in toxic cell killing

1989 • 856 citations

Interleukin-1 Stimulation of Astroglial Proliferation After Brain Injury

1985 • 855 citations

Ich-1, an Ice/ced-3-related gene, encodes both positive and negative regulators of programmed cell death

1994 • 843 citations

Structure and mechanism of interleukin-lβ converting enzyme

1994 • 842 citations

Inhibition of interleukin 1β converting enzyme family proteases reduces ischemic and excitotoxic neuronal damage

1997 • 835 citations

Endothelial Cell Gene Expression of a Neutrophil Chemotactic Factor by TNF-α, LPS, and IL-1β

1989 • 785 citations

Interleukin-1 Immunoreactive Innervation of the Human Hypothalamus

1988 • 771 citations

Involvement of an ICE-like protease in Fas-mediated apoptosis

1995 • 757 citations

Production of prostaglandin E and an interleukin-1 like factor by cultured astrocytes and C6 glioma cells.

1982 • 754 citations

Cytokines and the nervous system I: expression and recognition

1995 • 745 citations

In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains.

1996 • 731 citations

A novel IL-1 receptor, cloned from B cells by mammalian expression, is expressed in many cell types.

1991 • 677 citations

Molecular Cloning and Characterization of a Second Subunit of the Interleukin 1 Receptor Complex

1995 • 634 citations

Prevention of Vertebrate Neuronal Death by the crmA Gene

1994 • 618 citations

Requirement of an ICE/CED-3 protease for Fas/APO-1-mediated apoptosis

1995 • 616 citations

Interleukin 1 signaling occurs exclusively via the type I receptor.

1993 • 609 citations

Fas- and Tumor Necrosis Factor-induced Apoptosis Is Inhibited by the Poxvirus crmA Gene Product

1995 • 604 citations

Induction of apoptosis by the mouse Nedd2 gene, which encodes a protein similar to the product of the Caenorhabditis elegans cell death gene ced-3 and the mammalian IL-1 beta-converting enzyme.

1994 • 596 citations

Interleukin-1 injected into mammalian brain stimulates astrogliosis and neovascularization

1988 • 587 citations

Detection of interleukin-1 and interleukin-6 in adult rat brain, following mechanical injury, by in vivo microdialysis: evidence of a role for microglia in cytokine production

1991 • 579 citations

Interleukin-1 as a Pathogenetic Mediator of Ischemic Brain Damage in Rats

1995 • 572 citations

Crystal structure of the cysteine protease interleukin-1β-converting enzyme: A (p20/p10)2 homodimer

1994 • 567 citations

Interleukin-1 receptor antagonist inhibits ischaemic and excitotoxic neuronal damage in the rat

1992 • 547 citations

Increase in IL-6, IL-1 and TNF levels in rat brain following traumatic lesion

1993 • 517 citations

Identification of a monocyte specific pre-interleukin 1 beta convertase activity.

1989 • 501 citations

The role of glutamate in epilepsy and other CNS disorders.

1994 • 476 citations

A soluble receptor for interleukin-1β encoded by vaccinia virus: A novel mechanism of virus modulation of the host response to infection

1992 • 475 citations

Endothelial Cell Production of Nitrogen Oxides in Response to Interferon in Combination With Tumor Necrosis Factor, Interleukin-1, or Endotoxin

1990 • 474 citations

Type 1 interleukin‐1 receptor in the rat brain: Distribution, regulation, and relationship to sites of IL‐1–induced cellular activation

1995 • 470 citations

Local production of tumor necrosis factor alpha, interleukin 1, and interleukin 6 in meningococcal meningitis. Relation to the inflammatory response.

1989 • 461 citations

Neuroprotective Effects of Human Recombinant Interleukin-1 Receptor Antagonist in Focal Cerebral Ischaemia in the Rat

1996 • 456 citations

Visualization and characterization of interleukin 1 receptors in brain.

1987 • 451 citations

Sleep-promoting effects of endogenous pyrogen (interleukin-1)

1984 • 450 citations

Interleukin-1 is an astroglial growth factor in the developing brain

1988 • 442 citations

ICE Family Proteases: Mediators of All Apoptotic Cell Death?

1996 • 440 citations

Brain glia release factors with opposing actions upon neuronal survival

1993 • 437 citations

Activation of the Sphingomyelin Signaling Pathway in Intact EL4 Cells and in a Cell-Free System By IL-1β

1993 • 433 citations

Mch2, a new member of the apoptotic Ced-3/Ice cysteine protease gene family.

1995 • 407 citations

Mch3, a novel human apoptotic cysteine protease highly related to CPP32.

1995 • 391 citations

Recombinant human interleukin-1 induces meningitis and blood-brain barrier injury in the rat. Characterization and comparison with tumor necrosis factor.

1991 • 375 citations

Regulation of Nerve Growth Factor (NGF) Synthesis in the Rat Central Nervous System: Comparison between the Effects of Interleukin‐1 and Various Growth Factors in Astrocyte Cultures and in vivo

1990 • 369 citations

The Baculovirus p35 Protein Inhibits Fas- and Tumor Necrosis Factor-induced Apoptosis

1995 • 366 citations

HIV‐1, macrophages, glial cells, and cytokines in AIDS nervous system disease

1991 • 359 citations

Anti–Intercellular Adhesion Molecule–1 Antibody Reduces Ischemic Cell Damage After Transient But Not Permanent Middle Cerebral Artery Occlusion in the Wistar Rat

1995 • 346 citations

Immunoreactive interleukin-1β localization in the rat forebrain

1990 • 343 citations

INTERLEUKIN-1 STIMULATES ACTH RELEASE BY AN INDIRECT ACTION WHICH REQUIRES ENDOGENOUS CORTICOTROPIN RELEASING FACTOR

1987 • 340 citations

A monoclonal antibody that detects a novel antigen on endothelial cells that is induced by tumor necrosis factor, IL-1, or lipopolysaccharide.

1990 • 339 citations

Induction of Interleukin‐1β mRNA in Rat Brain After Transient Forebrain Ischemia

1992 • 336 citations

In situ histochemical localization of type I interleukin-1 receptor messenger RNA in the central nervous system, pituitary, and adrenal gland of the mouse

1992 • 335 citations

Interleukin-1 beta mRNA expression in ischemic rat cortex.

1993 • 335 citations

Interleukins-1 and -6 Stimulate the Release of Corticotropin-Releasing Hormone-41 from Rat Hypothalamusin Vitrovia the Eicosanoid Cyclooxygenase Pathway*

1991 • 331 citations

ICE-LAP3, a Novel Mammalian Homologue of the Caenorhabditis elegans Cell Death Protein Ced-3 Is Activated during Fas- and Tumor Necrosis Factor-induced Apoptosis

1996 • 327 citations

A novel human protease similar to the interleukin-1 beta converting enzyme induces apoptosis in transfected cells.

1995 • 313 citations

Cytokines and the nervous system I: expression and recognition

1995 • 307 citations

ICE-LAP6, a Novel Member of the ICE/Ced-3 Gene Family, Is Activated by the Cytotoxic T Cell Protease Granzyme B

1996 • 304 citations

Interleukin-1 Receptors in Mouse Brain:Characterization and Neuronal Localization

1990 • 302 citations

Alternative promoter usage of the Fos-responsive gene Fit-1 generates mRNA isoforms coding for either secreted or membrane-bound proteins related to the IL-1 receptor.

1994 • 295 citations

Excitatory amino acid receptors, neural membrane phospholipid metabolism and neurological disorders

1991 • 286 citations

Brain macrophages synthesize interleukin‐1 and interleukin‐1 mRNAs in vitro

1988 • 286 citations

Molecular Cloning and Pro-apoptotic Activity of ICErelII and ICErelIII, Members of the ICE/CED-3 Family of Cysteine Proteases

1995 • 281 citations

Synthesis of interleukin 1/endogenous pyrogen in the brain of endotoxin-treated mice: a step in fever induction?

1984 • 279 citations

Correlation of interleukin-1β and cachectin concentrations in cerebrospinal fluid and outcome from bacterial meningitis

1989 • 278 citations

Concomitant cortical expression of TNF-α and IL-1β mRNAs follows early response gene expression in transient focal ischemia

1994 • 278 citations

The interleukins 1

1989 • 276 citations

Characterization of microglial reaction after middle cerebral artery occlusion in rat brain

1993 • 274 citations

Interleukin-1 Costimulatory Activity on the Interleukin-2 Promoter Via AP-1

1989 • 271 citations

Cloning the interleukin 1 receptor from human T cells.

1989 • 267 citations

Cerebral Infarction

1974 • 266 citations

Identification and Characterization of ICH-2, a Novel Member of the Interleukin-1β-converting Enzyme Family of Cysteine Proteases

1995 • 262 citations

Development of tissue damage, inflammation and resolution following stroke: An immunohistochemical and quantitative planimetric study

1993 • 262 citations

Interleukin-1 receptor antagonist inhibits neuronal damage caused by fluid percussion injury in the rat

1995 • 252 citations

Attenuation of Stroke Size in Rats Using an Adenoviral Vector to Induce Overexpression of Interleukin-1 Receptor Antagonist in Brain

1995 • 245 citations

Interleukin-1 receptor antagonist decreases the number of necrotic neurons in rats with middle cerebral artery occlusion.

1995 • 238 citations

Induction of interleukin-1β mRNA after focal cerebral ischaemia in the rat

1994 • 236 citations

Identification and Characterization of Ich-3, a Member of the Interleukin-1β Converting Enzyme (ICE)/Ced-3 Family and an Upstream Regulator of ICE

1996 • 231 citations

The Progression and Topographic Distribution of Interleukin-1β Expression after Permanent Middle Cerebral Artery Occlusion in the Rat

1999 • 228 citations

Interleukin 1 signaling occurs exclusively via the typeI receptor

1993 • 228 citations

Identification and Characterization of CPP32/Mch2 Homolog 1, a Novel Cysteine Protease Similar to CPP32

1996 • 223 citations

In the Rat, Interleukin- 1α Acts at the Level of the Brain and the Gonads to Interfere with Gonadotropin and Sex Steroid Secretion*

1989 • 215 citations

Presence of a novel primary response gene ST2L, encoding a product highly similar to the interleukin 1 receptor type 1

1993 • 214 citations

pelle encodes a protein kinase required to establish dorsoventral polarity in the Drosophila embryo

1993 • 210 citations

An ICE inhibitor, z-VAD-DCB attenuates ischaemic brain damage in the rat

1996 • 207 citations

Peripheral Administration of Interleukin-1 Receptor Antagonist Inhibits Brain Damage after Focal Cerebral Ischemia in the Rat

1996 • 206 citations

Monocyte adherence to human vascular endothelium

1993 • 205 citations

Suppression of food intake during infection: is interleukin-1 involved?

1985 • 199 citations

Interleukin-1 Directly Stimulates the Release of Corticotrophin Releasing Factor from Rat Hypothalamus

1989 • 198 citations

Tumor Necrosis Factor-α is a Potent ACTH Secretagogue: Comparison to Interleukin-1β

1989 • 196 citations

Expression of interleukin (IL)‐1β, IL‐6 and their respective receptors in the normal rat brain and after injury

1992 • 191 citations

Cholinergic sprouting in the hippocampus: A proposed role for IL-1

1990 • 187 citations

Evidence for different interleukin 1 receptors in murine B- and T-cell lines.

1989 • 186 citations

Localization of type I interleukin-1 receptor mRNA in the rat brain

1994 • 183 citations

The Immune Logical Brain

1987 • 175 citations

Cytokines in neurodegeneration and repair

1995 • 165 citations

Growth-promoting effect of recombinant interleukin 1 and tumor necrosis factor for a human astrocytoma cell line.

1987 • 165 citations

The Interleukin-1 Receptor Antagonist (rhIL-1ra) Protects against Cerebral Infarction in a Rat Model of Hypoxia-Ischemia

1994 • 161 citations

Identification of a high-affinity receptor for interleukin-1 beta in rat brain

1988 • 160 citations

Convulsants induce interleukin-1β messenger RNA in rat brain

1990 • 158 citations

Brain IL-1-induced immunosuppression occurs through activation of both pituitary-adrenal axis and sympathetic nervous system by corticotropin- releasing factor

1990 • 157 citations

Intracerebral injection of proinflammatory cytokines or leukocyte chemotaxins induces minimal myelomonocytic cell recruitment to the parenchyma of the central nervous system.

1992 • 156 citations

Interleukin-1 derived from astrocytes enhances slow wave activity in sleep EEG of the rat

1984 • 154 citations

Expression of transforming growth factor-?1 and interleukin-1? mRNA in rat brain following transient forebrain ischemia

1993 • 150 citations

Increased Expression of IL-1β Converting Enzyme in Hippocampus after Ischemia: Selective Localization in Microglia

1996 • 149 citations

Interleukin-1 Receptor and Receptor Antagonist Gene Expression After Focal Stroke in Rats

1997 • 148 citations

Cytokines: Influence on Glial Cell Gene Expression and Function

1997 • 145 citations

Endogenous Interleukin-1 Receptor Antagonist is Neuroprotective

1997 • 139 citations

The Numerous Postulated Biological Manifestations of Interleukin-1

1984 • 136 citations

Transient Increase of Cytokine-Induced Neutrophil Chemoattractant, a Member of the Interleukin-8 Family, in Ischemic Brain Areas After Focal Ischemia in Rats

1995 • 132 citations

Neutrophil as a mediator of ischemic edema formation in the brain

1991 • 131 citations

Interferon-γ and interleukin-1β induce nitric oxide formation from primary mouse astrocytes

1993 • 115 citations

In situ hybridization study of interleukin-1β mRNA induced by kainic acid in the rat brain

1993 • 114 citations

Sleep and Cerebrospinal Fluid Interleukin-1-Like Activity in the Cat

1988 • 113 citations

Genetic and molecular characterization of tube, a Drosophila gene maternally required for embryonic dorsoventral polarity.

1991 • 113 citations

An in situ hybridization study on interleukin-1β mRNA induced by transient forebrain ischemia in the rat brain

1994 • 109 citations

Possible involvement of interleukin-1 in ischemic brain edema formation

1992 • 108 citations

Interleukin-1 induces analgesia in mice by a central action

1988 • 97 citations

An mRNA homologous to interleukin-1 receptor type I is expressed in cultured rat sympathetic ganglia

1993 • 94 citations

Cytokines and transcription factors

1990 • 91 citations

DNA Damage and Repair in Central Nervous System Injury

1996 • 88 citations

Interleukin-1 receptor antagonist attenuates the heat stroke-induced neuronal damage by reducing the cerebral ischemia in rats

1995 • 86 citations

Cloning and Characterization of an Alternatively Processed Human Type II Interleukin-1 Receptor mRNA

1996 • 86 citations

Astroglial and microglial reactions in the gerbil hippocampus with induced ischemic tolerance

1994 • 83 citations

Cloning of a cDNA encoding a novel interleukin-1 receptor related protein (IL1R-rp2)

1996 • 79 citations

Central activation of thermogenesis and fever by interleukin-1β and interleukin-1α involves different mechanisms

1989 • 74 citations

Interleukin 1 induction of the c-jun promoter.

1993 • 73 citations

Type I interleukin-1 receptors in the mouse brain-endocrine-immune axis labelled with [125I]recombinant human interleukin-1 receptor antagonist

1992 • 69 citations

Molecular cloning of the murine IL-1 beta converting enzyme cDNA.

1992 • 65 citations

Interleukin 1 beta (IL-1 beta) processing in murine macrophages requires a structurally conserved homologue of human IL-1 beta converting enzyme.

1993 • 61 citations

Rat homolog of mouse interleukin-1 receptor accessory protein: cloning, localization and modulation studies

1996 • 61 citations

Localization of lnterleukln-1 Receptor Messenger RNA in Murlne Hippocampus

1991 • 58 citations

Neural Mechanisms in the Pyrogenic and Acute-Phase Responses to Interleukin-1

1988 • 58 citations

Responses of thermosensitive preoptic and septal neurons to hippocampal and brain stem stimulation

1977 • 57 citations

Low Affinity Binding of Interleukin-1β and Intracellular Signaling via NF-κB Identify Fit-1 as a Distant Member of the Interleukin-1 Receptor Family

1995 • 51 citations

Chapter 1 Mechanisms of Nerve Cell Death: Apoptosis or Necrosis After Cerebral Ischaemia

1996 • 50 citations

Localization of Interleukin-1βP Converting Enzyme mRNA in Rat Brain Vasculature: Evidence that the Genes Encoding the Interleukin-1 System Are Constitutively Expressed in Brain Blood Vessels

1995 • 49 citations

Importance of brain IL-1 type II receptors in fever and thermogenesis in the rat

1993 • 45 citations

Murine ST2 gene is a member of the primary response gene family induced by growth factors

1992 • 44 citations

Immunoregulation of cells within the central nervous system

1988 • 41 citations

Interleukin-1 stimulates the expression of type I and type II interleukin-1 receptors in the rat insulinoma cell line Rinm5F; sequencing a rat type II interleukin-1 receptor cDNA.

1994 • 40 citations

Interleukin-1 induced gene expression of neutrophil activating protein (interleukin-8) and monocyte chemotactic peptide in human synovial cells

1991 • 38 citations

Cloning, Tissue Expression and Regulation of Rat Interleukin 1β Converting Enzyme

1995 • 34 citations

Impaired effects of interleukin-1 beta on fever and thermogenesis in genetically obese rats.

1989 • 31 citations

Regionally specific induction of ICE mRNA and enzyme activity in the rat brain and adrenal gland by LPS

1996 • 30 citations

Cytokines: Influence on Glial Cell Gene Expression and Function (Part 1 of 2)

1992 • 20 citations

Species differences in [125I]interleukin-1 binding in brain, endocrine and immune tissues

1993 • 20 citations

Contrasting Effects of Specific Lymphokines on the Survival of Hippocampal Neurons in Culture

1992 • 19 citations

Macrophages in the Brain: Friends or Enemies?

1994 • 18 citations

Evidence that the interleukin-1β-induced prostaglandin E2 release from rat hypothalamus is mediated by type I and type II interleukin-1 receptors

1995 • 18 citations

Hippocampal input to preoptic thermosensitive neurons in the rat

1982 • 17 citations

Leukocyte Adhesion to Endothelium

1993 • 17 citations

Cytokines and neurodegeneration

1997 • 7 citations

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