Reduced Expression of Bcl-2 in CD8+ T Cells Deficient in the IL-15 Receptor α-Chain

Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair

1993 • 1,638 citations

Interleukin-7 mediates the homeostasis of naïve and memory CD8 T cells in vivo

2000 • 1,596 citations

Reversible Defects in Natural Killer and Memory Cd8 T Cell Lineages in Interleukin 15–Deficient Mice

2000 • 1,578 citations

Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice.

1994 • 1,572 citations

Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine.

1995 • 1,447 citations

Cloning of a T Cell Growth Factor that Interacts with the β Chain of the Interleukin-2 Receptor

1994 • 1,423 citations

IL-15 Receptor Maintains Lymphoid Homeostasis by Supporting Lymphocyte Homing and Proliferation

1998 • 1,293 citations

Potent and Selective Stimulation of Memory-Phenotype CD8+ T Cells In Vivo by IL-15

1998 • 1,262 citations

bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes

1991 • 1,223 citations

Efficient in vivo manipulation of mouse genomic sequences at the zygote stage.

1996 • 1,124 citations

Interleukin (IL) 15 is a novel cytokine that activates human natural killer cells via components of the IL-2 receptor.

1994 • 1,079 citations

Defective lymphoid development in mice lacking expression of the common cytokine receptor γ chain

1995 • 1,024 citations

Utilization of the beta and gamma chains of the IL-2 receptor by the novel cytokine IL-15.

1994 • 1,008 citations

Interleukin 15: biology and relevance to human disease

2001 • 947 citations

Lymphoid development in mice with a targeted deletion of the interleukin 2 receptor gamma chain.

1995 • 881 citations

Control of Homeostasis of CD8 ⁺ Memory T Cells by Opposing Cytokines

2000 • 847 citations

Identification and cloning of a novel IL-15 binding protein that is structurally related to the alpha chain of the IL-2 receptor.

1995 • 627 citations

Bcl-2 Rescues T Lymphopoiesis in Interleukin-7 Receptor–Deficient Mice

1997 • 603 citations

The IL-2 Receptor Complex: Its Structure, Function, and Target Genes

1993 • 601 citations

Positive selection of lymphocytes

1994 • 563 citations

IL-15 has stimulatory activity for the induction of B cell proliferation and differentiation.

1995 • 445 citations

IL-2-induced activation-induced cell death is inhibited in IL-15 transgenic mice

2000 • 419 citations

Targeted disruption of Bcl-2 alpha beta in mice: occurrence of gray hair, polycystic kidney disease, and lymphocytopenia.

1994 • 396 citations

Functional Characterization of the Human Interleukin-15 Receptor αChain and Close Linkage of IL15RA and IL2RA Genes

1995 • 363 citations

Cutting Edge: Increased Expression of Bcl-2 in Antigen-Specific Memory CD8+ T Cells

2000 • 355 citations

The Earliest T Lineage–Committed Cells Depend on IL-7 for Bcl-2 Expression and Normal Cell Cycle Progression

1997 • 338 citations

Expression of the Bcl-2 protein in murine and human thymocytes and in peripheral T lymphocytes.

1993 • 286 citations

Modulation of hematopoiesis in mice with a truncated mutant of the interleukin-2 receptor gamma chain

1996 • 268 citations

Bcl-2 is upregulated at the CD4+ CD8+ stage during positive selection and promotes thymocyte differentiation at several control Points

1994 • 252 citations

CD69 cell surface expression identifies developing thymocytes which audition for T cell antigen receptor-mediated positive selection

1993 • 225 citations

Bcl-2 Rescues T Lymphopoiesis, but Not B or NK Cell Development, in Common γ Chain–Deficient Mice

1997 • 220 citations

Functional differences between memory and naive CD8 T cells

1999 • 211 citations

Death deflected: IL‐15 inhibits TNF‐α‐mediated apoptosis in fibroblasts by TRAF2 recruitment to the IL‐15Rα chain

1999 • 155 citations

Functional Roles of Fas and Bcl-2-Regulated Apoptosis of T Lymphocytes

1998 • 126 citations

Identification and cloning of a novel IL-15 binding protein that is structurally related to the α chain of the IL-2 receptor.

1995 • 107 citations

Bcl-2 expression during T-cell development: early loss and late return occur at specific stages of commitment to differentiation and survival.

1994 • 106 citations

Quiescence-Inducing and Antiapoptotic Activities of IL-15 Enhance Secondary CD4+ T Cell Responsiveness to Antigen

1998 • 79 citations

IL-15/IL-15Rα intracellular trafficking in human melanoma cells and signal transduction through the IL-15Rα

2000 • 72 citations

Interaction of IL-15 with the shared IL-2 receptor beta and gamma c subunits. The IL-15/beta/gamma c receptor-ligand complex is less stable than the IL-2/beta/gamma c receptor-ligand complex.

1996 • 56 citations

IL-15 promotes survival but not effector function differentiation of CD8+ TCRalphabeta+ intestinal intraepithelial lymphocytes.

1999 • 55 citations

Differential effects of IL-2 and IL-15 on the death and survival of activated TCR gamma delta+ intestinal intraepithelial lymphocytes.

1999 • 51 citations

Differential Effects of IL-2 and IL-15 on the Death and Survival of Activated TCRγδ+ Intestinal Intraepithelial Lymphocytes

1999 • 43 citations

IL-15 Promotes Survival But Not Effector Function Differentiation of CD8+ TCRαβ+ Intestinal Intraepithelial Lymphocytes

1999 • 43 citations

Role of Bcl-2 in alpha beta T cell development in mice deficient in the common cytokine receptor gamma-chain: the requirement for Bcl-2 differs depending on the TCR/MHC affinity.

1999 • 41 citations

Role of Bcl-2 in αβ T Cell Development in Mice Deficient in the Common Cytokine Receptor γ-Chain: The Requirement for Bcl-2 Differs Depending on the TCR/MHC Affinity

1999 • 40 citations