Naive CD4+ lymphocytes convert to anergic or memory-like cells in T cell-deprived recipients

RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement

1992 • 2,618 citations

Turnover of naive- and memory-phenotype T cells.

1994 • 900 citations

Differential Requirements for Survival and Proliferation of CD8 Naïve or Memory T Cells

1997 • 875 citations

The Peptide Ligands Mediating Positive Selection in the Thymus Control T Cell Survival and Homeostatic Proliferation in the Periphery

1999 • 742 citations

Selective development of CD4+ T cells in transgenic mice expressing a class II MHC-restricted antigen receptor

1989 • 646 citations

Naive T Cells Transiently Acquire a Memory-like Phenotype during Homeostasis-Driven Proliferation

2000 • 644 citations

CD5 Expression Is Developmentally Regulated By T Cell Receptor (TCR) Signals and TCR Avidity

1998 • 643 citations

Low-Affinity Ligands for the TCR Drive Proliferation of Mature CD8+ T Cells in Lymphopenic Hosts

1999 • 548 citations

Response of naïve and memory CD8+ T cells to antigen stimulation in vivo

2000 • 542 citations

Homeostasis-Stimulated Proliferation Drives Naive T Cells to Differentiate Directly into Memory T Cells

2000 • 527 citations

Cutting Edge: Naive T Cells Masquerading as Memory Cells

2000 • 476 citations

Peripheral T Cell Survival Requires Continual Ligation of the T Cell Receptor to Major Histocompatibility Complex–Encoded Molecules

1997 • 419 citations

Lymphocyte life-span and memory

1994 • 405 citations

Survival of Mature CD4 T Lymphocytes Is Dependent on Major Histocompatibility Complex Class II–expressing Dendritic Cells

1997 • 402 citations

MHC Class II Molecules Are Not Required for Survival of Newly Generated CD4+ T Cells, but Affect Their Long-Term Life Span

1996 • 377 citations

Homeostatic expansion and phenotypic conversion of naïve T cells in response to self peptide/MHC ligands

1999 • 341 citations

Designing and Maintaining the Mature TCR Repertoire

1999 • 323 citations

Homeostatic T Cell Proliferation

2000 • 279 citations

Lower receptor avidity required for thymic clonal deletion than for effector T-cell function

1991 • 263 citations

Specificity and flexibility in thymic selection

1994 • 221 citations

MHC Class II–Specific T Cells Can Develop in the CD8 Lineage When CD4 Is Absent

1996 • 218 citations

Targeted Complementation of MHC Class II Deficiency by Intrathymic Delivery of Recombinant Adenoviruses

1997 • 204 citations

Divergent Changes in the Sensitivity of Maturing T Cells to Structurally Related Ligands Underlies Formation of a Useful T Cell Repertoire

1999 • 176 citations

The peripheral T cell repertoire: independent homeostatic regulation of virgin and activated CD8⁺ T cell pools

1995 • 174 citations

Involvement of the same region of the T cell antigen receptor in thymic selection and foreign peptide recognition.

1992 • 159 citations

Tetracycline-controllable Selection of CD4+ T Cells: Half-Life and Survival Signals in the Absence of Major Histocompatibility Complex Class II Molecules

2000 • 158 citations

Mature T cell reactivity altered by peptide agonist that induces positive selection.

1996 • 148 citations

Naïve cytotoxic T lymphocytes spontaneously acquire effector function in lymphocytopenic recipients: A pitfall for T cell memory studies?

1999 • 146 citations

Tuning of activation thresholds explains flexibility in the selection and development of T cells in the thymus

1996 • 135 citations

Peripheral Selection of T Cell Repertoires: The Role of Continuous Thymus Output

1997 • 134 citations

Lymphocyte homeostasis

1997 • 133 citations

The life span of naive alpha/beta T cells in secondary lymphoid organs.

1993 • 130 citations

The organization of mature T-cell pools

1998 • 108 citations

Differential Survival of Naive CD4 and CD8 T Cells

2000 • 98 citations

Ligand thresholds at different stages of T cell development

1990 • 84 citations

Cell division in the compartment of naive and memory T lymphocytes

1996 • 84 citations

Selective Induction of Apoptosis in Mature T Lymphocytes by Variant T Cell Receptor Ligands

1998 • 72 citations

Critical role for the common cytokine receptor gamma chain in intrathymic and peripheral T cell selection.

1996 • 64 citations

Opening a Window on Thymic Positive Selection: Developmental Changes in the Influence of Cosignaling by Integrins and CD28 on Selection Events Induced by TCR Engagement

2000 • 43 citations