Monoassociation of SCID mice with Helicobacter muridarum, but not four other enterics, provokes IBD upon receipt of T cells

UNIDENTIFIED CURVED BACILLI IN THE STOMACH OF PATIENTS WITH GASTRITIS AND PEPTIC ULCERATION

1984 • 5,344 citations

Interleukin-10-deficient mice develop chronic enterocolitis

1993 • 4,225 citations

Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene

1993 • 1,762 citations

Resident Enteric Bacteria Are Necessary for Development of Spontaneous Colitis and Immune System Activation in Interleukin-10-Deficient Mice

1998 • 1,451 citations

A distinct array of proinflammatory cytokines is expressed in human colon epithelial cells in response to bacterial invasion.

1995 • 1,205 citations

Inhibition of Thl responses prevents inflammatory bowel disease in scid mice reconstituted with CD45RBhi CD4+ T cells

1994 • 1,129 citations

The germfree state prevents development of gut and joint inflammatory disease in HLA-B27 transgenic rats.

1994 • 1,128 citations

Phenotypically distinct subsets of CD4⁺ T cells induce or protect from chronic intestinal inflammation in C. B-17 scid mice

1993 • 1,064 citations

Normal luminal bacteria, especially Bacteroides species, mediate chronic colitis, gastritis, and arthritis in HLA-B27/human beta2 microglobulin transgenic rats.

1996 • 795 citations

Campylobacter pylori and Peptic Ulcer Disease

1989 • 760 citations

CD4+ T cells that express high levels of CD45RB induce wasting disease when transferred into congenic severe combined immunodeficient mice. Disease development is prevented by cotransfer of purified CD4+ T cells.

1993 • 471 citations

Commensal enteric bacteria engender a self-limiting humoral mucosal immune response while permanently colonizing the gut

1995 • 395 citations

CD4+ T Cells Reactive to Enteric Bacterial Antigens in Spontaneously Colitic C3H/HeJBir Mice: Increased T Helper Cell Type 1 Response and Ability to Transfer Disease

1998 • 393 citations

Segmented Filamentous Bacteria Are Potent Stimuli of a Physiologically Normal State of the Murine Gut Mucosal Immune System

1999 • 370 citations

Pathogenicity of Helicobacter pylori: a perspective

1993 • 327 citations

Analysis of intestinal lymphocytes in mouse colitis mediated by transfer of CD4+, CD45RBhigh T cells to SCID recipients.

1997 • 320 citations

Inflammatory bowel disease: an immunity-mediated condition triggered by bacterial infection with Helicobacter hepaticus

1997 • 318 citations

T cell specificity and cross reactivity towards enterobacteria,Bacteroides,Bifidobacterium, and antigens from resident intestinal flora in humans

1999 • 261 citations

Evaluation of the relatedness of Brucella spp. and Ochrobactrum anthropi and description of Ochrobactrum intermedium sp. nov., a new species with a closer relationship to Brucella spp.

1998 • 207 citations

Helicobacter muridarum sp. nov., a Microaerophilic Helical Bacterium with a Novel Ultrastructure Isolated from the Intestinal Mucosa of Rodents

1992 • 191 citations

Lymphoid Hyperplasia, Autoimmunity, and Compromised Intestinal Intraepithelial Lymphocyte Development in Colitis-Free Gnotobiotic IL-2-Deficient Mice

1998 • 180 citations

Persistent hepatitis and enterocolitis in germfree mice infected with Helicobacter hepaticus

1996 • 175 citations

Helicobacter bilis-induced inflammatory bowel disease in scid mice with defined flora

1997 • 169 citations

Nonlymphocyte-Derived Tumor Necrosis Factor Is Required for Induction of Colitis in Recombination Activating Gene (Rag)2−/− Mice upon Transfer of Cd4+Cd45rbhi T Cells

1999 • 124 citations

Isolation and characterization of a spiral bacterium from the crypts of rodent gastrointestinal tracts

1983 • 90 citations

Enteric bacterial antigens activate CD4+ T cells fromscid mice with inflammatory bowel disease

2001 • 90 citations

Alteration of Vβ Usage and Cytokine Production of CD4+ TCR ββ Homodimer T Cells by Elimination of Bacteroides vulgatus Prevents Colitis in TCR α-Chain-Deficient Mice

2000 • 68 citations

T cell control of the gut IgA response against commensal bacteria

2001 • 62 citations

Systemic Activation and Antigen-Driven Oligoclonal Expansion of T Cells in a Mouse Model of Colitis

2000 • 58 citations

Gut Colonization of Mice withactA-Negative Mutant ofListeria monocytogenesCan Stimulate a Humoral Mucosal Immune Response

2001 • 45 citations

Spiral bacterium associated with gastric, ileal and caecal mucosa of mice

1992 • 43 citations

Comparison of four diagnostic methods for detection of Helicobacter species in laboratory mice.

1998 • 33 citations

Selective engraftment of memory CD4⁺ T cells with an unusual recirculation pattern and a diverse T cell receptor‐Vβ repertoire into scid mice

1993 • 21 citations

Gastrointestinal Microflora

1983 • 15 citations

Alteration of Vβ Usage and Cytokine Production of CD4+ TCRββ Homodimer T Cells by Elimination of Bacteroides vulgatus Prevents Colitis in TCRα - Chain-Deficient Mice1

2001 • 5 citations