Neurotoxicant-induced animal models of Parkinson?s disease: understanding the role of rotenone, maneb and paraquat in neurodegeneration

Mutation in the α-Synuclein Gene Identified in Families with Parkinson's Disease

1997 • 7,814 citations

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

1998 • 5,063 citations

Chronic Parkinsonism in Humans Due to a Product of Meperidine-Analog Synthesis

1983 • 4,822 citations

α-Synuclein Locus Triplication Causes Parkinson's Disease

2003 • 4,187 citations

Chronic systemic pesticide exposure reproduces features of Parkinson's disease

2000 • 3,559 citations

α-Synuclein in filamentous inclusions of Lewy bodies from Parkinson’s disease and dementia with Lewy bodies

1998 • 2,898 citations

Reactive microglia are positive for HLA‐DR in the substantia nigra of Parkinson's and Alzheimer's disease brains

1988 • 2,754 citations

Mutations in the DJ-1 Gene Associated with Autosomal Recessive Early-Onset Parkinsonism

2003 • 2,691 citations

The new mutation, E46K, of α‐synuclein causes parkinson and Lewy body dementia

2003 • 2,591 citations

Mitochondrial Complex I Deficiency in Parkinson's Disease

1990 • 2,147 citations

Oxidative stress in Parkinson's disease

2003 • 2,001 citations

Parkinson's Disease

1998 • 1,953 citations

Generation of superoxide anion by the NADH dehydrogenase of bovine heart mitochondria

1980 • 1,609 citations

THE MITOCHONDRIAL ELECTRON TRANSPORT AND OXIDATIVE PHOSPHORYLATION SYSTEM

1985 • 1,599 citations

Oxidative Damage Linked to Neurodegeneration by Selective α-Synuclein Nitration in Synucleinopathy Lesions

2000 • 1,526 citations

Neuropathology of Parkinsonʼs Disease

1996 • 1,457 citations

6-hydroxy-dopamine induced degeneration of central monoamine neurons

1968 • 1,419 citations

Basal Lipid Peroxidation in Substantia Nigra Is Increased in Parkinson's Disease

1989 • 1,369 citations

Chronic parkinsonism secondary to intravenous injection of meperidine analogues

1979 • 1,356 citations

Alpha-synuclein and neurodegenerative diseases

2001 • 1,339 citations

Inhibition of NADH-linked oxidation in brain mitochondria by 1-methyl-4-phenyl-pyridine, a metabolite of the neurotoxin, 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine

1985 • 1,236 citations

Mechanism of Toxicity in Rotenone Models of Parkinson's Disease

2003 • 1,003 citations

Evidence of active nerve cell degeneration in the substantia nigra of humans years after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine exposure

1999 • 967 citations

Parkinson Disease in Twins<SUBTITLE>An Etiologic Study</SUBTITLE>

1999 • 861 citations

Regional Difference in Susceptibility to Lipopolysaccharide-Induced Neurotoxicity in the Rat Brain: Role of Microglia

2000 • 859 citations

Antioxidants, Oxidative Stress, and Degenerative Neurological Disorders

1999 • 828 citations

Oxidative DNA Damage in the Parkinsonian Brain: An Apparent Selective Increase in 8‐Hydroxyguanine Levels in Substantia Nigra

1997 • 822 citations

BLOCKADE OF ENDOGENOUS NOREPINEPHRINE SYNTHESIS BY ALPHA-METHYL-TYROSINE, AN INHIBITOR OF TYROSINE HYDROXYLASE.

1965 • 813 citations

Environmental Risk Factors and Parkinson's Disease: Selective Degeneration of Nigral Dopaminergic Neurons Caused by the Herbicide Paraquat

2002 • 804 citations

Association of Coffee and Caffeine Intake With the Risk of Parkinson Disease

2000 • 755 citations

Subcutaneous Rotenone Exposure Causes Highly Selective Dopaminergic Degeneration and α-Synuclein Aggregation

2002 • 695 citations

Prospective study of caffeine consumption and risk of Parkinson's disease in men and women

2001 • 659 citations

Complex I-mediated reactive oxygen species generation: modulation by cytochrome c and NAD(P)+ oxidation–reduction state

2002 • 656 citations

The Herbicide Paraquat Causes Up-regulation and Aggregation of α-Synuclein in Mice

2002 • 644 citations

Oxidative stress and nitration in neurodegeneration: Cause, effect, or association?

2003 • 634 citations

The risk of Parkinson's disease with exposure to pesticides, farming, well water, and rural living

1998 • 630 citations

Oxidative stress and nitration in neurodegeneration: Cause, effect, or association?

2003 • 626 citations

Environmental risk factors and Parkinson's disease

1997 • 605 citations

Animal models of Parkinson's disease

2002 • 580 citations

Protein Nitration in Parkinsonʼs Disease

1998 • 551 citations

A Generalised Increase in Protein Carbonyls in the Brain in Parkinson's but Not Incidental Lewy Body Disease

1997 • 549 citations

Role of oxidation in the neurotoxic effects of intrastriatal dopamine injections.

1996 • 544 citations

Manganese action in brain function

2003 • 531 citations

Redox Control of Cell Death

2002 • 531 citations

Iron and Aluminum Increase in the Substantia Nigra of Patients with Parkinson's Disease: An X‐Ray Microanalysis

1991 • 518 citations

Oxidative mechanisms in nigral cell death in Parkinson's disease.

1998 • 517 citations

Mitochondria, Oxidative Damage, and Inflammation in Parkinson's Disease

2003 • 512 citations

The respiratory‐chain NADH dehydrogenase (complex I) of mitochondria

1991 • 489 citations

A Protein-Chameleon: Conformational Plasticity of α-Synuclein, a Disordered Protein Involved in Neurodegenerative Disorders

2003 • 474 citations

Cytotoxic and genotoxic potential of dopamine

1999 • 465 citations

AETIOLOGY OF PARKINSON'S DISEASE

1983 • 463 citations

The Nigrostriatal Dopaminergic System as a Preferential Target of Repeated Exposures to Combined Paraquat and Maneb: Implications for Parkinson's Disease

2000 • 462 citations

Rotenone destroys dopaminergic neurons and induces parkinsonian symptoms in rats

2002 • 457 citations

Increased Protein Oxidation in Human Substantia Nigra Pars Compacta in Comparison with Basal Ganglia and Prefrontal Cortex Measured with an Improved Dinitrophenylhydrazine Assay

1998 • 440 citations

Distinct Role for Microglia in Rotenone-Induced Degeneration of Dopaminergic Neurons

2002 • 436 citations

Parkinson's disease and exposure to agricultural work and pesticide chemicals

1992 • 429 citations

Possible environmental, occupational, and other etiologic factors for Parkinson's disease

1996 • 424 citations

Neuromelanin-containing neurons of the substantia nigra accumulate iron and aluminum in Parkinson's disease: a LAMMA study

1992 • 423 citations

Occupational exposure to manganese, copper, lead, iron, mercury and zinc and the risk of Parkinson's disease.

1999 • 422 citations

Oxidative stress induces amyloid-like aggregate formation of NACP/α-synuclein in vitro

1999 • 421 citations

Paraquat elicited neurobehavioral syndrome caused by dopaminergic neuron loss

1999 • 416 citations

α‐Synuclein Up‐Regulation in Substantia Nigra Dopaminergic Neurons Following Administration of the Parkinsonian Toxin MPTP

2000 • 379 citations

Mechanisms of action of 6-hydroxydopamine

1975 • 353 citations

Pesticides directly accelerate the rate of α‐synuclein fibril formation: a possible factor in Parkinson's disease

2001 • 348 citations

The environment and Parkinson's disease: is the nigrostriatal system preferentially targeted by neurotoxins?

2003 • 348 citations

Locus ceruleus lesions and eosinophilic inclusions in MPTP‐treated monkeys

1986 • 347 citations

Alterations in the distribution of glutathione in the substantia nigra in Parkinson's disease

1997 • 340 citations

Complex I and Parkinson's Disease

2001 • 334 citations

Critical Role for Microglial NADPH Oxidase in Rotenone-Induced Degeneration of Dopaminergic Neurons

2003 • 328 citations

Chronic systemic complex I inhibition induces a hypokinetic multisystem degeneration in rats

2003 • 323 citations

Regulation of the Permeability Transition Pore in Skeletal Muscle Mitochondria

1998 • 321 citations

The role of α-synuclein in Parkinson's disease: insights from animal models

2003 • 318 citations

Parkinson's disease, pesticides, and glutathione transferase polymorphisms

1998 • 314 citations

Potentiated and preferential effects of combined paraquat and maneb on nigrostriatal dopamine systems: environmental risk factors for Parkinson’s disease?

2000 • 313 citations

Selective microglial activation in the rat rotenone model of Parkinson's disease

2003 • 308 citations

α‐Synuclein and Parkinson's disease

2004 • 305 citations

The role of inheritance in sporadic Parkinson's disease: Evidence from a longitudinal study of dopaminergic function in twins

1999 • 302 citations

Carcinogenicity, mutagenicity and teratogenicity of manganese compounds

2002 • 282 citations

Parkinson's disease

1993 • 281 citations

Widespread Nitration of Pathological Inclusions in Neurodegenerative Synucleinopathies

2000 • 276 citations

The role of environmental toxins in the etiology of Parkinson's disease

1989 • 274 citations

Familial Aggregation of Parkinson's Disease in Iceland

2000 • 274 citations

Age‐related irreversible progressive nigrostriatal dopaminergic neurotoxicity in the paraquat and maneb model of the Parkinson's disease phenotype

2003 • 268 citations

Part II: α-synuclein and its molecular pathophysiological role in neurodegenerative disease

2003 • 263 citations

Chronic exposure to the fungicide maneb may produce symptoms and signs of CNS manganese intoxication

1988 • 255 citations

Synergistic Dopaminergic Neurotoxicity of the Pesticide Rotenone and Inflammogen Lipopolysaccharide: Relevance to the Etiology of Parkinson's Disease

2003 • 248 citations

Apoptosis: biochemical aspects and clinical implications

2002 • 246 citations

Environmental Factors in Parkinson’s Disease

2002 • 238 citations

Nutritional and occupational factors influencing the risk of Parkinson's disease: A case-control study in southeastern Sweden

1999 • 236 citations

Manganese ethylene‐bis‐dithiocarbamate and selective dopaminergic neurodegeneration in rat: a link through mitochondrial dysfunction

2003 • 225 citations

Human Complex I deficiency: Clinical spectrum and involvement of oxygen free radicals in the pathogenicity of the defect

1998 • 220 citations

Mechanisms of Toxicity, Clinical Features, and Management of Diquat Poisoning: A Review

2000 • 216 citations

Developmental Exposure to the Pesticides Paraquat and Maneb and the Parkinson’s Disease Phenotype

2002 • 212 citations

Parkinsonism after chronic exposure to the fungicide maneb (manganese ethylene-bis-dithiocarbamate).

1994 • 196 citations

Synergistic Effects of Pesticides and Metals on the Fibrillation of α-Synuclein: Implications for Parkinson’s Disease

2002 • 194 citations

Diet and Parkinson's disease II

1996 • 191 citations

Manganese: brain transport and emerging research needs.

2000 • 187 citations

Rotenone induces non‐specific central nervous system and systemic toxicity

2004 • 184 citations

Dose-dependent protective effect of coffee, tea, and smoking in Parkinson's disease: a study in ethnic Chinese

2003 • 182 citations

The etiology of Parkinson's disease with emphasis on the MPTP story

1996 • 181 citations

Role of the Mitochondrial Membrane Permeability Transition (MPT) in Rotenone-Induced Apoptosis in Liver Cells

2000 • 181 citations

Neurologic Effects of Manganese in Humans: A Review

2003 • 178 citations

Nitric Oxide and Reactive Oxygen Species in Parkinson's Disease

2003 • 172 citations

“Apoptotic” biochemical cascades in synaptic compartments: Roles in adaptive plasticity and neurodegenerative disorders

1999 • 168 citations

Aluminum-containing antacids as a cause of idiopathic Parkinson's disease

1999 • 168 citations

Changes in dopamine levels in the corpus striatum following lesions in the substantia nigra

1969 • 161 citations

Calcium, magnesium and aluminum concentrations in Parkinson's disease.

1992 • 160 citations

The MPTP model: versatile contributions to the treatment of idiopathic Parkinson's disease

1990 • 159 citations

α-Synuclein and the Lewy body disorders

2001 • 157 citations

Risk Factors for Parkinson’s Disease: The Leisure World Cohort Study

2001 • 156 citations

Risk-factors for Parkinson's disease: case-control study in the province of Cáceres, Spain

2009 • 152 citations

Three-dimensional structure of NADH-dehydrogenase from Neurospora crassa by electron microscopy and conical tilt reconstruction

1997 • 151 citations

Comparative studies on the mechanisms of paraquat and 1-methyl-4-phenylpyridine (MPP+) cytotoxicity

1986 • 142 citations

In Vivo Labeling of Mitochondrial Complex I (NADH:UbiquinoneOxidoreductase) in Rat Brain Using [³H]Dihydrorotenone

2000 • 142 citations

Paraquat Poisoning

1990 • 139 citations

Rotenone Inhibits the Mitochondrial Permeability Transition-induced Cell Death in U937 and KB Cells

2001 • 135 citations

A case‐control study of Parkinson's disease in a horticultural region of British Columbia

1994 • 135 citations

Current Evidence for Neuroprotective Effects of Nicotine and Caffeine Against Parkinson??s Disease

2001 • 135 citations

Paraquat induces long-lasting dopamine overflow through the excitotoxic pathway in the striatum of freely moving rats

2003 • 133 citations

Functional coupling of PSST and ND1 subunits in NADH:ubiquinone oxidoreductase established by photoaffinity labeling

2001 • 128 citations

INHIBITION OF CATECHOLAMINE SYNTHESIS IN MAN WITH ALPHA-METHYL-TYROSINE, AN INHIBITOR OF TYROSINE HYDROXYLASE

1965 • 126 citations

The pesticide rotenone induces caspase‐3‐mediated apoptosis in ventral mesencephalic dopaminergic neurons

2003 • 125 citations

Genetics of Parkinson's disease

2001 • 124 citations

Molecular Signals for Glial Activation: Pro- and Anti-Inflammatory Cytokines in the Injured Brain

1999 • 124 citations

Oxidative Damage to Proteins, Lipids, and DNA in Cortical Brain Regions from Patients with Dementia with Lewy Bodies

1998 • 122 citations

Interaction of α‐Phenyl‐N‐tert‐Butyl Nitrone and Alternative Electron Acceptors with Complex I Indicates a Substrate Reduction Site Upstream from the Rotenone Binding Site

1998 • 118 citations

Mechanism for generation of hydrogen peroxide and change of mitochondrial membrane potential during rotenone-induced apoptosis

2003 • 117 citations

A Pure Parkinsonian Syndrome Following Acute Carbon Monoxide Intoxication

1982 • 114 citations

Participation of prostate apoptosis response-4 in degeneration of dopaminergic neurons in models of Parkinson's disease

1999 • 114 citations

Genetics of Parkinson's disease.

2004 • 108 citations

Prostate Apoptosis Response‐4 Production in Synaptic Compartments Following Apoptotic and Excitotoxic Insults

1999 • 94 citations

Parkinsons Disease and other α-Synucleinopathies

2001 • 94 citations

A Case-Control Study on Cigarette, Alcohol, and Coffee Consumption Preceding Parkinson’s Disease

2003 • 93 citations

Effects of metals on the nervous system of humans and animals.

2001 • 92 citations

[³H]Dihydrorotenone Binding to NADH: Ubiquinone Reductase (Complex I) of the Electron Transport Chain: An Autoradiographic Study

1996 • 91 citations

Models of Parkinson's disease

2003 • 89 citations

Paraquat leads to dopaminergic neural vulnerability in organotypic midbrain culture

2003 • 84 citations

Parkinsonism, pyramidal signs, polyneuropathy, and cognitive decline after long-term occupational solvent exposure

1999 • 83 citations

Rotenone-Induced G2/M Cell Cycle Arrest and Apoptosis in a Human B Lymphoma Cell Line PW

2001 • 77 citations

Maneb enhances MPTP neurotoxicity in mice.

1989 • 73 citations

Paraquat: A Useful Tool for the in vivo Study of Mechanisms of Neuronal Cell Death

1998 • 72 citations

Parkinsonism induced by solvent abuse

1994 • 68 citations

Parkinson’s Disease and Related Synucleinopathies are a New Class of Nervous System Amyloidoses

2002 • 65 citations

Paraquat- and Diquat-Induced Oxygen Radical Generation and Lipid Peroxidation in Rat Brain Microsomes

2002 • 63 citations

Combinatorial synthesis of novel and potent inhibitors of NADH:ubiquinone oxidoreductase

2000 • 62 citations

Environmental risk factors for Parkinson's disease in an urban multiethnic community

1998 • 62 citations

Genetics of parkinson's disease

1998 • 61 citations

Acute exposure to maneb alters some behavioral functions in the mouse

1989 • 60 citations

Paraquat and two endogenous analogues of the neurotoxic substance N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine do not damage dopaminergic nigrostriatal neurons in the mouse

1986 • 57 citations

The Parkinsonian Models: Invertebrates to Mammals

2000 • 51 citations

Dopamine is involved in selectivity of dopaminergic neuronal death by rotenone

2003 • 51 citations

Toxicity of fungicides containing ethylene-bis-dithiocarbamate in serumless dissociated mesencephalic-striatal primary coculture

1996 • 44 citations

Clinical and pathological features in hydrocarbon‐induced Parkinsonism

1996 • 41 citations

Evaluation of risk of Parkinson's disease in a cohort of licensed pesticide users

2002 • 37 citations

Ethylenebisdithiocarbamate enhances MPTP-induced striatal dopamine depletion in mice.

2000 • 32 citations

The role of environmental agents in Parkinson's disease

2001 • 31 citations

ACTIONS OF 6‐HYDROXYDOPAMINE QUINONES ON CATECHOLAMINE NEURONS¹

1975 • 30 citations

Parkinsonism from methanol poisoning: Benefit from treatment with anti-parkinson drugs

1999 • 28 citations

Mechanism of paraquat-stimulated lipid peroxidation in mouse brain and pulmonary microsomes

1991 • 26 citations

Different Effects of Paraquat on Microsomal Lipid Peroxidation in Mouse Brain, Lung and Liver

1991 • 22 citations

α-Synuclein and Parkinson’s disease

1999 • 9 citations

Seventeenth Annual Symposia on Etiology, Pathogenesis, and Treatment of Parkinson's Disease and Other Movement Disorders

2003 • 7 citations

Effects of MPTP, MPP+, and paraquat on NADPH-dependent lipid peroxidation in mouse brain and lung microsomes

1991 • 5 citations

Interaction between dual NADPH-dependent reactions of paraquat in mouse brain microsomes.

1991 • 2 citations

Deleted Work

1955 • 0 citations