The pesticide rotenone induces caspase‐3‐mediated apoptosis in ventral mesencephalic dopaminergic neurons

Caspases: Enemies Within

1998 • 6,923 citations

Chronic Parkinsonism in Humans Due to a Product of Meperidine-Analog Synthesis

1983 • 4,822 citations

Chronic systemic pesticide exposure reproduces features of Parkinson's disease

2000 • 3,559 citations

Mitochondrial Complex I Deficiency in Parkinson's Disease

1990 • 2,147 citations

ETIOLOGY AND PATHOGENESIS OF PARKINSON'S DISEASE

1999 • 1,387 citations

Calcium-binding proteins in the nervous system

1992 • 1,321 citations

Abnormalities of the electron transport chain in idiopathic parkinson's disease

1989 • 1,067 citations

Oxidative stress and the pathogenesis of Parkinson's disease

1996 • 967 citations

Parkinson Disease in Twins<SUBTITLE>An Etiologic Study</SUBTITLE>

1999 • 861 citations

Inhibition of interleukin 1β converting enzyme family proteases reduces ischemic and excitotoxic neuronal damage

1997 • 835 citations

Activation of CPP32-Like Caspases Contributes to Neuronal Apoptosis and Neurological Dysfunction after Traumatic Brain Injury

1997 • 584 citations

AnIn VitroModel of Parkinson's Disease: Linking Mitochondrial Impairment to Altered α-Synuclein Metabolism and Oxidative Damage

2002 • 575 citations

Distinct Role for Microglia in Rotenone-Induced Degeneration of Dopaminergic Neurons

2002 • 436 citations

Relative sparing in Parkinson's disease of substantia nigra dopamine neurons containing calbindin-D28K

1990 • 433 citations

Dopamine Transporter Is Required for In Vivo MPTP Neurotoxicity: Evidence from Mice Lacking the Transporter

1997 • 358 citations

BRAIN, SKELETAL MUSCLE AND PLATELET HOMOGENATE MITOCHONDRIAL FUNCTION IN PARKINSON'S DISEASE

1992 • 341 citations

Chronic systemic complex I inhibition induces a hypokinetic multisystem degeneration in rats

2003 • 323 citations

Midbrain Dopaminergic Cell Loss in Parkinson's Disease and MPTP‐Induced Parkinsonism: Sparing of Calbindin‐D_25k—Containing Cells^a

1992 • 314 citations

Caspase-9 Activation Results in Downstream Caspase-8 Activation and Bid Cleavage in 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Induced Parkinson's Disease

2001 • 310 citations

The parkinsonian neurotoxin MPP+ opens the mitochondrial permeability transition pore and releases cytochrome c in isolated mitochondria via an oxidative mechanism

1999 • 304 citations

MPTP Toxicity: Implications for Research in Parkinson's Disease

1988 • 287 citations

Caspase inhibition reduces apoptosis and increases survival of nigral transplants

1999 • 283 citations

Caspase-8 Is an Effector in Apoptotic Death of Dopaminergic Neurons in Parkinson's Disease, But Pathway Inhibition Results in Neuronal Necrosis

2001 • 265 citations

Substrate and Site Specificity of Hydrogen Peroxide Generation in Mouse Mitochondria

1998 • 237 citations

Chapter 36: Astrocytes and Parkinson's disease

1992 • 226 citations

Pesticides and Parkinson's disease

1999 • 204 citations

Do environmental toxins cause Parkinson's disease? A critical review.

1990 • 200 citations

Systemic administration of rotenone produces selective damage in the striatum and globus pallidus, but not in the substantia nigra

1997 • 200 citations

Parkinson's disease mortality and pesticide exposure in California 1984–1994

2000 • 199 citations

Caspase-Mediated Apoptosis in Neuronal Excitotoxicity Triggered by Nitric Oxide

1997 • 191 citations

Immunohistochemical markers in rat brain: colocalization of calretinin and calbindin-D28k with tyrosine hydroxylase

1992 • 165 citations

II. Selective accumulation of MPP+ in the substantia nigra: A key to neurotoxicity?

1985 • 163 citations

Calcium-binding proteins in primate basal ganglia

1996 • 124 citations

Genetics of Parkinson's disease

2001 • 124 citations

Effect of 1,25-dihydroxyvitamin D3 on cultured mesencephalic dopaminergic neurons to the combined toxicity caused by L-buthionine sulfoximine and 1-methyl-4-phenylpyridine

2000 • 122 citations

Genetics of Parkinson's disease.

2004 • 108 citations

Calbindin‐D_28K in the basal ganglia of patients with parkinsonism

1992 • 66 citations

Cell death induced by MPTP, a substrate for monoamine oxidase B

2000 • 49 citations

Dissecting Embryonic Neural Tissues for Transplantation

2000 • 27 citations

Nigral and Striatal Comparative Study of the Neurotoxic Action of 1‐Methyl‐4‐Phenylpyridinium Ion: Involvement of Dopamine Uptake System

1996 • 25 citations

Acute application of an interleukin-1β-converting enzyme-specific inhibitor delays axotomy-induced motoneurone death

1996 • 21 citations