Rotenone Inhibits the Mitochondrial Permeability Transition-induced Cell Death in U937 and KB Cells

Mitochondria and Apoptosis

1998 • 8,909 citations

Induction of Apoptotic Program in Cell-Free Extracts: Requirement for dATP and Cytochrome c

1996 • 5,133 citations

Molecular characterization of mitochondrial apoptosis-inducing factor

1999 • 4,031 citations

Smac, a Mitochondrial Protein that Promotes Cytochrome c–Dependent Caspase Activation by Eliminating IAP Inhibition

2000 • 3,415 citations

Mitochondrial control of cell death

2000 • 3,098 citations

The mitochondrial permeability transition

1995 • 2,412 citations

Identification of DIABLO, a Mammalian Protein that Promotes Apoptosis by Binding to and Antagonizing IAP Proteins

2000 • 2,344 citations

An APAF-1·Cytochrome c Multimeric Complex Is a Functional Apoptosome That Activates Procaspase-9

1999 • 2,088 citations

Mitochondria as the central control point of apoptosis

2000 • 1,875 citations

Mitochondrial Transport of Cations: Channels, Exchangers, and Permeability Transition

1999 • 1,509 citations

The mitochondrial permeability transition in cell death: a common mechanism in necrosis, apoptosis and autophagy

1998 • 1,381 citations

Cytotoxic activity of tumor necrosis factor is mediated by early damage of mitochondrial functions. Evidence for the involvement of mitochondrial radical generation.

1992 • 949 citations

Mitochondrial permeability transition is a central coordinating event of apoptosis.

1996 • 857 citations

Transient and Long-Lasting Openings of the Mitochondrial Permeability Transition Pore Can Be Monitored Directly in Intact Cells by Changes in Mitochondrial Calcein Fluorescence

1999 • 664 citations

BNIP3 and Genetic Control of Necrosis-Like Cell Death through the Mitochondrial Permeability Transition Pore

2000 • 605 citations

Alterations in mitochondrial structure and function are early events of dexamethasone-induced thymocyte apoptosis.

1995 • 598 citations

Depletion of the mitochondrial electron transport abrogates the cytotoxic and gene-inductive effects of TNF.

1993 • 581 citations

From calcium signaling to cell death: two conformations for the mitochondrial permeability transition pore. Switching from low- to high-conductance state

1998 • 568 citations

The Mitochondrial Permeability Transition, Release of Cytochrome c and Cell Death

2001 • 454 citations

Contribution of the mitochondrial permeability transition to lethal injury after exposure of hepatocytes to t-butylhydroperoxide

1995 • 384 citations

Regulation of the Permeability Transition Pore in Skeletal Muscle Mitochondria

1998 • 321 citations

Commitment to apoptosis is associated with changes in mitochondrial biogenesis and activity in cell lines conditionally immortalized with simian virus 40.

1994 • 320 citations

Hydrogen peroxide-induced apoptosis is CD95-independent, requires the release of mitochondria-derived reactive oxygen species and the activation of NF-κB

1999 • 319 citations

Mitochondria and cell death

2000 • 314 citations

Mitochondrial intermembrane junctional complexes and their role in cell death

2000 • 314 citations

The Cytotoxicity of Tumor Necrosis Factor Depends on Induction of the Mitochondrial Permeability Transition

1996 • 266 citations

A Ubiquinone-binding Site Regulates the Mitochondrial Permeability Transition Pore

1998 • 246 citations

The Mitochondrial Permeability Transition Pore is Modulated by Oxidative Agents Through Both Pyridine Nucleotides and Glutathione at Two Separate Sites

1996 • 233 citations

Release of Cytochrome c from Liver Mitochondria during Permeability Transition

1997 • 197 citations

Ethanol potentiates tumor necrosis factor-α cytotoxicity in hepatoma cells and primary rat hepatocytes by promoting induction of the mitochondrial permeability transition

2000 • 196 citations

Release of apoptogenic proteins from the mitochondrial intermembrane space during the mitochondrial permeability transition

1997 • 179 citations

Commitment to Apoptosis by GD3 Ganglioside Depends on Opening of the Mitochondrial Permeability Transition Pore

1999 • 166 citations

Three Classes of Ubiquinone Analogs Regulate the Mitochondrial Permeability Transition Pore through a Common Site

2000 • 148 citations

Progress on the mitochondrial permeability transition pore: regulation by complex I and ubiquinone analogs.

1999 • 144 citations

A Cytofluorometric Assay of Nuclear Apoptosis Induced in a Cell-Free System: Application to Ceramide-Induced Apoptosis

1997 • 73 citations

[20] Rapid separation of particulate and soluble fractions from isolated cell preparations (digitonin and cell cavitation procedures)

1979 • 46 citations

Tumor Necrosis Factor-α-induced Cell Killing and Activation of Transcription Factor NF-κB Are Uncoupled in L929 Cells

1998 • 45 citations

Tumor-induced apoptosis of T cells: amplification by a mitochondrial cascade.

2000 • 41 citations

Implications of the generation of reactive oxygen species by photoactivated calcein for mitochondrial studies

2000 • 38 citations

Stimulation of Oxygen Consumption Promotes Mitochondrial Calcium Accumulation, a Process Associated with, and Causally Linked to, Enhanced Formation oftert-Butylhydroperoxide-Induced DNA Single-Strand Breaks☆

1997 • 29 citations

Rotenone and pyruvate prevent the tert‐butylhydroperoxide‐induced necrosis of U937 cells and allow them to proliferate

1999 • 17 citations