Parkinsons Disease and other α-Synucleinopathies

Mutation in the α-Synuclein Gene Identified in Families with Parkinson's Disease

1997 • 7,814 citations

α-Synuclein in filamentous inclusions of Lewy bodies from Parkinson’s disease and dementia with Lewy bodies

1998 • 2,898 citations

A Drosophila model of Parkinson's disease

2000 • 2,062 citations

Dopaminergic Loss and Inclusion Body Formation in α-Synuclein Mice: Implications for Neurodegenerative Disorders

2000 • 1,729 citations

Comparative Genomics of the Eukaryotes

2000 • 1,688 citations

Mice Lacking α-Synuclein Display Functional Deficits in the Nigrostriatal Dopamine System

2000 • 1,628 citations

Synuclein: a neuron-specific protein localized to the nucleus and presynaptic nerve terminal

1988 • 1,518 citations

Stabilization of α-Synuclein Secondary Structure upon Binding to Synthetic Membranes

1998 • 1,507 citations

Acceleration of oligomerization, not fibrillization, is a shared property of both α-synuclein mutations linked to early-onset Parkinson's disease: Implications for pathogenesis and therapy

2000 • 1,497 citations

Accelerated in vitro fibril formation by a mutant α-synuclein linked to early-onset Parkinson disease

1998 • 1,460 citations

Neuropathology of Parkinsonʼs Disease

1996 • 1,457 citations

Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer disease.

1993 • 1,426 citations

The Lewy body variant of Alzheimer's disease

1990 • 1,057 citations

Identification of two distinct synucleins from human brain

1994 • 1,031 citations

Filamentous α-synuclein inclusions link multiple system atrophy with Parkinson's disease and dementia with Lewy bodies

1998 • 949 citations

Glial cytoplasmic inclusions in the CNS of patients with multiple system atrophy (striatonigral degeneration, olivopontocerebellar atrophy and Shy-Drager syndrome)

1989 • 931 citations

Fibrils Formed in Vitro from α-Synuclein and Two Mutant Forms Linked to Parkinson's Disease are Typical Amyloid

2000 • 767 citations

Fiber diffraction of synthetic α-synuclein filaments shows amyloid-like cross-β conformation

2000 • 714 citations

Both Familial Parkinson's Disease Mutations Accelerate α-Synuclein Aggregation

1999 • 695 citations

α-Synuclein Fibrillogenesis Is Nucleation-dependent

1999 • 686 citations

Glial cytoplasmic inclusions in white matter oligodendrocytes of multiple system atrophy brains contain insoluble α‐synuclein

1998 • 647 citations

Subcellular Localization of Wild-Type and Parkinson's Disease-Associated Mutant α-Synuclein in Human and Transgenic Mouse Brain

2000 • 629 citations

α-Synuclein immunoreactivity in glial cytoplasmic inclusions in multiple system atrophy

1998 • 599 citations

Senile dementia of Lewy body type

1990 • 573 citations

α-Synuclein Membrane Interactions and Lipid Specificity

2000 • 571 citations

Lewy Bodies Contain Altered α-Synuclein in Brains of Many Familial Alzheimer's Disease Patients with Mutations in Presenilin and Amyloid Precursor Protein Genes

1998 • 515 citations

Mutant and Wild Type Human α-Synucleins Assemble into Elongated Filaments with Distinct Morphologies in Vitro

1999 • 510 citations

Binding of α-Synuclein to Brain Vesicles Is Abolished by Familial Parkinson's Disease Mutation

1998 • 510 citations

Neuropathology in mice expressing human alpha-synuclein.

2000 • 499 citations

Neuropathology in Mice Expressing Human α-Synuclein

2000 • 456 citations

Synucleins in synaptic plasticity and neurodegenerative disorders

1999 • 430 citations

Interaction of Human α-Synuclein and Parkinson's Disease Variants with Phospholipids

2000 • 427 citations

Regulation of Phospholipase D2: Selective Inhibition of Mammalian Phospholipase D Isoenzymes by α- and β-Synucleins

1998 • 427 citations

Synthetic filaments assembled from C‐terminally truncated α‐synuclein

1998 • 408 citations

PHASE AND ELECTRON MICROSCOPIC OBSERVATIONS OF LEWY BODIES AND MELANIN GRANULES IN THE SUBSTANTIA NIGRA AND LOCUS CAERULEUS IN PARKINSONʼS DISEASE

1965 • 330 citations

Identification of a breast cancer-specific gene, BCSG1, by direct differential cDNA sequencing.

1997 • 328 citations

Antibodies to ?-synuclein detect Lewy bodies in many Down's syndrome brains with Alzheimer's disease

1999 • 290 citations

Effects of the mutations Ala³⁰ to Pro and Ala⁵³ to Thr on the physical and morphological properties of α‐synuclein protein implicated in Parkinson's disease

1998 • 263 citations

Membrane Association and Protein Conformation of α-Synuclein in Intact Neurons

2000 • 239 citations

Lewy bodies in cerebral cortex. Report of three cases

1978 • 230 citations

A panel of epitope-specific antibodies detects protein domains distributed throughout human ?-synuclein in lewy bodies of Parkinson's disease

2000 • 219 citations

Alpha synuclein in neurodegenerative disorders: Murderer or accomplice?

1998 • 190 citations

Parkinson's Disease-associated α-Synuclein Is More Fibrillogenic than β- and γ-Synuclein and Cannot Cross-seed Its Homologs

2000 • 177 citations

Lewy body in neurodegeneration with brain iron accumulation type 1 is immunoreactive for α-synuclein

1998 • 169 citations

Persyn, a Member of the Synuclein Family, Has a Distinct Pattern of Expression in the Developing Nervous System

1998 • 169 citations

Characterisation of isolated α-synuclein filaments from substantia nigra of Parkinson's disease brain

2000 • 152 citations

CONCENTRIC HYALINE INCLUSION BODY FORMATION IN MENTAL DISEASE ANALYSIS OF TWENTY-SEVEN CASES

1962 • 127 citations

Persyn, a member of the synuclein family, influences neurofilament network integrity

1998 • 122 citations

Microtubule-associated protein tau, heparan sulphate and α-synuclein in several neurodegenerative diseases with dementia

1999 • 71 citations

Widespread occurrence of α‐synuclein/NACP‐immunoreactive neuronal inclusions in juvenileand adult‐onset Hallervorden–Spatz diseasewith Lewy bodies

1999 • 62 citations