From acute ER stress to physiological roles of the Unfolded Protein Response

Proapoptotic BAX and BAK: A Requisite Gateway to Mitochondrial Dysfunction and Death

2001 • 3,867 citations

XBP1 mRNA Is Induced by ATF6 and Spliced by IRE1 in Response to ER Stress to Produce a Highly Active Transcription Factor

2001 • 3,799 citations

Endoplasmic Reticulum Stress Links Obesity, Insulin Action, and Type 2 Diabetes

2004 • 3,671 citations

Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-β

2000 • 3,241 citations

A central role for JNK in obesity and insulin resistance

2002 • 3,225 citations

Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase

1999 • 3,119 citations

Regulated Translation Initiation Controls Stress-Induced Gene Expression in Mammalian Cells

2000 • 3,071 citations

THE MAMMALIAN UNFOLDED PROTEIN RESPONSE

2005 • 2,964 citations

Coupling of Stress in the ER to Activation of JNK Protein Kinases by Transmembrane Protein Kinase IRE1

2000 • 2,831 citations

IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA

2002 • 2,702 citations

Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response

2000 • 2,696 citations

The mitochondrial permeability transition pore and its role in cell death

1999 • 2,326 citations

XBP-1 Regulates a Subset of Endoplasmic Reticulum Resident Chaperone Genes in the Unfolded Protein Response

2003 • 1,979 citations

CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum

1998 • 1,972 citations

Mammalian Transcription Factor ATF6 Is Synthesized as a Transmembrane Protein and Activated by Proteolysis in Response to Endoplasmic Reticulum Stress

1999 • 1,954 citations

Mitochondrial Dysfunction and Type 2 Diabetes

2005 • 1,950 citations

Perk Is Essential for Translational Regulation and Cell Survival during the Unfolded Protein Response

2000 • 1,933 citations

CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum

2004 • 1,854 citations

Gadd153 Sensitizes Cells to Endoplasmic Reticulum Stress by Down-Regulating Bcl2 and Perturbing the Cellular Redox State

2001 • 1,840 citations

ER Stress Induces Cleavage of Membrane-Bound ATF6 by the Same Proteases that Process SREBPs

2000 • 1,764 citations

ER Stress Regulation of ATF6 Localization by Dissociation of BiP/GRP78 Binding and Unmasking of Golgi Localization Signals

2002 • 1,368 citations

BAX and BAK Regulation of Endoplasmic Reticulum Ca ²⁺ : A Control Point for Apoptosis

2003 • 1,363 citations

A trip to the ER: coping with stress

2003 • 1,330 citations

Translational Control Is Required for the Unfolded Protein Response and In Vivo Glucose Homeostasis

2001 • 1,329 citations

ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats

2002 • 1,296 citations

Feedback Inhibition of the Unfolded Protein Response by GADD34-Mediated Dephosphorylation of eIF2α

2001 • 1,283 citations

Plasma cell differentiation requires the transcription factor XBP-1

2001 • 1,256 citations

Identification of the cis-Acting Endoplasmic Reticulum Stress Response Element Responsible for Transcriptional Induction of Mammalian Glucose-regulated Proteins

1998 • 1,216 citations

Diabetes Mellitus and Exocrine Pancreatic Dysfunction in Perk−/− Mice Reveals a Role for Translational Control in Secretory Cell Survival

2001 • 1,204 citations

Coupling endoplasmic reticulum stress to the cell death program

2004 • 1,172 citations

Cross-Talk between Two Cysteine Protease Families

2000 • 1,158 citations

IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response

2002 • 1,031 citations

XBP1, Downstream of Blimp-1, Expands the Secretory Apparatus and Other Organelles, and Increases Protein Synthesis in Plasma Cell Differentiation

2004 • 978 citations

Translation reinitiation at alternative open reading frames regulates gene expression in an integrated stress response

2004 • 928 citations

ATF6 Activated by Proteolysis Binds in the Presence of NF-Y (CBF) Directly to thecis-Acting Element Responsible for the Mammalian Unfolded Protein Response

2000 • 921 citations

A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells

1998 • 888 citations

Targeted disruption of the Chop gene delays endoplasmic reticulum stress–mediated diabetes

2002 • 858 citations

Immunoglobulin heavy chain binding protein

1983 • 849 citations

Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP-1

2003 • 843 citations

Activation of Caspase-12, an Endoplastic Reticulum (ER) Resident Caspase, through Tumor Necrosis Factor Receptor-associated Factor 2-dependent Mechanism in Response to the ER Stress

2001 • 832 citations

EIF2AK3, encoding translation initiation factor 2-α kinase 3, is mutated in patients with Wolcott-Rallison syndrome

2000 • 800 citations

Endoplasmic Reticulum Stress Activates Cleavage of CREBH to Induce a Systemic Inflammatory Response

2006 • 788 citations

ATF4 Is a Substrate of RSK2 and an Essential Regulator of Osteoblast Biology

2004 • 775 citations

Peptide-binding specificity of the molecular chaperone BiP

1991 • 763 citations

Identification and Characterization of Pancreatic Eukaryotic Initiation Factor 2 α-Subunit Kinase, PEK, Involved in Translational Control

1998 • 763 citations

Targeted disruption of the Chop gene delays endoplasmic reticulum stress–mediated diabetes

2002 • 724 citations

Complementary Signaling Pathways Regulate the Unfolded Protein Response and Are Required for C. elegans Development

2001 • 693 citations

Two Distinct Stress Signaling Pathways Converge Upon the CHOP Promoter During the Mammalian Unfolded Protein Response

2002 • 666 citations

Affinity panning of a library of peptides displayed on bacteriophages reveals the binding specificity of BiP

1993 • 650 citations

XBP1

2004 • 627 citations

The RAG Proteins and V(D)J Recombination: Complexes, Ends, and Transposition

2000 • 616 citations

Nitric oxide-induced apoptosis in pancreatic β cells is mediated by the endoplasmic reticulum stress pathway

2001 • 594 citations

The nontransmembrane tyrosine phosphatase PTP-1B localizes to the endoplasmic reticulum via its 35 amino acid C-terminal sequence

1992 • 593 citations

Bax and Bak can localize to the endoplasmic reticulum to initiate apoptosis

2003 • 586 citations

The PERK Eukaryotic Initiation Factor 2α Kinase Is Required for the Development of the Skeletal System, Postnatal Growth, and the Function and Viability of the Pancreas

2002 • 584 citations

A mutation in the insulin 2 gene induces diabetes with severe pancreatic β-cell dysfunction in the Mody mouse

1999 • 555 citations

An essential role in liver development for transcription factor XBP-1

2000 • 503 citations

Coupling Endoplasmic Reticulum Stress to the Cell Death Program

2002 • 480 citations

Involvement of Endoplasmic Reticulum Stress in Insulin Resistance and Diabetes

2004 • 467 citations

Stress-induced gene expression requires programmed recovery from translational repression

2003 • 450 citations

Ligand-independent Dimerization Activates the Stress Response Kinases IRE1 and PERK in the Lumen of the Endoplasmic Reticulum

2000 • 408 citations

The unfolded protein response coordinates the production of endoplasmic reticulum protein and endoplasmic reticulum membrane.

1997 • 408 citations

Control of mRNA translation preserves endoplasmic reticulum function in beta cells and maintains glucose homeostasis

2005 • 408 citations

Control of PERK eIF2α kinase activity by the endoplasmic reticulum stress-induced molecular chaperone P58 ^IPK

2002 • 360 citations

Sequential Waves of Functionally Related Proteins Are Expressed When B Cells Prepare for Antibody Secretion

2003 • 351 citations

Overexpression of GRP78 mitigates stress induction of glucose regulated proteins and blocks secretion of selective proteins in Chinese hamster ovary cells.

1992 • 348 citations

ATF6 as a Transcription Activator of the Endoplasmic Reticulum Stress Element: Thapsigargin Stress-Induced Changes and Synergistic Interactions with NF-Y and YY1

2000 • 345 citations

Diabetes and tolerance in transgenic mice expressing class II MHC molecules in pancreatic beta cells

1988 • 343 citations

Inhibition of a constitutive translation initiation factor 2α phosphatase, CReP, promotes survival of stressed cells

2003 • 309 citations

The unfolded protein response sensor IRE1α is required at 2 distinct steps in B cell lymphopoiesis

2005 • 302 citations

Activation of an Unfolded Protein Response during Differentiation of Antibody-secreting B Cells

2002 • 297 citations

A lag in intracellular degradation of mutant alpha 1-antitrypsin correlates with the liver disease phenotype in homozygous PiZZ alpha 1-antitrypsin deficiency.

1994 • 293 citations

Endoplasmic Reticulum Stress-Induced Formation of Transcription Factor Complex ERSF Including NF-Y (CBF) and Activating Transcription Factors 6α and 6β That Activates the Mammalian Unfolded Protein Response

2001 • 291 citations

OASIS, a CREB/ATF-family member, modulates UPR signalling in astrocytes

2005 • 286 citations

Endoplasmic Reticulum Stress-induced mRNA Splicing Permits Synthesis of Transcription Factor Hac1p/Ern4p That Activates the Unfolded Protein Response

1997 • 283 citations

The unfolded protein response sensor IRE1α is required at 2 distinct steps in B cell lymphopoiesis

2005 • 280 citations

A Mammalian Homologue of GCN2 Protein Kinase Important for Translational Control by Phosphorylation of Eukaryotic Initiation Factor-2α

2000 • 276 citations

A role for BiP as an adjustor for the endoplasmic reticulum stress-sensing protein Ire1

2004 • 271 citations

Characterization of a mammalian homolog of the GCN2 eukaryotic initiation factor 2α kinase

1999 • 254 citations

Genetic Interactions Due to Constitutive and Inducible Gene Regulation Mediated by the Unfolded Protein Response in C. elegans

2005 • 248 citations

P58IPK, a Novel Endoplasmic Reticulum Stress-inducible Protein and Potential Negative Regulator of eIF2α Signaling

2003 • 246 citations

Dimerization and Release of Molecular Chaperone Inhibition Facilitate Activation of Eukaryotic Initiation Factor-2 Kinase in Response to Endoplasmic Reticulum Stress

2002 • 245 citations

Membrane biogenesis during B cell differentiation: most endoplasmic reticulum proteins are expressed coordinately.

1990 • 226 citations

Stable Binding of ATF6 to BiP in the Endoplasmic Reticulum Stress Response

2005 • 221 citations

Pancreatic β-Cell Failure and Diabetes in Mice With a Deletion Mutation of the Endoplasmic Reticulum Molecular Chaperone Gene P58IPK

2005 • 207 citations

ATF6 modulates SREBP2-mediated lipogenesis

2004 • 206 citations

Protein-tyrosine Phosphatase 1B Potentiates IRE1 Signaling during Endoplasmic Reticulum Stress

2004 • 204 citations

Procollagen folding and assembly: The role of endoplasmic reticulum enzymes and molecular chaperones

1999 • 203 citations

Coordinated action of protein tyrosine phosphatases in insulin signal transduction

2002 • 187 citations

ATF4, the Osteoblast Accumulation of Which Is Determined Post-translationally, Can Induce Osteoblast-specific Gene Expression in Non-osteoblastic Cells

2004 • 178 citations

Interaction of heavy chain binding protein (BiP/GRP78) with adenine nucleotides.

1989 • 176 citations

Protein folding in the ER

1999 • 171 citations

Pancreatic β-cell growth and survival – a role in obesity-linked type 2 diabetes?

2002 • 168 citations

Alpha-1-antitrypsin deficiency: A new paradigm for hepatocellular carcinoma in genetic liver disease

2005 • 168 citations

Fluoride Induces Endoplasmic Reticulum Stress in Ameloblasts Responsible for Dental Enamel Formation

2005 • 164 citations

CREB-H: a novel mammalian transcription factor belonging to the CREB/ATF family and functioning via the box-B element with a liver-specific expression

2001 • 158 citations

Compensatory responses in mice carrying a null mutation for Ins1 or Ins2.

2001 • 134 citations

Nitric oxide and vascular responses in Type I diabetes

2000 • 118 citations

Structure and Intermolecular Interactions of the Luminal Dimerization Domain of Human IRE1α

2003 • 115 citations

Protein Serine/Threonine Phosphatase Ptc2p Negatively Regulates the Unfolded-Protein Response by Dephosphorylating Ire1p Kinase

1998 • 114 citations

Structure and assembly of the endoplasmic reticulum. The synthesis of three major endoplasmic reticulum proteins during lipopolysaccharide-induced differentiation of murine lymphocytes.

1985 • 107 citations

Luman is capable of binding and activating transcription from the unfolded protein response element

2005 • 92 citations

Tisp40, a spermatid specific bZip transcription factor, functions by binding to the unfolded protein response element via the Rip pathway

2005 • 67 citations

Mechanisms of β-Cell Death in Response to Double-Stranded (ds) RNA and Interferon-γ

2001 • 54 citations

A role for the unfolded protein response in optimizing antibody secretion

2004 • 45 citations

Structure and assembly of the endoplasmic reticulum

1989 • 45 citations

Biogenesis of the endoplasmic reticulum in activated B lymphocytes: Temporal relationships between the induction of protein N-glycosylation activity and the biosynthesis of membrane protein and phospholipid

1991 • 37 citations

Endoplasmic Reticulum Biogenesis

2007 • 9 citations